Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

Experimental Neurology

Volumn 229, Issue 2, 2011, Pages 381-390

  Vaz, Ana R ^a   Silva, Sandra L ^a   Barateiro, Andreia ^a   Fernandes, Adelaide ^a   Falcão, Ana S ^a   Brito, Maria A ^a   Brites, Dora ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

Bilirubin induced neurological dysfunction (BIND); Caspase activation; JNK1 2 signaling pathway; Neuronal NO NOS system; TNF +IL 1

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BILIRUBIN; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 9; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BILIRUBIN INDUCED NEUROLOGICAL DYSFUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPOSURE; FEMALE; FETUS; IN VITRO STUDY; INCUBATION TEMPERATURE; INCUBATION TIME; INFLAMMATION; JAUNDICE; MITOCHONDRION; NERVE CELL CULTURE; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANTHRACENES; BILIRUBIN; BLOTTING, WESTERN; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME INHIBITORS; INFLAMMATION; INTERLEUKIN-1BETA; MAP KINASE KINASE 4; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79956137679     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.03.004     Document Type: Article

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