The post-BART anti-fibrinolytic dilemma?

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 25, Issue 1, 2011, Pages 3-5

  Beattie, W Scott ^a   Karkouti, Keyvan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; APROTININ; TRANEXAMIC ACID;

ARTICLE; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; DELIRIUM; DRUG EFFECT; DRUG SAFETY; FIBRINOLYTIC THERAPY; HUMAN; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; SEIZURE; SURGICAL MORTALITY; SURGICAL RISK; TREATMENT OUTCOME;

EID: 79251534021     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2010.11.018     Document Type: Editorial

References (16)

1. D.A. Fergusson, P.C. Hebert, and C.D. Mazer A comparison of aprotinin and lysine analogues in high-risk cardiac surgery N Engl J Med 358 2008 2319 2331
2. K. Raghunathan, N.R. Connelly, and G.J. Kanter Epsilon-aminocaproic acid and clinical value in cardiac anesthesia J Cardiothorac Vasc Anesth 25 2011 16 19
3. K. Karkouti, D.N. Wijeysundera, and T.M. Yau The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery Anesth Analg 110 2010 21 29
4. G.L. Grunkemeier, Y. Wu, and A.P. Furnary What is the value of a p value? Ann Thorac Surg 87 2009 1337 1343
5. D.T. Mangano, I.C. Tudor, and C. Dietzel The risk associated with aprotinin in cardiac surgery N Engl J Med 354 2006 353 365
6. P.A. Carless, A.J. Moxey, and B.J. Stokes Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials BMC Cardiovasc Disord 5 2005 19
7. W.S. Beattie, and K. Karkouti Con: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery Anesth Analg 103 2006 1360 1364
8. K. Karkouti, and W.S. Beattie Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: No J Thromb Haemost 4 2006 1879 1881
9. D.A. Henry, A.J. Moxey, and P.A. Carless Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion Cochrane Database Syst Rev 2001 CD001886
10. K. Karkouti, D.N. Wijeysundera, and W.S. Beattie Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study Transfusion 47 2007 2081 2088
11. K. Karkouti, D.N. Wijeysundera, and T.M. Yau The independent association of massive blood loss with mortality in cardiac surgery Transfusion 44 2004 1453 1462
12. C.G. Koch, L. Li, and A.I. Duncan Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting Crit Care Med 34 2006 1608 1616
13. A.J. Wysenbeek, A. Sella, and I. Blum Acute delirious state after epsilon-amino caproic acid administration Clin Toxicol 14 1979 93 95
14. G. Galassi, M. Gibertoni, and L. Corradini Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review Ital J Neurol Sci 4 1983 489 492
15. J.M. Murkin, F. Falter, and J. Granton High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients Anesth Analg 110 2010 350 353
16. K. Martin, J. Knorr, and T. Brever Seizures after open heart surgery: Comparison of ε-aminocaproic acid and tranexamic acid J Cardiothorac Vasc Anesth 25 2011 20 25