Angiotensin II-induced hypertension contribution of Ras GTPase/mitogen-activated protein kinase and cytochrome P450 metabolites

Hypertension

Volumn 36, Issue 4, 2000, Pages 604-609

  Muthalif, Mubarack M ^a   Karzoun, Nour A ^a   Gaber, Lillian ^a   Khandekar, Zinat ^a   Benter, Ibrahim F ^b   Saeed, Abdelwahab E ^a   Parmentier, Jean Hugues ^a   Estes, Anne ^a   Malik, Kafait U ^a,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b SOUTHERN COLLEGE OF OPTOMETRY   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin II; Cytochrome P450; Hypertension, experimental; Kidney; Kinases; Ras

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN; BENZOTRIAZOLE DERIVATIVE; BMS 191563; CYTOCHROME P450; ENZYME INHIBITOR; FPT III; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0033778488     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.36.4.604     Document Type: Article

References (38)

1. Angiotensin actions in the kidney: Renewed insight into the old hormone
2. Ang II receptors and Ang II receptor antagonists
3. 1) receptors in vascular smooth muscle
4. Central role of the MAP kinase pathway in Ang II-mediated DNA synthesis and migration in rat VSMC
5. Aug II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells: Correlation with the expression of specific endogenous growth factors and reversal by suramin
6. Ang II signal transduction in vascular smooth muscle: Role of tyrosine kinases
7. Aug II signaling in vascular smooth muscle: New concepts
8. 60 c-src
9. Signal transduction mechanisms involved in Ang (1-7)-stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells
10. 2 in VSMC
11. Mechanism of Ang II-induced arachidonic acid metabolite release in aortic smooth muscle cell: Involvement of PLD
12. Interrelations between prostaglandins and vasoconstrictor hormones: Contribution to blood pressure regulation
13. The role of eicosanoids in angiotensin-dependent hypertension
14. Missing links: CYP450 arachidonate products, a new class of lipid mediators
15. Formation and action of a P450 4A metabolite of arachidonic acid in cat cerebral microvessels
16. Inhibition of renal arachidonic acid omcga-hydroxylase activity with ABT reduccs blood pressure in the SHR
17. Endothelin-1 and CYP450 arachidonate metabolites interact-to promote tissue injury in DOCA-salt hypertension
18. 20-HETE mediates calcium/calmodulin-dependent protein kinase II-induced MAP kinase activation in VSMC
19. CYP450 metabolites mediate norepinephrine-induced mitogenic signaling
20. MAP/extracellular signal-regulated kinase inhibition attenuates Ang II-mediated signaling and contraction in spontaneously hypertensive rat VSMCs
21. Role of extracellular signal-regulated kinases in Ang II-stimulated contraction of smooth muscle cells from human resistance arteries
22. Ang II-induced hypertension in the rat. Effect on the plasma concentratton, renal excretion and tissue release of prostaglandins
23. Contribtution of Ras GTPase/MAP kinase and CYP450 metabolites to deoxycorticosterone-salt-induced hypertension
24. 21 ras and the Ras-binding domain of the human Raf-1 protein kinase
25. Minimal Ras-binding domain of Raf-1 can be used as an activation-specific probe for Ras
26. Mammalian Ras interacts directly with the serine/threonine kinase Raf
27. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function
28. Role of lipoxygenase pathway in Ang II-induced vasoconstriction in the human placenta
29. 20-HETE contributes to the renal vasoconstrictor actions of Ang II
30. Activation of MAP kinases by arachidonic acid and its metabolites in VSMC
31. 2 mediated activation of MAP kihase by Ang II
32. Ang II stimulates MAP kinases and protein synthesis by a Ras-independent pathway in VSMC
33. 2+/calmodulin tyrosine kinase
34. Alterations in vascular smooth muscle mass in spontaneously hypertensive rat: Role of cellular hypertrophy, hyperploidy, and hyperplasia
35. Ang II receptor blockade and end-organ protection: Pharmacological rationale and evidence
36. 1 receptor antagonism and protection against cardiovascular end-organ damage
37. Impact of hypertension and antihypertensive treatment on organ damage
38. G protein-coupled receptors control vascular smooth muscle cell proliferation via ppboc-src and P21(ras)