Potential clinical applications of quantum dots

International Journal of Nanomedicine

Volumn 3, Issue 2, 2008, Pages 151-167

  Medintz, Igor L ^a   Mattousi, Hedi ^a   Clapp, Aaron R ^b  

^a NAVAL RESEARCH LABORATORY   (United States)

^b Iowa State University of Science and Technology   (United States)

Author keywords

Biosensor; Flourescence; FRET; Imaging; Immunoassay; Nanoparticle; Quantum dot; Toxicity

Indexed keywords

DNA; MERCAPTOUNDECANOIC ACID; NANOCRYSTAL; PROTEIN P53; QUANTUM DOT; STREPTAVIDIN; UNDECANOIC ACID;

ANTIBODY LABELING; BIOSENSOR; CARCINOGENESIS; CELL LABELING; CHEMICAL STRUCTURE; DIAGNOSTIC PROCEDURE; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; IMAGE DISPLAY; IMAGE QUALITY; IMMUNOASSAY; LIVER TOXICITY; LUMINESCENCE; MATERIAL COATING; NANOENCAPSULATION; NANOIMAGING; NANOMEDICINE; NANOTOXICOLOGY; NEPHROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; REVIEW; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TERATOGENESIS;

BIOSENSING TECHNIQUES; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMAGE ENHANCEMENT; IMMUNOASSAY; MICROSCOPY, FLUORESCENCE; QUANTUM DOTS;

EID: 69649109363     PISSN: 11769114     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

1. Akerman ME, Chan WCW, Laakkonen P, et al. 2002. Nanocrystal targeting in vivo. Proc Natl Acad Sci, 99:12617-21.
2. Alivisatos AP. 2004. The use of nanocrystals in biological detection. Nature Biotechnol, 22:47-52.
3. Aryal BP, Benson DE. 2006. Electron donor solvent effects provide biosensing with quantum dots. J Am Chem Soc, 128:15986-7.
4. Baird GS, Zacharias DA, Tsien RY. 2000. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci, 97:11984-9.
5. Bakalova R, Ohba H, Zhelev Z, et al. 2004a. Quantum dots as photosensitizers. Nature Biotechnol, 22:1360-1.
6. Bakalova R, Ohba H, Zhelev Z, et al. 2004b. Quantum dot anti-CD conjugates: Are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? Nano Letters, 4:1567-73.
7. Bakalova R, Zhelev Z, Ohba H, et al. 2005. Quantum dot-conjugated hybridization probes for preliminary screening of siRNA sequences. J Am Chem Soc, 127:11328-35.
8. Ballou B, Lagerholm BC, Ernst LA, et al. 2004. Noninvasive imaging of quantum dots in mice. Bioconjug Chem, 15:79-86.
9. Bentolila LA, Weiss S. 2006. Single-step multicolor fluorescence in situ hybridization using semiconductor quantum dot-DNA conjugates. Cell Biochem Biophys, 45:59-70.
10. Bentzen EL, House F, Utley TJ, et al. 2005. Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. Nano Letters, 5:591-5.
11. Bharali D, Lucey D, Harishankar J, et al. 2005. folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. J Am Chem Soc, 127:11364-71.
12. Bocsi J, Lenz D, Mittag A, et al. 2006. Automated four-color analysis of leukocytes by scanning fluorescence microscopy using quantum dots. Cytometry Part A, 69A:131-4.
13. Bruchez M Jr, Moronne M, Gin P, et al. 1998. Semiconductor nanocrystals as fluorescent biological labels. Science, 281:2013-16.
14. Chan PM, Yuen T, Ruf F, et al. 2005. Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res. 33:e161.
15. Chan WCW, Nie S. 1998. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science, 281:2016-8.
16. Chu MQ, Song X, Cheng D, et al. 2006a. Preparation of quantum dot-coated magnetic polystyrene nanospheres for cancer cell labelling and separation. Nanotechnology, 17:3268-73.
17. Chu TC, Shieh F, Lavery LA, et al. 2006b. Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens Bioelectron, 21:1859-66.
18. Clapp AR, Medintz IL, Mauro JM, et al. 2004. Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. J Am Chemical Society, 126:301-10.
19. Colton HM, Falls JG, Ni H, et al. 2004. Visualization and quantitation of peroxisomes using fluorescent nanocrystals: Treatment of rats and monkeys with fibrates and detection in the liver. Toxicol Sci. 80:183-92.
20. Colvin VL. 2003. The potential environmental impact of engineered nanomaterials. Nature Biotechnol, 21:1166-70.
21. Dabbousi BO, Rodriguez-Viejo J, Mikulec FV, et al. 1997. (CdSe)ZnS core-shell quantum dots: synthesis and optical and structural characterization of a size series of highly luminescent materials. J Phys Chem B, 101:9463-75.
22. de Farias PMA, Santos BS, de Menezes FD, et al. 2005. Investigation of red blood cell antigens with highly fluorescent and stable semiconductor quantum dots. J Biomed Optics, 10:044023.
23. De Rosa SC, Herzenberg LA, Herzenberg LA, et al. 2001. 11-color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med, 7:245-8.
24. Delehanty JB, Medintz IL, Pons T, et al. 2006. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjug Chem, 17:920-7.
25. Derfus AM, Chan WCW, Bhatia SN. 2004a. Intracellular delivery of quantum dots for live cell labeling and organelle tracking. Adv Mater, 16:961-6.
26. Derfus AM, Chan WCW, Bhatia SN. 2004b. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Letters, 4:11-18.
27. Dubertret B, Skourides P, Norris DJ, et al. 2002. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science, 298:1759-62.
28. Eastman PS, Ruan WM, Doctolero M, et al. 2006. Qdot nanobarcodes for multiplexed gene expression analysis. Nano Letters, 6:1059-64.
29. Fischer HC, Lichuan L, Pang KS, et al. 2006. Pharmacokinetics of Nanoscale Quantum Vivo Distribution, Sequestration, and Clearance in the Rat. Advanced Functional Materials, 16:1299-305.
30. Gao X, Cui Y, Levenson RM, et al. 2004. In vivo cancer targeting and imaging with semiconductor quantum dots. Nature Biotechnol, 22:969-76.
31. Gerion D, Chen F, Kannan B, et al. 2003. Room-Temperature Single-Nucleotide Polymorphism and Multiallele DNA Detection Using Fluorescent Nanocrystals and Microarrays. Anal Chem, 75:4766-72.
32. Gill R, Freeman R, Xu JP, et al. 2006. Probing biocatalytic transformations with CdSe-ZnS QDs. J Am Chem Soc, 128:15376-7.
33. Gill R, Willner I, Shweky I, et al. 2005. Fluorescence resonance energy transfer in CdSe/ZnS-DNA conjugates: Probing hybridization and DNA cleavage. J Phys Chem B, 109:23715-9.
34. Goldman ER, Clapp AR, Anderson GP, et al. 2004. Multiplexed Toxin Analysis Using Four Colors of Quantum Dot Fluororeagents. Anal Chem, 76:684-8.
35. Gu H, Zheng R, Zhang X, et al. 2004. Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: A conjugate of quantum dot and magnetic nanoparticles. J Am Chem Soc, 126:5664-5.
36. Guo W, Li JJ, Wang YA, et al. 2003. Conjugation chemistry and bioapplications of semiconductor box nanocrystals prepared via dendrimer bridging. Chem Mater, 15:3125-33.
37. Hardman R. 2006. A toxicological review of quantum dots:toxicity depends on physicochemical and environmental factors. Environ Health Perspect, 114:165-72.
38. Hoet PH, Bruske-Hohlfeld I, Salata OV. 2004. Nanoparticles - known and unknown health risks. J Nanobiotechnol, 2:2-12.
39. Hoshino A, Hanaki K, Suzuki K, et al. 2004. Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem Biophys Res Comm, 314:46-53.
40. Hu FQ, Ran YL, Zhou ZA, et al. 2006. Preparation of bioconjugates of CdTe nanocrystals for cancer marker detection. Nanotechnology, 17:2972-7.
41. Jaiswal JK, Goldman ER, Mattoussi H, et al. 2004. Use of quantum dots for live cell imaging. Nature Meth, 1:73-8.
42. Jaiswal JK, Mattoussi H, Mauro JM, et al. 2003. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nature Biotechnol, 21:47-51.
43. Kahn E, Vejux A, Menetrier F, et al. 2006. Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots - Investigation by flow cytometry and spectral imaging microscopy. Anal Quant Cytol Histol, 28:14-26.
44. Kaul Z, Yaguchi T, Kaul SC, et al. 2003. Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Res, 13:503-7.
45. Kim H, Achermann M, Balet LP, et al. 2005. Synthesis and characterization of Co/CdSe core/shell nanocomposites: Bifunctional magnetic-optical nanocrystals. J Am Chem Soc, 127:544-6.
46. Kim S, Bawendi MG. 2003. Oligomeric Ligands for Luminescent and Stable Nanocrystal Quantum Dots. J Am Chem Soc, 125:14652-3.
47. Kim S, Lim YT, Soltesz EG, et al. 2004. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nature Biotechnol, 22:93-7.
48. Kortan AR, Hull R, Opila RL, et al. 1990. Nucleation and growth of cadmium selendie on zinc sulfide quantum crystallite seeds, and vice versa, in inverse micelle media. J Am Chem Soc, 112:1327-32.
49. Lakowicz JR. 1999. Principles of Fluorescence Spectroscopy. Kluwer Academic/Plenum Publishers.
50. Larson DR, Zipfel WR, Williams RM, et al. 2003. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science, 300:1434-7.
51. Leatherdale CA, Woo WK, Mikulec FV, et al. 2002. On the absorption cross section of CdSe nanocrystal quantum dots. J Phys Chem B, 106:7619-22.
52. Lidke DS, Nagy P, Heintzmann R, et al. 2004. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nature Biotechnol, 22:198-203.
53. Lim YT, Kim S, Nakayama A, et al, 2003. Selection of quantum dot wave-lengths for biomedical assays and imaging. Mol Imag, 2:50-64.
54. Mattoussi H, Mauro JM, Goldman ER, et al. 2000. Self-assembly of Cdse-zns quantum dot bioconjugates using an engineered recombinant protein. J Am Chem Soc, 122:12142-50.
55. Medintz IL, Clapp AR, Brunel FM, et al. 2006. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates. Nature Mater, 5:581-9.
56. Medintz IL, Clapp AR, Mattoussi H, et al. 2003. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nature Mater, 2:630-8.
57. Medintz IL, Clapp AR, Melinger JS, et al. 2005a. A reagentless biosensing assembly based on quantum dot donor förster resonance energy transfer. Adv Mater, 17:2450-5.
58. Medintz IL, Konnert JH, Clapp AR, et al. 2004. A fluorescence resonance energy transfer derived structure of a quantum dot-protein bioconjugate nanoassembly. Proc Natl Acad Sci, 101:9612-17.
59. Medintz IL, Uyeda HT, Goldman ER, et al. 2005b. Quantum dot bioconjugates for imaging, labeling and sensing. Nature Mater, 4:435-46.
60. Michalet X, Pinaud FF, Bentolila LA, et al. 2005. Quantum dots for live cells, in vivo imaging, and diagnostics. Science, 307:538-44.
61. Mulder WJM, Koole R, Brandwijk RJ, et al. 2006. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Letters, 6:1-6.
62. Murray CB, Kagan CR, Bawendi MG. 2000. Synthesis and characterization of monodisperse nanocrystals and close-packed nanocrystal assemblies. Ann Rev Mater Sci, 30:545-610.
63. Nel A, Xia T, Madler L, et al. 2006. Toxic potential of materials at the nanolevel. Science, 311:622-7.
64. Parak WJ, Boudreau R, Le Gros M, et al. 2002. Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks. Adv Mater, 14:882-5.
65. Pathak S, Choi SK, Arnheim N, et al. 2001. Hydroxylated quantum dots as luminescent probes for in situ hybridization. J Am Chem Soc, 123:4103-4.
66. Patolsky F, Gill R, Weizmann Y, et al. 2003. Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots. J Am Chem Soc, 125:13918-19.
67. Pinaud F, King D, Moore H-P, et al. 2004. Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides. J Am Chem Soc, 126:6115-23.
68. Sandros MG, Gao D, Benson DE. 2005. A modular nanoparticle-based system for reagentless small molecule biosensing. J Am Chem Soc, 127:12198-9.
69. Shepard JRE. 2006. Polychromatic microarrays: Simultaneous multicolor array hybridization of eight samples. Anal Chem, 78:2478-86.
70. Shi L, DePaoli V, Rosenzweig N, et al. 2006. Synthesis and application of quantum dots FRET-based protease sensors. J Am Chem Soc, 128:10378-9.
71. Stsiapura V, Sukhanova A, Artemyev M, et al. 2004. Functionalized nanocrystal-tagged fluorescent polymer beads: synthesis, physicochemical characterization, and immunolabeling application. Anal Biochem, 334:257-65.
72. Sukhanova A, Devy M, Venteo L, et al. 2004. Biocompatible fluorescent nanocrystals for immunolabeling of membrane proteins and cells. Anal Biochem, 324:60-7.
73. Tan WB, Zhang Y. 2005. Multifunctional quantum-dot-based magnetic chitosan nanobeads. Adv Mater, 17:2375-80.
74. Tokumasu F, Dvorak J. 2003. Development and application of quantum dots for immunocytochemistry of human erythrocytes. J Microsc, 211:256-61.
75. Uyeda HT, Medintz IL, Jaiswal JK, et al. 2005. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J Am Chem Soc, 127:3870-8.
76. Wang HZ, Wang HY, Liang RQ, et al. 2004. Detection of tumor marker CA125 in ovarian carcinoma using quantum dots. Acta Biochim Biophys Sin, 36:681-6.
77. Wu X, Liu H, Liu J, et al. 2003. Corrigendum: Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nature Biotechnol, 21:452.
78. Xu HX, Sha MY, Wong EY, et al. 2003. Multiplexed SNP genotyping using the Qbead (TM) system: a quantum dot-encoded microsphere-based assay. Nucleic Acids Res, 31:e43.
79. Yeh HC, Ho YP, Shih IM, et al. 2006. Homogeneous point mutation detection by quantum dot-mediated two-color fluorescence coincidence analysis. Nucleic Acids Res, 34.
80. Zahavy E, Freeman E, Lustig S, et al. 2005. Double labeling and simultaneous detection of B- and T cells using fluorescent nano-crystal (q-dots) in paraffin-embedded tissues. J Fluoresc, 15:661-5.
81. Zhang C-Y, Johnson LW. 2006. Homogeneous rapid detection of nucleic acids using two-color quantum dots. The Analyst, 131:484-8.
82. Zhang CY, Yeh HC, Kuroki MT, et al. 2005. Single-quantum-dot-based DNA nanosensor. Nature Mater, 4:826-31.
83. Zhang TT, Stilwell JL, Gerion D, et al. 2006. Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Letters, 6:800-8.
84. Zhelev Z, Bakalova R, Ohba H, et al. 2006. Uncoated, broad fluorescent, and size-homogeneous CdSe quantum dots for bioanalyses. Anal Chem, 78:321-30.