Detoxication of structurally diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 25644-25654

  Zhang, Li ^a   Jin, Yi ^a   Chen, Mo ^c   Huang, Meng ^a   Harvey, Ronald G ^b   Blair, Ian A ^b   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALDO-KETO REDUCTASE; ANAEROBIC CONDITIONS; CATALYTIC EFFICIENCIES; CATECHOL-O-METHYLTRANSFERASE; DITHIOTHREITOL; HPLC-UV; HUMAN LUNG CELLS; IN-LINE; ISOMERIC PRODUCTS; LC-MS/MS; METABOLIC ACTIVATION; METHYL GROUP DONOR; O-METHYLATION; POSITIONAL ISOMERS; RADIOMETRIC DETECTION; REDOX-ACTIVE;

ALKYLATION; AMINO ACIDS; CELL CULTURE; CRYSTAL STRUCTURE; FUNCTIONAL GROUPS; HYDROCARBONS; ISOMERS; METABOLISM; METABOLITES; METHYLATION; POLYCYCLIC AROMATIC HYDROCARBONS;

PHENOLS;

BENZO[A]PYRENE 7,8 CATECHOL; CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; POLYCYCLIC AROMATIC HYDROCARBON; QUINONE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DETOXIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MASS SPECTROMETRY; METHYLATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOMETRY; ULTRAVIOLET RADIATION;

ANIMALS; CATALYTIC DOMAIN; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LUNG; METABOLIC DETOXICATION, DRUG; METHYLATION; MODELS, MOLECULAR; OXYGEN; POLYCYCLIC HYDROCARBONS, AROMATIC; QUINONES; RECOMBINANT PROTEINS; SWINE;

NICOTIANA TABACUM;

EID: 79960436551     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.240739     Document Type: Article

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