Normalization rate and cellular localization of phosphatidylethanol in whole blood from chronic alcoholics

Clinica Chimica Acta

Volumn 299, Issue 1-2, 2000, Pages 141-150

  Varga, Arthur ^a   Hansson, Per ^a   Johnson, Göran ^b   Alling, Christer ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood; Chronic alcoholics; Compartment; Half life; Normalization; Phosphatidylethanol

Indexed keywords

BIOCHEMICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; PHOSPHATIDYLETHANOL; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID ANALYSIS; MALE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL;

ALCOHOLISM; CELL SEPARATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROCYTES; ETHANOL; FEMALE; GLYCEROPHOSPHOLIPIDS; HALF-LIFE; HUMANS; LEUKOCYTES; MALE; REFERENCE VALUES; TEMPERANCE; TIME FACTORS;

EID: 0033949285     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(00)00291-6     Document Type: Article

References (18)

1. Hansson P., Caron M., Johnson G., Gustavsson L., Alling C. Blood phosphatidylethanol as a marker of alcohol abuse: Levels in alcoholic males during withdrawal. Alcohol Clin Exp Res. 21:1997;108-110.
2. Varga A., Hansson P., Lundqvist C., Alling C. Phosphatidylethanol in blood as a marker of ethanol consumption in healthy volunteers: Comparison with other markers. Alcohol Clin. Exp Res. 22:1998;1832-1837.
3. Alling C., Gustavsson L., Änggård E. An abnormal phospholipid in rat organs after ethanol treatment. FEBS Lett. 152:1983;24-28.
4. Gustavsson L., Alling C. Formation of phosphatidylethanol in rat brain by phospholipase D. Biochem Biophys Res Commun. 142:1987;958-963.
5. Kobayashi M., Kanfer J. Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D. J Neurochem. 48:1987;1597-1603.
6. Seidler L., Kaszkin M., Kinzel V. Primary alcohols and phosphatidylcholine metabolism in rat brain synaptosomal membranes via phospholipase D. Pharmacol Toxicol. 78:1996;249-253.
7. Yu C.-H., Liu S.-Y., Panagia V. The transphosphatidylation activity of phospholipase D. Mol Cell Biochem. 157:1996;101-105.
8. Liscovitch M., Czarny M., Fiucci G., Lavie Y., Tang X. Localization and possible functions of phospholipase D isozymes. Biochim Biophys Acta. 1439:1999;245-263.
9. Exton J.H. Phospholipase D, enzymology, mechanisms of regulation, and function. Physiol Rev. 77:1997;303-320.
10. Lundqvist C., Alling C., Aradottir S., Gustavsson L. Agonist-stimulated phospholipase D-activity and phosphatidylethanol accumulation in neutrophils from alcoholics. Alcohol Clin Exp Res. 18:1994;580-586.
11. Rakhimov M.M., Almatov K.T., Mirtalipov D.T., Kasimova G.M., Khodzhaeva N.I. Formation of phosphatidylethanol in alcoholic intoxication. Vopr Med Khim. 34:1988;101-107.
12. Cockcroft S. Phospholipase D: regulation by GTPases and protein kinase C and physiological relevance. Prog Lipid Res. 35:1997;345-370.
13. Gunnarsson T., Karlsson A., Hansson P., Johnson G., Alling C., Odham G. Determination of phosphatidylethanol in blood from alcoholic males using high-performance liquid chromatography and evaporative light scattering or electrospray mass spectrometric detection. J Chromatogr B. 705:1998;243-249.
14. Jeppson J.-O., Kristensson H., Firniani C. Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clin Chem. 39:1993;2115-2120.
15. Burtis C.A., Ashwood E.R. Tietz textbook of clinical chemistry. 2nd ed. 1994;Saunders, Philadelphia, PA.
16. Lundqvist C., Aradottir S., Alling C., Boyano-Adanez Md.C., Gustavsson L. Phosphatidylethanol formation and degradation in brains of acutely and repeatedly ethanol-treated rats. Neurosci Lett. 179:1994;127-131.
17. Stibler H., Borg S., Joustra M. Micro anion exchange chromatography of carbohydrate-deficient transferrin in serum in relation to alcohol consumption (Swedish patent 8400587-5). Alcohol Clin Exp Res. 10:1986;535-544.
18. Lesch O.M., Walter H., Antal J., Kanitz R.D., Kovacz A., Leitner A., Marx B., Neumeister A., Saletu M., Semler B., Stumpf I., Mader R. Alcohol dependence: is carbohydrate-deficient transferrin a marker for alcohol intake? Alcohol Alcohol. 31:1996;257-264.