Contributions of myeloperoxidase to proinflammatory events: More than an antimicrobial system

International Journal of Hematology

Volumn 74, Issue 2, 2001, Pages 125-133

  Nauseef, William M ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Atherosclerosis; Inflammation; Myeloperoxidase; Myeloperoxidase deficiency

Indexed keywords

ANTIINFECTIVE AGENT; HYPOCHLOROUS ACID; PEROXIDASE;

ANIMAL; ARTERIOSCLEROSIS; CENTRAL NERVOUS SYSTEM DISEASE; ENZYMOLOGY; GENETICS; HUMAN; INFLAMMATION; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; ANTI-INFECTIVE AGENTS; ARTERIOSCLEROSIS; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; HYPOCHLOROUS ACID; INFLAMMATION; PEROXIDASE;

EID: 0035431070     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02981994     Document Type: Article

References (23)

1. Agner K. Crystalline myeloperoxidase. Acta Chem Scand. 1958;1: 89-94.
2. Agner K. Verdoperoxidase: a ferment isolated from leukocytes. Acta Physiol Scand. 1941;2:1-62.
3. Klebanoff SJ. Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes. Science. 1970;169:1095-1097.
4. Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood. 1998;92:3007-3017.
5. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report. 1997;3:3-15.
6. Klebanoff SJ. Myeloperoxidase. Proc Assoc Am Physicians. 1999; 111:383-389.
7. Dunford HB. Myeloperoxidase and eosinophil peroxidase: phagocytosis and microbial killing. In: Heme Peroxidases. New York, NY: Wiley-VCH; 1999:349-385.
8. Jiang Q, Griffin DA, Barofsky DF, Hurst JK. Intraphagosomal chlorination dynamics and yields determinded using unique fluorescent bacterial mimics. Chem Res Toxicol. 1997;10:1080-1089.
9. Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. Human neutrophils employ chlorine gas as an oxidant during phagocytosis. J Clin Invest. 1996;98:1283-1289.
10. Jiang Q, Hurst JK. Relative chlorinating, nitrating, and oxidizing capabilities of neutrophils determined with phagocytosable probes. J Biol Chem. 1997;272:32767-32772.
11. Winterbourn CC, Kettle AJ. Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic Biol Med. 2000;29:403-409.
12. Zgliczynski JM, Stelmaszynska T, Domanski J, Ostrowski W. Chloramines as intermediates of oxidative reaction of amino acids by myeloperoxidase. Biochem Biophys Acta. 1971;235:419-424.
13. Dinauer MC, Nauseef WM, Newburger PE. Inherited disorders of phagocyte killing. In: Scriver CR, Beaudet AL, Valle D, et al, eds. The Metabolic and Molecular Bases of Inherited Diseases. New York NY: McGraw-Hill; 2001:4857-4887.
14. Podrez EA, Schmitt D, Hoff HF, Hazen SL. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. J Clin Invest. 1999;103:1547-1560.
15. Whitman SC, Hazen SL, Miller DB, Hegele RA, Heinecke JW, Huff MW. Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages. Arterioscler Thromb Vasc Biol. 1999;19:1238-1249.
16. Heller JI, Crowley JR, Hazen SL, et al. p-Hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modified phospholipid amino groups of low density lipoprotein in human atherosclerotic intima. J Biol Chem. 2000;275:9957-9962.
17. Reynolds WF. The role of myeloperoxidase in myeloid leukemia and multiple sclerosis. In: Nauseef WM, Petrides PE, eds. The Peroxidase Multigene Family of Enzymes. New York, NY: Springer-Verlag; 2000:93-101.
18. Nagra R, Becher B, Tourtellotte WW, et al. Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis. J Neuroimmunol. 1997;78:97-107.
19. Reynolds WF, Rhees J, Maciejewski D, et al. Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease. Exp Neurol. 1999;155:31-41.
20. Jolivalt C, Leininger-Muller B, Drozdz R, Naskalski JW, Siest G. Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain. Neurosci Lett. 1996;210: 61-64.
21. Reynolds WF, Hiltunen M, Pirskanen M, et al. MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males. Neurology. 2000;55:1284-1290.
22. Heinecke JW, Shapiro BM. Respiratory burst oxidase of fertilization. Proc Natl Acad Sci U S A. 1989;86:1259-1263.
23. Appelbaum PC. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis. 1992;15:77-83.