Evaluation of genome-wide association study-identified type 2 diabetes loci in african americans

American Journal of Epidemiology

Volumn 176, Issue 11, 2012, Pages 995-1001

  Long, Jirong ^a,b   Edwards, Todd ^a,b   Signorello, Lisa B ^a,b,c   Cai, Qiuyin ^a,b   Zheng, Wei ^a,b   Shu, Xiao Ou ^a,b   Blot, William J ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INTERNATIONAL EPIDEMIOLOGY INSTITUTE   (United States)

Author keywords

African Americans; diabetes mellitus, type 2; genetics; genome wide association study; molecular epidemiology; single nucleotide polymorphism

Indexed keywords

DNA;

AFRICAN AMERICAN; ANCESTRY; COHORT ANALYSIS; DIABETES; EPIDEMIOLOGY; GENOME; HEALTH RISK; MOLECULAR ANALYSIS; POLYMORPHISM; PUBLIC HEALTH; SPATIOTEMPORAL ANALYSIS;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; GENE LOCUS; GENOME ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

ADULT; AFRICAN AMERICANS; AGED; ALLELES; BODY MASS INDEX; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; KCNQ1 POTASSIUM CHANNEL; LOGISTIC MODELS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; RNA-BINDING PROTEINS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; UNITED STATES;

UNITED STATES;

EID: 84870395465     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kws176     Document Type: Article

References (28)

1. National Diabetes Information Clearinghouse, National Institute of Diabetes and Digestive and Kidney Diseases. National Diabetes Statistics, 2011. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases; 2011. (http://diabetes.niddk.nih.gov/dm/pubs/statistics). (Accessed June 22, 2011).
2. Zeggini E, Scott LJ, Saxena R, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40(5):638-645.
3. Winckler W, Weedon MN, Graham RR, et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes. 2007;56(3):685-693.
4. Sandhu MS, Weedon MN, Fawcett KA, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet. 2007;39(8):951-953.
5. Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38(3):320-323.
6. Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes. 2003;52(2): 568-572.
7. Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 2000;26(1): 76-80.
8. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445(7130):881-885.
9. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007;39(6):770-775.
10. Wellcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature. 2007;447(7145):661-678.
11. Yasuda K, Miyake K, Horikawa Y, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet. 2008;40(9):1092- 1097.
12. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316(5829):1341-1345.
13. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316(5829):1331-1336.
14. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316(5829):1336-1341.
15. Waters KM, Stram DO, Hassanein MT, et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet. 2010;6(8):pii:1001078. (doi:10.1371/journal.pgen.1001078).
16. Tishkoff SA, Reed FA, Friedlaender FR, et al. The genetic structure and history of Africans and African Americans. Science. 2009;324(5930):1035-1044.
17. Signorello LB, Hargreaves MK, Steinwandel MD, et al. Southern Community Cohort Study: establishing a cohort to investigate health disparities. J Natl Med Assoc. 2005; 97(7):972-979.
18. Roden DM, Pulley JM, Basford MA, et al. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther. 2008;84(3):362-369.
19. Ritchie MD, Denny JC, Crawford DC, et al. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet. 2010;86(4):560-572.
20. National Human Genome Research Institute. A Catalog of Published Genome-Wide Association Studies. Bethesda, MD
21. National Human Genome Research Institute; 2011. (http://www.genome.gov/ gwastudies). (Accessed October 11, 2010).
22. Price AL, Patterson NJ, Plenge RM, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8): 904-909.
23. Lewis JP, Palmer ND, Hicks PJ, et al. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008;57(8): 2220-2225.
24. Moore AF, Jablonski KA, McAteer JB, et al. Extension of type 2 diabetes genome-wide association scan results in the Diabetes Prevention Program. Diabetes. 2008;57(9): 2503-2510.
25. Saxena R, Elbers CC, Guo Y, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 2012;90(3):410-425
26. Humphries SE, Gable D, Cooper JA, et al. Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med (Berl). 2006; 84(12):1005-1014.
27. Palmer ND, Hester JM, An SS, et al. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011;60(2): 662-668.
28. Huizinga M, Elasy T, Villegas R, et al. Validation of diabetes self-report and characteristics of undiagnosed diabetes in the Southern Community Cohort Study [abstract]. Diabetes. 2009;58(suppl 1):A279.