Haloperidol induces demethylation and expression of the dual specificity phosphatase 6 gene in MIA PaCa-2 human pancreatic cancer cells

Life Sciences

Volumn 91, Issue 25-26, 2012, Pages 1317-1322

  Kim, Se Hyun ^a   Lee, Hee Young ^b   Yi, Heesun ^c   Ahn, Yong Min ^a,b,c   Kim, Yong Sik ^c,d  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Dongguk University Ilsan Hospital   (South Korea)

Author keywords

Antipsychotic agents; DNA methylation; DUSP6

Indexed keywords

AZACITIDINE; DUAL SPECIFICITY PHOSPHATASE 6; HALOPERIDOL;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DNA MODIFICATION; GROWTH RATE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PANCREAS CANCER; PROMOTER REGION; PROTEIN EXPRESSION; PYROSEQUENCING; REGULATORY MECHANISM;

ANTIPSYCHOTIC AGENTS; AZACITIDINE; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DUAL SPECIFICITY PHOSPHATASE 6; ENZYME INHIBITORS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HALOPERIDOL; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; PANCREATIC NEOPLASMS;

AGOUTI PACA;

EID: 84870294723     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.10.002     Document Type: Article

References (52)

1. Y.M. Ahn, M.S. Seo, S.H. Kim, Y. Kim, Y.S. Juhnn, and Y.S. Kim The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex Int J Neuropsychopharmacol 9 2006 451 456
2. G. Barreto, A. Schafer, J. Marhold, D. Stach, S.K. Swaminathan, and V. Handa Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation Nature 445 2007 671 675
3. A. Bromberg, J. Levine, B. Nemetz, R.H. Belmaker, and G. Agam No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients Schizophr Res 101 2008 50 57
4. C.J. Carter Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability Neurochem Int 50 2007 461 490
5. J.H. Choi, Y.R. Yang, S.K. Lee, S.H. Kim, Y.H. Kim, and J.Y. Cha Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival Ann N Y Acad Sci 1138 2008 393 403
6. I. Creese, D.R. Burt, and S.H. Snyder Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs Science 192 1976 481 483
7. A.B. Csoka, and M. Szyf Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology Med Hypotheses 73 2009 770 780
8. E. Di Daniel, A.W. Mudge, and P.R. Maycox Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons Bipolar Disord 7 2005 33 41
9. E. Dong, M. Nelson, D.R. Grayson, E. Costa, and A. Guidotti Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation Proc Natl Acad Sci U S A 105 2008 13614 13619
10. J.S. Driscoll, N.R. Melnick, F.R. Quinn, N. Lomax, J.P. Davignon, and R. Ing Psychotropic drugs as potential antitumor agents: a selective screening study Cancer Treat Rep 62 1978 45 74
11. T. Furukawa, M. Sunamura, F. Motoi, S. Matsuno, and A. Horii Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer Am J Pathol 162 2003 1807 1815
12. T. Furukawa, E. Tanji, S. Xu, and A. Horii Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells Biochem Biophys Res Commun 377 2008 317 320
13. D.P. Gavin, and R.P. Sharma Histone modifications, DNA methylation, and schizophrenia Neurosci Biobehav Rev 34 2010 882 888
14. D.R. Grayson, X. Jia, Y. Chen, R.P. Sharma, C.P. Mitchell, and A. Guidotti Reelin promoter hypermethylation in schizophrenia Proc Natl Acad Sci U S A 102 2005 9341 9346
15. D.R. Grayson, Y. Chen, E. Dong, M. Kundakovic, and A. Guidotti From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia Epigenetics 4 2009 144 149
16. L.A. Groom, A.A. Sneddon, D.R. Alessi, S. Dowd, and S.M. Keyse Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase EMBO J 15 1996 3621 3632
17. W.N. Hait, and G.L. Lee Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists Biochem Pharmacol 34 1985 3973 3978
18. K. Iwamoto, and T. Kato Epigenetic profiling in schizophrenia and major mental disorders Neuropsychobiology 60 2009 5 11
19. S.H. Kim, M.S. Seo, W.J. Jeon, H.S. Yu, H.G. Park, and G.A. Jung Haloperidol regulates the phosphorylation level of the MEK-ERK-p90RSK signal pathway via protein phosphatase 2A in the rat frontal cortex Int J Neuropsychopharmacol 11 2008 509 517
20. S.H. Kim, H.S. Yu, H.G. Park, W.J. Jeon, J.Y. Song, and U.G. Kang Dose-dependent effect of intracerebroventricular injection of ouabain on the phosphorylation of the MEK1/2-ERK1/2-RSK pathway in the rat brain related to locomotor activity Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1637 1642
21. S.H. Kim, S.Y. Shin, K.Y. Lee, E.J. Joo, J.Y. Song, and Y.M. Ahn The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity Prog Neuropsychopharmacol Biol Psychiatry 37 2012 41 49
22. R.J. Klose, and A.P. Bird Genomic DNA methylation: the mark and its mediators Trends Biochem Sci 31 2006 89 97
23. M. Kodama, D.S. Russell, and R.S. Duman Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain Neuropsychopharmacology 30 2005 360 371
24. J. Kornhuber, A. Schultz, J. Wiltfang, I. Meineke, C.H. Gleiter, and R. Zochling Persistence of haloperidol in human brain tissue Am J Psychiatry 156 1999 885 890
25. E.R. Korpi, B.H. Phelps, H. Granger, W.H. Chang, M. Linnoila, and J.L. Meek Simultaneous determination of haloperidol and its reduced metabolite in serum and plasma by isocratic liquid chromatography with electrochemical detection Clin Chem 29 1983 624 628
26. K.Y. Lee, Y.M. Ahn, E.J. Joo, J.S. Chang, and Y.S. Kim The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder Mol Psychiatry 11 2006 425 426
27. J. Li, Y. Guo, F.A. Schroeder, R.M. Youngs, T.W. Schmidt, and C. Ferris Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling J Neurochem 90 2004 1117 1131
28. D.K. Ma, M.H. Jang, J.U. Guo, Y. Kitabatake, M.L. Chang, and N. Pow-Anpongkul Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis Science 323 2009 1074 1077
29. F. Matrisciano, E. Dong, D.P. Gavin, F. Nicoletti, and A. Guidotti Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain Mol Pharmacol 80 2011 174 182
30. P.A. Melas, M. Rogdaki, U. Osby, M. Schalling, C. Lavebratt, and T.J. Ekstrom Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset FASEB J 26 2012 2712 2718
31. J. Mill, T. Tang, Z. Kaminsky, T. Khare, S. Yazdanpanah, and L. Bouchard Epigenomic profiling reveals DNA-methylation changes associated with major psychosis Am J Hum Genet 82 2008 696 711
32. J. Nordenberg, E. Fenig, M. Landau, R. Weizman, and A. Weizman Effects of psychotropic drugs on cell proliferation and differentiation Biochem Pharmacol 58 1999 1229 1236
33. Y. Numachi, S. Yoshida, M. Yamashita, K. Fujiyama, M. Naka, and H. Matsuoka Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain Ann N Y Acad Sci 1025 2004 102 109
34. S.K. Ooi, and T.H. Bestor The colorful history of active DNA demethylation Cell 133 2008 1145 1148
35. D.M. Owens, and S.M. Keyse Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases Oncogene 26 2007 3203 3213
36. R. Pidsley, and J. Mill Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research Biol Psychiatry 69 2011 146 156
37. L. Pozzi, K. Hakansson, A. Usiello, A. Borgkvist, M. Lindskog, and P. Greengard Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum J Neurochem 86 2003 451 459
38. W.B. Ruzicka, A. Zhubi, M. Veldic, D.R. Grayson, E. Costa, and A. Guidotti Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection Mol Psychiatry 12 2007 385 397
39. K.M. Schmitz, N. Schmitt, U. Hoffmann-Rohrer, A. Schafer, I. Grummt, and C. Mayer TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation Mol Cell 33 2009 344 353
40. M.S. Seo, S.H. Kim, Y.M. Ahn, Y. Kim, W.J. Jeon, and S.C. Yoon The effects of repeated administrations of MK-801 on ERK and GSK-3beta signalling pathways in the rat frontal cortex Int J Neuropsychopharmacol 10 2007 359 368
41. M. Shimabukuro, Y. Jinno, C. Fuke, and Y. Okazaki Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats Behav Brain Funct 2 2006 37
42. M. Shimabukuro, T. Sasaki, A. Imamura, T. Tsujita, C. Fuke, and T. Umekage Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia J Psychiatr Res 41 2007 1042 1046
43. J. Struyf, S. Dobrin, and D. Page Combining gene expression, demographic and clinical data in modeling disease: a case study of bipolar disorder and schizophrenia BMC Genomics 9 2008 531
44. M. Tahiliani, K.P. Koh, Y. Shen, W.A. Pastor, H. Bandukwala, and Y. Brudno Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Science 324 2009 930 935
45. D. Takai, and P.A. Jones The CpG island searcher: a new WWW resource In Silico Biol 3 2003 235 240
46. Y. Tsukada Hydroxylation mediates chromatin demethylation J Biochem 151 2012 229 246
47. W. Ukai, H. Ozawa, M. Tateno, E. Hashimoto, and T. Saito Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol J Neural Transm 111 2004 667 681
48. E. Valjent, C. Pages, D. Herve, J.A. Girault, and J. Caboche Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain Eur J Neurosci 19 2004 1826 1836
49. B. Weiss, W. Prozialeck, M. Cimino, M.S. Barnette, and T.L. Wallace Pharmacological regulation of calmodulin Ann N Y Acad Sci 356 1980 319 345
50. E.D. Wiklund, V.S. Catts, S.V. Catts, T.F. Ng, N.J. Whitaker, and A.J. Brown Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target Int J Cancer 126 2010 28 40
51. S. Xu, T. Furukawa, N. Kanai, M. Sunamura, and A. Horii Abrogation of DUSP6 by hypermethylation in human pancreatic cancer J Hum Genet 50 2005 159 167
52. P.X. Yuan, L.D. Huang, Y.M. Jiang, J.S. Gutkind, H.K. Manji, and G. Chen The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth J Biol Chem 276 2001 31674 31683