Protein folding and the order/disorder paradox

Journal of Cellular Biochemistry

Volumn 112, Issue 7, 2011, Pages 1949-1952

  Kulkarni, Prakash ^a,b   Rajagopalan, Krithika ^a   Yeater, David ^a   Getzenberg, Robert H ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cancer; Cancer testis antigens; Order disorder paradox; Proteasome; Protein folding

Indexed keywords

GLOBULAR PROTEIN; PROTEOME;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; DEGENERATIVE DISEASE; NEOPLASM; ORDER DISORDER PARADOX; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; QUALITY CONTROL; UBIQUITINATION;

ANTIGENS, NEOPLASM; GENES, X-LINKED; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINS;

EID: 80051482698     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23115     Document Type: Article

References (24)

1. Anfinsen CB. 1973. Principles that govern the folding of protein chains. Science 181:223-230.
2. Dunker KA, Brown CJ, Lawson JD, Iakoucheva LM, Obradović Z. 2002. Intrinsic disorder and protein function. Biochemistry 41:6573-6582. (Pubitemid 34547347)
3. Edwards YJ, Lobley AE, Pentony MM, Jones DT. 2009. Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol 10:R50.
4. Englander SW, Mayne L, Krishna MM. 2007. Protein folding and misfolding: Mechanism and principles. Q Rev Biophys 40:287-326. (Pubitemid 351569384)
5. Fink AL. 1995. Compact intermediate states in protein folding. Annu Rev Biophys Biomol Struct 24:495-522.
6. Gardner RG, Hampton RY. 1999. A 'distributed degron' allows regulated entry into the ER degradation pathway. EMBO J 18:5994-6004. (Pubitemid 29515676)
7. Goldberg AL. 2003. Protein degradation and protection against misfolded or damaged proteins. Nature 426:895-899. (Pubitemid 38056882)
8. Gsponer J, Futschik ME, Teichmann SA, Babu MM. 2008. Tight regulation of unstructured proteins: From transcript synthesis to protein degradation. Science 322:1365-1368. (Pubitemid 352775246)
9. Hartl FU, Hayer-Hartl M. 2009. Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol 16:574-581.
10. Hegyi H, Tompa P. 2008. Intrinsically disordered proteins display no preference for chaperone binding in vivo. PLoS Comput Biol 4(3):e1000017.
11. Korzhnev DM, Religa TL, Banachewicz W, Fersht AR, Kay LE. 2010. A transient and low-populated protein-folding intermediate at atomic resolution. Science 329:1312-1316.
12. Lee C, Schwartz MP, Prakash S, Iwakura M, Matouschek A. 2001. ATPdependent proteases degrade their substrates by processively unraveling them from the degradation signal. Mol Cell 7:627-637. (Pubitemid 32706354)
13. Morley JF, Morimoto RI. 2004. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15:657-664. (Pubitemid 38146482)
14. Nussbaum AK, Dick TP, Keilholz W, Schirle M, Stevanović S, Dietz K, Heinemeyer W, Groll M, Wolf DH, Huber R, Rammensee HG, Schild H. 1998. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci USA 95:12504-12509.
15. Prilusky J, Felder CE, Zeev-Ben-Mordehai T, Rydberg EH, Man O, Beckmann JS, Silman I, Sussman JL. 2005. FoldIndex: A simple tool to predict whether a given protein sequence is intrinsically unfolded. Bioinformatics 21:3435-3438. (Pubitemid 41222454)
16. Rauscher S, Pomès R. 2010. Molecular simulations of protein disorder. Biochem Cell Biol 88:269-290.
17. Scanlan MJ, Simpson AJ, Old LJ. 2004. The cancer/testis genes: Review, standardization, and commentary. Cancer Immun 4:1-15.
18. Schrader EK, Harstad KG, Matouschek A. 2009. Targeting proteins for degradation. Nat Chem Biol 5:815-822.
19. Thrower JS, Hoffman L, Rechsteiner M, Pickart CM. 2000. Recognition of the polyubiquitin proteolytic signal. EMBO J 19:94-102. (Pubitemid 30009229)
20. Tsvetkov P, Reuven N, Shaul Y. 2009. The nanny model for IDPs. Nat Chem Biol 5:778-781.
21. Uversky VN. 2003. Protein folding revisited. A polypeptide chain at the folding-misfolding-nonfolding cross-roads: Which way to go? Cell Mol Life Sci 60:1852-1871. (Pubitemid 37222583)
22. Uversky VN, Dunker K. 2010. Understanding protein non-folding. Biochim Biophys Acta 1804:1231-1264.
23. Uversky VN, Oldfield CJ, Dunker AK. 2008. Intrinsically disordered proteins in human diseases: Introducing the D2 concept. Annu Rev Biophys 37:215-246.
24. Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJ. 2008. Global protein stability profiling in mammalian cells. Science 322:918-923.