Efficiency of preoperative tranexamic acid in coronary bypass surgery: An analysis correlated with preoperative clopidogrel use

Heart Surgery Forum

Volumn 13, Issue 3, 2010, Pages

  Senay, Sahin ^a   Toraman, Fevzi ^a   Karabulut, Hasan ^a   Alhan, Cem ^a  

^a ACIBADEM UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; TRANEXAMIC ACID;

ADULT; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORRELATION ANALYSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROPHYLAXIS; RISK FACTOR; SURGICAL DRAINAGE; TREATMENT OUTCOME;

AGED; ANTIFIBRINOLYTIC AGENTS; BLOOD TRANSFUSION; CONFIDENCE INTERVALS; CORONARY ARTERY BYPASS; CORONARY ARTERY DISEASE; FEMALE; HEALTH STATUS INDICATORS; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PATIENT READMISSION; PLATELET AGGREGATION INHIBITORS; POSTOPERATIVE HEMORRHAGE; PREANESTHETIC MEDICATION; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RISK FACTORS; STATISTICS AS TOPIC; TICLOPIDINE; TRANEXAMIC ACID; TURKEY;

EID: 77953602180     PISSN: 10983511     EISSN: 15226662     Source Type: Journal    
DOI: 10.1532/HSF98.20091176     Document Type: Article

References (24)

1. Andreasen JJ, Nielsen C. 2004. Prophylactic tranexamic acid in elective, primary coronary artery bypass surgery using cardiopulmonary bypass. Eur J Cardiothorac Surg 26:311-7.
2. Brown JR, Birkmeyer NJ, O'Connor GT. 2007. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115:2801-13.
3. Casati V, Della Valle P, Benussi S, et al. 2004. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg 128:83-91.
4. Diprose P, Herbertson MJ, O'Shaughnessy D, Deakin CD, Gill RS. 2005. Reducing allogeneic transfusion in cardiac surgery: a randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage. Br J Anaesth 94:271-8.
5. Eagle KA, Guyton RA, Davidoff R, et al, for the American College of Cardiology and American Heart Association. 2004. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery). Circulation 110:e340-437.
6. Fergusson DA, Hébert PC, Mazer CD, et al, for the BART Investigators. 2008. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358:2319-31.
7. Fox KAA, Mehta SR, Peters R, et al. 2004. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome. The Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events (CURE) Trial. Circulation 110:1202-8.
8. Hartmann M, Sucker C, Boehm O, Koch A, Loer S, Zacharowski K. 2006. Effects of cardiac surgery on hemostasis. Transfus Med Rev 20:230-41.
9. Henry DA, Carless PA, Moxey AJ, et al. 2007. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion (Cochrane Review). Cochrane Database Syst Rev 2007:CD001886.
10. King SB 3rd, Smith SC Jr, Hirshfeld JW Jr, et al. 2008. 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/ American Heart Association Task Force on Practice guidelines. J Am Coll Cardiol 51:172-209.
11. Mannucci PM. 1998. Hemostatic drugs. N Engl J Med 339:245-53.
12. Paparella D, Brister SJ, Buchanan MR. 2004. Coagulation disorders of cardiopulmonary bypass: a review. Intensive Care Med 30:1873-81.
13. Parr KG, Patel MA, Dekker R, et al. 2003. Multivariate predictors of blood product use in cardiac surgery. J Cardiothorac Vasc Anesth 17:176-81.
14. Pollack CV Jr, Braunwald E. 2008. 2007 update to the ACC/AHA guidelines for the management of patients with unstable angina and non-STsegment elevation myocardial infarction: implications for emergency department practice. Ann Emerg Med 51:591-606.
15. Santos AT, Kalil RA, Bauemann C, Pereira JB, Nesralla IA. 2006. A randomized, double-blind, and placebo-controlled study with tranexamic acid of bleeding and fibrinolytic activity after primary coronary artery bypass grafting. Braz J Med Biol Res 39:63-9. (Pubitemid 43091529)
16. Sellman M, Intonti MA, Ivert T. 1997. Reoperations for bleeding after coronary artery bypass procedures during 25 years. Eur J Cardiothorac Surg 11:521-7.
17. Skubas NJ, Despotis GJ. 2001. Optimal management of bleeding complications after cardiac surgery. Semin Cardiothorac Vasc Anesth 5:217-28.
18. Umscheid CA, Kohl BA, Williams K. 2007. Antifibrinolytic use in adult cardiac surgery. Curr Opin Hematol 14:455-67.
19. Vanek T, Jares M, Fajt R, et al. 2005. Fibrinolytic inhibitors in offpump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo). Eur J Cardiothorac Surg 28:563-8.
20. Vanek T, Jares M, Snircova J, Maly M. 2007. Fibrinolysis in coronary artery surgery: detection by thromboelastography. Interact Cardiovasc Thorac Surg 6:700-4.
21. Vedin J, Antovic A, Ericsson A, Vaage J. 2005. Hemostasis in off-pump compared to on-pump coronary artery bypass grafting: a prospective, randomized study. Ann Thorac Surg 80:586-93.
22. Woodman RC, Harker LA. 1990. Bleeding complications associated with cardiopulmonary bypass. Blood 76:1680-97.
23. Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK, for the Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. 2001. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345:494-502.
24. Zabeeda D, Medalion B, Sverdlov M, et al. 2002. Tranexamic acid reduces bleeding and the need for blood transfusion in primary myocardial revascularization. Ann Thorac Surg 74:733-8.