Chiral analysis of metoprolol and two of its metabolites, α-hydroxymetoprolol and deaminated metoprolol, in wastewater using liquid chromatography-tandem mass spectrometry

Journal of Chromatography A

Volumn 1269, Issue , 2012, Pages 208-217

  Barclay, Victoria K H ^a   Tyrefors, Niklas L ^a   Johansson, I Monika ^a,b   Pettersson, Curt E ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Chiral stationary phase; Enantiomeric separation; LC MS; Metabolites; Metoprolol; Wastewater

Indexed keywords

ANALYTES; CHIRAL ANALYSIS; CHIRAL SEPARATIONS; CHIRAL STATIONARY PHASE; CHIRAL STATIONARY PHASIS; CHIRALCEL OD-H; DIASTEREOISOMERS; ENANTIOMERIC SEPARATION; ENVIRONMENTAL WATER SAMPLES; EXTRACTION RECOVERY; LC-MS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; METHOD DETECTION LIMITS; METOPROLOL; SOLID PHASE EXTRACTION METHOD; TREATED WASTEWATER; TRIPLE-QUADRUPOLE MASS SPECTROMETRY; WASTEWATER SAMPLES; WATER SAMPLES;

BIOMOLECULES; CHIRALITY; ENANTIOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; SEPARATION; STEREOCHEMISTRY; WASTEWATER;

WASTEWATER TREATMENT;

ALPHA HYDROXYMETOPROLOL; METOPROLOL;

ARTICLE; CHIRALITY; CONTROLLED STUDY; DEAMINATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ELUTION; ENANTIOMER; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; SWEDEN; TANDEM MASS SPECTROMETRY; WASTE WATER; WATER ANALYSIS; WATER SAMPLING;

ADRENERGIC BETA-ANTAGONISTS; CHROMATOGRAPHY, LIQUID; DEAMINATION; METOPROLOL; SOLID PHASE EXTRACTION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84870318866     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.09.090     Document Type: Article

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