Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 5, 2010, Pages 1120-1127

  Yang, Zhen ^a   Gao, Song ^a   Yin, Taijun ^a   Kulkarni, Kaustubh H ^a   Teng, Yang ^a   You, Ming ^b   Hu, Ming ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b USA   (United States)

Author keywords

Caco 2 cells; Matrine; Microsomes; Pharmacokinetics; Rat intestine perfusion; UPLC MS MS

Indexed keywords

MATRINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; COLON ABSORPTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; HUMAN CELL; INTESTINE MUCOSA PERMEABILITY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; RELIABILITY; SENSITIVITY ANALYSIS; SMALL INTESTINE ABSORPTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; BILE; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINES; MALE; MICROSOMES, LIVER; PERFUSION; PERMEABILITY; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 72749104889     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.11.020     Document Type: Article

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