Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis

Addiction Biology

Volumn 17, Issue 6, 2012, Pages 1057-1067

  Nissinen, Antti E ^a,b   Laitinen, L Maria ^a,b   Kakko, Sakari ^a,b   Helander, Anders ^c   Savolainen, Markku J ^a,b   Hörkkö, Sohvi ^a,b  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alcohol; antibody; ethanol; pancreatitis; phosphatidylethanol; phospholipid

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BIOCHEMICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PHOSPHATIDYLETHANOLAMINE;

ADULT; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLIC PANCREATITIS; ALCOHOLISM; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; ANTIBODIES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; FEMALE; GLYCEROPHOSPHOLIPIDS; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; PANCREATITIS, ALCOHOLIC; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84870665572     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2010.00279.x     Document Type: Article

References (58)

1. Alling C, Gustavsson L, Anggard E, (1983) An abnormal phospholipid in rat organs after ethanol treatment. FEBS Lett 152: 24-28.
2. Alling C, Gustavsson L, Månsson JE, Benthin G, Anggård E, (1984) Phosphatidylethanol formation in rat organs after ethanol treatment. Biochim Biophys Acta 793: 119-122.
3. Amore A, Roccatello D, Picciotto G, Emancipator SN, Ropolo R, Cacace G, Suriani A, Gianoglio B, Sena LM, Cirina P, Mazzucco G, Alfieri V, Piccoli G, Coppo R, De Filippi PG, (1997) Processing of IgA aggregates in a rat model of chronic liver disease. Clin Immunol Immunopathol 84: 107-114.
4. Aradóttir S, Lundqvist C, Alling C, (2002) Phosphatidylethanol in rat organs after ethanol exposure. Alcohol Clin Exp Res 26: 514-518.
5. Aradóttir S, Moller K, Alling C, (2004) Phosphatidylethanol formation and degradation in human and rat blood. Alcohol Alcohol 39: 8-13.
6. Blomstrand R, (1971) Observations of the formation of ethanol in the intestinal tract in man. Life Sci II 10: 575-582.
7. Bradley EL 3rd, (1993) A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg 128: 586-590.
8. Chang M, Wang Q, Norman DC, (2002) Diminished proliferation of B blast cell in response to cytokines in ethanol-consuming mice. Immunopharmacol Immunotoxicol 24: 69-82.
9. Chedid A, Chadalawada KR, Morgan TR, Moritz TE, Mendenhall CL, Hammond JB, Emblad PW, Cifuentes DC, Kwak JW, Gilman-Sachs A, Beaman KD, (1994) Phospholipid antibodies in alcoholic liver disease. Hepatology 20: 1465-1471.
10. Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL, (1995) Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376: 177-180.
11. Cook RT, (1998) Alcohol abuse, alcoholism, and damage to the immune system-a review. Alcohol Clin Exp Res 22: 1927-1942.
12. Cox D, Fox L, Tian R, Bardet W, Skaley M, Mojsilovic D, Gumperz J, Hildebrand W, (2009) Determination of cellular lipids bound to human CD1d molecules. Plos ONE 4: e5325.
13. Faria AMC, Weiner HL, (2005) Oral tolerance. Immunol Rev 206: 232-259.
14. Faricelli R, Esposito S, Toniato E, Flacco M, Conti P, Martinotti S, Robuffo I, (2008) A new diagnostic approach to better identify antiphospholipid syndrome. Int J Immunopathol Pharmacol 21: 387-392.
15. Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S, (2009) Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol 53: 2186-2196.
16. Friedman A, (1996) Induction of anergy in Th1 lymphocytes by oral tolerance. Importance of antigen dosage and frequency of feeding. Ann NY Acad Sci 778: 103-110.
17. Gnann H, Engelmann C, Skopp G, Winkler M, Auwärter V, Dresen S, Ferreirós N, Wurst FM, Weinmann W, (2010) Identification of 48 homologues of phosphatidylethanol in blood by LC-ESI-MS/MS. Anal Bioanal Chem 396: 2415-2423.
18. Gonzàlez-Quintela A, Alende MR, Gamallo R, Gonzàlez-Gil P, López-Ben S, Tomé S, Otero E, Torre JA, (2003) Serum immunoglobulins (IgG, IgA, IgM) in chronic hepatitis C. A comparison with non-cirrhotic alcoholic liver disease. Hepatogastroenterology 50: 2121-2126.
19. Gonzàlez-Quintela A, Alende R, Gude F, Campos J, Rey J, Meijide LM, Fernandez-Merino C, Vidal C, (2008) Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities. Clin Exp Immunol 151: 42-50.
20. Gunnarsson T, Karlsson A, Hansson P, Johnson G, Alling C, Odham G, (1998) Determination of phosphatidylethanol in blood from alcoholic males using high-performance liquid chromatography and evaporative light scattering or electrospray mass spectrometric detection. J Chromatogr B Biomed Sci Appl 705: 243-249.
21. Hannuksela ML, Liisanantti MK, Nissinen AET, Savolainen MJ, (2007) Biochemical markers of alcoholism. Clin Chem Lab Med 45: 953-961.
22. Hansson P, Caron M, Johnson G, Gustavsson L, Alling C, (1997) Blood phosphatidylethanol as a marker of alcohol abuse: levels in alcoholic males during withdrawal. Alcohol Clin Exp Res 21: 108-110.
23. Hartmann S, Aradottir S, Graf M, Wiesbeck G, Lesch O, Ramskogler K, Wolfersdorf M, Alling C, Wurst FM, (2007) Phosphatidylethanol as a sensitive and specific biomarker: comparison with gamma-glutamyl transpeptidase, mean corpuscular volume and carbohydrate-deficient transferrin. Addict Biol 12: 81-84.
24. Helander A, Zheng Y, (2009) Molecular species of the alcohol biomarker phosphatidylethanol in human blood measured by LC-MS. Clin Chem 55: 1395-1405.
25. Hietala J, Koivisto H, Latvala J, Anttila P, Niemelä O, (2006) IgAs against acetaldehyde-modified red cell protein as a marker of ethanol consumption in male alcoholic subjects, moderate drinkers, and abstainers. Alcohol Clin Exp Res 30: 1693-1698.
26. Hughes GRV, (2008) Hughes Syndrome (the antiphospholipid syndrome): ten clinical lessons. Autoimmun Rev 7: 262-266.
27. Kankaanpää J, Turunen SP, Moilanen V, Hörkkö S, Remes AM, (2009) Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease. Neurobiol Dis 33: 467-472.
28. Karvonen J, Päivänsalo M, Kesäniemi YA, Hörkkö S, (2003) Immunoglobulin M type of autoantibodies to oxidized low-density lipoprotein has an inverse relation to carotid artery atherosclerosis. Circulation 108: 2107-2112.
29. Keller AC, Mucida D, Gomes E, Faquim-Mauro E, Faria AMC, Rodriguez D, Russo M, (2006) Hierarchical suppression of asthma-like responses by mucosal tolerance. J Allergy Clin Immunol 117: 283-290.
30. Krebs HA, Perkins JR, (1970) The physiological role of liver alcohol dehydrogenase. Biochem J 118: 635-644.
31. Kusner DJ, Hall CF, Jackson S, (1999) Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles. J Immunol 162: 2266-2274.
32. Leitinger N, (2008) The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans. Subcell Biochem 49: 325-350.
33. Lundqvist C, Alling C, Aradottir S, Gustavsson L, (1994) Agonist-stimulated and basal phosphatidylethanol formation in neutrophils from alcoholics. Alcohol Clin Exp Res 18: 580-586.
34. Marques P, Tippetts S, Allen J, Javors M, Alling C, Yegles M, Pragst F, Wurst F, (2010) Estimating driver risk using alcohol biomarkers, interlock blood alcohol concentration tests and psychometric assessments: initial descriptives. Addiction 105: 226-239.
35. McDermott M, Wakelam MJO, Morris AJ, (2004) Phospholipase D. Biochem Cell Biol 82: 225-253.
36. McMillan SA, Douglas JP, Archbold GP, McCrum EE, Evans AE, (1997) Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations. J Clin Pathol 50: 819-822.
37. Melamed D, Friedman A, (1993) Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin. Eur J Immunol 23: 935-942.
38. Nakos G, Tziakou E, Maneta-Peyret L, Nassis C, Lekka ME, (2005) Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome. Intensive Care Med 31: 1401-1408.
39. Niemelä O, (2007) Biomarkers in alcoholism. Clin Chim Acta 377: 39-49.
40. Nissinen AE, Mäkelä SM, Vuoristo JT, Liisanantti MK, Hannuksela ML, Hörkkö S, Savolainen MJ, (2008) Immunological detection of in vitro formed phosphatidylethanol-an alcohol biomarker-with monoclonal antibodies. Alcohol Clin Exp Res 32: 921-928.
41. Pannequin J, Delaunay N, Darido C, Maurice T, Crespy P, Frohman MA, Balda MS, Matter K, Joubert D, Bourgaux J, Bali J, Hollande F, (2007) Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure. Mol Cancer Res 5: 1147-1157.
42. Roccatello D, Picciotto G, Torchio M, Ropolo R, Ferro M, Franceschini R, Quattrocchio G, Cacace G, Coppo R, Sena LM, De Filippi PG, Piccoli G, (1993) Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients. The role of asialoglycoprotein receptors. Lab Invest 69: 714-723.
43. Rolla R, Vay D, Mottaran E, Parodi M, Traverso N, Aricó S, Sartori M, Bellomo G, Klassen LW, Thiele GM, Tuma DJ, Albano E, (2000) Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology 31: 878-884.
44. Rolla R, Vay D, Mottaran E, Parodi M, Vidali M, Sartori M, Rigamonti C, Bellomo G, Albano E, (2001) Antiphospholipid antibodies associated with alcoholic liver disease specifically recognise oxidised phospholipids. Gut 49: 852-859.
45. Sacanella E, Estruch R, Gayà A, Fernández-Solà J, Antúnez E, Urbano-Márquez A, (1998) Activated lymphocytes (CD25+ CD69+ cells) and decreased CD19+ cells in well-nourished chronic alcoholics without ethanol-related diseases. Alcohol Clin Exp Res 22: 897-901.
46. Sämpi M, Ukkola O, Päivänsalo M, Kesäniemi YA, Binder CJ, Hörkkö S, (2008) Plasma interleukin-5 levels are related to antibodies binding to oxidized low-density lipoprotein and to decreased subclinical atherosclerosis. J Am Coll Cardiol 52: 1370-1378.
47. Sarkola T, Eriksson CJ, (2001) Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans. Alcohol Clin Exp Res 25: 513-516.
48. Schifferli JA, Ng YC, Peters DK, (1986) The role of complement and its receptor in the elimination of immune complexes. N Engl J Med 315: 488-495.
49. Sonier B, Patrick C, Ajjikuttira P, Scott FW, (2009) Intestinal immune regulation as a potential diet-modifiable feature of gut inflammation and autoimmunity. Int Rev Immunol 28: 414-445.
50. Stevens T, Conwell DL, Zuccaro G, (2004) Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments. Am J Gastroenterol 99: 2256-2270.
51. Tsimikas S, Witztum JL, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG, (2004) High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation 110: 1406-1412.
52. Varga A, Alling C, (2002) Formation of phosphatidylethanol in vitro in red blood cells from healthy volunteers and chronic alcoholics. J Lab Clin Med 140: 79-83.
53. Varga A, Hansson P, Johnson G, Alling C, (2000) Normalization rate and cellular localization of phosphatidylethanol in whole blood from chronic alcoholics. Clin Chim Acta 299: 141-150.
54. Worrall S, de Jersey J, Wilce PA, Seppä K, Hurme L, Sillanaukee P, (1996) Relationship between alcohol intake and immunoglobulin a immunoreactivity with acetaldehyde-modified bovine serum albumin. Alcohol Clin Exp Res 20: 836-840.
55. Wurst FM, Thon N, Aradottir S, Hartmann S, Wiesbeck GA, Lesch O, Skala K, Wolfersdorf M, Weinmann W, Alling C, (2010) Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports. Addict Biol 15: 88-95.
56. Yang SF, Freer S, Benson AA, (1967) Transphosphatidylation by phospholipase D. J Biol Chem 242: 477-484.
57. Zhang X, Izikson L, Liu L, Weiner HL, (2001) Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 167: 4245-4253.
58. Zima T, Fialová L, Mikulíková L, Malbohan IM, Popov P, Nespor K, (1998) Antibodies against phospholipids and oxidized LDL in alcoholic patients. Physiol Res 47: 351-355.