Population Genetics of Streptococcus

Bacterial Population Genetics in Infectious Disease

Volumn , Issue , 2010, Pages 345-377

  Bessen, Debra E ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Group A Streptococcus (GAS) and group B Streptococcusi (GBS) population; MLST data analysis and limitations; Streptococcus population genetics multilocus sequence typing (MLST)

Indexed keywords

EID: 84870352592     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470600122.ch17     Document Type: Chapter

References (137)

1. Abbot , E. L. , Smith , W. D. , Siou , G. P. , Chiriboga , C. , Smith , R. J. , Wilson , J. A. , Hirst , B. H. , and Kehoe , M. A. ( 2007 ) Pili mediate specifi c adhesion of Streptococcus pyogenes to human tonsil and skin . Cellular Microbiology 9 , 1822-1833 .
2. Aguiar , S. I. , Serrano , I. , Pinto , F. R. , Melo - Cristino , J. , and Ramirez , M. ( 2008 ) The presence of the pilus locus is a clonal property among pneumococcal invasive isolates . BMC Microbiology 8 , 41 .
3. Ahmad , Y. , Gertz , R. E. Jr ., Li , Z. , Sakota , V. , Broyles , L. N. , Van Beneden , C. , Facklam , R. , Shewmaker , P. L. , Reingold , A. , Farley , M. M. , and Beall , B. W. ( 2009 ) Genetic relationships deduced from emm and multilocus sequence typing of invasive S. dysgalactiae subsp. equisimilis and S. canis recovered in the United States . Journal of Clinical Microbiology 47 , 2046-2054 .
4. Ayer , V. , Tewodros , W. , Manoharan , A. , Skariah , S. , Luo , F. , and Bessen , D. E. ( 2007 ) Tetracycline resistance in group a streptococci: Emergence on a global scale and infl uence on multiple - drug resistance . Antimicrobial Agents and Chemotherapy 51 , 1865-1868 .
5. Barrangou , R. , Fremaux , C. , Deveau , H. , Richards , M. , Boyaval , P. , Moineau , S. , Romero , D. A. , and Horvath , P. ( 2007 ) CRISPR provides acquired resistance against viruses in prokaryotes . Science 315 , 1709-1712 .
6. Beachey , E. H. , Seyer , J. M. , Dale , J. B. , Simpson , W. A. and Kang , A. H. ( 1981 ) Type - specifi c protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein . Nature 292 , 457-459 .
7. Beall , B. , Facklam , R. , and Thompson , T. ( 1996 ) Sequencing emm - specifi c PCR products for routine and accurate typing of group A streptococci . Journal of Clinical Microbiology 34 , 953-958 .
8. Beall , B. , Gherardi , G. , Lovgren , M. , Forwick , B. , Facklam , R. and Tyrrell , G. ( 2000 ) Emm and sof gene sequence variation in relation to serological typing of opacity factor positive group A streptococci . Microbiology 146 , 1195-1209 .
9. Bellanger , X. , Roberts , A. P. , Morel , C. , Choulet , F. , Pavlovic , G. , Mullany , P. , Decaris , B. , and Guedon , G. ( 2009 ) Conjugative transfer of the integrative conjugative elements ICESt1 and ICESt3 from Streptococcus thermophilus . Journal of Bacteriology 191 , 2764-2775 .
10. Bentley , S. D. , Aanensen , D. M. , Mavroidi , A. , Saunders , D. , Rabbinowitsch , E. , Collins , M. , Donohoe , K. , Harris , D. , Murphy , L. , Quail , M. A. , Samuel , G. , Skovsted , I. C. , Kaltoft , M. S. , Barrell , B. , Reeves , P. R. , Parkhill , J. , and Spratt , B. G. ( 2006 ) Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes . PLoS Genetics 2 , e31 .
11. Beres , S. B. and Musser , J. M. ( 2007 ) Contribution of exogenous genetic elements to the group A Streptococcus metagenome . P LoS One 2 , e800 .
12. Beres , S. B. , Richter , E. W. , Nagiec , M. J. , Sumby , P. , Porcella , S. F. , Deleo , F. R. , and Musser , J. M. ( 2006) Molecular genetic anatomy of inter - and intraserotype variation in the human bacterial pathogen group A Streptococcus . Proceedings of the National Academy of Sciences of the United States of America 103 , 7059-7064 .
13. Beres , S. B. , Sesso , R. , Pinto , S. W. , Hoe , N. P. , Porcella , S. F. , Deleo , F. R. , and Musser , J. M. ( 2008 ) Genome sequence of a Lancefi eld group C Streptococcus zooepidemicus strain causing epidemic nephritis: New information about an old disease . PLoS One 3 , e3026 .
14. Bessen , D. E. , ( 2009 ) Population biology of the human restricted pathogen, Streptococcus pyogenes . Infection, Genetics and Evolution 9 , 581-593 .
15. Bessen , D. E. , Carapetis , J. R. , Beall , B. , Katz , R. , Hibble , M. , Currie , B. J. , Collingridge , T. , Izzo , M. W. , Scaramuzzino , D. A. , and Sriprakash , K. S. ( 2000 ) Contrasting molecular epidemiology of group A streptococci causing tropical and non - tropical infections of the skin and throat . Journal of Infectious Diseases 182 , 1109-1116 .
16. Bessen , D. E. and Kalia , A. ( 2002 ) Genomic localization of a T - serotype locus to a recombinatorial zone encoding extracellular matrix - binding proteins in Streptococcus pyogenes . Infection and Immunity 70 , 1159-1167 .
17. Bessen , D. E. , Manoharan , A. , Luo , F. , Wertz , J. E. , and Robinson , D. A. ( 2005 ) Evolution of transcription regulatory genes is linked to niche specialization in the bacterial pathogen Streptococcus pyogenes . Journal of Bacteriology 187 , 4163-4172 .
18. Bessen , D. E. , McGregor , K. F. , and Whatmore , A. M. ( 2008 ) Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes . BMC Microbiology 8 , 59 .
19. Bisharat , N. , Crook , D. W. , Leigh , J. , Harding , R. M. , Ward , P. N. , Coffey , T. J. , Maiden , M. C. , Peto T. , and Jones , N. ( 2004 ) Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor . Journal of Clinical Microbiology 42 , 2161-2167 .
20. Bishop , C. J. , Aanensen , D. M. , Jordan , G. E. , Kilian , M. , Hanage , W. P. , and Spratt , B. G. ( 2009 ) Assigning strains to bacterial species via the internet . BMC Biology 7 , 3 .
21. Bisno , A. L. , Rubin , F. A. , Cleary , P. P. , and Dale , J. B. ( 2005 ) Prospects for a group A streptococcal vaccine: Rationale, feasibility, and obstacles - Report of a National Institute of Allergy and Infectious Diseases workshop . Clinical Infectious Diseases 41 , 1150-1156 .
22. Bisno , A. L. and Stevens , D. L. ( 2000) Streptococcus pyogenes . In Principles and Practice of Infectious Diseases . (eds. G. L. Mandell , R. G. Douglas , and R. Dolin ), pp. 2101-2117 .Churchill Livingstone , Philadelphia, PA .
23. Bohnsack , J. F. , Whiting , A. , Gottschalk , M. , Dunn , D. M. , Weiss , R. , Azimi , P. H. , Philips , J. B. III , Weisman , L. E. , Rhoads , G. G. , and Lin , F. Y. ( 2008 ) Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999 . Journal of Clinical Microbiology 46 , 1285-1291 .
24. Brochet , M. , Couve , E. , Glaser , P. , Guedon , G. , and Payot , S. ( 2008a ) Integrative conjugative elements and related elements are major contributors to the genome diversity of Streptococcus agalactiae . Journal of Bacteriology 190 , 6913-6917 .
25. Turner , K. M. , Hanage , W. P. , Fraser , C. , Connor , T. R. , and Spratt , B. G. ( 2007 ) Assessing the reliability of eBURST using simulated populations with known ancestry . BMC Microbiology 7 , 30 .
26. Brochet , M. , Rusniok ,, C. , Couve , E. , Dramsi , S. , Poyart , C. , Trieu - Cuot , P. , Kunst , F. , and Glaser P. ( 2008b ) Shaping a bacterial genome by large chromosomal replacements, the evolutionary history of Streptococcus agalactiae . Proceedings of the National Academy of Sciences of the United States of America 105 , 15961-15966 .
27. Broyles , L. N. , Van Beneden , C. , Beall , B. , Facklam , R. , Shewmaker , P. L. , Malpiedi , P. , Daily , P. , Reingold , A. , and Farley , M. M. ( 2009 ) Population - based study of invasive disease due to beta - hemolytic streptococci of groups other than A and B . Clinical Infectious Diseases 48 , 706-712 .
28. Brueggemann , A. B. , Pai , R. , Crook , D. W. , and Beall , B. ( 2007 ) Vaccine escape recombinants emerge after pneumococcal vaccination in the United States . PLoS Pathogens 3 , e168 .
29. Carapetis , J. , Currie , B. , and Kaplan , E. ( 1999 ) Epidemiology and prevention of group A streptococcal infections: Acute respiratory tract infections, skin infections, and their sequelae at the close of the twentieth century . Clinical Infectious Diseases 28 , 205-210 .
30. Carapetis , J. R. , Steer , A. C. , Mulholland , E. K. , and Weber , M. ( 2005 ) The global burden of group A streptococcal diseases [Review] . Lancet Infectious Diseases 5 , 685-694 .
31. Caufi eld , P. W. ( 2009 ) Tracking human migration patterns through the oral bacterial fl ora . Clinical Microbiology and Infection 15 ( Suppl 1 ), 37-39 .
32. Chaffi n , D. O. , Beres , S. B. , Yim , H. H. , and Rubens , C. E. ( 2000 ) The serotype of type Ia and III group B streptococci is determined by the polymerase gene within the polycistronic capsule operon . Journal of Bacteriology 182 , 4466-4477 .
33. Claverys , J. P. , Martin , B. , and Havarstein , L. S. ( 2007) Competence - induced fratricide in streptococci . Molecular Microbiology 64 , 1423-1433 .
34. Coffey , T. J. , Enright , M. C. , Daniels , M. , Morona , J. K. , Morona , R. , Hryniewicz , W. , Paton , J. C. , and Spratt , B. G. ( 1998 ) Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae . Molecular Microbiology 27 , 73-83 .
35. Coffey , T. J. , Pullinger , G. D. , Urwin , R. , Jolley , K. A. , Wilson , S. M. , Maiden , M. C. , and Leigh , J. A. ( 2006 ) First insights into the evolution of Streptococcus uberis: A multilocus sequence typing scheme that enables investigation of its population biology . Applied and Environmental Microbiology 72 , 1420-1428 .
36. Dagan , R. and Klugman , K. P. ( 2008 ) Impact of conjugate pneumococcal vaccines on antibiotic resistance . Lancet of Infectious Diseases 8 , 785-795 .
37. Dale , J. B. , Penfound , T. , Chiang , E. Y. , Long , V. , Shulman , S. T. , and Beall , B. ( 2005 ) Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes . Clinical and Diagnostic Laboratory Immunology 12 , 833-836 .
38. Davies , M. R. , McMillan , D. J. , Beiko , R. G. , Barroso , V. , Geffers , R. , Sriprakash , K. S. , and Chhatwal , G. S. ( 2007 ) Virulence profi ling of Streptococcus dysgalactiae subspecies equisimilis isolated from infected humans reveals two distinct genetic lineages which do not segregate with their phenotypes or propensity to cause diseases . Clinical Infectious Diseases , 44 , 1442-1454 .
39. Delorme , C. , Poyart , C. , Ehrlich , S. D. , and Renault , P. ( 2007 ) Extent of horizontal gene transfer in evolution of streptococci of the salivarius group . Journal of Bacteriology 189 , 1330-1341 .
40. Didelot , X. , Darling , A. , and Falush , D. ( 2009 ) Inferring genomic fl ux in bacteria . Genome Research 19 , 306-317 .
41. Didelot , X. and Falush , D. ( 2007 ) Inference of bacterial microevolution using multilocus sequence data . Genetics 175 , 1251-1266 .
42. Domelier , A. S. , van der Mee - Marquet , N. , Arnault , L. , Mereghetti , L. , Lanotte , P. , Rosenau , A. , Lartigue , M. F. , and Quentin , R. ( 2008 ) Molecular characterization of erythromycin - resistant Streptococcus agalactiae strains . Journal of Antimicrobial Chemotherapy 62 , 1227-1233 .
43. Enright , M. C. and Spratt , B. G. ( 1998 ) A multilocus sequence typing scheme for Streptococcus pneumoniae: Identifi cation of clones associated with invasive disease . Microbiology 144 , 3049-3060 .
44. Enright , M. C. , Spratt , B. G. , Kalia , A. , Cross , J. H. , and Bessen , D. E. ( 2001 ) Multilocus sequence typing of Streptococcus pyogenes and the relationship between emm - type and clone . Infection and Immunity 69 , 2416-2427 .
45. Eriksson , B. K. G. , Villasenor - Sierra , A. , Norgren , M. , and Stevens , D. L. ( 2001 ) Opsonization of T1M1 group A Streptococcus: Dynamics of antibody production and strain specifi city . Clinical Infectious Diseases 32 , E24 - E30 .
46. Euler , C. W. , Ryan , P. A. , Martin , J. M. , and Fischetti , V. A. ( 2007 ) M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifi es the genome of Streptococcus pyogenes . Journal of Bacteriology 189 , 1044-1054 .
47. Facklam , R. , ( 2002 ) What happened to the streptococci: Overview of taxonomic and nomenclature changes [Review ]. C linical Microbiology Reviews 15 , 613-630 .
48. Falugi , F. , Zingaretti , C. , Pinto , V. , Mariani , M. , Amodeo , L. , Manetti , A. G. , Capo , S. , Musser , J. M. , Orefi ci , G. , Margarit , I. , Telford , J. L. , Grandi , G. , and Mora , M. ( 2008 ) Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefi eld T serotypes . Journal of Infectious Diseases 198 , 1834-1841 .
49. Feil , E. J. , Holmes , E. C. , Bessen , D. E. , Chan , M. - S. , Day , N. P. J. , Enright , M. C. , Goldstein , R. , Hood , D. , Kalia , A. , Moore , C. E. , Zhou , J. , and Spratt , B. G. ( 2001 ) Recombination within natural populations of pathogenic bacteria: Short - term empirical estimates and long - term phylogenetic consequences . Proceedings of the National Academy of Sciences of the United States of America 98 , 182-187 .
50. Feil , E. J. , Li , B. C. , Aanensen , D. M. , Hanage , W. P. , and Spratt , B. G. ( 2004 ) eBURST: Inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data . Journal of Bacteriology 186 , 1518-1530 .
51. Feil , E. J. , Smith , J. M. , Enright , M. C. , and Spratt , B. G. ( 2000 ) Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data . Genetics 154 , 1439-1450 .
52. Feil , E. J. and Spratt , B. G. ( 2001 ) Recombination and the population structures of bacterial pathogens . Annual Review of Microbiology 55 , 561-590 .
53. Ferretti , J. J. , McShan , W. M. , Ajdic , D. , Savic , D. J. , Savic , G. , Lyon , K. , Primeaux , C. , Sezate , S. , Suvorov , A. N. , Kenton , S. , Lai , H. S. , Lin , S. P. , Qian , Y. , Jia , H. G. , Najar , F. Z. , Ren , Q. , Zhu , H. , Song , L. , White , J. , Yuan , X. , Clifton , S. W. , Roe , B. A. , and McLaughlin , R. ( 2001 ) Complete genome sequence of an M1 strain of Streptococcus pyogenes . Proceedings of the National Academy of Sciences of the United States of America 98 , 4658-4663 .
54. Fischetti , V. A. ( 1989 ) Streptococcal M protein: Molecular design and biological behavior . Clinical Microbiology Reviews 2 , 285-314 .
55. Fraser , C. , Hanage , W. P. , and Spratt , B. G. ( 2005 ) Neutral microepidemic evolution of bacterial pathogens . Proceedings of the National Academy of Sciences of the United States of America 102 , 1968-1973 .
56. Fraser , C. , Hanage , W. P. , and Spratt , B. G. ( 2007 ) Recombination and the nature of bacterial speciation . Science 315 , 476-480 .
57. Fujita , K. , Murono , K. , Yoshikawa , M. , and Murai , T. ( 1994 ) Decline of erythromycin resistance of group A streptococci in Japan . Pediatric Infectious Disease Journal 13 , 1075-1078 .
58. Gillen , C. M. , Courtney , H. S. , Schulze , K. , Rohde , M. , Wilson , M. R. , Timmer , A. M. , Guzman , C. A. , Nizet , V. , Chhatwal , G. S. , and Walker , M. J. ( 2008 ) Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete . Journal of Biological Chemistry 283 , 6359-6366 .
59. Gould , C. V. , Sniegowski , P. D. , Shchepetov , M. , Metlay , J. P. , and Weiser , J. N. ( 2007 ) Identifying mutator phenotypes among fl uoroquinolone - resistant strains of Streptococcus pneumoniae using fl uctuation analysis . Antimicrobial Agents and Chemotherapy 51 , 3225-3229 .
60. Green , N. M. , Zhang , S. , Porcella , S. F. , Nagiec , M. J. , Barbian , K. D. , Beres , S. B. , LeFebvre , R. B. , and Musser , J. M. ( 2005 ) Genome sequence of a serotype M28 strain of group a streptococcus: Potential new insights into puerperal sepsis and bacterial disease specifi city . Journal of Infectious Diseases 192 , 760-770 .
61. Grundmann , H. , Hori , S. , and Tanner , G. ( 2001 ) Determining confi dence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms . Journal of Clinical Microbiology 39 , 4190-4192 .
62. Gupta , S. , Maiden , M. C. J. , Feavers , I. M. , Nee , S. , May , R. M. , and Anderson , R. M. ( 1996 ) The maintenance of strain structure in populations of recombining infectious agents . Nature Medicine 2 , 437-442 .
63. Hanage , W. P. , Fraser C. , and Spratt , B. G. ( 2006 ) The impact of homologous recombination on the generation of diversity in bacteria . Journal of Theoretical Biology 239 , 210-219 .
64. Hava , D. L. , Hemsley , C. J. , and Camilli , A. ( 2003 ) Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA . Journal of Bacteriology 185 , 413-421 .
65. Heather , Z. , Holden , M. T. , Steward , K. F. , Parkhill , J. , Song , L. , Challis , G. L. , Robinson , C. , Davis - Poynter , N. , and Waller , A. S. ( 2008 ) A novel streptococcal integrative conjugative element involved in iron acquisition . Molecular Microbiology 70 , 1274-1292 .
66. Hery - Arnaud , G. , Bruant , G. , Lanotte , P. , Brun , S. , Picard , B. , Rosenau , A. , van der Mee - Marquet , N. , Rainard , P. , Quentin , R. , and Mereghetti , L. ( 2007 ) Mobile genetic elements provide evidence for a bovine origin of clonal complex 17 of Streptococcus agalactiae . Applied and Environmental Microbiology 73 , 4668-4672 .
67. Hicks , L. A. , Harrison , L. H. , Flannery , B. , Hadler , J. L. , Schaffner , W. , Craig , A. S. , Jackson , D. , Thomas , A. , Beall , B. , Lynfi eld , R. , Reingold , A. , Farley , M. M. , and Whitney , C. G. ( 2007 ) Incidence of pneumococcal disease due to non - pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998 - 2004 . Journal of Infectious Diseases 196 , 1346-1354 .
68. Hidalgo - Grass , C. , Ravins , M. , Dan - Goor , M. , Jaffe , J. , Moses , A. E. , and Hanski , E. ( 2002 ) A locus of group A Streptococcus involved in invasive disease and DNA transfer . Molecular Microbiology 46 , 87-99 .
69. Hiller , N. L. , Janto , B. , Hogg , J. S. , Boissy , R. , Yu , S. , Powell , E. , Keefe , R. , Ehrlich , N. E. , Shen , K. , Hayes , J. , Barbadora , K. , Klimke , W. , Dernovoy , D. , Tatusova , T. , Parkhill , J. , Bentley , S. D. , Post J. C. , Ehrlich , G. D. , and Hu , F. Z. ( 2007 ) Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: Insights into the pneumococcal supragenome . Journal of Bacteriology 189 , 8186-8195 .
70. Holden , M. T. , Heather , Z. , Paillot , R. , Steward , K. F. , Webb , K. , Ainslie , F. , Jourdan , T. , Bason , N. C. , Holroyd , N. E. , Mungall , K. , Quail , M. A. , Sanders , M. , Simmonds , M. , Willey , D. , Brooks , K. , Aanensen , D. M. , Spratt , B. G. , Jolley , K. A. , Maiden , M. C. , Kehoe , M. , Chanter , N. , Bentley , S. D. , Robinson , C. , Maskell , D. J. , Parkhill , J. , and Waller , A. S. ( 2009 ) Genomic evidence for the evolution of Streptococcus equi: Host restriction, increased virulence, and genetic exchange with human pathogens . PLoS Pathogens 5 , e1000346 .
71. Hollingshead , S. K. , Readdy , T. , Arnold , J. , and Bessen , D. E. ( 1994 ) Molecular evolution of a multi - gene family in group A streptococci . Molecular Biology and Evolution 11 , 208-219 .
72. Hollingshead , S. K. , Readdy , T. L. , Yung , D. L. , and Bessen , D. E. ( 1993 ) Structural heterogeneity of the emm gene cluster in group A streptococci . Molecular Microbiology 8 , 707-717 .
73. Hondorp , E. R. and McIver , K. S. ( 2007 ) The Mga virulence regulon: Infection where the grass is greener . Molecular Microbiology 66 , 1056-1065 .
74. Horn , D. , Zabriskie , J. , Austrian , R. , Cleary , P. , Ferretti , J. , Fischetti , V. , Gotschlich , E. , Kaplan , E. , McCarty , M. , Opal , S. , Roberts , R. , Tomasz , A. , and Wachtfogel , Y. ( 1998 ) Why have group A streptococci remained susceptible to penicillin? Report on a symposium . Clinical Infectious Diseases 26 , 1341-1345 .
75. Huang , S. S. , Platt , R. , Rifas - Shiman , S. L. , Pelton , S. I. , Goldmann , D. , and Finkelsteins J. A. ( 2005 ) Post - PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004 . Pediatrics 116 , e408 - e413 .
76. Towers , R. J. , Gal , D. , McMillan , D. , Sriprakash , K. S. , Currie , B. J. , Walker , M. J. , Chhatwal , G. S. , and Fagan , P. K. ( 2004 ) Fibronectin - binding protein gene recombination and horizontal transfer between group A and G streptococci . Journal of Clinical Microbiology 42 , 5357-5361 .
77. Jaggi , P. , Tanz , R. R. , Beall , B. , and Shulman , S. T. ( 2005 ) Age infl uences the emm type distribution of pediatric group A streptococcal pharyngeal isolates . Pediatric Infectious Disease Journal 24 , 1089-1092 .
78. Johnson , D. R. , Kaplan , E. L. , VanGheem , A. , Facklam , R. R. , and Beall , B. ( 2006 ) Characterization of group A streptococci ( Streptococcus pyogenes ): Correlation of M - protein and emm - gene type with T - protein agglutination pattern and serum opacity factor . Journal of Medical Microbiology 55 , 157-164 .
79. Johri , A. K. , Paoletti , L. C. , Glaser , P. , Dua , M. , Sharma , P. K. , Grandi , G. , and Rappuoli , R. ( 2006 ) Group B Streptococcus: Global incidence and vaccine development . Nature Reviews. Microbiology 4 , 932-942 .
80. Jones , K. F. , Hollingshead , S. K. , Scott , J. R. , and Fischetti , V. A. ( 1988 ) Spontaneous M6 protein size mutants of group A streptococci display variation in antigenic and opsonogenic epitopes . Proceedings of the National Academy of Sciences of the United States of America 85 , 8271-8275 .
81. Jones , N. , Bohnsack , J. F. , Takahashi , S. , Oliver , K. A. , Chan , M. S. , Kunst , F. , Glaser , P. , Rusniok , C. , Crook , D. W. , Harding , R. M. , Bisharat , N. , and Spratt , B. G. ( 2003 ) Multilocus sequence typing system for group B Streptococcus . Journal of Clinical Microbiology 41 , 2530-2536 .
82. Jones , N. , Oliver , K. A. , Barry , J. , Harding , R. M. , Bisharat , N. , Spratt , B. G. , Peto , T. , and Crook , D. W. ( 2006 ) Enhanced invasiveness of bovine - derived neonatal sequence type 17 group B Streptococcus is independent of capsular serotype . Clinical Infectious Diseases 42 , 915-924 .
83. Kalia , A. and Bessen , D. E. ( 2004 ) Natural selection and evolution of streptococcal virulence genes involved in tissue - specifi c adaptations . Journal of Bacteriology 186 , 110-121 .
84. Kalia , A. , Spratt , B. G. , Enright , M. C. , and Bessen , D. E. ( 2002 ) Infl uence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes . Infection and Immunity 70 , 1971-1983 .
85. Kelly , T. , Dillard , J. P. , and Yother , J. ( 1994 ) Effect of genetic switching of capsular type on virulence of Streptococcus pneumoniae . Infection and Immunity 62 , 1813-1819 .
86. Kilian , M. , Poulsen , K. , Blomqvist , T. , Havarstein , L. S. , Bek - Thomsen , M. , Tettelin , H. , and Sorensen , U. B. ( 2008 ) Evolution of Streptococcus pneumoniae and its close commensal relatives . PLoS One 3 , e2683 .
87. King , S. J. , Leigh , J. A. , Heath , P. J. , Luque , I. , Tarradas , C. , Dowson , C. G. , and Whatmore , A. M. ( 2002 ) Development of a multilocus sequence typing scheme for the pig pathogen Stre p tococcus suis: Identifi cation of virulent clones and potential capsular serotype exchange . Journal of Clinical Microbiology 40 , 3671-3680 .
88. Kratovac , Z. , Manoharan , A. , Luo , F. , Lizano , S. , and Bessen , D. E. ( 2007 ) Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenes . Journal of Bacteriology 189 , 1299-1310 .
89. Kreikemeyer , B. , McIver , K. S. , and Podbielski , A. ( 2003 ) Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen - host interactions . Trends in Microbiology 11 , 224-232 .
90. Kreikemeyer , B. , Nakata , M. , Oehmcke , S. , Gschwendtner , C. , Normann J. , and Podbielski , A. ( 2005 ) Streptococcus pyogenes collagen type I - binding Cpa surface protein - Expression profi le, binding characteristics, biological functions, and potential clinical impact . Journal of Biological Chemistry 280 , 33228-33239 .
91. Lancefi eld , R. C. ( 1962 ) Current knowledge of the type specifi c M antigens of group A streptococci . Journal of Immunology 89 , 307-313 .
92. Lefebure , T. and Stanhope , M. J. ( 2007 ) Evolution of the core and pan - genome of Streptococcus: Positive selection, recombination, and genome composition . Genome Biology 8 , R71 .
93. Lipsitch , M. ( 1997 ) Vaccination against colonizing bacteria with multiple serotypes . Proceedings of the National Academy of Sciences of the United States of America 94 , 6571-6576 .
94. Lipsitch , M. , O ' Neill , K. , Cordy , D. , Bugalter , B. , Trzcinski , K. , Thompson , C. M. , Goldstein , R. , Pelton , S. , Huot , H. , Bouchet , V. , Reid , R. , Santosham , M. , and O ' Brien , K. L. ( 2007 ) Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster - randomized clinical trial of the 7 - valent pneumococcal conjugate vaccine . Journal of Infectious Diseases 196 , 1221-1227 .
95. Luan , S. L. , Granlund , M. , Sellin , M. , Lagergard , T. , Spratt , B. G. , and Norgren , M. ( 2005 ) Multilocus sequence typing of Swedish invasive group B Streptococcus isolates indicates a neonatally associated genetic lineage and capsule switching . Journal of Clinical Microbiology 43 , 3727-3733 .
96. Manetti , A. G. , Zingaretti , C. , Falugi , F. , Capo , S. , Bombaci , M. , Bagnoli , F. , Gambellini , G. , Bensi , G. , Mora , M. , Edwards , A. M. , Musser , J. M. , Graviss , E. A. , Telford , J. L. , Grandi , G. , and Margarit , I. ( 2007 ) Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofi lm formation . Molecular Microbiology 64 , 968-983 .
97. Margarit , I. , Rinaudo , C. D. , Galeotti , C. L. , Maione , D. , Ghezzo , C. , Buttazzoni , E. , Rosini , R. , Runci , Y. , Mora , M. , Buccato , S. , Pagani , M. , Tresoldi , E. , Berardi , A. , Creti , R. , Baker , C. J. , Telford , J. L. , and Grandi , G. ( 2009 ) Preventing bacterial infections with pilus - based vaccines: The group B Streptococcus paradigm . J ournal of Infectious Diseases 1 99 , 108-115 .
98. Marri , P. R. , Hao , W. , and Golding , G. B. ( 2006 ) Gene gain and gene loss in streptococcus: Is it driven by habitat? Molecular Biology and Evolution 23 , 2379-2391 .
99. Martin , J. M. , Green , M. , Barbadora , K. A. , and Wald , E. R. ( 2002 ) Erythromycin - resistant group A streptococci in schoolchildren in Pittsburgh . New England Journal of Medicine 346 , 1200-1206 .
100. Martins , E. R. , Pessanha , M. A. , Ramirez , M. , and Melo - Cristino , J. ( 2007 ) Analysis of group B streptococcal isolates from infants and pregnant women in Portugal revealing two lineages with enhanced invasiveness . Journal of Clinical Microbiology 45 , 3224-3229 .
101. Mavroidi , A. , Aanensen , D. M. , Godoy , D. , Skovsted , I. C. , Kaltoft , M. S. , Reeves , P. R. , Bentley , S. D. , and Spratt , B. G. ( 2007 ) Genetic relatedness of the Streptococcus pneumoniae capsular biosynthetic loci . Journal of Bacteriology 189 , 7841-7855 .
102. McDonald , M. I. , Towers , R. J. , Andrews , R. , Benger , N. , Fagan , P. , Currie , B. J. , and Carapetis , J. R. ( 2007a ) The dynamic nature of group A streptococcal epidemiology in tropical communities with high rates of rheumatic heart disease . Epidemiology and Infection 00 , 1-11 .
103. McDonald , M. I. , Towers , R. J. , Fagan , P. , Carapetis , J. R. , and Currie , B. J. ( 2007b ) Molecular typing of Streptococcus pyogenes from remote aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection . Epidemiology and Infection 135 , 1398-1405 .
104. McGregor , K. , Bilek , N. , Bennett , A. , Kalia , A. , Beall , B. , Carapetis , J. , Currie , B. , Sriprakash , K. , Spratt , B. , and Bessen , D. ( 2004a ) Group A streptococci from a remote community have novel multilocus genotypes but share emm - types and housekeeping alleles . Journal of Infectious Diseases 189 , 717-723 .
105. McGregor , K. F. , Spratt , B. G. , Kalia , A. , Bennett , A. , Bilek , N. , Beall , B. , and Bessen , D. E. ( 2004b ) Multi - locus sequence typing of Streptococcus pyogenes representing most known emm - types and distinctions among sub - population genetic structures . Journal of Bacteriology 186 , 4285-4294 .
106. McNeil , S. A. , Halperin , S. A. , Langley , J. M. , Smith , B. , Warren , A. , Sharratt , G. P. , Baxendale , D. M. , Reddish , M. A. , Hu , M. C. , Stroop , S. D. , Linden , J. , Fries , L. F. , Vink , P. E. , and Dale , J. B. ( 2005 ) Safety and immunogenicity of 26 - valent group A Streptococcus vaccine in healthy adult volunteers . Clinical Infectious Diseases 41 , 1114-1122 .
107. Moore , M. R. , Gertz , R. E. Jr ., Woodbury , R. L. , Barkocy - Gallagher , G. A. , Schaffner , W. , Lexau , C. , Gershman , K. , Reingold , A. , Farley , M. , Harrison , L. H. , Hadler , J. L. , Bennett , N. M. , Thomas , A. R. , McGee , L. , Pilishvili , T. , Brueggemann , A. B. , Whitney , C. G. , Jorgensen , J. H. , and Beall , B. ( 2008 ) Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005 . Journal of Infectious Diseases 197 , 1016-1027 .
108. Mora , M. , Bensi , G. , Capo , S. , Falugi , F. , Zingaretti , C. , Manetti , A. G. O. , Maggi , T. , Taddei , A. R. , Grandi , G. , and Telford , J. L. ( 2005 ) Group A Streptococcus produce pilus - like structures containing protective antigens and Lancefi eld T antigens . Proceedings of the National Academy of Sciences of the United States of America 102 , 15641-15646 .
109. Nakano , K. , Lapirattanakul , J. , Nomura , R. , Nemoto , H. , Alaluusua , S. , Gronroos , L. , Vaara , M. , Hamada , S. , Ooshima , T. , and Nakagawa , I. ( 2007 ) Streptococcus mutans clonal variation revealed by multilocus sequence typing . Journal of Clinical Microbiology 45 , 2616-2625 .
110. Obert , C. , Sublett , J. , Kaushal , D. , Hinojosa , E. , Barton , T. , Tuomanen , E. I. , and Orihuela , C. J. ( 2006 ) Identifi cation of a candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease . Infection and Immunity 74 , 4766-4777 .
111. O ' Brien , K. L. , Millar , E. V. , Zell , E. R. , Bronsdon , M. , Weatherholtz , R. , Reid , R. , Becenti , J. , Kvamme , S. , Whitney , C. G. , and Santosham , M. ( 2007 ) Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community - randomized trial . Journal of Infectious Diseases 196 , 1211-1220 .
112. Pericone , C. D. , Bae , D. , Shchepetov , M. , McCool , T. , and Weiser , J. N. ( 2002 ) Short - sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae . Journal of Bacteriology 184 , 4392-4399 .
113. Persson , J. , Beall , B. , Linse , S. , and Lindahl , G. ( 2006 ) Extreme sequence divergence but conserved ligand - binding specifi city in Streptococcus pyogenes M protein . PLoS Pathogens 2 , e47 .
114. Phares , C. R. , Lynfi eld , R. , Farley , M. M. , Mohle - Boetani , J. , Harrison , L. H. , Petit , S. , Craig , A. S. , Schaffner , W. , Zansky , S. M. , Gershman , K. , Stefonek , K. R. , Albanese , B. A. , Zell , E. R. , Schuchat , A. , and Schrag , S. J. ( 2008 ) Epidemiology of invasive group B streptococcal disease in the United States, 1999 - 2005 . JAMA 299 , 2056-2065 .
115. Robinson , D. , Sutcliffe , J. , Tewodros , W. , Manoharan , A. , and Bessen , D. ( 2006 ) Evolution and global dissemination of macrolide resistant group A streptococci . Antimicrobial Agents and Chemotherapy 50 , 2903-2911 .
116. Sakota , V. , Fry , A. M. , Lietman , T. M. , Facklam , R. R. , Li , Z. Y. , and Beall , B. ( 2006 ) Genetically diverse group A streptococci from children in Far - Western Nepal share high genetic relatedness with isolates from other countries . Journal of Clinical Microbiology 44 , 2160-2166 .
117. Schmidt , H. and Hensel , M. ( 2004 ) Pathogenicity islands in bacterial pathogenesis . Clinical Microbiology Reviews 17 , 14-56 .
118. Schneewind , O. , Jones , K. F. , and Fischetti , V. A. ( 1990 ) Sequence and structural characterization of the trypsin - resistant T6 surface protein of group A streptococci . Journal of Bacteriology 172 , 3310-3317 .
119. Scott , J. , Thompson - Mayberry , P. , Lahmamsi , S. , King , C. J. , and McShan , W. M. ( 2008 ) Phage - associated mutator phenotype in group A streptococcus . Journal of Bacteriology 190 , 6290-6301 .
120. Seppala , H. , Klaukka , T. , Vuopio - Varkila , J. , Muotiala , A. , Helenius , H. , Lager , K. , and Huovinen , P. ( 1997 ) The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance . New England Journal of Medicine 337 , 441-446 .
121. Shulman , S. ( 2004 ) Group A streptococcal pharyngitis serotype surveillance in North America, 2000 - 2002 . Clinical Infectious Diseases 39 , 325-332 .
122. Shulman , S. T. , Stollerman , G. , Beall , B. , Dale , J. B. , and Tanz , R. R. ( 2006 ) Temporal changes in streptococcal M protein types and the near - disappearance of acute rheumatic fever in the United States . Clinical Infectious Diseases 42 , 441-447 .
123. Sitkiewicz , I. , Nagiec , M. J. , Sumby , P. , Butler , S. D. , Cywes - Bentley , C. , and Musser , J. M. ( 2006 ) Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2 . Proceedings of the National Academy of Sciences of the United States of America 103 , 16009-16014 .
124. Slotved , H. C. , Kong , F. , Lambertsen , L. , Sauer , S. , and Gilbert , G. L. ( 2007 ) Serotype IX, a proposed new Streptococcus agalactiae serotype . Journal of Clinical Microbiology 45 , 2929-2936 .
125. Stalhammar - Carlemalm , M. , Areschoug , T. , Larsson C. , and Lindahl , G. ( 1999 ) The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells . Molecular Microbiology 33 , 208-219 .
126. Stollerman , G. H. and Dale , J. B. ( 2008 ) The importance of the group a streptococcus capsule in the pathogenesis of human infections: A historical perspective . Clinical Infectious Diseases 46 , 1038-1045 .
127. Telford , J. , Barocchi , M. , Margarit , I. , Rappuoli , R. , and Grandi , G. , ( 2006 ) Pili in gram - positive pathogens . Nature Reviews. Microbiology 4 , 509-519 .
128. Tettelin , H. , Masignani V. , Cieslewicz , M. J. , Donati , C. , Medini , D. , Ward , N. L. , Angiuoli , S. V. , Crabtree , J. , Jones , A. L. , Durkin , A. S. , Deboy , R. T. , Davidsen , T. M. , Mora , M. , Scarselli , M. , Margarit y Ros , I. , Peterson , J. D. , Hauser , C. R. , Sundaram , J. P. , Nelson , W. C. , Madupu , R. , Brinkac , L. M. , Dodson , R. J. , Rosovitz , M. J. , Sullivan , S. A. , Daugherty , S. C. , Haft , D. H. , Selengut , J. , Gwinn , M. L. , Zhou , L. , Zafar , N. , Khouri , H. , Radune , D. , Dimitrov , G. , Watkins , K. , O ' Connor , K. J. , Smith , S. , Utterback , T. R. , White , O. , Rubens , C. E. , Grandi , G. , Madoff , L. C. , Kasper , D. L. , Telford , J. L. , Wessels , M. R. , Rappuoli , R. , and Fraser , C. M. ( 2005 ) Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial " pan - genome. " Proceedings of the National Academy of Sciences of the United States of America 102 , 13950-13955 .
129. Tettelin , H. , Masignani , V. , Cieslewicz , M. J. , Eisen , J. A. , Peterson , S. , Wessels , M. R. , Paulsen , I. T. , Nelson , K. E. , Margarit , I. , Read , T. D. , Madoff , L. C. , Wolf , A. M. , Beanan , M. J. , Brinkac , L. M. , Daugherty , S. C. , DeBoy , R. T. , Durkin , A. S. , Kolonay , J. F. , Madupu , R. , Lewis , M. R. , Radune , D. , Fedorova , N. B. , Scanlan , D. , Khouri , H. , Mulligan , S. , Carty , H. A. , Cline , R. T. , Van Aken , S. E. , Gill , J. , Scarselli , M. , Mora , M. , Iacobini , E. T. , Brettoni , C. , Galli , G. , Mariani , M. , Vegni , F. , Maione , D. , Rinaudo , D. , Rappuoli , R. , Telford , J. L. , Kasper , D. L. , Grandi , G. , and Fraser , C. M. ( 2002 ) Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae . Proceedings of the National Academy of Sciences of the United States of America 99 , 12391-12396 .
130. Tettelin , H. , Nelson , K. E. , Paulsen , I. T. , Eisen , J. A. , Read , T. D. , Peterson , S. , Heidelberg , J. , DeBoy , R. T. , Haft , D. H. , Dodson , R. J. , Durkin , A. S. , Gwinn M. , Kolonay , J. F. , Nelson , W. C. , Peterson , J. D. , Umayam , L. A. , White , O. , Salzberg , S. L. , Lewis , M. R. , Radune , D. , Holtzapple , E. , Khouri , H. , Wolf , A. M. , Utterback , T. R. , Hansen , C. L. , McDonald , L. A. , Feldblyum , T. V. , Angiuoli , S. , Dickinson , T. , Hickey , E. K. , Holt , I. E. , Loftus , B. J. , Yang , F. , Smith , H. O. , Venter , J. C. , Dougherty , B. A. , Morrison , D. A. , Hollingshead , S. K. , and Fraser , C. M. ( 2001 ) Complete genome sequence of a virulent isolate of Streptococcus pneumoniae . Science 293 , 498-506 .
131. Vos , M. and Didelot , X. ( 2009 ) A comparison of homologous recombination rates in bacteria and archaea . ISME Journal 3 , 199-208 .
132. Tomita , T. , Meehan , B. , Wongkattiya , N. , Malmo , J. , Pullinger , G. , Leigh , J. , and Deighton , M. ( 2008 ) Identifi cation of Streptococcus uberis multilocus sequence types highly associated with mastitis . Applied and Environmental Microbiology 74 , 114-124 .
133. Varaldo , P. E. , Montanari , M. P. , and Giovanetti , E. ( 2009 ) Genetic elements responsible for erythromycin resistance in streptococci . Antimicrobial Agents and Chemotherapy 53 , 343-353 .
134. Wannamaker , L. W. ( 1970 ) Differences between streptococcal infections of the throat and of the skin . New England Journal of Medicine 282 , 23-31 .
135. Ward , P. N. , Holden , M. T. , Leigh , J. A. , Lennard , N. , Bignell , A. , Barron , A. , Clark , L. , Quail , M. A. , Woodward , J. , Barrell , B. G. , Egan , S. A. , Field , T. R. , Maskell , D. , Kehoe , M. , Dowson , C. G. , Chanter , N. , Whatmore , A. M. , Bentley , S. D. , and Parkhill , J. ( 2009 ) Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis . BMC Genomics 10 , 54 .
136. Webb , K. , Jolley , K. A. , Mitchell , Z. , Robinson , C. , Newton , J. R. , Maiden , M. C. , and Waller , A. ( 2008 ) Development of an unambiguous and discriminatory multilocus sequence typing scheme for the Streptococcus zooepidemicus group . Microbiology 154 , 3016-3024 .
137. Zadoks , R. N. , Schukken , Y. H. , and Wiedmann , M. ( 2005 ) Multilocus sequence typing of Streptococcus uberis provides sensitive and epidemiologically relevant subtype information and reveals positive selection in the virulence gene pauA . Journal of Clinical Microbiology 43 , 2407-2417 .