The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

BMC Immunology

Volumn 13, Issue , 2012, Pages

  Wesselius, Anke ^a   Bours, Martijn J L ^a   Arts, Ilja C W ^a,b   Theunisz, Esther H E ^c   Geusens, Piet ^c   Dagnelie, Pieter C ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ATP; Inflammation; P2X7; Polymorphism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL PROTECTION; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME RELEASE; EX VIVO STUDY; EXPERIMENTAL MODEL; FEMALE; HUMAN; INFLAMMATION; LOSS OF FUNCTION MUTATION; MALE; P2X7 GENE; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AGED; AMINO ACID SUBSTITUTION; CELL DEATH; CYTOKINES; CYTOPROTECTION; FEMALE; HUMANS; L-LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, PURINERGIC P2X7; TETRADECANOYLPHORBOL ACETATE;

EID: 84870330653     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-13-64     Document Type: Article

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