Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure

Molecular Cancer Research

Volumn 5, Issue 11, 2007, Pages 1147-1157

  Pannequin, Julie ^a,b   Delaunay, Nathalie ^a,b   Darido, Charbel ^a,b   Maurice, Tangui ^c   Crespy, Philippe ^a,b   Frohman, Michael A ^e   Balda, Maria S ^f   Matter, Karl ^f   Joubert, Dominique ^a,b   Bourgaux, Jean François ^d   Bali, Jean Pierre ^a,b   Hollande, Frédéric ^a,b  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b UNIV MONTPELLIER   (France)

^c University of Montpellier   (France)

^d DEPARTMENT OF NEUROLOGY   (France)

^e STONY BROOK UNIVERSITY   (United States)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL DEHYDROGENASE; ALCOHOL DERIVATIVE; CLAUDIN 1; PHOSPHATIDYLETHANOL; PHOSPHOLIPASE D; PROTEIN ZO1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZONAB; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; HYPERPLASIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ADENOCARCINOMA; ALCOHOL DEHYDROGENASE; ANIMALS; CACO-2 CELLS; CCAAT-ENHANCER-BINDING PROTEINS; CELL COUNT; COLONIC NEOPLASMS; ENDOCYTOSIS; ETHANOL; GLYCEROPHOSPHOLIPIDS; HEAT-SHOCK PROTEINS; HUMANS; HYPERPLASIA; INTESTINES; MEMBRANE PROTEINS; MICE; PHOSPHOLIPASE D; PHOSPHOPROTEINS;

MUS;

EID: 36249011285     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-0198     Document Type: Article

References (45)

1. Boffetta P, Hashibe M. Alcohol and cancer. Lancet Oncol 2006;7:149-56.
2. Roy HK, Gulizia JM, Karolski WJ, Ratashak A, Sorrell MF, Tuma D. Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev 2002;11:1499-502.
3. Seitz HK, Matsuzaki S, Yokoyama A, Homann N, Vakevainen S, Wang XD. Alcohol and cancer. Alcohol Clin Exp Res 2001;25:137-43S.
4. Rajendram R, Preedy VR. Effect of alcohol consumption on the gut. Dig Dis 2005;23:214-21.
5. Rao RK, Seth A, Sheth P. Recent advances in alcoholic liver disease. I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004;286:G881-4.
6. Seitz HK, Simanowski UA, Homann N, Waldherr R. Cell proliferation and its evaluation in the colorectal mucosa: effect of ethanol. Z Gastroenterol 1998;36:645-55.
7. Simanowski UA, Homann N, Knuhl M, et al. Increased rectal cell proliferation following alcohol abuse. Gut 2001;49:418-22.
8. Ma TY, Nguyen D, Bui V, Nguyen H, Hoa N. Ethanol modulation of intestinal epithelial tight junction barrier. Am J Physiol 1999;276:G965-74.
9. Matter K, Aijaz S, Tsapara A, Balda MS. Mammalian tight junctions in the regulation of epithelial differentiation and proliferation. Curr Opin Cell Biol 2005;17:453-8.
10. Seitz HK, Simanowski UA, Garzon FT, et al. Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology 1990;98:406-13.
11. Jelski W, Zalewski B, Chrostek L, Szmitkowski M. The activity of class I, II, III, IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in colorectal cancer. Dig Dis Sci 2004;49:977-81.
12. Vaglenova J, Martinez SE, Porte S, Duester G, Farres J, Pares X. Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract. Eur J Biochem 2003;270:2652-62.
13. Koivisto T, Salaspuro M. Effects of acetaldehyde on brush border enzyme activities in human colon adenocarcinoma cell line Caco-2. Alcohol Clin Exp Res 1997;21:1599-605.
14. Vincon P, Wunderer J, Simanowski UA, et al. Inhibition of alcohol-associated colonic hyperregeneration by a-tocopherol in the rat. Alcohol Clin Exp Res 2003;27:100-6.
15. Jenkins GM, Frohman MA. Phospholipase D: a lipid centric review. Cell Mol Life Sci 2005;62:2305-16.
16. McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol 2004;82:225-53.
17. Aradottir S, Lundqvist C, Alling C. Phosphatidylethanol in rat organs after ethanol exposure. Alcohol Clin Exp Res 2002;26:514-8.
18. Aradottir S, Seidl S, Wurst FM, Jonsson BA, Alling C. Phosphatidylethanol in human organs and blood: a study on autopsy material and influences by storage conditions. Alcohol Clin Exp Res 2004;28:1718-23.
19. Mueller GC, Fleming MF, LeMahieu MA, Lybrand GS, Barry KJ. Synthesis of phosphatidylethanol - a potential marker for adult males at risk for alcoholism. Proc Natl Acad Sci U S A 1988;85:9778-82.
20. Hoek JB, Rubin E. Alcohol and membrane-associated signal transduction. Alcohol Alcohol 1990;25:143-56.
21. Lundqvist C, Rodriguez FD, Simonsson P, Alling C, Gustavsson L. Phosphatidylethanol affects inositol 1,4,5-trisphosphate levels in NG108-15 neuroblastoma x glioma hybrid cells. J Neurochem 1993;60:738-44.
22. Seitz HK, Salaspuro M, Savolainen M, et al. From alcohol toxicity to treatment. Alcohol Clin Exp Res 2005;29:1341-50.
23. Chen Q, Barros H, Floren CH, Nilsson A. Absorption and incorporation into tissue lipids of 3H-arachidonic- and 14C-linoleic acid: effects of ethanol in jejunal tissue cultures and in vivo. Scand J Clin Lab Invest 1994;54:495-504.
24. Koivisto T, Salaspuro M. Acetaldehyde alters proliferation, differentiation and adhesion properties of human colon adenocarcinoma cell line Caco-2. Carcinogenesis 1998;19:2031-6.
25. Forest V, Pierre F, Bassonga E, Meflah K, Menanteau J. Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15Rα complex and CD4+ CD25+ T cells are the main targets. Cancer Immunol Immunother 2005;54:78-86.
26. Whitehead RH, VanEeden PE, Noble MD, Ataliotis P, Jat PS. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A 1993;90:587-91.
27. Hughes WE, Elgundi Z, Huang P, Frohman MA, Biden TJ. Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic β-cells. J Biol Chem 2004;279:27534-41.
28. Gustavsson L, Alling C. Formation of phosphatidylethanol in rat brain by phospholipase D. Biochem Biophys Res Commun 1987;142:958-63.
29. Kobayashi M, Kanfer JN. Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D. J Neurochem 1987;48:1597-603.
30. Hu T, Exton JH. 1-Butanol interferes with phospholipase D1 and protein kinase Ca association and inhibits phospholipase D1 basal activity. Biochem Biophys Res Commun 2005;327:1047-51.
31. Basuroy S, Sheth P, Mansbach CM, Rao RK. Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine. Am J Physiol Gastrointest Liver Physiol 2005;289:G367-75.
32. Mariadason JM, Bordonaro M, Aslam F, et al. Down-regulation of β-catenin TCF signaling is linked to colonic epithelial cell differentiation. Cancer Res 2001;61:3465-71.
33. Korinek V, Barker N, Morin PJ, et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997;275:1784-7.
34. Sancho E, Batlle E, Clevers H. Live and let die in the intestinal epithelium. Curr Opin Cell Biol 2003;15:763-70.
35. Balda MS, Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J 2000;19:2024-33.
36. Balda MS, Garrett MD, Matter K. The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol 2003;160:423-32.
37. Sourisseau T, Georgiadis A, Tsapara A, et al. Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol Cell Biol 2006;26:2387-98.
38. Tsapara A, Matter K, Balda MS. The heat shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB. Mol Biol Cell 2006;17:1322-30.
39. Matsuda M, Kubo A, Furuse M, Tsukita S. A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells. J Cell Sci 2004;117:1247-57.
40. Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A. Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 2005;19:923-33.
41. Omodeo-Sale F, Lindi C, Palestini P, Masserini M. Role of phosphatidylethanol in membranes. Effects on membrane fluidity, tolerance to ethanol, and activity of membrane-bound enzymes. Biochemistry 1991;30:2477-82.
42. Chantret I, Rodolosse A, Barbat A, et al. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation. J Cell Sci 1994;107:213-25.
43. Hollande F, Blanc EM, Bali JP, et al. HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line. Am J Physiol Gastrointest Liver Physiol 2001;280:G910-21.
44. Meunier J, Demeilliers B, Celerier A, Maurice T. Compensatory effect by sigma1 (σ1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task. Behav Brain Res 2006;166:166-76.
45. Hollande F, Lee DJ, Choquet A, Roche S, Baldwin GS. Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. J Cell Sci 2003;116:1187-97.