Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: A dose ranging experimental study

Phytomedicine

Volumn 18, Issue 10, 2011, Pages 879-886

  Bitto, A ^a   Marini, H ^b   Burnett, B P ^c   Polito, F ^a,b   Levy, R M ^c   Irrera, N ^a   Minutoli, L ^a   Adamo, E B ^b   Squadrito, F ^a   Altavilla, D ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c PRIMUS PHARMACEUTICALS INC   (United States)

Author keywords

b ALP; BMD; CTX; Genistein aglycone; OPG; sRANKL

Indexed keywords

AGLYCONE; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALCIUM CARBONATE; COLECALCIFEROL; COLLAGEN; GENISTEIN; GENISTEIN AGLYCONE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TELOPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE STRENGTH; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; EXCISION; EXPERIMENTAL STUDY; HISTOLOGY; HUMAN; MOUSE; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; UTERUS WEIGHT;

ALKALINE PHOSPHATASE; ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE DISEASES, METABOLIC; CALCIUM CARBONATE; CHOLECALCIFEROL; COMPRESSIVE STRENGTH; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FEMALE; FEMUR; GENISTEIN; OSTEOPROTEGERIN; OVARIECTOMY; PLANT EXTRACTS; RANDOM ALLOCATION; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; SOPHORA; UTERUS;

ANIMALIA; RATTUS;

EID: 79960025375     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.02.003     Document Type: Article

References (36)

1. K. Alaimo, R.R. Briefel, E.A. Frongillo Jr., and C.M. Olson Food insufficiency exists in the United States: results from the third National Health and Nutrition Examination Survey (NHANES III) Am. J. Public Health 88 1998 419 426 (Pubitemid 28154944)
2. D.L. Alekel, M.D. Van Loan, K.J. Koehler, L.N. Hanson, J.W. Stewart, K.B. Hanson, M.S. Kurzer, and C.T. Peterson The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women Am. J. Clin. Nutr. 91 2010 218 230
3. American Association of Clinical Endocrinologists Medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis Endocr. Pract. 9 2003 545 564
4. J. Arts, G.G. Kuiper, J.M. Janssen, J.A. Gustafsson, C.W. Löwik, H.A. Pols, and J.P. van Leeuwen Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells Endocrinology 138 1997 5067 5070 (Pubitemid 27460951)
5. D.D. Bikle Role of vitamin D, its metabolites, and analogs in the management of osteoporosis Rheum. Dis. Clin. North Am. 20 1994 759 775 (Pubitemid 24271587)
6. H.A. Bischoff-Ferrari, B. Dawson-Hughes, J.A. Baron, P. Burckhardt, R. Li, D. Spiegelman, B. Specker, J.E. Orav, J.B. Wong, H.B. Staehelin, E. O'Reilly, D.P. Kiel, and W.C. Willett Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials Am. J. Clin. Nutr. 86 2007 1780 1790 (Pubitemid 350232196)
7. A. Bitto, F. Polito, F. Squadrito, H. Marini, R. D'Anna, N. Irrera, L. Minutoli, R. Granese, and D. Altavilla Genistein aglycone: a dual mode of actio anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation Curr. Med. Chem. 17 2010 3007 3018
8. A. Bitto, B.P. Burnett, F. Polito, R.M. Levy, H. Marini, V. Di Stefano, N. Irrera, M. Armbruster, L. Minutoli, D. Altavilla, and F. Squadrito Genistein aglycone reverses glucocorticoid-induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate Br. J. Pharmacol. 156 2009 1287 1295
9. A. Bitto, F. Polito, B. Burnett, R. Levy, V. Di Stefano, M. Armbruster, H. Marini, L. Minutoli, D. Altavilla, and F. Squadrito Protective effect of genistein aglycone on the development of osteonecrosis of the fermoral head and secondary osteoporosis induced by methylprednisolone in rats J. Endocrinol. 201 2009 321 328
10. A. Bitto, B.P. Burnett, F. Polito, H. Marini, R.M. Levy, M.A. Armbruster, L. Minutoli, V. Di Stefano, N. Irrera, S. Antoci, R. Granese, F. Squadrito, and D. Altavilla Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol Br. J. Pharmacol. 155 2008 896 905
11. M.J. Bolland, A. Avenell, J.A. Baron, A. Grey, G.S. MacLennan, G.D. Gamble, and I.R. Reid Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis BMJ 341 2010 c3691 10.1136/bmj.c3691
12. S. Bord, A. Horner, S. Beavan, and J. Compston Estrogen receptors alpha and beta are differentially expressed in developing human bone J. Clin. Endocrinol. Metab. 86 2001 2309 2314 (Pubitemid 32472956)
13. A. Cassidy, P. Albertazzi, I. Lise-Nielsen, W. Hall, G. Williamson, I. Tetens, S. Atkins, H. Cross, Y. Manios, A. Wolk, C. Steiner, and F. Branca Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women Proc. Nutr. Soc. 65 2006 76 92 (Pubitemid 43259987)
14. H.S. Cross, M. Lipkin, and E. Kállay Nutrients regulate the colonic vitamin D system in mice: relevance for human colon malignancy J. Nutr. 136 2006 561 564 (Pubitemid 43363735)
15. DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe BMJ January 2010 10.1136/bmj.b5463
16. E.J. Freireich, E.A. Gehan, D.P. Rall, L.H. Schmidt, and H.E. Skipper Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man Cancer Chemother. Rep. 50 1966 219 244
17. M.F. Holick, E.S. Siris, N. Binkley, M.K. Beard, A. Khan, J.T. Katzer, R.A. Petruschke, E. Chen, and A.E. de Papp Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy J. Clin. Endocrinol. Metab. 90 2005 3215 3224 (Pubitemid 41014278)
18. M.F. Holick Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease Am. J. Clin. Nutr. 80 2004 1678S 1688S
19. J.Z. Ilich, and J.E. Kerstetter Nutrition in bone health revisited: a story beyond calcium J. Am. Coll. Nutr. 19 2000 715 737 (Pubitemid 32064154)
20. A.M. Kenny, K.M. Mangano, R.H. Abourizk, R.S. Bruno, D.E. Anamani, A. Kleppinger, S.J. Walsh, K.M. Prestwood, and J.E. Kerstetter Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial Am. J. Clin. Nutr. 90 2009 234 242
21. P. Lips Worldwide status of vitamin D nutrition J. Steroid Biochem. Mol. Biol. 121 2010 297 300
22. H. Marini, A. Bitto, D. Altavilla, B.P. Burnett, F. Polito, V. Di Stefano, L. Minutoli, M. Atteritano, R.M. Levy, R. D'Anna, N. Frisina, S. Mazzaferro, F. Cancellieri, M.L. Cannata, F. Corrado, A. Frisina, V. Adamo, C. Lubrano, C. Sansotta, R. Marini, E.B. Adamo, and F. Squadrito Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study J. Clin. Endocrinol. Metab. 93 2008 4787 4796
23. H. Marini, L. Minutoli, F. Polito, A. Bitto, D. Altavilla, M. Atteritano, A. Gaudio, S. Mazzaferro, A. Frisina, N. Frisina, C. Lubrano, M. Bonaiuto, R. D'Anna, M.L. Cannata, F. Corrado, F. Cancellieri, M. Faraci, R. Marini, E.B. Adamo, S. Wilson, and F. Squadrito OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration J. Bone Miner. Res. 23 2008 715 720 (Pubitemid 351575025)
24. H. Marini, L. Minutoli, F. Polito, A. Bitto, D. Altavilla, M. Atteritano, A. Gaudio, S. Mazzaferro, A. Frisina, N. Frisina, C. Lubrano, M. Bonaiuto, R. D'Anna, M.L. Cannata, F. Corrado, E.B. Adamo, S. Wilson, and F. Squadrito Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial Ann. Intern. Med. 146 2007 839 847 (Pubitemid 351650484)
25. National Osteoporosis Foundation Clinician's Guide to Prevention and Treatment of Osteoporosis 2010 National Osteoporosis Foundation
26. J.W. Nieves, and R. Lindsay Calcium and fracture risk Am. J. Clin. Nutr. 86 2007 1579 1580 (Pubitemid 350232169)
27. J.W. Nieves Nutritional therapies (including fosteum) Curr. Osteoporos. Rep. 7 2009 5 11
28. R.L. Prince, A. Devine, S.S. Dhaliwal, and I.M. Dick Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women Arch. Intern. Med. 166 2006 869 875
29. P.D. Ross, H. Norimatsu, J.W. Davis, K. Yano, R.D. Wasnich, S. Fujiwara, Y. Hosoda, and L.J. Melton 3rd A comparison of hip fracture incidence among native Japanese Americans, and American Caucasians Am. J. Epidemiol. 133 1991 801 809
30. A.V. Schwartz, J.L. Kelsey, S. Maggi, M. Tuttleman, S.C. Ho, P.V. Jónsson, G. Poór, J.A. Sisson de Castro, L. Xu, C.C. Matkin, L.M. Nelson, and S.P. Heyse International variation in the incidence of hip fractures: cross-national project on osteoporosis for the World Health Organization Program for Research on Aging Osteoporos. Int. 9 1999 242 253 (Pubitemid 29182376)
31. USDA Agriculture Research Service Continuing Survey of Food Intakes by Individuals CSFII/DHKS 1994-1996, 1998 http://www ars usda gov/Services/docs htm?docid=7716 2007
32. T. Usui Pharmaceutical prospects of phytoestrogens Endocr. J. 53 2006 7 20
33. P.M. Vupadhyayula, J.C. Gallagher, T. Templin, S.M. Logsdon, and L.M. Smith Effects of soy protein isolate on bone mineral density and physical performance indices in postmenopausal women - a 2-year randomized, double-blind, placebo-controlled trial Menopause 16 2009 320 328
34. L. Xu, A. Lu, X. Zhao, X. Chen, and S.R. Cummings Very low rates of hip fracture in Beijing, People's Republic of China the Beijing Osteoporosis Project Am. J. Epidemiol. 144 1996 901 907 (Pubitemid 26374959)
35. M. Yamaguchi, Y.H. Gao, and Z.J. Ma Synergistic effect of genistein and zinc on bone components in the femoral-metaphyseal tissues of female rats J. Bone Miner. Metab. 18 2000 77 83 (Pubitemid 30133664)
36. Y. Zhang, W.F. Chen, W.P. Lai, and M.S. Wong Soy isoflavones and their bone protective effects Inflammopharmacology 6 2008 213 215