A structure-activity relationship study for 2′-deoxyadenosine analogs at a9 position in the catalytic core of 10-23 DNAzyme for rate enhancement

Nucleic Acid Therapeutics

Volumn 22, Issue 6, 2012, Pages 423-427

  Wang, Qi ^a   Zhang, Di ^b   Liu, Yang ^a   Cheng, Maosheng ^b   He, Junlin ^a   Liu, Keliang ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

8 AZA 7 DEAZA 2' DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; DNA; DNAZYME; HYDROXYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CATALYTIC DOMAIN; DEOXYADENOSINES; DNA, CATALYTIC; DNA, SINGLE-STRANDED; ENZYME ACTIVATORS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; RNA CLEAVAGE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870539726     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2012.0365     Document Type: Article

References (32)

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