4'-aminochalcones as novel inhibitors of the chlorinating activity of myeloperoxidase

Current Medicinal Chemistry

Volumn 19, Issue 31, 2012, Pages 5405-5413

  Zeraik, M L ^a   Ximenes, V F ^a   Regasini, L O ^a   Dutra, L A ^a   Silva, D H S ^a   Fonseca, L M ^a   Coelho, D ^b   MacHado, S A S ^b   Bolzani, V S ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aminochalcones; Anti inflammatory; Antioxidant; Chalcones; Hypochlorous acid; Myeloperoxidase inhibition; Neutrophils; Reactive oxygen species; Redox potential; Scavenger capacity

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 4' AMINO 4 FLUOROCHALCONE; 4' AMINO 4 HYDROXYCHALCONE; 4' AMINO 4 METHYLCHALCONE; 4' AMINOCHALCONE; 4' HYDROXYCHALCONE; 5 FLUOROTRYPTAMINE; ANTIOXIDANT; CHALCONE; CHALCONE DERIVATIVE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; QUERCETIN; SCAVENGER; TRYPAN BLUE; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; HUMAN EXPERIMENT; IC 50; INFLAMMATORY DISEASE; INFORMATION PROCESSING; NEUTROPHIL; NORMAL HUMAN; OXIDATION;

CELL SURVIVAL; CELLS, CULTURED; CHALCONES; ENZYME INHIBITORS; HALOGENATION; HUMANS; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; PROTEIN BINDING; SUPEROXIDES;

EID: 84870460707     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712803833344     Document Type: Article

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