Traditional Herbal Medicine Use Associated with Liver Fibrosis in Rural Rakai, Uganda

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Auerbach, Brandon J ^a,b   Reynolds, Steven J ^c,d   Lamorde, Mohammed ^a,e   Merry, Concepta ^a,e,f   Kukunda Byobona, Collins ^a   Ocama, Ponsiano ^a,b   Semeere, Aggrey S ^a   Ndyanabo, Anthony ^g   Boaz, Iga ^g   Kiggundu, Valerian ^g   Nalugoda, Fred ^g   Gray, Ron H ^g,h   Wawer, Maria J ^g,h   Thomas, David L ^d   Kirk, Gregory D ^h   Quinn, Thomas C ^c,d   Stabinski, Lara ^c,h  

^a MAKERERE UNIVERSITY   (Uganda)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TRINITY COLLEGE DUBLIN   (Ireland)

^f ST JAMES S HOSPITAL   (Ireland)

^g RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

^h JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPILIA AFRICANA EXTRACT; CALLISTEMON CITRINUS EXTRACT; CYPHOSTEMMA ADENOCAULE EXTRACT; GARLIC EXTRACT; HERBACEOUS AGENT; HOSLUNDIA OPPOSITA EXTRACT; INDIGO CONGESTA EXTRACT; MAESA LANCEOLATA EXTRACT; MANGIFERA INDICA EXTRACT; MICROGLOSSA DENSIFLORA EXTRACT; OCIMUM GRATISSIMUM EXTRACT; PSEUDARTHRIA HOOKERI EXTRACT; RHUS NATALENIS EXTRACT; RHUS VULGARIS EXTRACT; SAPIUM ELLIPTICUM EXTRACT; SOLANUM INCANUM EXTRACT; SPATHODEA CAMPANULATA EXTRACT; UNCLASSIFIED DRUG; VERNONIA AMYGDALINA EXTRACT;

ADULT; ALLERGY; AMARYLLIDACEAE; ANACARDIACEAE; ARTICLE; ASTERACEAE; BACKACHE; BIGNONIACEAE; CONTROLLED STUDY; COUGHING; CROSS-SECTIONAL STUDY; DIGESTIVE SYSTEM ULCER; DISEASE ASSOCIATION; DRUG MEGADOSE; DRUG USE; DYSMENORRHEA; ELASTOGRAPHY; EPIGASTRIC PAIN; EPILEPSY; EUPHORBIACEAE; FABACEAE; FEMALE; FEVER; HEALTH PROGRAM; HERBAL MEDICINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HYPERTENSION; INDIGESTION; JAUNDICE; LAMIACEAE; LIVER FIBROSIS; LIVER TOXICITY; LOOSE FECES; MALE; MYRTACEAE; NEWBORN JAUNDICE; PEPTIC ULCER; PRIMULACEAE; RHINITIS; RURAL AREA; SEXUALLY TRANSMITTED DISEASE; SINUSITIS; SOLANACEAE; THORAX PAIN; UGANDA; VITACEAE; VOMITING; WOUND;

ADULT; ANTI-HIV AGENTS; CROSS-SECTIONAL STUDIES; FEMALE; HERBAL MEDICINE; HIV INFECTIONS; HUMANS; LIVER CIRRHOSIS; MALE; MEDICINE, TRADITIONAL; PLANTS, MEDICINAL; RURAL POPULATION; UGANDA;

ASTERACEAE; FABACEAE; LAMIACEAE;

EID: 84870269234     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041737     Document Type: Article

References (50)

1. Hamill FA, Apio S, Mubiru NK, Mosango M, Bukenya-Ziraba R, et al. (2000) Traditional herbal drugs of southern Uganda, I. J Ethnopharmacol 70: 281-300.
2. Langlois-Klassen D, Kipp W, Rubaale T, (2008) Who's talking? Communication between health providers and HIV-infected adults related to herbal medicine for AIDS treatment in western Uganda. Soc Sci Med 67: 165-176.
3. Tabuti J, Lye K, Dhillion S, (2003) Traditional herbal drugs of Bulamogi, Uganda: plants, use, and administration. J Ethnopharmacol 88: 19-44.
4. Dara L, Hewett J, Lim JK, (2008) Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol 14: 6999-7004.
5. Teschke R, Fuchs J, Bahre R, Genthner A, Wolff A, (2010) Kava hepatotoxicity: comparative study of two structured quantitative methods for causality assessment. J Clin Pharm Ther 35: 545-563.
6. Ashafa AO, Sunmonu TO, Afolayan AJ, (2010) Toxicological evaluation of aqueous leaf and berry extracts of Phytolacca dioica L. in male Wistar rats. Food Chem Toxicol 48: 1886-1889.
7. Asres K, Sporer F, Wink M, (2007) Identification and quantification of hepatotoxic pyrrolizidine alkaloids in the Ethiopian medicinal plant Solanecio gigas (Asteraceae). Pharmazie 62: 709-713.
8. Lamorde M, Tabuti JR, Obua C, Kukunda-Byobona C, Lanyero H, et al. (2010) Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda. J Ethnopharmacol 130: 43-53.
9. Stabinski L, Reynolds S, Ocama P, Laeyendecker O, Ndyanabo A, et al. (2011) High Prevalence of Liver Fibrosis Associated with HIV Infection: A Study in Rural Rakai, Uganda. Antiviral Therapy 16: 405-411.
10. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Paxton L, et al. (1998) A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda. AIDS 12: 1211-1225.
11. AIDS Clinical Trials Group (1994) Table for grading the severity of adult and pediatric adverse advents. Rockville (Maryland): National Institutes of Health, Division of AIDS.
12. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, et al. (2002) Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137: 1-10.
13. Ruhl CE, Everhart JE, (2012) Upper limits of normal for alanine aminotransferase activity in the United States population. Hepatology 55: 447-454.
14. Andersen ES, Christensen PB, Weis N, (2009) Transient elastography for liver fibrosis diagnosis. Eur J Intern Med 20: 339-342.
15. Kirk GD, Astemborski J, Mehta SH, Spoler C, Fisher C, et al. (2009) Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV- hepatitis C virus coinfection. Clin Infect Dis 48: 963-972.
16. Barros AJ, Hirakata VN, (2003) Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol 3: 21.
17. Chen Z, Huo JR, (2010) Hepatic veno-occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations. Neth J Med 68: 252-260.
18. Ridker PM, McDermott WV, (1989) Comfrey herb tea and hepatic veno-occlusive disease. Lancet 1: 657-658.
19. Prakash AS, Pereira TN, Reilly PE, Seawright AA, (1999) Pyrrolizidine alkaloids in human diet. Mutat Res 443: 53-67.
20. Chen T, Mei N, Fu PP, (2010) Genotoxicity of pyrrolizidine alkaloids. J Appl Toxicol 30: 183-196.
21. Yeong ML, Wakefield SJ, Ford HC, (1993) Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats. Int J Exp Pathol 74: 211-217.
22. Tabuti J, Collins B, Kukunda C, Waako P, (2010) Medicinal plants used by traditional medicine practitioners in the treatment of tuberculosis and related ailments in Uganda. J Ethnopharmacol 127: 130-136.
23. Iwalokun BA, Efedede BU, Alabi-Sofunde JA, Oduala T, Magbagbeola OA, et al. (2006) Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen- induced hepatic damage in mice. J Med Food 9: 524-530.
24. Adesanoye O, Farombi E, (2009) Hepatoprotective effects of Vernonia amygdalina (Asteraceae) in rats treated with carbon tertachloride. Exp Toxicol Pathol 62: 197-206.
25. Effraim K, Jacks T, Sodipo O, (2002) Histopathological studies on the toxicity of Ocimum gratissimum leave extract on some organs of rabbit. African Journal of Biomedical Research 6: 21-25.
26. Yang HN, Kim DJ, Kim YM, Kim BH, Sohn KM, et al. (2010) Aloe-induced toxic hepatitis. J Korean Med Sci 25: 492-495.
27. van den Bout-van den Beukel CJ, Koopmans PP, van der Ven AJ, De Smet PA, Burger DM, (2006) Possible drug-metabolism interactions of medicinal herbs with antiretroviral agents. Drug Metab Rev 38: 477-514.
28. Barry M, Mulcahy F, Merry C, Gibbons S, Back D, (1999) Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection. Clin Pharmacokinet 36: 289-304.
29. Dickinson L, Khoo S, Back D, (2010) Pharmacokinetics and drug-drug interactions of antiretrovirals: an update. Antiviral Res 85: 176-189.
30. Mills E, Foster BC, van Heeswijk R, Phillips E, Wilson K, et al. (2005) Impact of African herbal medicines on antiretroviral metabolism. AIDS 19: 95-97.
31. Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J, (2002) The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 34: 234-238.
32. Akah P, Okafor C, (1992) Blood sugar lowering effect of Vernonia amygdalina (del) in an experimental rabbit model. Phytotherapy Research 6: 171-173.
33. Mukazayire MJ, Allaeys V, Buc Calderon P, Stevigny C, Bigendako MJ, et al. (2010) Evaluation of the hepatotoxic and hepatoprotective effect of Rwandese herbal drugs on in vivo (guinea pigs barbiturate-induced sleeping time) and in vitro (rat precision-cut liver slices, PCLS) models. Exp Toxicol Pathol 62: 289-299.
34. Tamokou JD, Kuiate JR, Tene M, Tane P, (2009) Antimicrobial clerodane diterpenoids from Microglossa angolensis Oliv. et Hiern. Indian J Pharmacol 41: 60-63.
35. Kuiate J, Zollo PA, Lamaty G, Mentu C, Besseiere J, (1999) Composition of essential oils from the leaves of two varieties of Aspilia africana (Pers) C.D Adams from Cameroon. Flavor and Fragrance 14: 167-169.
36. Taziebou LC, Etoa FX, Nkegoum B, Pieme CA, Dzeufiet DP, (2006) Acute and subacute toxicity of Aspilia africana leaves. Afr J Tradit Complement Altern Med 4: 127-134.
37. Njamen D, Magne Nde CB, Tanee Fomum Z, Vollmer G, (2008) Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats. Pharmazie 63: 164-168.
38. Bakasso S, Lamien-Meda A, Lamien CE, Kiendrebeogo M, Millogo J, et al. (2008) Polyphenol contents and antioxidant activities of five Indigofera species (Fabaceae) from Burkina Faso. Pak J Biol Sci 11: 1429-1435.
39. Matias EF, Santos KK, Almeida TS, Costa JG, Coutinho HD, (2010) Phytochemical screening and modulation of antibiotic activity by Ocimum gratissimum L. Biomed Pharmacother 23: 23.
40. Gundidza GM, Deans SG, Svoboda KP, Mavi S, (1992) Antimicrobial activity of essential oil from Hoslundia opposita. Cent Afr J Med 38: 290-293.
41. Kanwal Q, Hussain I, Latif Siddiqui H, Javaid A (2010) Antifungal activity of flavonoids.
42. Ajila CM, Rao LJ, Rao UJ, (2010) Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. Food Chem Toxicol 48: 3406-3411.
43. Foubert K, Cuyckens F, Vleeschouwer K, Theunis M, Vlietinck A, et al. (2010) Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS. Talanta 81: 1258-1263.
44. Arot Manguro LO, Midiwo JO, Kraus W, Ugi I, (2003) Benzoquinone derivatives of Myrsine africana and Maesa lanceolata. Phytochemistry 64: 855-862.
45. Adesegun SA, Elechi NA, Coker HA, (2008) Antioxidant activities of methanolic extract of Sapium ellipticum. Pak J Biol Sci 11: 453-457.
46. Nahdi A, Hammami I, Brasse-Lagnel C, Pilard N, Hamdaoui MH, et al. (2010) Influence of garlic or its main active component diallyl disulfide on iron bioavailability and toxicity. Nutr Res 30: 85-95.
47. Ngouela S, Tsamo E, Sondengam BL, (1988) Extractives from bignoniaceae: constituents of the stem bark of Spathodea campanulata. Planta Med 54: 476.
48. Beaman-Mbaya V, Muhammed SI (1976) Antibiotic action of Solanum incanum Linnaeus.
49. Al-Duais M, Hohbein J, Werner S, Bohm V, Jetschke G, (2009) Contents of vitamin C, carotenoids, tocopherols, and tocotrienols in the subtropical plant species Cyphostemma digitatum as affected by processing. J Agric Food Chem 57: 5420-5427.
50. Oyedeji OO, Lawal OA, Shode FO, Oyedeji AO, (2009) Chemical composition and antibacterial activity of the essential oils of Callistemon citrinus and Callistemon viminalis from South Africa. Molecules 14: 1990-1998.