NMI mediates transcription-independent ARF regulation in response to cellular stresses

Molecular Biology of the Cell

Volumn 23, Issue 23, 2012, Pages 4635-4646

  Li, Zengpeng ^a   Hou, Jingjing ^a   Sun, Li ^a   Wen, Taoyong ^a   Wang, Liqin ^a   Zhao, Xinmeng ^a   Xie, Qingqing ^a   Zhang, Si Qing ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ARF PROTEIN; MYC PROTEIN; STAT PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; CELL NUCLEUS; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN METABOLISM;

DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; STRESS, PHYSIOLOGICAL; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84870493632     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-04-0304     Document Type: Article

References (53)

1. Bao J, Zervos AS (1996). Isolation and characterization of Nmi, a novel partner of Myc proteins. Oncogene 12, 2171-2176. (Pubitemid 26168426)
2. Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL, Vousden KH (1998). p14ARF links the tumour suppressors RB and p53. Nature 395, 124-125. (Pubitemid 28425642)
3. Bertwistle D, Sugimoto M, Sherr CJ (2004). Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23. Mol Cell Biol 24, 985-996. (Pubitemid 38112164)
4. Britton S, Salles B, Calsou P (2008). c-MYC protein is degraded in response to UV irradiation. Cell Cycle 7, 63-70.
5. Chen D, Kon N, Li M, Zhang W, Qin J, Gu W (2005). ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121, 1071-1083. (Pubitemid 40884397)
6. Chen D, Shan J, Zhu WG, Qin J, Gu W (2010). Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature 464, 624-627.
7. Chung JC, Oh MJ, Choi SH, Bae CD (2008). Proteomic analysis to identify biomarker proteins in pancreatic ductal adenocarcinoma. ANZ J Surg 78, 245-251. (Pubitemid 351432692)
8. Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG (2005). Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 25, 8874-8886. (Pubitemid 41429079)
9. Datta A, Nag A, Pan W, Hay N, Gartel AL, Colamonici O, Mori Y, Raychaudhuri P (2004). Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem 279, 36698-36707. (Pubitemid 39129016)
10. de Stanchina E et al. (1998). E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 12, 2434-2442.
11. di Tommaso A, Hagen J, Tompkins V, Muniz V, Dudakovic A, Kitzis A, Ladeveze V, Quelle DE (2009). Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities. Exp Cell Res 315, 1326-1335.
12. Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S (2006). p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. Mol Cell Biol 26, 4339-4350. (Pubitemid 43788032)
13. Fillmore RA, Mitra A, Xi Y, Ju J, Scammell J, Shevde LA, Samant RS (2009). Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth. Int J Cancer 125, 556-564.
14. Garcia MA, Collado M, Munoz-Fontela C, Matheu A, Marcos-Villar L, Arroyo J, Esteban M, Serrano M, Rivas C (2006). Antiviral action of the tumor suppressor ARF. EMBO J 25, 4284-4292. (Pubitemid 44435226)
15. He L, Fan C, Ning X, Feng X, Liu Y, Chen B, Tang D (2008). Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer. Cell Biol Int 32, 1302-1309.
16. Herkert B et al. (2010). The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J Cell Biol 188, 905-918.
17. Huang Y, Wu M, Li HY (2008). Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. J Biol Chem 283, 11453-11460.
18. Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y (2003). Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell 12, 1151-1164. (Pubitemid 37487925)
19. Itahana K, Zhang Y (2008). Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell 13, 542-553. (Pubitemid 351763900)
20. Jiang MR, Li YC, Yang Y, Wu JR (2003). c-Myc degradation induced by DNA damage results in apoptosis of CHO cells. Oncogene 22, 3252-3259. (Pubitemid 36712937)
21. Kamijo T, Bodner S, van de Kamp E, Randle DH, Sherr CJ (1999). Tumor spectrum in ARF-deficient mice. Cancer Res 59, 2217-2222. (Pubitemid 29217688)
22. Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ (1998). Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci USA 95, 8292-8297. (Pubitemid 28326106)
23. Khan SH, Moritsugu J, Wahl GM (2000). Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci USA 97, 3266-3271. (Pubitemid 30183290)
24. Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K (2005). Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J 24, 3724-3736. (Pubitemid 41581689)
25. Korgaonkar C, Zhao L, Modestou M, Quelle DE (2002). ARF function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol 22, 196-206. (Pubitemid 33144268)
26. Kuo ML, den Besten W, Bertwistle D, Roussel MF, Sherr CJ (2004). N-terminal polyubiquitination and degradation of the Arf tumor suppressor. Genes Dev 18, 1862-1874. (Pubitemid 39025096)
27. Lebrun SJ, Shpall RL, Naumovski L (1998). Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi. J Interferon Cytokine Res 18, 767-771. (Pubitemid 28458010)
28. Lee C, Smith BA, Bandyopadhyay K, Gjerset RA (2005). DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF. Cancer Res 65, 9834-9842. (Pubitemid 41541462)
29. Li H, Lee TH, Avraham H (2002). A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. J Biol Chem 277, 20965-20973. (Pubitemid 34967407)
30. Lindstrom MS, Klangby U, Inoue R, Pisa P, Wiman KG, Asker CE (2000). Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus. Exp Cell Res 256, 400-410. (Pubitemid 30244199)
31. Llanos S, Clark PA, Rowe J, Peters G (2001). Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat Cell Biol 3, 445-452. (Pubitemid 32422079)
32. Miao L, Song Z, Jin L, Zhu YM, Wen LP, Wu M (2010). ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene 29, 711-722.
33. Palmero I, Pantoja C, Serrano M (1998). p19ARF links the tumour suppressor p53 to Ras. Nature 395, 125-126. (Pubitemid 28425643)
34. Peters G, Rodway H, Llanos S, Rowe J (2004). Stability of nucleolar versus non-nucleolar forms of human p14(ARF). Oncogene 23, 6186-6192. (Pubitemid 39215288)
35. Pollice A, Nasti V, Ronca R, Vivo M, Lo Iacono M, Calogero R, Calabro V, La Mantia G (2004). Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1. J Biol Chem 279, 6345-6353. (Pubitemid 38248767)
36. Pomerantz J et al. (1998). The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92, 713-723. (Pubitemid 28155311)
37. Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR (2004). p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature 431, 712-717. (Pubitemid 39382620)
38. Quelle DE, Zindy F, Ashmun RA, Sherr CJ (1995). Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000. (Pubitemid 26006540)
39. Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N (1998). p19(Arf) induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation. Proc Natl Acad Sci USA 95, 13194-13199.
40. Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (2003). Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem 278, 4981-4989. (Pubitemid 36801007)
41. Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND (2005). Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24, 1157-1169. (Pubitemid 40516599)
42. Sandoval R, Xue J, Pilkinton M, Salvi D, Kiyokawa H, Colamonici OR (2004). Different requirements for the cytostatic and apoptotic effects of type I interferons. Induction of apoptosis requires ARF but not p53 in osteosarcoma cell lines. J Biol Chem 279, 32275-32280. (Pubitemid 39014677)
43. Sherr CJ (2006). Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 6, 663-673.
44. Stott FJ et al. (1998). The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 17, 5001-5014. (Pubitemid 28408466)
45. Tao W, Levine AJ (1999). P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci USA 96, 6937-6941. (Pubitemid 29274988)
46. Wang J, He X, Luo Y, Yarbrough WG (2006). A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J 393, 489-501. (Pubitemid 43099088)
47. Weber JD, Brady SN, Yu Y, Maggi LB (2004). ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol 24, 9327-9338. (Pubitemid 39391671)
48. Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D (1999). Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1, 20-26. (Pubitemid 129495005)
49. Zhang K, Zheng G, Yang YC (2007). Stability of Nmi protein is controlled by its association with Tip60. Mol Cell Biochem 303, 1-8. (Pubitemid 47261295)
50. Zhang Y, Xiong Y (1999). Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell 3, 579-591. (Pubitemid 29268441)
51. Zhang Y, Xiong Y, Yarbrough WG (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734. (Pubitemid 28155312)
52. Zhou X, Liao J, Meyerdierks A, Feng L, Naumovski L, Bottger EC, Omary MB (2000). Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. J Biol Chem 275, 21364-21371. (Pubitemid 30481836)
53. Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF (1998). Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12, 2424-2433. (Pubitemid 28371361)