The Fidelity, Occasional Promiscuity, and Versatility of T Cell Receptor Recognition

Immunity

Volumn 28, Issue 3, 2008, Pages 304-314

  Godfrey, Dale I ^a   Rossjohn, Jamie ^b   McCluskey, James ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Australian Government Australian Research Council   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CD1D ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADAPTIVE IMMUNITY; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; EVOLUTION; HUMAN; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD1; GLYCOLIPIDS; HUMANS; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 40449086783     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.02.004     Document Type: Review

References (127)

1. Ambrosino E., Terabe M., Halder R.C., Peng J., Takaku S., Miyake S., Yamamura T., Kumar V., and Berzofsky J.A. Cross-regulation between type I and type II NKT cells in regulating tumor immunity: A new immunoregulatory axis. J. Immunol. 179 (2007) 5126-5136
2. Baker B.M., Turner R.V., Gagnon S.J., Wiley D.C., and Biddison W.E. Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors. J. Exp. Med. 193 (2001) 551-562
3. Barral D.C., and Brenner M.B. CD1 antigen presentation: How it works. Nat. Rev. Immunol. 7 (2007) 929-941
4. Batuwangala T., Shepherd D., Gadola S.D., Gibson K.J., Zaccai N.R., Fersht A.R., Besra G.S., Cerundolo V., and Jones E.Y. The crystal structure of human CD1b with a bound bacterial glycolipid. J. Immunol. 172 (2004) 2382-2388
5. Borg N.A., Ely L.K., Beddoe T., Macdonald W.A., Reid H.H., Clements C.S., Purcell A.W., Kjer-Nielsen L., Miles J.J., Burrows S.R., et al. The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat. Immunol. 6 (2005) 171-180
6. Borg N.A., Wun K.S., Kjer-Nielsen L., Wilce M.C., Pellicci D.G., Koh R., Besra G.S., Bharadwaj M., Godfrey D.I., McCluskey J., and Rossjohn J. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 448 (2007) 44-49
7. Brigl M., and Brenner M.B. CD1: Antigen presentation and T cell function. Annu. Rev. Immunol. 22 (2004) 817-890
8. Burrows S.R., Rossjohn J., and McCluskey J. Have we cut ourselves too short in mapping CTL epitopes?. Trends Immunol. 27 (2006) 11-16
9. Buslepp J., Wang H., Biddison W.E., Appella E., and Collins E.J. A correlation between TCR Valpha docking on MHC and CD8 dependence: Implications for T cell selection. Immunity 19 (2003) 595-606
10. Cabaniols J.P., Fazilleau N., Casrouge A., Kourilsky P., and Kanellopoulos J.M. Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. J. Exp. Med. 194 (2001) 1385-1390
11. Cantu III C., Benlagha K., Savage P.B., Bendelac A., and Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: Low affinity, low specificity for CD1d, high affinity for alphabeta TCRs. J. Immunol. 170 (2003) 4673-4682
12. Chen J.L., Stewart-Jones G., Bossi G., Lissin N.M., Wooldridge L., Choi E.M., Held G., Dunbar P.R., Esnouf R.M., Sami M., et al. Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J. Exp. Med. 201 (2005) 1243-1255
13. Chiba A., Oki S., Miyamoto K., Hashimoto H., Yamamura T., and Miyake S. Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum. 50 (2004) 305-313
14. Chiu Y.H., Jayawardena J., Weiss A., Lee D., Park S.H., Dautry-Varsat A., and Bendelac A. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J. Exp. Med. 189 (1999) 103-110
15. Chiu Y.H., Park S.H., Benlagha K., Forestier C., Jayawardena-Wolf J., Savage P.B., Teyton L., and Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat. Immunol. 3 (2002) 55-60
16. Clements C.S., Dunstone M.A., Macdonald W.A., McCluskey J., and Rossjohn J. Specificity on a knife-edge: The alphabeta T cell receptor. Curr. Opin. Struct. Biol. 16 (2006) 787-795
17. Cobb B.A., Wang Q., Tzianabos A.O., and Kasper D.L. Polysaccharide processing and presentation by the MHCII pathway. Cell 117 (2004) 677-687
18. Colf L.A., Bankovich A.J., Hanick N.A., Bowerman N.A., Jones L.L., Kranz D.M., and Garcia K.C. How a single T cell receptor recognizes both self and foreign MHC. Cell 129 (2007) 135-146
19. Coppieters K., Van Beneden K., Jacques P., Dewint P., Vervloet A., Vander Cruyssen B., Van Calenbergh S., Chen G., Franck R.W., Verbruggen G., et al. A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J. Immunol. 179 (2007) 2300-2309
20. Cui J.Q., Shin T., Kawano T., Sato H., Kondo E., Toura I., Kaneko Y., Koseki H., Kanno M., and Taniguchi M. Requirement for V(Alpha)14 NKT cells in Il-12-mediated rejection of tumors. Science 278 (1997) 1623-1626
21. Dai S., Huseby E.S., Rubtsova K., Scott-Browne J., Crawford F., Macdonald W.A., Marrack P., and Kappler J.W. Crossreactive T Cells Spotlight the Germline Rules for ab T Cell-Receptor Interactions with MHC Molecules. Immunity 28 (2008) 324-334 this issue
22. Dascher C.C. Evolutionary biology of CD1. Curr. Top. Microbiol. Immunol. 314 (2007) 3-26
23. De Libero G., and Mori L. Mechanisms of lipid-antigen generation and presentation to T cells. Trends Immunol. 27 (2006) 485-492
24. Degano M., Garcia K.C., Apostolopoulos V., Rudolph M.G., Teyton L., and Wilson I.A. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity 12 (2000) 251-261
25. Deng L., and Mariuzza R.A. Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends Biochem. Sci. 32 (2007) 500-508
26. Deng L., Langley R.J., Brown P.H., Xu G., Teng L., Wang Q., Gonzales M.I., Callender G.G., Nishimura M.I., Topalian S.L., and Mariuzza R.A. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nat. Immunol. 8 (2007) 398-408
27. Ding Y.H., Smith K.J., Garboczi D.N., Utz U., Biddison W.E., and Wiley D.C. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8 (1998) 403-411
28. Ding Y.H., Baker B.M., Garboczi D.N., Biddison W.E., and Wiley D.C. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity 11 (1999) 45-56
29. Dougan S.K., Salas A., Rava P., Agyemang A., Kaser A., Morrison J., Khurana A., Kronenberg M., Johnson C., Exley M., et al. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J. Exp. Med. 202 (2005) 529-539
30. Ely L.K., Green K.J., Beddoe T., Clements C.S., Miles J.J., Bottomley S.P., Zernich D., Kjer-Nielsen L., Purcell A.W., McCluskey J., et al. Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: Implications for allograft rejection. J. Immunol. 174 (2005) 5593-5601
31. Ely L.K., Beddoe T., Clements C.S., Matthews J.M., Purcell A.W., Kjer-Nielsen L., McCluskey J., and Rossjohn J. Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction. Proc. Natl. Acad. Sci. USA 103 (2006) 6641-6646
32. Feng D., Bond C.J., Ely L.K., Maynard J., and Garcia K.C. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nat. Immunol. 8 (2007) 975-983
33. Forestier C., Takaki T., Molano A., Im J.S., Baine I., Jerud E.S., Illarionov P., Ndonye R., Howell A.R., Santamaria P., et al. Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator. J. Immunol. 178 (2007) 1415-1425
34. Gadola S.D., Zaccai N.R., Harlos K., Shepherd D., Castro-Palomino J.C., Ritter G., Schmidt R.R., Jones E.Y., and Cerundolo V. Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. Nat. Immunol. 3 (2002) 721-726
35. Gadola S.D., Koch M., Marles-Wright J., Lissin N.M., Shepherd D., Matulis G., Harlos K., Villiger P.M., Stuart D.I., Jakobsen B.K., et al. Structure and binding kinetics of three different human CD1d-{alpha}-galactosylceramide-specific T cell receptors. J. Exp. Med. 203 (2006) 699-710
36. Gagnon S.J., Borbulevych O.Y., Davis-Harrison R.L., Baxter T.K., Clemens J.R., Armstrong K.M., Turner R.V., Damirjian M., Biddison W.E., and Baker B.M. Unraveling a hotspot for TCR recognition on HLA-A2: Evidence against the existence of peptide-independent TCR binding determinants. J. Mol. Biol. 353 (2005) 556-573
37. Garbi N., Hämmerling G., and Tanaka S. Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes. Curr. Opin. Immunol. 19 (2007) 99-105
38. Garboczi D.N., Ghosh P., Utz U., Fan Q.R., Biddison W.E., and Wiley D.C. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384 (1996) 134-141
39. Garcia K.C., Degano M., Stanfield R.L., Brunmark A., Jackson M.R., Peterson P.A., Teyton L., and Wilson I.A. An alpha-beta T cell receptor structure at 2.5 angstoms and its orientation in the TCR-MHC complex. Science 274 (1996) 209-220
40. Garcia K.C., Degano M., Pease L.R., Huang M., Peterson P.A., Teyton L., and Wilson I.A. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279 (1998) 1166-1172
41. Giabbai B., Sidobre S., Crispin M.D., Sanchez-Ruiz Y., Bachi A., Kronenberg M., Wilson I.A., and Degano M. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: A molecular basis for NKT cell activation. J. Immunol. 175 (2005) 977-984
42. Godfrey D.I., and Berzins S.P. Control points in NKT-cell development. Nat. Rev. Immunol. 7 (2007) 505-518
43. Godfrey D.I., and Kronenberg M. Going both ways: Immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114 (2004) 1379-1388
44. Godfrey D.I., MacDonald H.R., Kronenberg M., Smyth M.J., and Van Kaer L. NKT cells: What's in a name?. Nat. Rev. Immunol. 4 (2004) 231-237
45. Godfrey D.I., McCluskey J., and Rossjohn J. CD1d antigen presentation: Treats for NKT cells. Nat. Immunol. 6 (2005) 754-756
46. Grant E.P., Degano M., Rosat J.P., Stenger S., Modlin R.L., Wilson I.A., Porcelli S.A., and Brenner M.B. Molecular recognition of lipid antigens by T cell receptors. J. Exp. Med. 189 (1999) 195-205
47. Grant E.P., Beckman E.M., Behar S.M., Degano M., Frederique D., Besra G.S., Wilson I.A., Porcelli S.A., Furlong S.T., and Brenner M.B. Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. J. Immunol. 168 (2002) 3933-3940
48. Gras S., Kjer-Nielsen L., Burrows S.R., McCluskey J., and Rossjohn J. T-cell receptor bias and immunity. Curr. Opin. Immunol. 20 (2008) 119-125
49. Hahn M., Nicholson M.J., Pyrdol J., and Wucherpfennig K.W. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat. Immunol. 6 (2005) 490-496
50. Halder R.C., Aguilera C., Maricic I., and Kumar V. Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J. Clin. Invest. 117 (2007) 2302-2312
51. Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T., Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., et al. A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. Immunity 27 (2007) 23-34
52. Hennecke J., Carfi A., and Wiley D.C. Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J. 19 (2000) 5611-5624
53. Hoare H.L., Sullivan L.C., Pietra G., Clements C.S., Lee E.J., Ely L.K., Beddoe T., Falco M., Kjer-Nielsen L., Reid H.H., et al. Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nat. Immunol. 7 (2006) 256-264
54. Jahng A., Maricic I., Aguilera C., Cardell S., Halder R.C., and Kumar V. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J. Exp. Med. 199 (2004) 947-957
55. Karlsson L. DM and DO shape the repertoire of peptide-MHC-class-II complexes. Curr. Opin. Immunol. 17 (2005) 65-70
56. Kawano T., Cui J.Q., Koezuka Y., Toura I., Kaneko Y., Motoki K., Ueno H., Nakagawa R., Sato H., Kondo E., et al. Cd1d-restricted and TCR-mediated activation of V(Alpha)14 NKT cells by glycosylceramides. Science 278 (1997) 1626-1629
57. Kinjo Y., Wu D., Kim G., Xing G.W., Poles M.A., Ho D.D., Tsuji M., Kawahara K., Wong C.H., and Kronenberg M. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434 (2005) 520-525
58. Kinjo Y., Tupin E., Wu D., Fujio M., Garcia-Navarro R., Benhnia M.R., Zajonc D.M., Ben-Menachem G., Ainge G.D., Painter G.F., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7 (2006) 978-986
59. Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., and Rossjohn J. The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure 10 (2002) 1521-1532
60. Kjer-Nielsen L., Clements C.S., Purcell A.W., Brooks A.G., Whisstock J.C., Burrows S.R., McCluskey J., and Rossjohn J. A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity. Immunity 18 (2003) 53-64
61. Kjer-Nielsen L., Borg N.A., Pellicci D.G., Beddoe T., Kostenko L., Clements C.S., Williamson N.A., Smyth M.J., Besra G.S., Reid H.H., et al. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J. Exp. Med. 203 (2006) 661-673
62. Koch M., Stronge V.S., Shepherd D., Gadola S.D., Mathew B., Ritter G., Fersht A.R., Besra G.S., Schmidt R.R., Jones E.Y., and Cerundolo V. The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat. Immunol. 6 (2005) 819-826
63. Li Y., Huang Y., Lue J., Quandt J.A., Martin R., and Mariuzza R.A. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J. 24 (2005) 2968-2979
64. Luz J.G., Huang M., Garcia K.C., Rudolph M.G., Apostolopoulos V., Teyton L., and Wilson I.A. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: A buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J. Exp. Med. 195 (2002) 1175-1186
65. Macdonald W.A., Purcell A.W., Mifsud N.A., Ely L.K., Williams D.S., Chang L., Gorman J.J., Clements C.S., Kjer-Nielsen L., Koelle D.M., et al. A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J. Exp. Med. 198 (2003) 679-691
66. Manning T.C., Schlueter C.J., Brodnicki T.C., Parke E.A., Speir J.A., Garcia K.C., Teyton L., Wilson I.A., and Kranz D.M. Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition. Immunity 8 (1998) 413-425
67. Marsh S.G., Albert E.D., Bodmer W.F., Bontrop R.E., Dupont B., Erlich H.A., Geraghty D.E., Hansen J.A., Hurley C.K., Mach B., et al. Nomenclature for factors of the HLA system, 2004. Tissue Antigens 65 (2005) 301-369
68. Maruoka T., Tanabe H., Chiba M., and Kasahara M. Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals. Immunogenetics 57 (2005) 590-600
69. Mattner J., Debord K.L., Ismail N., Goff R.D., Cantu III C., Zhou D., Saint-Mezard P., Wang V., Gao Y., Yin N., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434 (2005) 525-529
70. Maynard J., Petersson K., Wilson D.H., Adams E.J., Blondelle S.E., Boulanger M.J., Wilson D.B., and Garcia K.C. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity 22 (2005) 81-92
71. Mazza C., Auphan-Anezin N., Gregoire C., Guimezanes A., Kellenberger C., Roussel A., Kearney A., van der Merwe P.A., Schmitt-Verhulst A.M., and Malissen B. How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?. EMBO J. 26 (2007) 1972-1983
72. McCarthy C., Shepherd D., Fleire S., Stronge V.S., Koch M., Illarionov P.A., Bossi G., Salio M., Denkberg G., Reddington F., et al. The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J. Exp. Med. 204 (2007) 1131-1144
73. Miles J.J., Elhassen D., Borg N.A., Silins S.L., Tynan F.E., Burrows J.M., Purcell A.W., Kjer-Nielsen L., Rossjohn J., Burrows S.R., and McCluskey J. CTL recognition of a bulged viral peptide involves biased TCR selection. J. Immunol. 175 (2005) 3826-3834
74. Miles J.J., Borg N.A., Brennan R.M., Tynan F.E., Kjer-Nielsen L., Silins S.L., Bell M.J., Burrows J.M., McCluskey J., Rossjohn J., and Burrows S.R. TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. J. Immunol. 177 (2006) 6804-6814
75. Miller M.M., Wang C., Parisini E., Coletta R.D., Goto R.M., Lee S.Y., Barral D.C., Townes M., Roura-Mir C., Ford H.L., et al. Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family. Proc. Natl. Acad. Sci. USA 102 (2005) 8674-8679
76. Miller P.J., Pazy Y., Conti B., Riddle D., Appella E., and Collins E.J. Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J. Mol. Biol. 373 (2007) 315-327
77. Miyamoto K., Miyake S., and Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing T(H)2 bias of natural killer T cells. Nature 413 (2001) 531-534
78. Moody D.B. Immunology: How a T cell sees sugar. Nature 448 (2007) 36-37
79. Moody D.B., Briken V., Cheng T.Y., Roura-Mir C., Guy M.R., Geho D.H., Tykocinski M.L., Besra G.S., and Porcelli S.A. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat. Immunol. 3 (2002) 435-442
80. Moody D.B., Zajonc D.M., and Wilson I.A. Anatomy of CD1-lipid antigen complexes. Nat. Rev. Immunol. 5 (2005) 387-399
81. Mukherjee S., Soe T.T., and Maxfield F.R. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J. Cell Biol. 144 (1999) 1271-1284
82. Nicholson M.J., Hahn M., and Wucherpfennig K.W. Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity 23 (2005) 351-360
83. Reid S.W., McAdam S., Smith K.J., Klenerman P., O'Callaghan C.A., Harlos K., Jakobsen B.K., McMichael A.J., Bell J.I., Stuart D.I., and Jones E.Y. Antagonist HIV-1 Gag peptides induce structural changes in HLA B8. J. Exp. Med. 184 (1996) 2279-2286
84. Reinherz E.L., Tan K., Tang L., Kern P., Liu J., Xiong Y., Hussey R.E., Smolyar A., Hare B., Zhang R., et al. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science 286 (1999) 1913-1921
85. Reiser J.B., Darnault C., Guimezanes A., Gregoire C., Mosser T., Schmitt-Verhulst A.M., Fontecilla-Camps J.C., Malissen B., Housset D., and Mazza G. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat. Immunol. 1 (2000) 291-297
86. Reiser J.B., Gregoire C., Darnault C., Mosser T., Guimezanes A., Schmitt-Verhulst A.M., Fontecilla-Camps J.C., Mazza G., Malissen B., and Housset D. A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity 16 (2002) 345-354
87. Reiser J.B., Darnault C., Gregoire C., Mosser T., Mazza G., Kearney A., van der Merwe P.A., Fontecilla-Camps J.C., Housset D., and Malissen B. CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat. Immunol. 4 (2003) 241-247
88. Rock E.P., Sibbald P.R., Davis M.M., and Chien Y.H. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179 (1994) 323-328
89. Rodgers J.R., and Cook R.G. MHC class Ib molecules bridge innate and acquired immunity. Nat. Rev. Immunol. 5 (2005) 459-471
90. Rossjohn J., and McCluskey J. How a home-grown T cell receptor interacts with a foreign landscape. Cell 129 (2007) 19-20
91. Rudolph M.G., Stanfield R.L., and Wilson I.A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24 (2006) 419-466
92. Schmieg J., Yang G., Franck R.W., and Tsuji M. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide. J. Exp. Med. 198 (2003) 1631-1641
93. Schumann J., Voyle R.B., Wei B.Y., and MacDonald H.R. Cutting edge: Influence of the TCR Vbeta domain on the avidity of CD1d:alpha-galactosylceramide binding by invariant Valpha14 NKT cells. J. Immunol. 170 (2003) 5815-5819
94. Schumann J., Mycko M.P., Dellabona P., Casorati G., and Macdonald H.R. Cutting edge: Influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. J. Immunol. 176 (2006) 2064-2068
95. Scott-Browne J.P., Matsuda J.L., Mallevaey T., White J., Borg N.A., McCluskey J., Rossjohn J., Kappler J., Marrack P., and Gapin L. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat. Immunol. 8 (2007) 1105-1113
96. Sidobre S., Naidenko O.V., Sim B.C., Gascoigne N.R.J., Garcia K.C., and Kronenberg M. The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J. Immunol. 169 (2002) 1340-1348
97. Speir J.A., Stevens J., Joly E., Butcher G.W., and Wilson I.A. Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. Immunity 14 (2001) 81-92
98. Sriram V., Du W., Gervay-Hague J., and Brutkiewicz R.R. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur. J. Immunol. 35 (2005) 1692-1701
99. Starr T.K., Jameson S.C., and Hogquist K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21 (2003) 139-176
100. Stewart-Jones G.B., McMichael A.J., Bell J.I., Stuart D.I., and Jones E.Y. A structural basis for immunodominant human T cell receptor recognition. Nat. Immunol. 4 (2003) 657-663
101. Sullivan L.C., Hoare H.L., McCluskey J., Rossjohn J., and Brooks A.G. A structural perspective on MHC class Ib molecules in adaptive immunity. Trends Immunol. 27 (2006) 413-420
102. Teng M.W., Westwood J.A., Darcy P.K., Sharkey J., Tsuji M., Franck R.W., Porcelli S.A., Besra G.S., Takeda K., Yagita H., et al. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res. 67 (2007) 7495-7504
103. Turner S.J., Kedzierska K., Komodromou H., La Gruta N.L., Dunstone M.A., Webb A.I., Webby R., Walden H., Xie W., McCluskey J., et al. Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat. Immunol. 6 (2005) 382-389
104. Turner S.J., Doherty P.C., McCluskey J., and Rossjohn J. Structural determinants of T-cell receptor bias in immunity. Nat. Rev. Immunol. 6 (2006) 883-894
105. Tynan F.E., Borg N.A., Miles J.J., Beddoe T., El-Hassen D., Silins S.L., van Zuylen W.J., Purcell A.W., Kjer-Nielsen L., McCluskey J., et al. High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance. J. Biol. Chem. 280 (2005) 23900-23909
106. Tynan F.E., Burrows S.R., Buckle A.M., Clements C.S., Borg N.A., Miles J.J., Beddoe T., Whisstock J.C., Wilce M.C., Silins S.L., et al. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 6 (2005) 1114-1122
107. Tynan F.E., Elhassen D., Purcell A.W., Burrows J.M., Borg N.A., Miles J.J., Williamson N.A., Green K.J., Tellam J., Kjer-Nielsen L., et al. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. J. Exp. Med. 202 (2005) 1249-1260
108. Tynan F.E., Reid H.H., Kjer-Nielsen L., Miles J.J., Wilce M.C., Kostenko L., Borg N.A., Williamson N.A., Beddoe T., Purcell A.W., et al. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat. Immunol. 8 (2007) 268-276
109. Ueno Y., Tanaka S., Sumii M., Miyake S., Tazuma S., Taniguchi M., Yamamura T., and Chayama K. Single dose of OCH improves mucosal T helper type 1/T helper type 2 cytokine balance and prevents experimental colitis in the presence of valpha14 natural killer T cells in mice. Inflamm. Bowel Dis. 11 (2005) 35-41
110. van der Merwe P.A., and Davis S.J. Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 21 (2003) 659-684
111. Van Laethem F., Sarafova S.D., Park J.-H., Tai X., Pobezinsky L., Guinter T.I., Adoro S., Adams A., Sharrow S.O., Feigenbaum L., and Singer A. Deletion of CD4 and CD8 coreceptors permits generation of αβT cells that recognize antigens independently of the MHC. Immunity 27 (2007) 735-750
112. Van Rhijn I., Young D.C., Im J.S., Levery S.B., Illarionov P.A., Besra G.S., Porcelli S.A., Gumperz J., Cheng T.Y., and Moody D.B. CD1d-restricted T cell activation by nonlipidic small molecules. Proc. Natl. Acad. Sci. USA 101 (2004) 13578-13583
113. Wei D.G., Curran S.A., Savage P.B., Teyton L., and Bendelac A. Mechanisms imposing the V{beta} bias of V{alpha}14 natural killer T cells and consequences for microbial glycolipid recognition. J. Exp. Med. 203 (2006) 1197-1207
114. Willcox B.E., Gao G.F., Wyer J.R., Ladbury J.E., Bell J.I., Jakobsen B.K., and van der Merwe P.A. TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity 10 (1999) 357-365
115. Williams A.P., Peh C.A., Purcell A.W., McCluskey J., and Elliot T.J. Optimization of the MHC class I peptide cargo is dependent on tapasin. Immunity 16 (2002) 509-520
116. Wu L.C., Tuot D.S., Lyons D.S., Garcia K.C., and Davis M.M. Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature 418 (2002) 552-556
117. Wu D., Zajonc D.M., Fujio M., Sullivan B.A., Kinjo Y., Kronenberg M., Wilson I.A., and Wong C.H. Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc. Natl. Acad. Sci. USA 103 (2006) 3972-3977
118. Yu K.O., Im J.S., Molano A., Dutronc Y., Illarionov P.A., Forestier C., Fujiwara N., Arias I., Miyake S., Yamamura T., et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of {alpha}-galactosylceramides. Proc. Natl. Acad. Sci. USA 102 (2005) 3383-3388
119. Zajonc D.M., Elsliger M.A., Teyton L., and Wilson I.A. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat. Immunol. 4 (2003) 808-815
120. Zajonc D.M., Cantu III C., Mattner J., Zhou D., Savage P.B., Bendelac A., Wilson I.A., and Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat. Immunol. 6 (2005) 810-818
121. Zajonc D.M., Crispin M.D., Bowden T.A., Young D.C., Cheng T.Y., Hu J., Costello C.E., Rudd P.M., Dwek R.A., Miller M.J., et al. Molecular mechanism of lipopeptide presentation by CD1a. Immunity 22 (2005) 209-219
122. Zajonc D.M., Maricic I., Wu D., Halder R., Roy K., Wong C.H., Kumar V., and Wilson I.A. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J. Exp. Med. 202 (2005) 1517-1526
123. Zajonc D.M., and Wilson I.A. Architecture of CD1 proteins. Curr. Top. Microbiol. Immunol. 314 (2007) 27-50
124. Zajonc D.M., Savage P.B., Bendelac A., Wilson I.A., and Teyton L. Crystal structures of mouse CD1d-iGb3 complex and its cognate V[alpha]14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J. Mol. Biol. (2008) 10.1016/j.jmb.2008.01.061 Published online January 31, 2008
125. Zarling A.L., Polefrone J.M., Evans A.M., Mikesh L.M., Shabanowitz J., Lewis S.T., Engelhard V.H., and Hunt D.F. From the cover: Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy. Proc. Natl. Acad. Sci. USA 103 (2006) 14889-14894
126. Zeng Z., Castano A.R., Segelke B.W., Stura E.A., Peterson P.A., and Wilson I.A. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science 277 (1997) 339-345
127. Zinkernagel R.M., and Doherty P.C. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 251 (1974) 547-548