Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein

Genes and Development

Volumn 14, Issue 14, 2000, Pages 1741-1749

  Tago, Ken Ichi ^a,b   Nakamura, Tsutomu ^a   Nishita, Michiru ^c   Hyodo, Junko ^c   Nagai, Shin Ichi ^c   Murata, Yoji ^a   Adachi, Shungo ^a   Ohwada, Susumu ^b   Morishita, Yasuo ^b   Shibuya, Hiroshi ^c   Akiyama, Tetsu ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

catenin; ICAT; Signaling; TCF; Wnt

Indexed keywords

BETA CATENIN; ICAT PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; BODY PATTERNING; CELL CYCLE PROTEINS; CELL DIVISION; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; GENES, DOMINANT; GOOSECOID PROTEIN; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; MICE; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MUTAGENESIS; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES; WNT PROTEINS; XENOPUS; XENOPUS PROTEINS; ZEBRAFISH PROTEINS;

EID: 0034661142     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Behrens, J., von Kries, J.P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 382: 638-642.
2. Behrens, J., Jerchow, B.A., Wurtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuhl, M., Wedlich, D., and Birchmeier, W. 1998. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280: 596-599.
3. Bienz, M. 1998. TCF: Transcriptional activator or repressor? Curr. Opin. Cell Biol. 10: 366-372.
4. _. 1999. APC: The plot thickens. Curr. Opin. Genet. Dev. 9: 595-603.
5. Brannon, M., Gomperts, M., Sumoy, L., Moon, R.T., and Kimelman, D. 1997. A β-catenin/XTcf-3 complex binds to the Siamois promoter to regulate dorsal axis specification in Xenopus. Genes & Dev. 11: 2359-2370.
6. Brunner, E., Peter, O., Schweizer, L., and Basler, K. 1997. pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385: 829-833.
7. Cadigan, K.M. and Nusse, R. 1997. Wnt signaling: A common theme in animal development. Genes & Dev. 11: 3286-3305.
8. Cavallo, R.A., Cox, R.T., Moline, M.M., Roose, J., Polevoy, G.A., Clevers, H., Peifer, M., and Bejsovec, A. 1998. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature 395: 604-608.
9. Clevers, H. and van de Wetering, M. 1997. TCF/LEF factor earn their wings. Trends Genet. 13: 485-489.
10. Eastman, Q. and Grosschedl, R. 1999. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell Biol. 11: 233-240.
11. Fan, M.J., Gruning, W., Walz, G., and Sokol, S.Y. 1998. Wnt signaling and transcription control of Siamois in Xenopus embryo. PTOC. Natl. Acad. Sci. 95: 5626-5631.
12. -/- mice. Genes & Dev. 13: 709-717.
13. Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S., Suzuki, A., Fujita, F., Shibuya, H., Toyoshima, K., Ueno, N., et al. 1999. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283: 1739-1742.
14. Hart, M.J., de los Santos, R., Albert, I.N., Rubinfeld, B., and Polakis, P. 1998. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β. Curr Biol 8: 573-581.
15. Hsu, S.C., Galceran, J., and Grosschedl, R. 1998. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with β-catenin. Mol Cell. Biol. 18:4807-4818.
16. Huber, A.H., Nelson, W.J., and Weis, W.I. 1997. Three-dimensional structure of the armadillo repeat region of β-catenin. Cell 90: 871-882.
17. Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., and Kikuchi, A. 1998, Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin. EMBO J. 17: 1371-1384.
18. Itoh, K., Krupnik, V.E., and Sokol, S.Y. 1998. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin. Curr. Biol. 8: 591-594.
19. Kinzler, K.W. and Vogelstein, B. 1996. Lessons from hereditary colorectal cancer. Cell 87: 159-170.
20. Korinek, V., Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. 1997. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 275: 1784-1787.
21. Larabell, C.A., Torres, M., Rowning, B.A., Yost, C., Miller, J.R., Wu, M., Kimelman, D., and Moon, R.T. 1997. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J. Cell Biol. 136: 1123-1136.
22. Laurent, M.N., Blitz, I.L., Hashimoto, C., Rothbacher, U., and Cho, K.W.-Y. 1997. The Xenopus gene Twin mediates Wnt induction of Goosecoid in establishment of Spemann's organizer. Development 124: 4905-4916.
23. Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G.H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., and Akiyama, T. 1996. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272: 1020-1023.
24. Miller, J.R. and Moon, R.T. 1996. Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes & Dev. 10: 2527-2539.
25. Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destree, O., and Clevers, H. 1996. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 86: 391-399.
26. Moon, R.T. and Christian, J.L. 1989. Microinjection and expression of synthetic mRNAs in Xenopus embryos. Technique 1: 76-89.
27. Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K.W. 1997. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275: 1787-1790.
28. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. 1995. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. 92: 3046-3050.
29. Nakamura, T., Hamada, F., Ishidate, T., Anai, K., Kawahara, K., Toyoshima, K., and Akiyama, T. 1998. Axin, an inhibitor of the Wnt signalling pathway, interacts with β-catenin, GSK-3β and APC and reduces the β-catenin level. Genes Cells 3: 395-403.
30. Polakis, P. 1997. The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta 1332: F127-F147.
31. Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S.C., Grosschedl, R., and Bienz, M. 1997. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 88: 777-787.
32. Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. 1998. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395: 608-612.
33. Rubinfeld, B., Robbins, P., El-Gamil, M., Albert, I., Porfiri, E., and Polakis, P. 1997. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science 275: 1790-1792.
34. Rupp, R.A., Snider, L., and Weintraub, H. 1994. Xenopus em-bryos regulate the nuclear localization of XMyoD. Genes & Dev. 8: 1311-1323.
35. Sakanaka, C., Weiss, J.B., and Williams, L.T. 1998. Bridging of β-catenin and glycogen synthase kinase-3β by axin and inhibition of β-catenin-mediated transcription. Proc. Natl. Acad. Sci. 95: 3020-3023.
36. Shibuya, H., Iwata, H., Masuyama, N., Gotoh, Y., Yamaguchi, K., Irie, K., Matsumoto, K., Nishida, E., and Ueno, N. 1998. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 17: 1019-1028.
37. van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A. et al. 1997. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88: 789-799.
38. Willert, K., Logan, C.Y., Arora, A., Fish, M., and Nusse, R. 1999. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development 126: 4165-4173.
39. Wilson, P.A. and Hemmati-Brivanlou, A. 1995. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376: 331-333.
40. Wilson, P.A. and Melton, D.A. 1994. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4: 676-686.