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Volumn 7, Issue 3, 2012, Pages 175-179

Review of the fibrinolytic system: Comparison of different antifibrinolytics used during cardiopulmonary bypass

Author keywords

Antifibrinolytics; Aprotinin; Epsilon aminocaproic acid; Fibrinolysis; Tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; AMINOCAPROIC ACID EPSILON; ANTIFIBRINOLYTIC AGENT; APROTININ; KALLIKREIN; PLACEBO; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

EID: 84870215086     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489012803832793     Document Type: Review
Times cited : (11)

References (48)
  • 1
    • 33744509867 scopus 로고    scopus 로고
    • Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting
    • Koch C. Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med 2006; 34:1608-16.
    • (2006) Crit Care Med , vol.34 , pp. 1608-1616
    • Koch, C.1
  • 3
    • 77649202241 scopus 로고    scopus 로고
    • Reoperation for bleeding in patients undergoing coronary artery bypass surgery: Incidence, risk factors, time trends, and outcomes
    • Mehta RH, Sheng S, O'Brien SM, Grover FL, Gammie JS, Ferguson TB, et al. Reoperation for bleeding in patients undergoing coronary artery bypass surgery: Incidence, risk factors, time trends, and outcomes. Circ Cardiovasc Qual Outcomes 2009; 2: 583-90.
    • (2009) Circ Cardiovasc Qual Outcomes , vol.2 , pp. 583-590
    • Mehta, R.H.1    Sheng, S.2    O'Brien, S.M.3    Grover, F.L.4    Gammie, J.S.5    Ferguson, T.B.6
  • 8
    • 79952757420 scopus 로고    scopus 로고
    • Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era
    • Koster A, Schirmer U. Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era. Curr Opin Anaesthesiol 2011; 24: 92-97.
    • (2011) Curr Opin Anaesthesiol , vol.24 , pp. 92-97
    • Koster, A.1    Schirmer, U.2
  • 9
    • 0020975360 scopus 로고
    • Fibrin-associated plasminogen activation in alpha 2-plasmin inhibitor deficiency
    • Aoki N, Sakata Y, Ichinose A. Fibrin-associated plasminogen activation in alpha 2-plasmin inhibitor deficiency. Blood 1983; 62:1118-22.
    • (1983) Blood , vol.62 , pp. 1118-1122
    • Aoki, N.1    Sakata, Y.2    Ichinose, A.3
  • 11
    • 0035118319 scopus 로고    scopus 로고
    • Aprotinin and the Systemic Inflammatory Response After Cardiopulmonary Bypass
    • Mojcik C. Aprotinin and the Systemic Inflammatory Response After Cardiopulmonary Bypass. Ann Thorac Surg 2001;71:745-54.
    • (2001) Ann Thorac Surg , vol.71 , pp. 745-754
    • Mojcik, C.1
  • 12
    • 79951486084 scopus 로고    scopus 로고
    • Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy
    • Weber CF, Gorlinger K, Byhahn C, Moritz A, Hanke AA, Zacharowski K, et al. Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy. Eur J Anaesthesiol 2011;28:57-62.
    • (2011) Eur J Anaesthesiol , vol.28 , pp. 57-62
    • Weber, C.F.1    Gorlinger, K.2    Byhahn, C.3    Moritz, A.4    Hanke, A.A.5    Zacharowski, K.6
  • 13
    • 0342981747 scopus 로고    scopus 로고
    • Endothelial cell injury in cardiovascular surgery: The systemic inflammatory response
    • Boyle EM, Jr., Pohlman TH, Johnson MC, Verrier ED. Endothelial cell injury in cardiovascular surgery: the systemic inflammatory response. Ann Thorac Surg 1997;63:277-84.
    • (1997) Ann Thorac Surg , vol.63 , pp. 277-284
    • Boyle Jr., E.M.1    Pohlman, T.H.2    Johnson, M.C.3    Verrier, E.D.4
  • 14
    • 0030943328 scopus 로고    scopus 로고
    • Cardiopulmonary bypass and the inflammatory response: A role for serine protease inhibitors?
    • Murkin JM. Cardiopulmonary bypass and the inflammatory response: A role for serine protease inhibitors? J Cardiothorac Vasc Anesth 1997;11:19-23
    • (1997) J Cardiothorac Vasc Anesth , vol.11 , pp. 19-23
    • Murkin, J.M.1
  • 15
    • 38549180575 scopus 로고    scopus 로고
    • Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial
    • Jimenez JJ, Iribarren JL, Lorente L, Rodriguez JM, Hernandez D, Nassar I, et al. Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial. Crit Care 2007;11:R117.
    • (2007) Crit Care , vol.11
    • Jimenez, J.J.1    Iribarren, J.L.2    Lorente, L.3    Rodriguez, J.M.4    Hernandez, D.5    Nassar, I.6
  • 16
    • 0345356441 scopus 로고    scopus 로고
    • Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin
    • Greilich PE, Brouse CF, Whitten CW, Chi L, Dimaio JM, Jessen ME. Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. J Thorac Cardiovasc Surg 2003;126:1498-1503.
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 1498-1503
    • Greilich, P.E.1    Brouse, C.F.2    Whitten, C.W.3    Chi, L.4    Dimaio, J.M.5    Jessen, M.E.6
  • 17
    • 0026522071 scopus 로고
    • Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)--Kallikrein system and blood loss
    • Fuhrer G, Gallimore MJ, Heller W, Hoffmeister HE. Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)--Kallikrein system and blood loss. Blood Coagul Fibrinolysis 1992; 3: 99-104.
    • (1992) Blood Coagul Fibrinolysis , vol.3 , pp. 99-104
    • Fuhrer, G.1    Gallimore, M.J.2    Heller, W.3    Hoffmeister, H.E.4
  • 18
    • 34249913425 scopus 로고    scopus 로고
    • Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery
    • Brown JR, Birkmeyer NJ, O'Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 2007;115:2801-2813.
    • (2007) Circulation , vol.115 , pp. 2801-2813
    • Brown, J.R.1    Birkmeyer, N.J.2    O'Connor, G.T.3
  • 21
    • 79951977022 scopus 로고    scopus 로고
    • Can we really believe that aprotinin is safe in congenital heart surgery?
    • Faraoni D. Can we really believe that aprotinin is safe in congenital heart surgery? Ann Thorac Surg 2011; 9: 987-8.
    • (2011) Ann Thorac Surg , vol.9 , pp. 987-988
    • Faraoni, D.1
  • 22
    • 0028298296 scopus 로고
    • Pharmacokinetics of aprotinin in preoperative cardiac surgical patients
    • Levy JH, Bailey JM, Salmenpera M. Pharmacokinetics of aprotinin in preoperative cardiac surgical patients. Anesthesiology 1994; 80:1013-8.
    • (1994) Anesthesiology , vol.80 , pp. 1013-1018
    • Levy, J.H.1    Bailey, J.M.2    Salmenpera, M.3
  • 23
    • 67650081255 scopus 로고    scopus 로고
    • Tranexamic acid and aprotinin in low- and intermediate-risk cardiac surgery: A non-sponsored, double-blind, randomised, placebo-controlled trial
    • Later AF, Maas JJ, Engbers FH, Versteegh MI, Bruggemans EF, Dion RA, et al. Tranexamic acid and aprotinin in low- and intermediate-risk cardiac surgery: A non-sponsored, double-blind, randomised, placebo-controlled trial. Eur J Cardiothorac Surg 2009; 36: 322-9.
    • (2009) Eur J Cardiothorac Surg , vol.36 , pp. 322-329
    • Later, A.F.1    Maas, J.J.2    Engbers, F.H.3    Versteegh, M.I.4    Bruggemans, E.F.5    Dion, R.A.6
  • 25
    • 77953602180 scopus 로고    scopus 로고
    • Efficiency of preoperative tranexamic Acid in coronary bypass surgery: An analysis correlated with preoperative clopidogrel use
    • Senay S, Toraman F, Karabulut H, Alhan C. Efficiency of preoperative tranexamic Acid in coronary bypass surgery: an analysis correlated with preoperative clopidogrel use. Heart Surg Forum 2010;13: E149-154.
    • (2010) Heart Surg Forum , vol.13
    • Senay, S.1    Toraman, F.2    Karabulut, H.3    Alhan, C.4
  • 26
    • 77955117750 scopus 로고    scopus 로고
    • Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis
    • Sander M, Spies CD, Martiny V, Rosenthal C, Wernecke KD, von Heymann C. Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis. Crit Care 2010;14:R148.
    • (2010) Crit Care , vol.14
    • Sander, M.1    Spies, C.D.2    Martiny, V.3    Rosenthal, C.4    Wernecke, K.D.5    von Heymann, C.6
  • 27
    • 67650687046 scopus 로고    scopus 로고
    • The effect of epsilon-aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: A randomized, double-blind, placebo-controlled, noninferiority trial
    • Greilich PE, Jessen ME, Satyanarayana N, Whitten CW, Nuttall GA, Beckham JM, et al. The effect of epsilon-aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: A randomized, double-blind, placebo-controlled, noninferiority trial. Anesth Analg 2009; 109: 15-24.
    • (2009) Anesth Analg , vol.109 , pp. 15-24
    • Greilich, P.E.1    Jessen, M.E.2    Satyanarayana, N.3    Whitten, C.W.4    Nuttall, G.A.5    Beckham, J.M.6
  • 28
    • 77952582367 scopus 로고    scopus 로고
    • Lessons from aprotinin: Is the routine use and inconsistent dosing of tranexamic acid prudent? Meta-analysis of randomised and large matched observational studies
    • Ngaage DL, Bland JM. Lessons from aprotinin: Is the routine use and inconsistent dosing of tranexamic acid prudent? Meta-analysis of randomised and large matched observational studies. Eur J Cardiothorac Surg 2010; 37: 1375-83.
    • (2010) Eur J Cardiothorac Surg , vol.37 , pp. 1375-1383
    • Ngaage, D.L.1    Bland, J.M.2
  • 29
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006; 354: 353-65.
    • (2006) N Engl J Med , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3
  • 31
    • 79251578607 scopus 로고    scopus 로고
    • Seizures after open heart surgery: Comparison of epsilon-aminocaproic acid and tranexamic acid
    • Martin K, Knorr J, Breuer T, Gertler R, Macguill M, Lange R, et al. Seizures after open heart surgery: Comparison of epsilon-aminocaproic acid and tranexamic acid. J Cardiothorac Vasc Anesth 2011; 25: 20-25.
    • (2011) J Cardiothorac Vasc Anesth , vol.25 , pp. 20-25
    • Martin, K.1    Knorr, J.2    Breuer, T.3    Gertler, R.4    Macguill, M.5    Lange, R.6
  • 32
    • 44349148810 scopus 로고    scopus 로고
    • The aprotinin story--is BART the final chapter?
    • Ray WA, Stein CM. The aprotinin story--is BART the final chapter? N Engl J Med 2008; 358: 2398-400.
    • (2008) N Engl J Med , vol.358 , pp. 2398-2400
    • Ray, W.A.1    Stein, C.M.2
  • 34
    • 79954600429 scopus 로고    scopus 로고
    • High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement
    • Keyl C, Uhl R, Beyersdorf F, Stampf S, Lehane C, Wiesenack C, et al. High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg 2011;39: e114-121.
    • (2011) Eur J Cardiothorac Surg , vol.39
    • Keyl, C.1    Uhl, R.2    Beyersdorf, F.3    Stampf, S.4    Lehane, C.5    Wiesenack, C.6
  • 35
    • 58149293358 scopus 로고    scopus 로고
    • The risks of aprotinin and tranexamic acid in cardiac surgery: A one-year follow-up of 1188 consecutive patients
    • Martin K, Wiesner G, Breuer T, Lange R, Tassani P. The risks of aprotinin and tranexamic acid in cardiac surgery: A one-year follow-up of 1188 consecutive patients. Anesth Analg 2008;107: 1783-90.
    • (2008) Anesth Analg , vol.107 , pp. 1783-1790
    • Martin, K.1    Wiesner, G.2    Breuer, T.3    Lange, R.4    Tassani, P.5
  • 36
    • 76249100902 scopus 로고    scopus 로고
    • High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients
    • Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010;110: 350-3.
    • (2010) Anesth Analg , vol.110 , pp. 350-353
    • Murkin, J.M.1    Falter, F.2    Granton, J.3    Young, B.4    Burt, C.5    Chu, M.6
  • 37
    • 84856941122 scopus 로고    scopus 로고
    • Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: A case-control study
    • Montes FR, Pardo DF, Carreno M, Arciniegas C, Dennis RJ, Umana JP. Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: A case-control study. Ann Cardiac Anaesth 2012; 15: 6-12.
    • (2012) Ann Cardiac Anaesth , vol.15 , pp. 6-12
    • Montes, F.R.1    Pardo, D.F.2    Carreno, M.3    Arciniegas, C.4    Dennis, R.J.5    Umana, J.P.6
  • 38
    • 84055192250 scopus 로고    scopus 로고
    • High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass
    • Kalavrouziotis D, Voisine P, Mohammadi S, Dionne S, Dagenais F. High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. Ann Thorac Surg 2012; 93:148-154.
    • (2012) Ann Thorac Surg , vol.93 , pp. 148-154
    • Kalavrouziotis, D.1    Voisine, P.2    Mohammadi, S.3    Dionne, S.4    Dagenais, F.5
  • 44
    • 84856971781 scopus 로고    scopus 로고
    • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial)
    • Bokesch PM, Szabo G, Wojdyga R, Grocott HP, Smith PK, David Mazer C, et al. A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovac Surg 2012; 143:1022-9.
    • (2012) J Thorac Cardiovac Surg , vol.143 , pp. 1022-1029
    • Bokesch, P.M.1    Szabo, G.2    Wojdyga, R.3    Grocott, H.P.4    Smith, P.K.5    David Mazer, C.6
  • 45
  • 46
    • 73149106987 scopus 로고    scopus 로고
    • Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery
    • Szabo G, Veres G, Radovits T, Haider H, Krieger N, Bahrle S, et al. Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery. J Thorac Cardiovac Surg 2010;139:181-8.
    • (2010) J Thorac Cardiovac Surg , vol.139 , pp. 181-188
    • Szabo, G.1    Veres, G.2    Radovits, T.3    Haider, H.4    Krieger, N.5    Bahrle, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.