UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP

Drug Metabolism and Disposition

Volumn 40, Issue 2, 2012, Pages 336-345

  Jiang, Wen ^a   Xu, Beibei ^a   Wu, Baojian ^a   Yu, Rong ^b   Hu, Ming ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; APIGENIN; BREAST CANCER RESISTANCE PROTEIN; FLAVONOID; GENISTEIN; GLUCURONOSYLTRANSFERASE 1A9; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; SMALL INTERFERING RNA;

ARTICLE; CELL ENGINEERING; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME SUBSTRATE; EXPERIMENTAL MODEL; GENE OVEREXPRESSION; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE;

APIGENIN; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; GENE SILENCING; GENISTEIN; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HELA CELLS; HUMANS; KINETICS; LEUKOTRIENE C4; MEMBRANE TRANSPORT MODULATORS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OSMOLAR CONCENTRATION; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 84855986942     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.041467     Document Type: Article

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