Vitamin D interactions with soy isoflavones on bone after menopause: A review

Nutrients

Volumn 4, Issue 11, 2012, Pages 1610-1621

  Park, Clara Y ^a   Weaver, Connie M ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Bone; Phytoestrogen; Postmenopause; Soy isoflavones; Vitamin d

Indexed keywords

25 HYDROXYERGOCALCIFEROL; 25 HYDROXYVITAMIN D; BIOCHANIN A; CALBINDIN; CALCITRIOL; CALCIUM; CASPASE 3; CASPASE 8; DAIDZEIN; ESTROGEN RECEPTOR; GENISTEIN; ISOFLAVONE; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PHYTOESTROGEN; PLACEBO; PUERARIN; TRANSCRIPTION FACTOR RUNX; VITAMIN D; VITAMIN D RECEPTOR;

BONE DENSITY; CALCIUM ABSORPTION; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM METABOLISM; CYP24 GENE; CYP27B1 GENE; DRUG ABSORPTION; DRUG EXCRETION; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; FRACTURE; GENE; GENE OVEREXPRESSION; GENE REPRESSION; HALF LIFE TIME; HORMONE SUBSTITUTION; HUMAN; LOW DRUG DOSE; MENOPAUSE; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVIEW; RISK REDUCTION; SPINE DISEASE; TREATMENT DURATION; VITAMIN SUPPLEMENTATION;

EID: 84870608189     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu4111610     Document Type: Review

References (69)

1. Pubmed Health: Osteoporosis-Overview. Available online: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001400/ (accessed on 22 March 2012).
2. What Is Osteoporosis? Available online: http://www.nof.org/articles/7 (accessed on 15 November 2012).
3. Russo, A.; Holmquist, L.; Elixhauser, A. U.S. Hospitalizations Involving Osteoporosis and Injury, 2006; Statistical Brief #76; Agency for Health Care Policy and Research (US): Rockville, MD, USA, 2009
4. Heaney, R.P.; Weaver, C.M. Calcium and vitamin D. Endocrinol. Metab. Clin. North Am. 2003, 32, 181-194
5. Schuit, S.C.; van der Klift, M.; Weel, A.E.; de Laet, C.E.; Burger, H.; Seeman, E.; Hofman, A.; Uitterlinden, A.G.; van Leeuwen, J.P.; Pols, H.A. Fracture incidence and association with bone mineral density in elderly men and women: The Rotterdam Study. Bone 2004, 34, 195-202
6. Lips, P. Vitamin D physiology. Prog. Biophys. Mol. Biol. 2006, 92, 4-8
7. Heaney, R.P.; Barger-Lux, M.J.; Dowell, M.S.; Chen, T.C.; Holick, M.F. Calcium absorptive effects of vitamin D and its major metabolites. J. Clin. Endocrinol. Metab. 1997, 2, 4111-4116
8. Francis, R.M.; Peacock, M. Local action of oral 1,25-dihydroxycholecalciferol on calcium absorption in osteoporosis. Am. J. Clin. Nutr. 1987, 46, 315-318
9. Heaney, R.P.; Dowell, M.S.; Hale, C.A.; Bendich, A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J. Am. Coll. Nutr. 2003, 22, 142-146
10. Need, A.G.; Nordin, B.E. Misconceptions-vitamin D insufficiency causes malabsorption of calcium. Bone 2008, 42, 1021-1024
11. Need, A.G.; O'Loughlin, P.D.; Morris, H.A.; Coates, P.S.; Horowitz, M.; Nordin, B.E. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J. Bone Miner. Res. 2008, 23, 1859-1863
12. Hansen, K.E.; Jones, A.N.; Lindstrom, M.J.; Davis, L.A.; Engelke, J.A.; Shafer, M.M. Vitamin D insufficiency: Disease or no disease? J. Bone Miner. Res. 2008, 23, 1052-1060
13. Zhu, K.; Devine, A.; Dick, I.M.; Wilson, S.G.; Prince, R.L. Effects of calcium and vitamin D supplementation on hip bone mineral density and calcium-related analytes in elderly ambulatory Australian women: A five-year randomized controlled trial. J. Clin. Endocrinol. Metab. 2008, 93, 743-749
14. Aloia, J.F.; Chen, D.G.; Yeh, J.K.; Chen, H. Serum vitamin D metabolites and intestinal calcium absorption efficiency in women. Am. J. Clin. Nutr. 2010, 92, 835-840
15. Need, A.G.; Kemp, A.; Giles, N.; Morris, H.A.; Horowitz, M.; Nordin, B.E. Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women. Osteoporos. Int. 2002, 13, 83-88
16. Schnatz, P.F.; Marakovits, K.A.; O'Sullivan, D.M.; Ethun, K.; Clarkson, T.B.; Appt, S.E. Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. J. Womens Health (Larchmt.) 2012, 21, 858-864
17. Bischoff-Ferrari, H.A.; Kiel, D.P.; Dawson-Hughes, B.; Orav, J.E.; Li, R.; Spiegelman, D.; Dietrich, T.; Willett, W.C. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J. Bone Miner. Res. 2009, 24, 935-942
18. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D; The National Academies Press: Washington, DC, USA, 2011
19. Viljakainen, H.T.; Natri, A.M.; Kärkkäinen, M.; Huttunen, M.M.; Palssa, A.; Jakobsen, J.; Cashman, K.D.; Mølgaard, C.; Lamberg-Allardt, C. A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention. J. Bone Miner. Res. 2006, 21, 836-844
20. Abrams, S.A.; Hicks, P.D.; Hawthorne, K.M. Higher serum 25-hydroxyvitamin D levels in school-age children are inconsistently associated with increased calcium absorption. J. Clin. Endocrinol. Metab. 2009, 94, 2421-2427
21. 44Ca) among Northern Chinese adolescents with low vitamin D status. J. Orthop. Surg. (Hong Kong) 2002, 10, 61-66
22. Park, C.Y.; Hill, K.M.; Elble, A.E.; Martin, B.R.; DiMeglio, L.A.; Peacock, M.; McCabe, G.P.; Weaver, C.M. Daily supplementation with 25 μg cholecalciferol does not increase calcium absorption or skeletal retention in adolescent girls with low serum 25-hydroxyvitamin D. J. Nutr. 2010, 140, 2139-2144
23. Howard, G.A.; Turner, R.T.; Sherrard, D.J.; Baylink, D.J. Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. J. Biol. Chem. 1981, 256, 7738-7740
24. Van Leeuwen, J.P.; van Driel, M.; van den Bemd, G.J.; Pols, H.A. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit. Rev. Eukaryot. Gene Expr. 2001, 11, 199-226
25. Gardiner, E.M.; Baldock, P.A.; Thomas, G.P.; Sims, N.A.; Henderson, N.K.; Hollis, B.; White, C.P.; Sunn, K.L.; Morrison, N.A.; Walsh, W.R.; Eisman, J.A. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J. 2000, 14, 1908-1916
26. Anderson, P.H.; Sawyer, R.K.; Moore, A.J.; May, B.K.; O'Loughlin, P.D.; Morris, H.A. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J. Bone Miner. Res. 2008, 23, 1789-1797
27. Fleet, J.C.; Gliniak, C.; Zhang, Z.; Xue, Y.; Smith, K.B.; McCreedy, R.; Adedokun, S.A. Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice. J. Nutr. 2008, 138, 1114-1120
28. Hohman, E.E.; Martin, B.R.; Lachcik, P.J.; Gordon, D.T.; Fleet, J.C.; Weaver, C.M. Bioavailability and efficacy of vitamin D2 from UV-irradiated yeast in growing, vitamin D-deficient rats. J. Agric. Food Chem. 2011, 59, 2341-2346
29. Iwamoto, J.; Takeda, T.; Ichimura, S.; Sato, Y.; Yeh, J.K. Differential effect of vitamin K and vitamin D supplementation on bone mass in young rats fed normal or low calcium diet. Yonsei Med. J. 2004, 45, 314-324
30. Peacock, M.; Liu, G.; Carey, M.; McClintock, R.; Ambrosius, W.; Hui, S.; Johnston, C.C. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J. Clin. Endocrinol. Metab. 2000, 85, 3011-3019
31. Chapuy, M.C.; Arlot, M.E.; Duboeuf, F.; Brun, J.; Crouzet, B.; Arnaud, S.; Delmas, P.D.; Meunier, P.J. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N. Engl. J. Med. 1992, 327, 1637-1642
32. Dawson-Hughes, B.; Harris, S.S.; Dallal, G.E.; Krall, E.A.; Dallal, G.E. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N. Engl. J. Med. 1997, 337, 670-676
33. Grant, A.M.; Avenell, A.; Campbell, M.K.; McDonald, A.M.; MacLennan, G.S.; McPherson, G.C.; Anderson, F.H.; Cooper, C.; Francis, R.M.; Donaldson, C. et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): A randomised placebo-controlled trial. Lancet 2005, 365, 1621-1628
34. Chung, M.; Balk, E.M.; Brendel, M.; Ip, S.; Lau, J.; Lee, J.; Lichtenstein, A.; Patel, K.; Raman, G.; Tatsioni, A. et al. Vitamin D and Calcium: A Systematic Review of Health Outcomes; Evidence Reports/Technology Assessments, No. 183; Agency for Healthcare Research and Quality: Rockville, MD, USA, August 2009
35. Venken, K.; Callewaert, F.; Boonen, S.; Vanderschueren, D. Sex hormones, their receptors and bone health. Osteoporos. Int. 2008, 19, 1517-1525
36. Riggs, B.L.; Khosla, S.; Melton, L.J. A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. 1998, 13, 763-773
37. Bone Health and Osteoporosis: A Report of the Surgeon General; Office of the Surgeon General (US): Rockville, MD, USA, 2004
38. Riggs, B.L.; Khosla, S.; Atkinson, E.J.; Dunstan, C.R.; Melton, L.J. Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency. Osteoporos. Int. 2003, 14, 728-733
39. Wimalawansa, S.J. A four-year randomized controlled trial of hormone replacement and bisphosphonate, alone or in combination, in women with postmenopausal osteoporosis. Am. J. Med. 1998, 104, 219-226
40. Rossouw, J.E.; Anderson, G.L.; Prentice, R.L.; LaCroix, A.Z.; Kooperberg, C.; Stefanick, M.L.; Jackson, R.D.; Beresford, S.A.; Howard, B.V.; Johnson, K.C. et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002, 288, 321-333
41. Li, Y.Q.; Xing, X.H.; Wang, H.; Weng, X.L.; Yu, S.B.; Dong, G.Y. Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone. Acta Pharmacol. Sin. 2012, 33, 66-74
42. Cotter, A.A.; Cashman, K.D. Lack of dose-responsive effect of dietary phyto-oestrogens on transepithelial calcium transport in human intestinal-like Caco-2 cells. Br. J. Nutr. 2004, 91, 5-9
43. Cotter, A.A.; Jewell, C.; Cashman, K.D. The effect of oestrogen and dietary phyto-oestrogens on transepithelial calcium transport in human intestinal-like Caco-2 cells. Br. J. Nutr. 2003, 89, 755-765
44. Cheong, J.M.; Martin, B.R.; Jackson, G.S.; Elmore, D.; McCabe, G.P.; Nolan, J.R.; Barnes, S.; Peacock, M.; Weaver, C.M. Soy isoflavones do not affect bone resorption in postmenopausal women: A dose-response study using a novel approach with 41Ca. J. Clin. Endocrinol. Metab. 2007, 92, 577-582
45. Weaver, C.M.; Martin, B.R.; Jackson, G.S.; McCabe, G.P.; Nolan, J.R.; McCabe, L.D.; Barnes, S.; Reinwald, S.; Boris, M.E.; Peacock, M. Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using 41Ca methodology. J. Clin. Endocrinol. Metab. 2009, 94, 3798-3805
46. Mun, J.G.; Grannan, M.D.; Lachcik, P.J.; Rogers, R.B.; Yousef, G.G.; Grace, M.H.; Janle, E.M.; Wu, Q.L.; Simon, J.E.; Weaver, C.M.; Lila, M.A. Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. Exp. Biol. Med. (Maywood) 2010, 235, 1224-1235
47. De Wilde, A.; Lieberherr, M.; Colin, C.; Pointillart, A. A low dose of daidzein acts as an ERbeta-selective agonist in trabecular osteoblasts of young female piglets. J. Cell. Physiol. 2004, 200, 253-262
48. Simonet, W.S.; Lacey, D.L.; Dunstan, C.R.; Kelley, M.; Chang, M.-S.; Lothy, R.; Nguyen, H.Q.; Wooden, S.; Bennett, L.; Boone, T. et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997, 89, 309-319
49. Rassi, C.M.; Lieberherr, M.; Chaumaz, G.; Pointillart, A.; Cournot, G. Down-regulation of osteoclast differentiation by daidzein via caspase 3. J. Bone Miner. Res. 2002, 17, 630-638
50. Marini, H.; Minutoli, L.; Polito, F.; Bitto, A.; Altavilla, D.; Atteritano, M.; Gaudio, A.; Mazzaferro, S.; Frisina, A.; Frisina, N. et al. OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration. J. Bone Miner. Res. 2008, 23, 715-720
51. Legette, L.L.; Lee, W.H.; Martin, B.R.; Story, J.A.; Arabshahi, A.; Barnes, S.; Weaver, C.M. Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects. Menopause 2011, 18, 923-931
52. Mathey, J.; Mardon, J.; Fokialakis, N.; Puel, C.; Kati-Coulibaly, S.; Mitakou, S.; Bennetau-Pelissero, C.; Lamothe, V.; Davicco, M.J.; Lebecque, P. et al. Modulation of soy isoflavones bioavailability and subsequent effects on bone health in ovariectomized rats: The case for equol. Osteoporos. Int. 2007, 18, 671-679
53. Phrakonkham, P.; Chevalier, J.; Desmetz, C.; Pinnert, M.F.; Bergès, R.; Jover, E.; Davicco, M.J.; Bennetau-Pelissero, C.; Coxam, V.; Artur, Y.; Canivenc-Lavier, M.C. Isoflavonoid-based bone-sparing treatments exert a low activity on reproductive organs and on hepatic metabolism of estradiol in ovariectomized rats. Toxicol. Appl. Pharmacol. 2007, 224, 105-115
54. Legette, L.L.; Martin, B.R.; Shahnazari, M.; Lee, W.H.; Helferich, W.G.; Qian, J.; Waters, D.J.; Arabshahi, A.; Barnes, S.; Welch, J. et al. Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. J. Nutr. 2009, 139, 1908-1913
55. Marini, H.; Minutoli, L.; Polito, F.; Bitto, A.; Altavilla, D.; Atteritano, M.; Gaudio, A.; Mazzaferro, S.; Frisina, A.; Frisina, N. et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: A randomized trial. Ann. Intern. Med. 2007, 146, 839-847
56. Potter, S.M.; Baum, J.A.; Teng, H.; Stillman, R.J.; Shay, N.F.; Erdman, J.W. Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 1998, 68, 1375S-1379S.
57. Wong, W.W.; Lewis, R.D.; Steinberg, F.M.; Murray, M.J.; Cramer, M.A.; Amato, P.; Young, R.L.; Barnes, S.; Ellis, K.J.; Shypailo, R.J. et al. Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial. Am. J. Clin. Nutr. 2009, 90, 1433-1439
58. Tai, T.Y.; Tsai, K.S.; Tu, S.T.; Wu, J.S.; Chang, C.I.; Chen, C.L.; Shaw, N.S.; Peng, H.Y.; Wang, S.Y.; Wu, C.H. The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: A 2-year randomized double-blind placebo-controlled study. Osteoporos. Int. 2012, 23, 1571-1580
59. Levis, S.; Strickman-Stein, N.; Ganjei-Azar, P.; Xu, P.; Doerge, D.R.; Krischer, J. Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: A randomized, double-blind trial. Arch. Intern. Med. 2011, 171, 1363-1369
60. Setchell, K.D.; Brown, N.M.; Lydeking-Olsen, E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J. Nutr. 2002, 132, 3577-3584
61. Franke, A.A.; Lai, J.F.; Halm, B.M.; Pagano, I.; Kono, N.; Mack, W.J.; Hodis, H.N. Equol production changes over time in postmenopausal women. J. Nutr. Biochem. 2012, 23, 573-579
62. Gilad, L.A.; Tirosh, O.; Schwartz, B. Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells. J. Endocrinol. 2006, 191, 387-398
63. Liel, Y.; Kraus, S.; Levy, J.; Shany, S. Evidence that estrogens modulate activity and increase the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells (ROS 17/2.8). Endocrinology 1992, 130, 2597-2601
64. Ishibe, M.; Nojima, T.; Ishibashi, T.; Koda, T.; Kaneda, K.; Rosier, R.N.; Puzas, J.E. 17 beta-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells. Calcif. Tissue Int. 1995, 57, 430-435
65. Somjen, D.; Katzburg, S.; Kohen, F.; Gayer, B.; Sharon, O.; Hendel, D.; Posner, G.H.; Kaye, A.M. Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a "less-calcemic" analog of 1,25 dihydroxyvitamin D3: JK 1624F2-2 (JKF). J. Steroid Biochem. Mol. Biol. 2006, 98, 139-146
66. Chennaiah, S.; Vijayalakshmi, V.; Suresh, C. Effect of the supplementation of dietary rich phytoestrogens in altering the vitamin D levels in diet induced osteoporotic rat model. J. Steroid Biochem. Mol. Biol. 2010, 121, 268-272
67. Song, L.; Zhang, X.; Zhou, Y. A synergetic role of 1,25-dihydroxyvitamin D3 in 17β-estradial induced-proliferation and differentiation of osteoblastic MC3T3-E1 cells. Eur. J. Pharmacol. 2011, 659, 273-280
68. Tuppurainen, M.T.; Komulainen, M.; Kröger, H.; Honkanen, R.; Jurvelin, J.; Puntila, E.; Heikkinen, A.M.; Alhava, E.; Saarikoski, S. Does vitamin D strengthen the increase in femoral neck BMD in osteoporotic women treated with estrogen? Osteoporos. Int. 1998, 8, 32-38
69. Bitto, A.; Marini, H.; Burnett, B.P.; Polito, F.; Levy, R.M.; Irrera, N.; Minutoli, L.; Adamo, E.B.; Squadrito, F.; Altavilla, D. Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: A dose ranging experimental study. Phytomedicine 2011, 18, 879-886.