메뉴 건너뛰기




Volumn 372, Issue 1-2, 2013, Pages 161-168

HBx induces HepG-2 cells autophagy through PI3K/Akt-mTOR pathway

Author keywords

Autophagy; HBx; HCC; HepG 2; PI3K Akt mTOR

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BECLIN 1; HEPATITIS B VIRUS X PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53;

EID: 84870409543     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1457-x     Document Type: Article
Times cited : (66)

References (44)
  • 1
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • 15508102 10.1053/j.gastro.2004.09.011
    • Bosch FX, Ribes J, Diaz M, Cleries R (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology 127(5 Suppl 1):S5-S16
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 2
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000, the global picture
    • Parkin DM, Bray FI, Devesa SS (2001) Cancer burden in the year 2000, The global picture. Eur J Cancer 37 (Suppl 8):S4-S66
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 4
    • 0034057803 scopus 로고    scopus 로고
    • Hepatitis B virus biology
    • 10.1128/MMBR.64.1.51-68.2000
    • Seeger C, Mason WS (2000) Hepatitis B virus biology. Microbiol Mol Biol Rev 1:51-68
    • (2000) Microbiol Mol Biol Rev , vol.1 , pp. 51-68
    • Seeger, C.1    Mason, W.S.2
  • 5
    • 33748288087 scopus 로고    scopus 로고
    • Molecular functions and biological roles of hepatitis B virus x protein
    • 10.1111/j.1349-7006.2006.00299.x
    • Tang H, Oishi N, Kaneko S, Murakami S (2006) Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci 10:977-983
    • (2006) Cancer Sci , vol.10 , pp. 977-983
    • Tang, H.1    Oishi, N.2    Kaneko, S.3    Murakami, S.4
  • 6
    • 0035896631 scopus 로고    scopus 로고
    • X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
    • 10.1074/jbc.M006026200
    • Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA et al (2001) X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem 11:8328-8340
    • (2001) J Biol Chem , vol.11 , pp. 8328-8340
    • Diao, J.1    Khine, A.A.2    Sarangi, F.3    Hsu, E.4    Iorio, C.5    Tibbles, L.A.6
  • 7
    • 77950023333 scopus 로고    scopus 로고
    • HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1 and NF-jB-dependent pathway
    • 10.1016/j.jmb.2010.02.016
    • Kim JY, Song EH, Lee HJ, Oh YK, Choi KH, Yu DY et al (2010) HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1 and NF-jB-dependent pathway. J Mol Biol 4:917-931
    • (2010) J Mol Biol , vol.4 , pp. 917-931
    • Kim, J.Y.1    Song, E.H.2    Lee, H.J.3    Oh, Y.K.4    Choi, K.H.5    Yu, D.Y.6
  • 8
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    • 11125170 1:CAS:528:DC%2BD3MXjtVGgtA%3D%3D
    • Pan J, Duan LX, Sun BS, Feitelson MA (2001) Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. J Gen Virol 82:171-182
    • (2001) J Gen Virol , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3    Feitelson, M.A.4
  • 9
    • 0032403765 scopus 로고    scopus 로고
    • The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway
    • 10.1093/emboj/17.23.7066
    • Lara-Pezzi E, Armesilla AL, Majano PL, Redondo JM, Lopez-Cabrera M (1998) The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. EMBO J 23:7066-7077
    • (1998) EMBO J , vol.23 , pp. 7066-7077
    • Lara-Pezzi, E.1    Armesilla, A.L.2    Majano, P.L.3    Redondo, J.M.4    Lopez-Cabrera, M.5
  • 10
    • 77649112712 scopus 로고    scopus 로고
    • The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication
    • 10.1128/JVI.02196-09
    • Gearhart TL, Bouchard MJ (2010) The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. J Virol 6:2675-2686
    • (2010) J Virol , vol.6 , pp. 2675-2686
    • Gearhart, T.L.1    Bouchard, M.J.2
  • 12
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitinlike systems
    • 11265251 10.1038/35056522 1:CAS:528:DC%2BD3MXhvFyjtr8%3D
    • Ohsumi Y (2001) Molecular dissection of autophagy: two ubiquitinlike systems. Nat Rev Mol Cell Biol 2:211-216
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 13
    • 4344594807 scopus 로고    scopus 로고
    • Apoptosis, autophagy, and more
    • 10.1016/j.biocel.2004.04.011 1:CAS:528:DC%2BD2cXmvFemu78%3D
    • Lockshin RA, Zakeri Z (2004) Apoptosis, autophagy, and more. J Biochem Cell Biol 36:2405-2419
    • (2004) J Biochem Cell Biol , vol.36 , pp. 2405-2419
    • Lockshin, R.A.1    Zakeri, Z.2
  • 14
    • 38949136372 scopus 로고    scopus 로고
    • To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells
    • 17986849
    • Eskelinen EL (2008) To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells. Autophagy 4:257-260
    • (2008) Autophagy , vol.4 , pp. 257-260
    • Eskelinen, E.L.1
  • 15
    • 38949112123 scopus 로고    scopus 로고
    • An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid
    • 18094625 1:CAS:528:DC%2BD1cXksFGruro%3D
    • Wang Y, Hang R, Liang ZQ, Wu JC, Zhang XD, Gu ZL et al (2008) An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 4:214-226
    • (2008) Autophagy , vol.4 , pp. 214-226
    • Wang, Y.1    Hang, R.2    Liang, Z.Q.3    Wu, J.C.4    Zhang, X.D.5    Gu, Z.L.6
  • 16
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    • 11125170 1:CAS:528:DC%2BD3MXjtVGgtA%3D%3D
    • Pan J, Duan LX, Sun BS (2001) Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. J Gen Virol 82:171-182
    • (2001) J Gen Virol , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3
  • 17
    • 0035896631 scopus 로고    scopus 로고
    • X protein of hepatitis B virus inhibits Fasmediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
    • 11099494 10.1074/jbc.M006026200 1:CAS:528:DC%2BD3MXitFKgtro%3D
    • Diao J, Khine AA, Sarangi F (2001) X protein of hepatitis B virus inhibits Fasmediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem 276:8328-8340
    • (2001) J Biol Chem , vol.276 , pp. 8328-8340
    • Diao, J.1    Khine, A.A.2    Sarangi, F.3
  • 18
    • 8644286664 scopus 로고    scopus 로고
    • Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression
    • 15542843 10.1128/MCB.24.23.10352-10365.2004 1:CAS:528:DC%2BD2cXhtVart7vE
    • Wang WH, Gregori G, Hullinger RL (2004) Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression. Mol Cell Biol 24:10352-10365
    • (2004) Mol Cell Biol , vol.24 , pp. 10352-10365
    • Wang, W.H.1    Gregori, G.2    Hullinger, R.L.3
  • 19
    • 0030760174 scopus 로고    scopus 로고
    • The hepatitis B virus X gene induces p53-mediated programmed cell death
    • 9223332 10.1073/pnas.94.15.8162 1:CAS:528:DyaK2sXksl2qt7c%3D
    • Chirillo P, Pagano S, Natoli G (1997) The hepatitis B virus X gene induces p53-mediated programmed cell death. Proc Natl Acad Sci USA 94:8162-8167
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8162-8167
    • Chirillo, P.1    Pagano, S.2    Natoli, G.3
  • 20
    • 0038192317 scopus 로고    scopus 로고
    • Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression
    • 12730674 10.1038/sj.onc.1206320
    • Stöckl L, Berting A, Malkowski B, Foerste R, Hofschneider PH, Hildt E (2003) Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression. Oncogene 22:2604-2610
    • (2003) Oncogene , vol.22 , pp. 2604-2610
    • Stöckl, L.1    Berting, A.2    Malkowski, B.3    Foerste, R.4    Hofschneider, P.H.5    Hildt, E.6
  • 21
    • 0035860752 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
    • 11461911 10.1074/jbc.M104105200 1:CAS:528:DC%2BD3MXmvFCltLw%3D
    • Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM (2001) Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 276:34671-34680
    • (2001) J Biol Chem , vol.276 , pp. 34671-34680
    • Tarn, C.1    Lee, S.2    Hu, Y.3    Ashendel, C.4    Andrisani, O.M.5
  • 22
    • 7744229935 scopus 로고    scopus 로고
    • Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: Involvement of invasive potential
    • 15132991 10.1096/fj.04-2126com 1:CAS:528:DC%2BD2cXlslKktr8%3D
    • Chung TW, Lee YC, Kim CH (2004) Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18:1123-1125
    • (2004) FASEB J , vol.18 , pp. 1123-1125
    • Chung, T.W.1    Lee, Y.C.2    Kim, C.H.3
  • 23
    • 78751472196 scopus 로고    scopus 로고
    • Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the phosphatidylinositol 3-kinase/Akt pathway
    • 10.1258/ebm.2010.010179 1:CAS:528:DC%2BC3MXivVKru7Y%3D
    • Wang FZ, Fei HR, Lian LH, Wang JM, Qiu YY (2011) Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the phosphatidylinositol 3-kinase/Akt pathway. Exp Biol Med 236:62-69
    • (2011) Exp Biol Med , vol.236 , pp. 62-69
    • Wang, F.Z.1    Fei, H.R.2    Lian, L.H.3    Wang, J.M.4    Qiu, Y.Y.5
  • 24
    • 25844451103 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
    • 16173017 10.1002/jmv.20466 1:CAS:528:DC%2BD2MXhtFGitb7K
    • Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Ye L et al (2005) Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol 77:374-381
    • (2005) J Med Virol , vol.77 , pp. 374-381
    • Zhang, X.1    Dong, N.2    Yin, L.3    Cai, N.4    Ma, H.5    You, J.6    Ye, L.7
  • 25
    • 0038418494 scopus 로고    scopus 로고
    • Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells
    • 12839924 1:CAS:528:DC%2BD3sXltVGrtL4%3D
    • Chung TW, Lee YC, Ko JH, Kim CH (2003) Hepatitis B virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res 63:3453-3458
    • (2003) Cancer Res , vol.63 , pp. 3453-3458
    • Chung, T.W.1    Lee, Y.C.2    Ko, J.H.3    Kim, C.H.4
  • 26
    • 0038558163 scopus 로고    scopus 로고
    • Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
    • 12727877 10.1093/emboj/cdg210 1:CAS:528:DC%2BD3sXjsVKmu7g%3D
    • Kim KH, Seong BL (2003) Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 22:2104-2116
    • (2003) EMBO J , vol.22 , pp. 2104-2116
    • Kim, K.H.1    Seong, B.L.2
  • 27
    • 0030700736 scopus 로고    scopus 로고
    • Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells
    • 9364326 10.1002/(SICI)1097-4547(19971101)50:3<413: AID-JNR7>3.0.CO;2-L 1:CAS:528:DyaK2sXnt1ensbY%3D
    • Satoh T, Enokido Y, Aoshima H, Uchiyama Y, Hatanaka H (1997) Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells. J Neurosci Res 50:413-420
    • (1997) J Neurosci Res , vol.50 , pp. 413-420
    • Satoh, T.1    Enokido, Y.2    Aoshima, H.3    Uchiyama, Y.4    Hatanaka, H.5
  • 28
    • 34848920863 scopus 로고    scopus 로고
    • ROS, mitochondria and the regulation of autophagy
    • 17804237 10.1016/j.tcb.2007.07.009 1:CAS:528:DC%2BD2sXhtFeiur%2FI
    • Scherz-Shouval R, Elazar Z (2007) ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 17:422-427
    • (2007) Trends Cell Biol , vol.17 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 29
    • 37349067228 scopus 로고    scopus 로고
    • Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
    • 17917680 10.1038/sj.cdd.4402233 1:CAS:528:DC%2BD2sXhsVegurrM
    • Chen Y, McMillan-Ward E, Kong J et al (2008) Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15:171-182
    • (2008) Cell Death Differ , vol.15 , pp. 171-182
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3
  • 30
    • 77954643043 scopus 로고    scopus 로고
    • Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines
    • Jun Fu Shao CJ, Chen FR, Ng HK, Chen ZP (2010) Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro-Oncology 12(4):328-340
    • (2010) Neuro-Oncology , vol.12 , Issue.4 , pp. 328-340
    • Jun Fu Shao, C.J.1    Chen, F.R.2    Ng, H.K.3    Chen, Z.P.4
  • 31
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • 14638851 1:CAS:528:DC%2BD3sXhtVSmtLvP
    • Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A et al (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112:1809-1820
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3    Furuya, N.4    Hibshoosh, H.5    Troxel, A.6
  • 32
    • 77950509348 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • 20035753 10.1016/j.febslet.2009.12.034 1:CAS:528:DC%2BC3cXjs12msrc%3D
    • Chen N, Debnath J (2010) Autophagy and tumorigenesis. FEBS Lett 584:1427-1435
    • (2010) FEBS Lett , vol.584 , pp. 1427-1435
    • Chen, N.1    Debnath, J.2
  • 33
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • 19524509 10.1016/j.cell.2009.03.048 1:CAS:528:DC%2BD1MXps1eiu74%3D
    • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY et al (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137:1062-1075
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 34
    • 64349123107 scopus 로고    scopus 로고
    • Autophagy mediates the mitotic senescence transition
    • 19279323 10.1101/gad.519709 1:CAS:528:DC%2BD1MXks1SrtbY%3D
    • Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF et al (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23:798-803
    • (2009) Genes Dev , vol.23 , pp. 798-803
    • Young, A.R.1    Narita, M.2    Ferreira, M.3    Kirschner, K.4    Sadaie, M.5    Darot, J.F.6
  • 35
    • 73449101095 scopus 로고    scopus 로고
    • Hypoxia-induced downregulation of autophagy mediator Beclin 1 reduces the susceptibility of malignant intestinal epithelial cells to hypoxia-dependent apoptosis
    • 19901551 10.4161/auto.5.8.10167 1:CAS:528:DC%2BC3cXkvVeit7o%3D
    • Yoo BH, Wu X, Derouet M, Haniff M, Eskelinen EL, Rosen K (2009) Hypoxia-induced downregulation of autophagy mediator Beclin 1 reduces the susceptibility of malignant intestinal epithelial cells to hypoxia-dependent apoptosis. Autophagy 5:1166-1179
    • (2009) Autophagy , vol.5 , pp. 1166-1179
    • Yoo, B.H.1    Wu, X.2    Derouet, M.3    Haniff, M.4    Eskelinen, E.L.5    Rosen, K.6
  • 36
    • 45849147350 scopus 로고    scopus 로고
    • A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
    • 18598947 10.1016/j.ccr.2008.06.004 1:CAS:528:DC%2BD1cXos1ektL0%3D
    • Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ (2008) A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 14:90-102
    • (2008) Cancer Cell , vol.14 , pp. 90-102
    • Turcotte, S.1    Chan, D.A.2    Sutphin, P.D.3    Hay, M.P.4    Denny, W.A.5    Giaccia, A.J.6
  • 37
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • 18094039 10.1091/mbc.E07-10-1092 1:CAS:528:DC%2BD1cXlslemsr8%3D
    • Fung C, Lock R, Gao S, Salas E, Debnath J (2008) Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 19:797-806
    • (2008) Mol Biol Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 38
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • 17613433 10.1016/j.ccr.2007.05.008 1:CAS:528:DC%2BD2sXotVyqsr0%3D
    • Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 39
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • 9461583 10.1074/jbc.273.7.3963 1:CAS:528:DyaK1cXht1ahsr8%3D
    • Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273:3963-3966
    • (1998) J Biol Chem , vol.273 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 40
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • 15296714 10.1016/j.devcel.2004.07.009 1:CAS:528:DC%2BD2cXnsVKntr0%3D
    • Scott RC, Schuldiner O, Neufeld TP (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7:167-178
    • (2004) Dev Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 41
    • 0034683568 scopus 로고    scopus 로고
    • Tor- mediated induction of autophagy via an Apg1 protein kinase complex
    • 10995454 10.1083/jcb.150.6.1507 1:CAS:528:DC%2BD3cXmslGlsr4%3D
    • Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y (2000) Tor- mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150:1507-1513
    • (2000) J Cell Biol , vol.150 , pp. 1507-1513
    • Kamada, Y.1    Funakoshi, T.2    Shintani, T.3    Nagano, K.4    Ohsumi, M.5    Ohsumi, Y.6
  • 42
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • 15718470 10.1126/science.1106148 1:CAS:528:DC%2BD2MXhtlSrtbY%3D
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 43
    • 33845924783 scopus 로고    scopus 로고
    • AMP-activated protein kinase and the regulation of autophagic proteolysis
    • 16990266 10.1074/jbc.M605488200 1:CAS:528:DC%2BD28XhtF2gtbjP
    • Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P et al (2006) AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 281:34870-34879
    • (2006) J Biol Chem , vol.281 , pp. 34870-34879
    • Meley, D.1    Bauvy, C.2    Houben-Weerts, J.H.3    Dubbelhuis, P.F.4    Helmond, M.T.5    Codogno, P.6
  • 44
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • 12172553 10.1038/ncb839 1:CAS:528:DC%2BD38Xms1ahtL4%3D
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 4:648-657
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.