Quantum dots: Heralding a brighter future for clinical diagnostics

Nanomedicine

Volumn 7, Issue 11, 2012, Pages 1755-1769

  Samir, Tamer M ^a   Mansour, Mai M H ^a   Kazmierczak, Steven C ^b   Azzazy, Hassan M E ^a  

^a The American University in Cairo   (Egypt)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

clinical diagnostics; fluorescence; imaging; nanocrystals; nanoparticles; quantum dots

Indexed keywords

OLIGONUCLEOTIDE; PROTEIN; QUANTUM DOT;

BIOMEDICINE; CHEMICAL COMPOSITION; CONJUGATION; HUMAN; IMAGING SYSTEM; IMMUNOASSAY; IN VITRO STUDY; LABORATORY TEST; MOLECULAR DIAGNOSIS; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYNTHESIS; TOXICITY TESTING;

ANIMALS; HUMANS; IMMUNOASSAY; MICROSCOPY; MOLECULAR DIAGNOSTIC TECHNIQUES; NANOCONJUGATES; NANOTECHNOLOGY; OLIGONUCLEOTIDES; PROTEINS; QUANTUM DOTS; TOXICITY TESTS;

EID: 84870604264     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.147     Document Type: Review

References (69)

1. Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 4(6), 435-446 (2005).
2. Jamieson T, Bakhshi R, Petrova D, Pocock R, Imani M, Seifalian AM. Biological applications of quantum dots. Biomaterials 28(31), 4717-4732 (2007).
3. Michalet X, Pinaud F, Bentolila L et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307(5709), 538-544 (2005).
4. Azzazy HM, Mansour MM, Kazmierczak SC. From diagnostics to therapy: prospects of quantum dots. Clin. Biochem. 40(13-14), 917-927 (2007).
5. Fomenko V, Nesbitt DJ. Solution control of radiative and nonradiative lifetimes: a novel contribution to quantum dot blinking suppression. Nano Lett. 8(1), 287-293 (2008).
6. Alivisatos A P, Gu W, Larabell C. Quantum dots as cellular probes. Annu. Rev. Biomed. Eng. 7, 55-76 (2005).
7. Jaiswal JK, Simon SM. Potentials and pitfalls of fuorescent quantum dots for biological imaging. Trends Cell Biol. 14 (9), 497-504 (2004).
8. Delehanty J, Mattoussi H, Medintz I. Delivering quantum dots into cells: strategies, progress and remaining issues. Anal. Bioanal. Chem. 393(4), 1091-1105 (2009).
9. Tang B, Cao L, Xu K et al. A new nanobiosensor for glucose with high sensitivity and selectivity in serum based on fuorescence resonance energy transfer (FRET) between CdTe quantum dots and Au nanoparticles. Chemistry 14 (12), 3637-3644 (2008).
10. Dabbousi BO, Rodriguez-Viejo J, Mikulec FV et al. (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J. Phys. Chem. B 101(46), 9463-9475 (1997).
11. Anand M, Odom LA, Roberts CB. Finely controlled size-selective precipitation and separation of CdSe/ZnS semiconductor nanocrystals using CO2-gas-expanded liquids. Langmuir 23(13), 7338-7343 (2007).
12. He R, You X, Tian H, Gao F, Cui D, Gu H. Synthesis and characterization of monodisperse CdSe quantum dots in different organic solvents. Front. Chem. China 1(4), 378-383 (2006).
13. Pinaud F, King D, Moore HP, Weiss S. Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides. J. Am. Chem. Soc. 126(19), 6115-6123 (2004).
14. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298 (5599), 1759-1762 (2002).
15. Gao X, Cui Y, Levenson RM, Chung LW, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22(8), 969-976 (2004).
16. Poselt E, Fischer S, Foerster S, Weller H. Highly stable biocompatible inorganic nanoparticles by self-assembly of triblock-copolymer ligands. Langmuir 25(24), 13906-13913 (2009).
17. Mattheakis LC, Dias JM, Choi YJ et al. Optical coding of mammalian cells using semiconductor quantum dots. Anal. Biochem. 327(2), 200-208 (2004).
18. Sperling R, Parak W. Surface modifcation, functionalization and bioconjugation of colloidal inorganic nanoparticles. Phil. Trans. R. Soc. A 368(1915), 1333-1383 (2010).
19. Chan WC, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281(5385), 2016-2018 (1998).
20. Mattoussi H, Mauro JM, Goldman ER et al. Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J. Am. Chem. Soc. 122(49), 12142-12150 (2000).
21. Gerion D, Pinaud F, Williams SC et al. Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J. Phys. Chem. B 105(37), 8861-8871 (2001).
22. Resch-Genger U, Grabolle M, Cavaliere-Jaricot S, Nitschke R, Nann T. Quantum dots versus organic dyes as fuorescent labels. Nat. Methods 5(9), 763-775 (2008).
23. Hermanson GT. Bioconjugate Techniques (2nd Edition). Academic Press, London, UK (2008).
24. Xue F, Chen J, Guo J et al. Enhancement of intracellular delivery of CdTe quantum dots (QDs) to living cells by tat conjugation. J. Fluoresc. 17(2), 149-154 (2007).
25. Pathak S, Davidson MC, Silva GA. Characterization of the functional binding properties of antibody conjugated quantum dots. Nano Lett. 7(7), 1839-1845 (2007).
26. Mahmoud W, Rousserie G, Reveil B et al. Advanced procedures for labeling of antibodies with quantum dots. Anal. Biochem. 416(2), 180-185 (2011).
27. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater. 2(9), 630-638 (2003).
28. Medintz IL, Clapp AR, Brunel FM et al. Proteolytic activity monitored by fuorescence resonance energy transfer through quantum-dot-peptide conjugates. Nat. Mater. 5(7), 581-589 (2006).
29. Pathak S, Choi SK, Arnheim N, Thompson ME. Hydroxylated quantum dots as luminescent probes for in situ hybridization. J. Am. Chem. Soc. 123(17), 4103-4104 (2001).
30. Sperling R, Parak W. Surface modifcation, functionalization and bioconjugation of colloidal inorganic nanoparticles. Phil. Trans. R. Soc. A 368(1915), 1333-1383 (2010).
31. Parak WJ, Gerion D, Zanchet D et al. Conjugation of DNA to silanized colloidal semiconductor nanocrystalline quantum dots. Chem. Mater. 14(5), 2113-2119 (2002).
32. Sukhanova A, Nabiev I. Fluorescent nanocrystal-encoded microbeads for multiplexed cancer imaging and diagnosis. Crit. Rev. Oncol. Hematol. 68(1), 39-59 (2008).
33. Medintz IL, Mattoussi H, Clapp AR. Potential clinical applications of quantum dots. Int. J. Nanomedicine 3(2), 151-167 (2008).
34. Jaiswal J, Mattoussi H, Mauro J, Simon S. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotech. 21(1), 47-51 (2003).
35. Maysinger D, Lovric J, Eisenberg A, Savic R. Fate of micelles and quantum dots in cells. Eur. J. Pharm. Biopharm. 65 (3), 270-281 (2007).
36. Misra RD. Quantum dots for tumor-targeted drug delivery and cell imaging. Nanomedicine (Lond.) 3(3), 271-274 (2008).
37. Derfus AM, Chan WCW, Bhatia SN. Intracellular delivery of quantum dots for live cell labeling and organelle tracking. Adv. Mater. 16(12), 961-966 (2004).
38. Yum K, Na S, Xiang Y, Wang N, Yu MF. Mechanochemical delivery and dynamic tracking of fuorescent quantum dots in the cytoplasm and nucleus of living cells. Nano Lett. 9(5), 2193-2198 (2009).
39. Zeng Q, Zhang Y, Song K, Kong X, Aalders MC, Zhang H. Enhancement of sensitivity and specifcity of the fuoroimmunoassay of hepatitis B virus surface antigen through "fexible" coupling between quantum dots and antibody. Talanta 80(1), 307-312 (2009).
40. Luo Y, Zhang B, Chen M et al. Sensitive and rapid quantifcation of C-reactive protein using quantum dot-labeled microplate immunoassay. J. Transl Med. 10, 24 (2012).
41. Sapsford KE, Spindel S, Jennings T et al. Optimizing two-color semiconductor nanocrystal immunoassays in single well microtiter plate formats. Sensors (Basel) 11 (8), 7879-7891 (2011).
42. Cao Z, Li H, Lau C, Zhang Y. Cross-talk-free simultaneous fuoroimmunoassay of two biomarkers based on dual-color quantum dots. Anal. Chim. Acta 698(1-2), 44-50 (2011).
43. Chen L, Zhang X, Zhou G et al. Simultaneous determination of human enterovirus 71 and Coxsackievirus B3 by dual-color quantum dots and homogeneous immunoassay. Anal. Chem. 84(7), 3200-3207 (2012).
44. Liandris E, Gazouli M, Andreadou M, Sechi LA, Rosu V, Ikonomopoulos J. Detection of pathogenic mycobacteria based on functionalized quantum dots coupled with immunomagnetic separation. PLoS ONE 6(5), e20026 (2011).
45. Parrish NM, Carroll KC. Role of the clinical mycobacteriology laboratory in diagnosis and management of tuberculosis in low-prevalence settings. J. Clin. Microbiol. 49(3), 772-776 (2011).
46. Yu-Hong W, Rui C, Ding L. A quantum dots and superparamagnetic nanoparticle-based method for the detection of HPV DNA. Nanoscale Res. Lett. 6, 461 (2011).
47. Algar WR, Krull UJ. Toward a multiplexed solid-phase nucleic acid hybridization assay using quantum dots as donors in fuorescence resonance energy transfer. Anal. Chem. 81(10), 4113-4120 (2009).
48. Geng L, Zhang HL, Peng HB. The formation of acetylcholine receptor clusters visualized with quantum dots. BMC Neurosci. 10, 80 (2009).
49. Liang Y, Shilagard T, Xiao SY et al. Visualizing hepatitis C virus infections in human liver by two-photon microscopy. Gastroenterology 137(4), 1448-1458 (2009).
50. Lee KH, Galloway JF, Park J et al. Quantitative molecular profling of biomarkers for pancreatic cancer with functionalized quantum dots. Nanomedicine doi:10.1016/j.nano.2012.01.005 (2012) (Epub ahead of print).
51. Maestro LM, Ramirez-Hernandez JE, Bogdan N et al. Deep tissue bio-imaging using two-photon excited CdTe fuorescent quantum dots working within the biological window. Nanoscale 4(1), 298-302 (2012).
52. Tu C, Ma X, Pantazis P, Kauzlarich SM, Louie AY. Paramagnetic, silicon quantum dots for magnetic resonance and two-photon imaging of macrophages. J. Am. Chem. Soc. 132, 2016-2023 (2010).
53. Mulder WJ, Castermans K, van Beijnum JR et al. Molecular imaging of tumor angiogenesis using v3-integrin targeted multimodal quantum dots. Angiogenesis 12(1), 17-24 (2009).
54. Mulder WJM, Koole R, Brandwijk RJ et al. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett. 6(1), 1-6 (2006).
55. Chen HL, Peng J, Zhu XB et al. Detection of EBV in nasopharyngeal carcinoma by quantum dot fuorescent in situ hybridization. Exp. Mol. Pathol. 89(3), 367-371 (2010).
56. Kim S, Lim Y T, Soltesz EG et al. Near-infrared fuorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22(1), 93-97 (2004).
57. Kim YG, Moon S, Kuritzkes DR, Demirci U. Quantum dot-based HIV capture and imaging in a microfuidic channel. Biosens. Bioelectron. 25(1), 253-258 (2009).
58. Noh YW, Lim YT, Chung BH. Noninvasive imaging of dendritic cell migration into lymph nodes using near-infrared fuorescent semiconductor nanocrystals. FASEB J. 22(11), 3908-3918 (2008).
59. Sudhagar S, Sathya S, Pandian K, Lakshmi BS. Targeting and sensing cancer cells with ZnO nanoprobes in vitro. Biotechnol. Lett. 33(9), 1891-1896 (2011).
60. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 114(2), 165-172 (2006).
61. Hild WA, Breunig M, Goepferich A. Quantum dots-nano-sized probes for the exploration of cellular and intracellular targeting. Eur. J. Pharm. Biopharm. 68(2), 153-168 (2008).
62. Erogbogbo F, Yong K T, Roy I, Xu GX, Prasad PN, Swihart MT. Biocompatible luminescent silicon quantum dots for imaging of cancer cells. ACS Nano 2(5), 873-878 (2008).
63. Tian J, Zhao H, Liu M, Chen Y, Quan X. Detection of infuenza A virus based on fuorescence resonance energy transfer from quantum dots to carbon nanotubes. Anal. Chim. Acta 723, 83-87 (2012).
64. Yang C, Xu C, Wang X, Hu X. Quantum-dot-based biosensor for simultaneous detection of biomarker and therapeutic drug: frst steps toward an assay for quantitative pharmacology. Analyst 137(5), 1205-1209 (2012).
65. Lowe SB, Dick JA, Cohen BE, Stevens MM. Multiplex sensing of protease and kinase enzyme activity via orthogonal coupling of quantum dot-peptide conjugates. ACS Nano 6(1), 851-857 (2012).
66. Li Z, Wang Y, Wang J, Tang Z, Pounds JG, Lin Y. Rapid and sensitive detection of protein biomarker using a portable fuorescence biosensor based on quantum dots and a lateral fow test trip. Anal. Chem. 82(16), 7008-7014 (2010).
67. Hu M, Yan J, He Y et al. Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfuidic protein chip. ACS Nano 4(1), 488-494 (2010).
68. Fu X, Huang K, Liu S. A rapid and universal bacteria-counting approach using CdSe/ZnS/SiO(2) composite nanoparticles as fuorescence probe. Anal. Bioanal. Chem. 396(4), 1397-1404 (2010).
69. Li YQ, Guan LY, Wang JH et al. Simultaneous detection of dual single-base mutations by capillary electrophoresis using quantum dot-molecular beacon probe. Biosens. Bioelectron. 26(5), 2317-2322 (2011).