Learning about retinoblastoma from mouse models that missed

Neuromethods

Volumn 77, Issue , 2013, Pages 141-152

  Cobrinik, David ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cancer; Mouse models; p107; p130; RB; Retina; Retinoblastoma

Indexed keywords

RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; EXPERIMENTAL MOUSE; GENE; GENE INACTIVATION; GENE MUTATION; GENETIC RISK; HISTOPATHOLOGY; HUMAN; INTERNEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; RB GENE; RETINA NERVE CELL; RETINOBLASTOMA; SIGNAL TRANSDUCTION; TUMOR MODEL;

MUS;

EID: 84870525178     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/7657_2011_25     Document Type: Article

References (45)

1. Chow RL, Lang RA (2001) Early eye development in vertebrates. Annu Rev Cell Dev Biol 17:255-2966
2. Albert DM (1987) Historic review of retinoblastoma. Ophthalmology 94:654-6622
3. Weller CV (1941) The inheritance of retinoblastoma and its relationship to practical eugenics. Cancer Res 1:517-5355
4. Knudson AG Jr (1971) Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-8233
5. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL (1983) Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779-7844
6. Dunn JM, Phillips RA, Becker AJ, Gallie BL (1988) Identification of germline and somatic mutations affecting the retinoblastoma gene. Science 241:1797-18000
7. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643-6466
8. Corson TW, Gallie BL (2007) One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer 46:617-6344
9. Dimaras H, Khetan V, Halliday W, Orlic M, Prigoda NL, Piovesan B, Marrano P, Corson TW, Eagle RC Jr, Squire JA, Gallie BL (2008) Loss of RB1 induces non-proliferative retinoma; increasing genomic instability correlates with progression to retinoblastoma. Hum Mol Genet 17(10): 1363-13722
10. Abramson DH, Gombos DS (1996) The topography of bilateral retinoblastoma lesions. Retina 16:232-2399
11. Balmer A, Munier F, Gailloud C (1991) Retinoma. Case studies. Ophthalmic Paediatr Genet 12:131-1377
12. Singh AD, Santos CM, Shields CL, Shields JA, Eagle RC Jr (2000) Observations on 177 patients with retinocytoma. Arch Ophthalmol 118:199-2055
13. Flexner S (1891) A peculiar glioma (neuroepithelioma?) of the retina. Bull Johns Hopkins Hosp Balt 2:115-1199
14. Ts'o MO, Zimmerman LE, Fine BS (1970) The nature of retinoblastoma. I. Photoreceptor differentiation: A clinical and histopathologic study. Am J Ophthalmol 69:339-3499
15. Gonzalez-Fernandez F, Lopes MB, Garcia-Fernandez JM, Foster RG, De Grip WJ, Rosemberg S, Newman SA, VandenBerg SR (1992) Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma. Am J Pathol 141:363-3755
16. Nork TM, Schwartz TL, Doshi HM, Millecchia LL (1995) Retinoblastoma. Cell of origin. Arch Ophthalmol 113:791-8022
17. Rodrigues MM, Rajagopalan S, Lee L, Nair CN, Advani SH, Donoso L, Chader GJ, Wiggert B (1992) Retinoblastoma: Messenger RNA for interphotoreceptor retinoid binding protein. Curr Eye Res 11:425-4333
18. Bogenmann E, Lochrie MA, Simon MI (1988) Cone cell-specific genes expressed in retinoblastoma. Science 240:76-788
19. Kyritsis AP, Tsokos M, Triche TJ, Chader GJ (1984) Retinoblastoma-origin from a primitive neuroectodermal cell?Nature 307:471-4733
20. Virtanen I, Kivela T, Bugnoli M, Mencarelli C, Pallini V, Albert DM, Tarkkanen A (1988) Expression of intermediate filaments and synaptophysin show neuronal properties and lack of glial characteristics in Y79 retinoblastoma cells. Lab Invest 59:649-6566
21. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 359:295-3000
22. Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288-2944
23. Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A, te Riele H (1992) Requirement for a functional Rb-1 gene in murine development. Nature 359:328-3300
24. Hu N, Gutsmann A, Herbert DC, Bradley A, Lee WH, Lee EY (1994) Heterozygous Rb-11 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9:1021-10277
25. Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T (1994) Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet 7:480-4844
26. Maandag EC, van der Valk M, Vlaar M, Feltkamp C, O'Brien J, van Roon M, van der Lugt N, Berns A, te Riele H (1994) Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J 13:4260-42688
27. Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T (1994) Extensive contribution of Rbdeficient cells to adult chimeric mice with limited histopathological consequences. EMBO J 13:4251-42599
28. Classon M, Dyson N (2001) p107 and p130: Versatile proteins with interesting pockets. Exp Cell Res 264:135-1477
29. Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T (1996) Targeted disruption of p107: Functional overlap between p107 and Rb. Genes Dev 10:1621-16322
30. Dannenberg JH, Schuijff L, Dekker M, van der Valk M, te Riele H (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 18:2952-29622
31. Robanus-Maandag E, Dekker M, van der Valk M, Carrozza ML, Jeanny JC, Dannenberg JH, Berns A, te RieleH(1998) p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev 12:1599-16099
32. Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R (2004) Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5:539-5511
33. MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T (2004) Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18:1681-16944
34. Zhang J, Schweers B, Dyer MA (2004) The first knockout mouse model of retinoblastoma. Cell Cycle 3:952-9599
35. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA (2004) Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 36:351-3600
36. Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger MW, Leone G, Bremner R (2007) Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol 5:e1799
37. MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T (2007) Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J 26:784-7944
38. Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA (2007) Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell 131:378-3900
39. Xu XL, Fang Y, Lee TC, Forrest D, Gregory-Evans C, Almeida D, Liu A, Jhanwar SC, Abramson DH, Cobrinik D (2009) Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling. Cell 137:1018-10311
40. Xu XL, Lee TC,Offor N, Cheng C, Liu A, Fang Y, Jhanwar SC, Abramson DH, Cobrinik D (2010) Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5. Am J Pathol 177:424-4355
41. Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR (1998) E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 9:113-1188
42. Lomazzi M, Moroni MC, Jensen MR, Frittoli E, Helin K (2002) Suppression of the p53-or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet 31:190-1944
43. Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM (1997) Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 16:2985-29955
44. Rangarajan A, Weinberg RA (2003) Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice. Nat Rev Cancer 3:952-9599
45. Demetrius L (2005) Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans. EMBO Rep 6(S1):S39-S444