The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: A 2-year randomized double-blind placebo-controlled study

Osteoporosis International

Volumn 23, Issue 5, 2012, Pages 1571-1580

  Tai, T Y ^a,f   Tsai, K S ^b   Tu, S T ^c   Wu, J S ^d   Chang, C I ^a   Chen, C L ^e   Shaw, N S ^e   Peng, H Y ^b   Wang, S Y ^c   Wu, C H ^d  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f Taipei Jen Chi Relief Institution   (Taiwan)

Author keywords

Bone mineral density; Postmenopausal women; Soy isoflavone

Indexed keywords

AGLYCONE; ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; CALCIUM; COLECALCIFEROL; CREATININE; DAIDZEIN; GENISTEIN;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE DENSITY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FEMUR; FRACTURE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOLYSIS; PARALLEL DESIGN; PATIENT COMPLIANCE; POSTMENOPAUSE; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; X RAY SPECTROMETRY;

ABSORPTIOMETRY, PHOTON; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; FEMUR; GENISTEIN; HUMANS; ISOFLAVONES; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PHYTOESTROGENS; PLACEBOS; TREATMENT OUTCOME;

EID: 84863611286     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-011-1750-7     Document Type: Article

References (41)

1. Torgerson DJ, Bell-Syer SE (2001) Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials. BMC Musculoskelet Disord 2:7
2. Torgerson DJ, Bell-Syer SE (2001) Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. JAMA 285:2891-2897 (Pubitemid 32537354)
3. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333 (Pubitemid 34761611)
4. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, Chlebowski R, Curb D, Gass M, Hays J, Heiss G, Hendrix S, Howard BV, Hsia J, Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, O'Sullivan MJ, Phillips L, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291:1701-1712 (Pubitemid 38489892)
5. Miksicek RJ (1994) Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 49:153-160 (Pubitemid 24237089)
6. Zava DT, Duwe G (1997) Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr Cancer 27:31-40 (Pubitemid 26424313)
7. Brandi ML (1997) Natural and synthetic isoflavones in the prevention and treatment of chronic diseases. Calcif Tissue Int 61(SUPPL. 1):S5-S8 (Pubitemid 27318327)
8. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68:1375S-1379S (Pubitemid 28550915)
9. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T (2000) Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72:844-852 (Pubitemid 30667108)
10. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D'Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito F (2002) Effects of genistein and hormonereplacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res 17:1904-1912
11. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL (2003) Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 88:4740-4747 (Pubitemid 37357520)
12. Dalais FS, Ebeling PR, Kotsopoulos D, McGrath BP, Teede HJ (2003) The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin Endocrinol (Oxf) 58:704-709 (Pubitemid 36702729)
13. Kotsopoulos D, Dalais FS, Liang YL, McGrath BP, Teede HJ (2000) The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women. Climacteric 3:161-167
14. Quella SK, Loprinzi CL, Barton DL, Knost JA, Sloan JA, LaVasseur BI, Swan D, Krupp KR, Miller KD, Novotny PJ (2000) Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: a North Central Cancer Treatment Group Trial. J Clin Oncol 18:1068-1074 (Pubitemid 30123785)
15. Nikander E, Kilkkinen A, Metsa-Heikkila M, Adlercreutz H, Pietinen P, Tiitinen A, Ylikorkala O (2003) A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients. Obstet Gynecol 101:1213-1220 (Pubitemid 36694346)
16. Franke AA, Custer LJ, Wang W, Shi CY (1998) HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids. Proc Soc Exp Biol Med 217:263-273
17. Booth M (2000) Assessment of physical activity: an international perspective. Res Q Exerc Sport 71:S114-S120
18. Liu YM (2004) Validation of the Taiwan International Physical Activity Questionnaire-Short Form (Doctoral Dissertation in Chinese), in Institute of Nursing, National Taiwan University, Taipei, Taiwan
19. Hsu HF, Chang CL, Chu YH (2000) Flavonoids amounts and antioxidant analysis in several vegetables. Taiwanese J Agric Chem Food Sci 38:377-387
20. Liu SW (2003) Validation of a food frequency questionnaire estimating flavonoids, isoflavones and carotenoids intake among elderly population. (Master Dissertation in Chinese). In Institute of Nutritional Science, Fu-Jen Catholic University, Taipei, Taiwan
21. US Food and Drug Administration, Center for Drug Evaluation and Research (1993) Coding symbols for thesaurus of adverse reaction terms (COSTART), 4th edn. US Food and Drug Administration, Rockville
22. Xin Y, Yang HY (2006) Influence of daidzein tablets on climacteric syndrome and bone mineral density of women. Chin J Osteoporos 12:149-151
23. Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, Gaudio A, Mazzaferro S, Frisina A, Frisina N, Lubrano C, Bonaiuto M, D'Anna R, Cannata ML, Corrado F, Adamo EB, Wilson S, Squadrito F (2007) Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 146:839-847 (Pubitemid 351650484)
24. Taku K, Melby MK, Kurzer MS, Mizuno S, Watanabe S, Ishimi Y (2010) Effects of soy isoflavone SUPPL.ements on bone turnover markers in menopausal women: systematic review and metaanalysis of randomized controlled trials. Bone 47:413-423
25. Taku K, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S (2010) Effect of soy isoflavone extract SUPPL.ements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr 19:33-42
26. Gallagher JC, Satpathy R, Rafferty K, Haynatzka V (2004) The effect of soy protein isolate on bone metabolism. Menopause 11:290-298 (Pubitemid 40362183)
27. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EH, Aleman A, Lampe JW, van der Schouw YT (2004) Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292:65-74 (Pubitemid 38923795)
28. Arjmandi BH, Lucas EA, Khalil DA, Devareddy L, Smith BJ, McDonald J, Arquitt AB, Payton ME, Mason C (2005) One year soy protein SUPPL.ementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J 4:8
29. Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y (2006) Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res 21:780-789
30. Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT (2007) Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause 14:481-488
31. Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F (2008) Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 87:761-770 (Pubitemid 351364559)
32. Kenny AM, Mangano KM, Abourizk RH, Bruno RS, Anamani DE, Kleppinger A, Walsh SJ, Prestwood KM, Kerstetter JE (2009) Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr 90:234-242
33. Vupadhyayula PM, Gallagher JC, Templin T, Logsdon SM, Smith LM (2009) Effects of soy protein isolate on bone mineral density and physical performance indices in postmenopausal women-a 2-year randomized, double-blind, placebo-controlled trial. Menopause 16:320-328
34. Alekel DL, Van Loan MD, Koehler KJ, Hanson LN, Stewart JW, Hanson KB, Kurzer MS, Peterson CT (2010) The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women. Am J Clin Nutr 91:218-230
35. Weaver CM, Cheong JM (2005) Soy isoflavones and bone health: the relationship is still unclear. J Nutr 135:1243-1247 (Pubitemid 40638336)
36. Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T (2004) Soymilk or progesterone for prevention of bone loss-a 2 year randomized, placebo-controlled trial. Eur J Nutr 43:246-257 (Pubitemid 39222536)
37. Newton KM, LaCroix AZ, Levy L, Li SS, Qu P, Potter JD, Lampe JW (2006) Soy protein and bone mineral density in older men and women: a randomized trial. Maturitas 55:270-277 (Pubitemid 44397353)
38. Whitten PL, Patisaul HB (2001) Cross-species and interassay comparisons of phytoestrogen action. Environ Health Perspect 109(SUPPL. 1):5-20 (Pubitemid 32303226)
39. Tsai KS, Hsu SH, Cheng JP, Yang RS (1997) Vitamin D stores of urban women in Taipei: effect on bone density and bone turnover, and seasonal variation. Bone 20:371-374 (Pubitemid 27196660)
40. Lee MS, Li HL, Hung TH, Chang HY, Yang FL, Wahlqvist ML (2008) Vitamin D intake and its food sources in Taiwanese. Asia Pac J Clin Nutr 17:397-407
41. Zhang X, Shu XO, Li H, Yang G, Li Q, Gao YT, Zheng W (2005) Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 165:1890-1895 (Pubitemid 41352084)