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Volumn 580, Issue 3, 2008, Pages 291-297

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function

(6) Bower, Kiowa S a Price, Kerry L b Sturdee, Laura E C b Dayrell, Mariza b Dougherty, Dennis A a Lummis, Sarah C R b

a CALIFORNIA INSTITUTE OF TECHNOLOGY (United States)

b UNIVERSITY OF CAMBRIDGE (United Kingdom)

Author keywords

Binding site; Cys loop receptor; Homology model; Ligand gated ion channel; Partial agonist; Serotonin receptor

Indexed keywords

5 FLUOROTRYPTAMINE; ION CHANNEL; LIGAND GATED ION CHANNEL; SEROTONIN 3 RECEPTOR; TRYPTAMINE; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; BINDING SITE; CELL CULTURE; CELL STRAIN HEK293; CHANNEL GATING; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; RECEPTOR BINDING;

5-METHOXYTRYPTAMINE; AMINO ACID SEQUENCE; ANIMALS; BICYCLO COMPOUNDS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG PARTIAL AGONISM; ELECTROPHYSIOLOGY; FEMALE; GLYCINE; GRANISETRON; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OOCYTES; RADIOLIGAND ASSAY; RECEPTORS, DRUG; RECEPTORS, SEROTONIN, 5-HT3; SEQUENCE HOMOLOGY, AMINO ACID; SEROTONIN ANTAGONISTS; TRYPTAMINES; XENOPUS;

EID: 38349142833 PISSN: 00142999 EISSN: None Source Type: Journal
DOI: 10.1016/j.ejphar.2007.11.014 Document Type: Article

Times cited : (18)

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