Radioprotective effects of ATP in human blood ex vivo

Biochemical and Biophysical Research Communications

Volumn 367, Issue 2, 2008, Pages 383-387

  Swennen, Els L R ^a   Dagnelie, Pieter C ^a   Van den Beucken, Twan ^b   Bast, Aalt ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ATP; Blood; DNA damage; IL 10; Inflammation; Irradiation; Oxidative stress; Radioprotection; TNF

Indexed keywords

ADENOSINE KINASE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; PURINERGIC P2Y11 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DAMAGE; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; IRRADIATION; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PROTECTION;

ADENOSINE TRIPHOSPHATE; ADULT; BLOOD PHYSIOLOGY; BLOOD PROTEINS; CYTOKINES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; MALE; OXIDATIVE STRESS; RADIATION DOSAGE; RADIATION-PROTECTIVE AGENTS;

EID: 38349060709     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.125     Document Type: Article

References (43)

1. Movsas B., Raffin T.A., Epstein A.H., and Link Jr. C.J. Pulmonary radiation injury. Chest 111 (1997) 1061-1076
2. Abratt R.P., and Morgan G.W. Lung toxicity following chest irradiation in patients with lung cancer. Lung Cancer 35 (2002) 103-109
3. McDonald S., Rubin P., Phillips T.L., and Marks L.B. Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems. Int. J. Radiat. Oncol. Biol. Phys. 31 (1995) 1187-1203
4. Hong J.H., Chiang C.S., Tsao C.Y., Lin P.Y., McBride W.H., and Wu C.J. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. Int. J. Radiat. Biol. 75 (1999) 1421-1427
5. Nair C.K., Parida D.K., and Nomura T. Radioprotectors in radiotherapy. J. Radiat. Res. (Tokyo) 42 (2001) 21-37
6. Swennen E.L., Bast A., and Dagnelie P.C. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur. J. Immunol. 35 (2005) 852-858
7. Swennen E.L., Bast A., and Dagnelie P.C. Purinergic receptors involved in the immunomodulatory effects of ATP in human blood. Biochem. Biophys. Res. Commun. 348 (2006) 1194-1199
8. Agteresch H.J., Dagnelie P.C., van den Berg J.W., and Wilson J.H. Adenosine triphosphate: established and potential clinical applications. Drugs 58 (1999) 211-232
9. Agteresch H.J., Van Rooijen M., van den Berg J., Minderman-voortman G., Wilson J.H., and Dagnelie P.C. Growth inhibition of lung cancer cells by adenosine 5′-triphosphate. Drug Dev. Res. 60 (2003) 196-203
10. Yamada T., Okajima F., Akbar M., Tomura H., Narita T., Ohwada S., Morishita Y., and Kondo Y. Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro. Oncol. Rep. 9 (2002) 113-117
11. Conigrave A.D., van der Weyden L., Holt L., Jiang L., Wilson P., Christopherson R.I., and Morris M.B. Extracellular ATP-dependent suppression of proliferation and induction of differentiation of human HL-60 leukemia cells by distinct mechanisms. Biochem. Pharmacol. 60 (2000) 1585-1591
12. White N., and Burnstock G. P2 receptors and cancer. Trends Pharmacol. Sci. 27 (2006) 211-217
13. El-Tayeb A., Griessmeier K.J., and Muller C.E. Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors. Bioorg. Med. Chem. Lett. 15 (2005) 5450-5452
14. Hofmann M.A., Schiekofer S., Isermann B., Kanitz M., Henkels M., Joswig M., Treusch A., Morcos M., Weiss T., Borcea V., Abdel Khalek A.K., Amiral J., Tritschler H., Ritz E., Wahl P., Ziegler R., Bierhaus A., and Nawroth P.P. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia 42 (1999) 222-232
15. Mercken E.M., Hageman G.J., Schols A.M., Akkermans M.A., Bast A., and Wouters E.F. Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 172 (2005) 994-1001
16. Vandeputte C., Guizon I., Genestie-Denis I., Vannier B., and Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell. Biol. Toxicol. 10 (1994) 415-421
17. Fischer M.A., Gransier T.J., Beckers L.M., Bekers O., Bast A., and Haenen G.R. Determination of the antioxidant capacity in blood. Clin. Chem. Lab. Med. 43 (2005) 735-740
18. Lux O., Naidoo D., and Salonikas C. Improved HPLC method for the simultaneous measurement of allantoin and uric acid in plasma. Ann. Clin. Biochem. 29 Pt. 6 (1992) 674-675
19. Lepage G., Munoz G., Champagne J., and Roy C.C. Preparative steps necessary for the accurate measurement of malondialdehyde by high-performance liquid chromatography. Anal. Biochem. 197 (1991) 277-283
20. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
21. McCormick D. Method for the determination of erythrocyte glutathione reductase activity. In: Tietz N.M. (Ed). Textbook of Clinical Chemistry (1986), WB Saunders Company, Philadelphia
22. Habig W.H., and Jakoby W.B. Assays for differentiation of glutathione S-transferases. Methods Enzymol. 77 (1981) 398-405
23. Cengiz M., Akbulut S., Atahan I.L., and Grigsby P.W. Acute phase response during radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 49 (2001) 1093-1096
24. Gridley D.S., Bonnet R.B., Bush D.A., Franke C., Cheek G.A., Slater J.D., and Slater J.M. Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 60 (2004) 759-766
25. Hong J.H., Chiang C.S., Campbell I.L., Sun J.R., Withers H.R., and McBride W.H. Induction of acute phase gene expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33 (1995) 619-626
26. Hallahan D.E. Radiation-mediated gene expression in the pathogenesis of the clinical radiation response. Semin. Radiat. Oncol. 6 (1996) 250-267
27. Morgan G.W., and Breit S.N. Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury. Int. J. Radiat. Oncol. Biol. Phys. 31 (1995) 361-369
28. Rubin P., Johnston C.J., Williams J.P., McDonald S., and Finkelstein J.N. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 33 (1995) 99-109
29. Van der Vliet A., and Bast A. Effect of oxidative stress on receptors and signal transmission. Chem. Biol. Interact. 85 (1992) 95-116
30. Barnes P.J., and Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336 (1997) 1066-1071
31. Flohe L., Brigelius-Flohe R., Saliou C., Traber M.G., and Packer L. Redox regulation of NF-kappa B activation. Free Radic. Biol. Med. 22 (1997) 1115-1126
32. Schoonbroodt S., and Piette J. Oxidative stress interference with the nuclear factor-kappa B activation pathways. Biochem. Pharmacol. 60 (2000) 1075-1083
33. Rahman I. Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochem. Pharmacol. 64 (2002) 935-942
34. Chandel N.S., Trzyna W.C., McClintock D.S., and Schumacker P.T. Role of oxidants in NF-kappaB activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 165 (2000) 1013-1021
35. Li N., and Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J. 13 (1999) 1137-1143
36. Linard C., Marquette C., Mathieu J., Pennequin A., Clarencon D., and Mathe D. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kappaB inhibitor. Int. J. Radiat. Oncol. Biol. Phys. 58 (2004) 427-434
37. Li L., Story M., and Legerski R.J. Cellular responses to ionizing radiation damage. Int. J. Radiat. Oncol. Biol. Phys. 49 (2001) 1157-1162
38. Muller W.U., Bauch T., Stuben G., Sack H., and Streffer C. Radiation sensitivity of lymphocytes from healthy individuals and cancer patients as measured by the comet assay. Radiat. Environ. Biophys. 40 (2001) 83-89
39. Burger S., Schindler D., Fehn M., Muhl B., Mahrhofer H., Flentje M., Hoehn H., Seemanova E., and Djuzenova C.S. Radiation-induced DNA damage and repair in peripheral blood mononuclear cells from Nijmegen breakage syndrome patients and carriers assessed by the Comet assay. Environ. Mol. Mutagen. 47 (2006) 260-270
40. Swennen E.L., Dagnelie P.C., and Bast A. ATP inhibits hydroxyl radical formation and the inflammatory response of stimulated whole blood even under circumstances of severe oxidative stress. Free Radic. Res. 40 (2006) 53-58
41. Prasad N.R., Menon V.P., Vasudev V., and Pugalendi K.V. Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology 209 (2005) 225-235
42. Navarro J., Obrador E., Pellicer J.A., Aseni M., Vina J., and Estrela J.M. Blood glutathione as an index of radiation-induced oxidative stress in mice and humans. Free Radic. Biol. Med. 22 (1997) 1203-1209
43. Emin Buyukokuroglu M., Taysi S., Koc M., and Bakan N. Dantrolene protects erythrocytes against oxidative stress during whole-body irradiation in rats. Cell. Biochem. Funct. 21 (2003) 127-131