The role of human aldo-keto reductases in the metabolic activation and detoxication of polycyclic aromatic hydrocarbons: Interconversion of PAH catechols and PAH o-quinones

Frontiers in Pharmacology

Volumn 3 NOV, Issue , 2012, Pages

  Zhang, Li ^a   Jin, Yi ^a   Huang, Meng ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aldo keto reductases; Conjugation reactions; O quinones; Phase II metabolism; Polycyclic aromatic hydrocarbons; Redox cycling

Indexed keywords

7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; ALDO KETO REDUCTASE; ALDO KETO REDUCTASE 1A1; ALDO KETO REDUCTASE 1B1; ALDO KETO REDUCTASE 1B10; ALDO KETO REDUCTASE 1C1; ALDO KETO REDUCTASE 1C2; ALDO KETO REDUCTASE 1C3; ALDO KETO REDUCTASE 1C4; ALDO KETO REDUCTASE 1C9; ALDO KETO REDUCTASE 7A2; BENZO[A]PYRENE 7,8 CATECHOL; BENZO[A]PYRENE 7,8 DIONE; BENZO[A]PYRENE DERIVATIVE; CARBONYL REDUCTASE; CATECHOL METHYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; OXIDOREDUCTASE; POLYCYCLIC AROMATIC HYDROCARBON CATECHOL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DIHYDRODIOL; POLYCYCLIC AROMATIC HYDROCARBON O QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A3; SULFOTRANSFERASE 1E1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CHEMICAL STRUCTURE; CONJUGATION; DETOXIFICATION; DNA DAMAGE; ENZYME SPECIFICITY; HUMAN; INTERCONVERSION; LUNG ALVEOLUS CELL; LUNG CARCINOGENESIS; METABOLIC ACTIVATION; METABOLISM; MOLECULAR DYNAMICS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN FUNCTION; STEREOCHEMISTRY;

EID: 84870690777     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00193     Document Type: Article

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