Virulence profiling of Streptococcus dysgalactiae subspecies equisimilis isolated from infected humans reveals 2 distinct genetic lineages that do not segregate with their phenotypes or propensity to cause diseases

Clinical Infectious Diseases

Volumn 44, Issue 11, 2007, Pages 1442-1454

  Davies, Mark R ^a   McMillan, David J ^a   Baiko, Robert G ^b   Barroso, Vanessa ^c   Geffers, Robert ^c   Sriprakash, Kadaba S ^a   Chhatwal, Gursharan S ^c  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; VIRULENCE FACTOR;

ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CLUSTER ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; GENE CLUSTER; GENETIC ANALYSIS; HUMAN; MICROARRAY ANALYSIS; MOLECULAR PHYLOGENY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STREPTOCOCCUS DYSGALACTIAE; STREPTOCOCCUS DYSGALACTIAE EQUISIMILIS; STREPTOCOCCUS GROUP A; STREPTOCOCCUS GROUP C; STREPTOCOCCUS GROUP G; STREPTOCOCCUS INFECTION;

CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHYLOGENY; STREPTOCOCCUS; VIRULENCE; VIRULENCE FACTORS;

EID: 34249063343     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/516780     Document Type: Article

References (37)

1. Facklam R. What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev 2002; 15:613-30.
2. Poyart C, Quesne G, Coulon S, Berche P, Trieu-Cuot P. Identification of streptococci to species level by sequencing the gene encoding the manganese-dependent superoxide dismutase. J Clin Microbiol 1998; 36:41-7.
3. Tapp J, Thollesson M, Herrmann B. Phylogenetic relationships and genotyping of the genus Streptococcus by sequence determination of the RNase P RNA gene, rnpB. Int J Syst Evol Microbiol 2003; 53:1861-71.
4. Cohen-Poradosu R, Jaffe J, Lavi D, et al. Group G streptococcal bacteremia in Jerusalem. Emerg Infect Dis 2004; 10:1455-60.
5. Ekelund K, Skinhoj P, Madsen J, Konradsen HB. Invasive group A, B, C and G streptococcal infections in Denmark 1999-2002: epidemiological and clinical aspects. Clin Microbiol Infect 2005; 11:569-76.
6. Hindsholm M, Schonheyder HC. Clinical presentation and outcome of bacteraemia caused by beta-haemolytic streptococci serogroup G. APMIS 2002; 110:554-8.
7. Laupland KB, Ross T, Church DL, Gregson DB. Population-based surveillance of invasive pyogenic streptococcal infection in a large Canadian region. Clin Microbiol Infect 2006; 12:224-30.
8. Sylvetsky B, Raveh D, Schlesinger Y, Rudensky B, Yinnon AM. Bacteremia due to beta-hemolytic Streptococcus group G: increasing incidence and clinical characteristics of patients. Am J Med 2002; 112:622-6.
9. Efstratiou A. Pyogenic streptococci of Lancefield groups C and G as pathogens in man. Soc Appl Bacteriol Symp Ser 1997; 26:72S-9S.
10. Davies MR, Tran TN, McMillan DJ, Gardiner DL, Currie BJ, Sriprakash KS. Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions, Microbes Infect 2005; 7:1128-38.
11. Haidan A, Talay SR, Rohde M, Sriprakash KS, Currie BJ, Chhatwal GS. Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. Lancet 2000; 356:1167-9.
12. Kalia A, Enright MC, Spratt BG, Bessen DE. Directional gene movement from human-pathogenic to commensal-like streptococci. Infect Immun 2001; 69:4858-69.
13. Kalia A, Spratt BG, Enright MC, Bessen DE. Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes. Infect Immun 2002; 70:1971-83.
14. Musser JM. Molecular population genetic analysis of emerged bacterial pathogens: selected insights. Emerg Infect Dis 1996; 2:1-17.
15. Tettelin H, Masignani V, Cieslewicz MJ, et al. of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome." Proc Natl Acad Sci USA 2005; 102:13950-5.
16. Chatellier S, Ihendyane N, Kansal RG, et al. Genetic relatedness and. superantigen expression in group A streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases, Infect Immun 2000; 68:3523-34.
17. Aziz RK, Edwards RA, Taylor WW, Low DE, McGeer A, Kotb M. Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes. J Bacteriol 2005; 187:3311-8.
18. Sumby P, Porcella SF, Madrigal AG, et al. Evolutionary origin and emergence of a highly successful clone of serotype M1 group A streptococcus involved multiple horizontal gene transfer events, J Infect Dis 2005; 192:771-82.
19. DelVecchio A, Maley M, Currie BJ, Sriprakash KS. NAD-glycohydrolase production and speA and speC distribution in group A streptococcus (GAS) isolates do not correlate with severe GAS diseases in the Australian population. J Clin Microbiol 2002; 40:2642-4.
20. Descheemaeker P, Van Loock F, Hauchecorne M, Vandamme P, Goossens H. Molecular characterisation of group A streptococci from invasive and non-invasive disease episodes in Belgium during 1993-1994. J Med Microbiol 2000; 49:467-71.
21. Musser JM, Kapur V, Kanjilal S, et al. Geographic and temporal distribution and molecular characterization of two highly pathogenic clones of Streptococcus pyogenes expressing allelic variants of pyrogenic exotoxin A (scarlet fever toxin). J Infect Dis 1993; 167:337-46.
22. Cleary PP, Kaplan EL, Handley JP, et al. Clonal basis for resurgence of serious Streptococcus pyogenes disease in the 1980s. Lancet 1992; 339:518-21.
23. Hauser AR, Stevens DL, Kaplan EL, Schlievert PM. Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome. J Clin Microbiol 1991; 29:1562-7.
24. Jones KF, Fischetti VA. Biological and immunochemical identity of M protein on group G streptococci with M protein on group A streptococci. Infect Immun 1987; 55:502-6.
25. Hashikawa S, Iinuma Y, Furushita M, et al. Characterization of group C and G streptococcal strains that cause streptococcal toxic shock syndrome. J Clin Microbiol 2004; 42:186-92.
26. Igwe EI, Shewmaker PL, Facklam RR, Farley MM, van Beneden C, Beall B. Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans. FEMS Microbiol Lett 2003; 229:259-64.
27. Ikebe T, Murayama S, Saitoh K, et al. Surveillance of severe invasive group G streptococcal infections and molecular typing of the isolates in Japan. Epidemiol Infect 2004; 132:145-9.
28. Kalia A, Bessen DE. Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci. FEMS Microbiol Lett 2003; 219:291-5.
29. Sachse S, Seidel P, Gerlach D, et al. Superantigen-like gene(s) in human pathogenic Streptococcus dysgalactiae subsp. equisimilis: genomic localisation of the gene encoding streptococcal pyrogenic exotoxin G ( speG(dys)). FEMS Immunol Med Microbiol 2002; 34:159-67.
30. Towers RJ, Gal D, McMillan D, et al. Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci. J Clin Microbiol 2004; 42:5357-61.
31. McMillan DJ, Beiko RG, Geffers R, et al. Genes for the majority of group A streptococcal virulence factors and extracellular surface proteins do not confer an increased propensity to cause invasive disease. Clin Infect Dis 2006; 43:884-91.
32. Beiko RG, Charlebois RL. GANN: genetic algorithm neural networks for the detection of conserved combinations of features in DNA. BMC Bioinformatics 2005; 6:36.
33. Bert F, Branger C, Poutrel B, Lambert-Zechovsky N. Differentiation of human and animal strains of Streptococcus dysgalactiae by pulsed-field gel electrophoresis. FEMS Microbiol Lett 1997; 150:107-12.
34. Vandamme P, Pot B, Falsen E, Kersters K, Devriese LA. Taxonomic study of Lancefield streptococcal groups C, G, and L (Streptococcus dysgalactiae) and proposal of S. dysgalactiae subsp. equisimilis subsp. nov. Int J Syst Bacteriol 1996; 46:774-81.
35. Vieira VV, Teixeira LM, Zahner V, et al. Genetic relationships among the different phenotypes of Streptococcus dysgalactiae strains. Int J Syst Bacteriol 1998; 48:1231-43.
36. McMillan DJ, Geffers R, Buer J, Vlaminckx BJ, Sriprakash KS, Chhatwal GS. Variations in the distribution of genes encoding virulence and extracellular proteins in group A streptococcus are largely restricted to eleven genomic loci. Microbes Infect 2007; 9:259-70.
37. Kotb M, Norrby-Teglund A, McGeer A, et al. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 2002; 8:1398-404.