Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice

Hypertension

Volumn 60, Issue 6, 2012, Pages 1510-1516

  Jennings, Brett L ^a   Estes, Anne M ^a   Anderson, Larry J ^a   Fang, Xiao R ^a   Yaghini, Fariborz A ^a   Fan, Zheng ^a   Gonzalez, Frank J ^b   Campbell, William B ^c   Malik, Kafait U ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

cardiac dysfunction; cytochrome P450 1B1; deoxycorticosterone acetate salt; hypertension; inflammation; oxidative stress; renal fibrosis

Indexed keywords

CATECHOLAMINE; DEOXYCORTICOSTERONE ACETATE; ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM CHLORIDE; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL HYPERTROPHY; CYTOCHROME P450 1B1 GENE; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE; GENOTYPE; HEART DISEASE; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HYPERTENSION; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY VASCULAR RESISTANCE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; SYSTOLIC BLOOD PRESSURE; T LYMPHOCYTE; VASCULAR DISEASE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DESOXYCORTICOSTERONE; HYPERTENSION; INFLAMMATION; KIDNEY DISEASES; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SODIUM CHLORIDE, DIETARY;

EID: 84870242580     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.202606     Document Type: Article

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