Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae

Molecular Microbiology

Volumn 27, Issue 1, 1998, Pages 73-83

  Coffey, Tracey J ^a,b   Enright, Mark C ^a   Daniels, Maggie ^a   Morona, Judy K ^c   Morona, Renato ^c   Hryniewicz, Waleria ^d   Paton, James C ^c   Spratt, Brian G ^a,b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^d Sera & Vaccines Central Research Laboratory Warszawa   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

POLYSACCHARIDE;

ANTIBIOTIC RESISTANCE; ARTICLE; GENETIC ANALYSIS; GENETIC ORGANIZATION; GENETIC RECOMBINATION; GENOTYPE; HOUSEKEEPING GENE; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROTYPE; STREPTOCOCCUS PNEUMONIAE;

BASE SEQUENCE; CROSSING OVER, GENETIC; DNA FINGERPRINTING; DNA, BACTERIAL; DRUG RESISTANCE, MULTIPLE; MOLECULAR SEQUENCE DATA; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYSACCHARIDES, BACTERIAL; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SEROTYPING; SPAIN; STREPTOCOCCUS PNEUMONIAE;

ALIA; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 0031962770     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00658.x     Document Type: Article

References (45)

1. Arrecubieta, C., López, R., and García, E. (1994) Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae serotype 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome. J Bacteriol 176: 6375-6383.
2. Austrian, R. (1981) Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention. Rev Inf Dis 3: S1-S17.
3. Barnes, D.M., Whittier, S., Gilligan, P.H., Soares, S., Tomasz, A., and Henderson, F.W. (1995) Transmission of multidrug-resistant serotype 23F Streptococcus pneumoniae in group day care: evidence suggesting capsular transformation of the resistant strain in vivo. J Infect Dis 171: 890-896.
4. Coffey, T.J., Dowson, C.G., Daniels, M., Zhou, J., Martin, C., Spratt, B.G., and Musser, J.M. (1991) Horizontal gene transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes in natural populations of Streptococcus pneumoniae. Mol Microbiol 5: 2255-2260.
5. Coffey, T.J., Dowson, C.G., Daniels, M., and Spratt, B.G. (1995) Genetics and molecular biology of β-lactam-resistant pneumococci. Microb Drug Res 1, 25-30.
6. Coffey, T.J., Berrón, S., Daniels, M., Garcia-Leoni, E., Cercenado, E., Bouza, E., Fenoll, A., and Spratt, B.G. (1996) Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-94): novel major clones of serotypes, 14, 19F and 15F. Microbiology 142: 2747-2757.
7. Coffey, T.J., Enright, M.C., Daniels, M., Wilkinson, P., Berron, S., Fenoll, A., and Spratt, B.G. (1997) Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae. Microb Drug Res (in press).
8. Dillard, J.P., and Yother, J. (1994) Genetic and molecular characterization of capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 3. Mol Microbiol 12: 959-972.
9. Dillard, J., Vandersea, M.W., and Yother, J. (1995) Characterization of the cassette containing genes for the type 3 capsular polysaccharide in Streptococcus pneumoniae. J Exp Med 181: 973-983.
10. Feldman, C., and Klugman, K.P. (1997) Pneumococcal infections. Curr Opin Infect Dis 10: 109-115.
11. Fenoll, A., Martin Bourgon, C., Muñoz, R., Vicioso, D., and Casal, J. (1991) Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing systemic infections in Spain, 1979-89. Rev Infect Dis 13: 56-60.
12. García, E., and López, R. (1997) Molecular biology of the capsular genes of Streptococcus pneumoniae. FEMS Microbiol Lett 149: 1-10.
13. García, E., García, P., and López, R. (1993) Cloning and sequencing of a gene involved in the synthesis of the capsular polysaccharide of Streptococcus pneumoniae type 3. Mol Gen Genet 239: 188-195.
14. García, E., Arrecubieta, C., Muñoz, R., Mollerach, M., and López, R. (1997) A functional analysis of the Streptococcus pneumoniae genes involved in the synthesis of type 1 and type 3 capsular polysaccharides. Microb Drug Res 3: 73-88.
15. Guidolin, A., Morona, J.K., Morona, R., Hansman, D., and Paton, J.C. (1994) Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F. Infect Immun 62: 5384-5396.
16. Hall, L.M.C., Whiley, R.A., Duke, B., George, R.C., and Efstratiou, A. (1996) Genetic relatedness within and between serotypes of Streptococcus pneumoniae from the United Kingdom - analysis of multilocus enzyme electrophoresis, pulsed-field gel electrophoresis, and antimicrobial resistance patterns. J Clin Microbiol 34: 853-859.
17. Henrichsen, J. (1995) Six newly recognized types of Streptococcus pneumoniae. J Clin Microbiol 33: 2759-2762.
18. Kayhty, H., and Eskola, J. (1996) New vaccines for the prevention of pneumococcal infections. Emerg Infect Dis 2: 289-298.
19. Kell, C.M., Jordans, J.Z., Daniels, M., Coffey, T.J., Bates, J., Paul, J., Gilks, C., and Spratt, B.G. (1993) Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya. Infect Immun 61: 4382-4391.
20. Kelly, T., Dillard, J.P., and Yother, J. (1994) Effect of genetic switching of capsular type on virulence of Streptococcus pneumoniae. Infect Immun 62: 1813-1819.
21. Klugman, K.P. (1996) Epidemiology, control, and treatment of multiresistant pneumococci. Drugs 52 (S2): 42-46.
22. Klugman, K.P., Coffey, T.J., Smith, A., Wasas, A., Myers, M., and Spratt, B.G. (1994) Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa. Eur J Clin Microbiol 13: 171-174.
23. Kolkman, M.A.B., Morrison, D.A., van der Zeijst, B.A.M., and Nuijten, P.J.M. (1996) The capsule polysaccharide synthesis locus of Streptococcus pneumoniae serotype 14: identification of the glycosyl transferase gene cps14E. J Bacteriol 178: 3736-3741.
24. Kumar, S., Tamura, K., and Nei, M. (1993) MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers. CABIOS 10: 189-191.
25. Leinonen, M. (1983) Antibody responses against pneumococcal polysaccharide antigens in vaccinated persons. Ann Clin Res 14: 267-271.
26. Mäkelä, P.H., and Stocker, B.A.D. (1969) Genetics of polysaccharide biosynthesis. Annu Rev Genet 3: 291-322.
27. McDougal, L.K., Facklam, R., Reeves, M., Hunter, S., Swenson, J.M., Hill, B.C., and Tenover, F.C. (1992) Analysis of multiply antimicrobial-resistant isolates of Streptococcus pneumoniae from the United States. Antimicrob Agents Chemother 36: 2176-2184.
28. McDougal, L.K., Rasheed, J.K., Biddle, J.W., and Tenover, F.C. (1995) Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob Agents Chemother 39: 2282-2288.
29. Morona, J.K., Guidolin, A., Morona, R., Hansman, D., and Paton, J.C. (1994) Isolation, characterization, and nucleotide sequence of IS 1202, an insertion sequence of Streptococcus pneumoniae. J Bacteriol 176: 4437-4443.
30. Morona, J.K., Morona, R., and Paton, J.C. (1997) Characterization of the locus encoding biosynthesis of Streptococcus pneumoniae type 19F capsular polysaccharide. Mol Microbiol 23: 751-763.
31. Muñoz, R., Coffey, T.J., Daniels, M., Dowson, C.G., Laible, G., Casal, J., Hakenbeck, R., Jacobs, M., Musser, J.M., Spratt, B.G., and Tomasz, A. (1991) Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis 164: 302-606.
32. Muñoz, R., Mollerach, M., López, R., and García, E. (1997) Molecular organization of the genes required for the synthesis of type 1 capsular polysaccharide of Streptococcus pneumoniae: formation of binary encapsulated pneumococci and identification of cryptic dTDP-rhamnose biosynthesis genes. Mol Microbiol 25: 79-92.
33. Murphy, T.V., White, K.E., Pastor, P., Gabriel, L., Medley, F., Granoff, D.M., and Osterholm, MT. (1993) Declining incidence of Haemophilus influenzae type b disease since introduction of vaccination. JAMA 269: 246-248.
34. Musser, J.M., Kroll, J.S., Moxon, E.R., and Selander, R.K. (1988) Evolutionary genetics of the encapsulated strains of Hemophilus influenzae. Proc Natl Acad Sci USA 85, 7758-7762.
35. Page, R.D.M. (1996) TreeView: An application to display phylogenetic trees on personal computers. CABIOS 12: 357-358.
36. Paton, J.C., Berry, A.M., and Lock, R.A. (1997) Molecular analysis of putative pneumococcal virulence proteins. Microb Drug Resist 3: 1-10.
37. Robbins, J.B., Austrian, R., Lee, C.J., Rastogi, S.C., Schiffman, G., Henrichsen, J., et al. (1983) Considerations for formulating the 2nd generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis 148: 1136-1159.
38. Roberts, I.S. (1996) The biochemistry and genetics of capsular polysaccharide production in bacteria. Annu Rev Microbiol 50: 285-315.
39. Scott, J.A.G., Hall, A.J., Dagan, R., Dixon, J.M.S., Eykyn, S.J., Fenoll, A., et al. (1996) Serogroup-specific epidemiology of Streptococcus pneumoniae - associations with age, sex, and geography in 7000 episodes of invasive disease. Clin infect Dis 22, 973-981.
40. Sibold, C., Wang, J., Henrichsen, J., and, Hakenbeck, R. (1992) Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect Immun 60: 4119-4126.
41. Tarasi, A., Chong, Y.S., Lee, K.W., and Tomasz, A. (1997) Spread of the serotype 23F multidrug-resistant Streptococcus pneumoniae clone to South Korea. Microb Drug Res 3: 105-109.
42. Tomasz, A. (1997) Antibiotic resistance in Streptococcus pneumoniae. Clin Intect Dis 24: S85-S88.
43. Van Dam, J.E.G., Fleer, A., and Snippe, H. (1990) Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharides. Ant. van Leeuw. J Microbiol 56: 1-47.
44. Urwin, G., Yuan, M.F., Hall, L.M.C., Brown, K., Efstratiou, A., and Feldman, R.A. (1996) Pneumococcal meninigitis in the North East Thames Region UK: epidemiology and molecular analysis of isolates. Epidemiol Infect 117: 95-102.
45. Versalovic, J., Kapur, V., Mason, E.O., Shah, V., Keouth, T., Lupski, J.R., and Musser, J.M. (1993) Penicillin-resistant Streptococcus pneumoniae strains recovered in Houston: identification and molecular characterization of multiple clones. J Inf Dis 167: 850-856.