IgAs against acetaldehyde-modified red cell protein as a marker of ethanol consumption in male alcoholic subjects, moderate drinkers, and abstainers

Alcoholism: Clinical and Experimental Research

Volumn 30, Issue 10, 2006, Pages 1693-1698

  Hietala, Johanna ^a   Koivisto, Heidi ^a   Latvala, Jaana ^a   Anttila, Petra ^a   Niemelä, Onni ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b SEINÄJOKI CENTRAL HOSPITAL   (Finland)

Author keywords

Acetaldehyde; Ethanol; Immune Responses; Marker

Indexed keywords

ACETALDEHYDE MODIFIED RED CELL PROTEIN; ALCOHOL; BIOCHEMICAL MARKER; IMMUNOGLOBULIN A; UNCLASSIFIED DRUG;

ADULT; ALCOHOL ABSTINENCE; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRINKING BEHAVIOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; INTERVIEW; LABORATORY DIAGNOSIS; LIVER FUNCTION; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY;

ACETALDEHYDE; ADULT; ALCOHOL DRINKING; ALCOHOLISM; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CROSS-SECTIONAL STUDIES; DRINKING BEHAVIOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; ERYTHROCYTES; ETHANOL; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULIN A; INTERVIEWS; INTERVIEWS AS TOPIC; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; TEMPERANCE;

EID: 33749079901     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00204.x     Document Type: Article

References (20)

1. Amore A, Coppo R, Roccatello D, Piccoli G, Mazzucco G, Gomez-Chiarri M, Lamm ME, Emancipator SN (1994) Experimental IgA nephropathy secondary to hepatocellular injury induced by dietary deficiencies and heavy alcohol intake. Lab Invest 70:68-77.
2. Anttila P, Järvi K, Latvala J, Blake JE, Niemelä O (2003) A new modified gamma-%CDT method improves the detection of problem drinking: studies in alcoholics with or without liver disease. Clin Chim Acta 338:45-51.
3. Israel Y, Hurwitz E, Niemelä O, Arnon R (1986) Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc Natl Acad Sci U S A 83:7923-7927.
4. Koskinas J, Kenna JG, Bird GL, Alexander GJ, Williams R (1992) Immunoglobulin A antibody to a 200-kilodalton cytosolic acetaldehyde adduct in alcoholic hepatitis. Gastroenterology 103:1860-1867.
5. Kovacs EJ, Messingham KA (2002) Influence of alcohol and gender on immune response. Alcohol Res Health 26:257-263.
6. Latvala J, Hietala J, Koivisto H, Järvi K, Anttila P, Niemelä O (2005) Immune responses to ethanol metabolites and cytokine profiles differentiate alcoholics with or without liver disease. Am J Gastroenterol 100:1303-1310.
7. Makkonen K, Viitala KI, Parkkila S, Niemelä O (2001) Serum IgG and IgE antibodies against mold-derived antigens in patients with symptoms of hypersensitivity. Clin Chim Acta 305:89-98.
8. Niemelä O (2001) Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury. Free Radic Biol Med 31:1533-1538.
9. Niemelä O, Israel Y (1992) Hemoglobin-acetaldehyde adducts in human alcohol abusers. Lab Invest 67:246-252.
10. Salaspuro M (1996) Bacteriocolonic pathway for ethanol oxidation: characteristics and implications. Ann Med 28:195-200.
11. Seitz HK, Gartner U, Egerer G, Simanowski UA (1994) Ethanol metabolism in the gastrointestinal tract and its possible consequences. Alcohol Alcohol 2 (suppl): 157-162.
12. Sillanaukee P, Olsson U (2001) Improved diagnostic classification of alcohol abusers by combining carbohydrate-deficient transferrin and gamma-glutamyltransferase. Clin Chem 47:681-685.
13. Tuma DJ, Klassen LW (1992) Immune responses to acetaldehyde-protein adducts: role in alcoholic liver disease. Gastroenterology 103:1969-1973.
14. van de Wiel A, van Hattum J, Schuurman HJ, Kater L (1988) Immunoglobulin A in the diagnosis of alcoholic liver disease. Gastroenterology 94:457-462.
15. Viitala K, Israel Y, Blake JE, Niemelä O (1997) Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: relationship to liver disease severity and alcohol consumption. Hepatology 25:1418-1424.
16. Visapää JP, Jokelainen K, Nosova T, Salaspuro M (1998) Inhibition of intracolonic acetaldehyde production and alcoholic fermentation in rats by ciprofloxacin. Alcohol Clin Exp Res 22:1161-1164.
17. Worrall S, de Jersey J, Shanley BC, Wilce PA (1991) Antibodies against acetaldehyde-modified epitopes: an elevated IgA response in alcoholics. Eur J Clin Invest 21:90-95.
18. Worrall S, de Jersey J, Wilce PA, Seppä K, Hurme L, Sillanaukee P (1996) Relationship between alcohol intake and immunoglobulin a immunoreactivity with acetaldehyde-modified bovine serum albumin. Alcohol Clin Exp Res 20:836-840.
19. Worrall S, de Jersey J, Wilce PA, Seppä K, Hurme L, Sillanaukee P (1998) Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption. Alcohol Clin Exp Res 22:1921-1926.
20. Xu D, Thiele GM, Beckenhauer JL, Klassen LW, Sorrell MF, Tuma DJ (1998) Detection of circulating antibodies to malondialdehydeacetaldehyde adducts in ethanol-fed rats. Gastroenterology 115:686-692.