메뉴 건너뛰기




Volumn 139, Issue 1, 2010, Pages 181-188

Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ANTIFIBRINOLYTIC AGENT; APROTININ; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 12A; CU 2010; CU 2020; NITROPRUSSIDE SODIUM; PLASMA KALLIKREIN; PLASMIN; PROTAMINE; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

EID: 73149106987     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2009.09.019     Document Type: Article
Times cited : (16)

References (23)
  • 3
    • 13244275133 scopus 로고    scopus 로고
    • Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions
    • Beierlein W., Scheule A.M., Dietrich W., and Ziemer G. Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg 79 (2005) 741-748
    • (2005) Ann Thorac Surg , vol.79 , pp. 741-748
    • Beierlein, W.1    Scheule, A.M.2    Dietrich, W.3    Ziemer, G.4
  • 4
    • 0034930014 scopus 로고    scopus 로고
    • Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies
    • Dietrich W., Spath P., Zuhlsdorf M., Dalichau H., Kirchhoff P.G., Kuppe H., et al. Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies. Anesthesiology 95 (2001) 64-71
    • (2001) Anesthesiology , vol.95 , pp. 64-71
    • Dietrich, W.1    Spath, P.2    Zuhlsdorf, M.3    Dalichau, H.4    Kirchhoff, P.G.5    Kuppe, H.6
  • 5
    • 0035194282 scopus 로고    scopus 로고
    • Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets
    • Katz B.A., Sprengeler P.A., Luong C., Verner E., Elrod K., Kirtley M., et al. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem Biol 8 (2001) 1107-1121
    • (2001) Chem Biol , vol.8 , pp. 1107-1121
    • Katz, B.A.1    Sprengeler, P.A.2    Luong, C.3    Verner, E.4    Elrod, K.5    Kirtley, M.6
  • 6
    • 0031793958 scopus 로고    scopus 로고
    • Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial
    • Alderman E.L., Levy J.H., Rich J.B., Nili M., Vidne B., Schaff H., et al. Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. J Thorac Cardiovasc Surg 116 (1998) 716-730
    • (1998) J Thorac Cardiovasc Surg , vol.116 , pp. 716-730
    • Alderman, E.L.1    Levy, J.H.2    Rich, J.B.3    Nili, M.4    Vidne, B.5    Schaff, H.6
  • 7
    • 1842736393 scopus 로고    scopus 로고
    • Does use of aprotinin in coronary artery bypass graft surgery affect graft patency?
    • Kalkat A., Levine, and Dunning J. Does use of aprotinin in coronary artery bypass graft surgery affect graft patency?. Interact Cardiovasc Thorac Surg 3 (2004) 124-128
    • (2004) Interact Cardiovasc Thorac Surg , vol.3 , pp. 124-128
    • Kalkat, A.1    Levine2    Dunning, J.3
  • 9
    • 4644360059 scopus 로고    scopus 로고
    • Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest
    • Khan T.A., Bianchi C., Voisine O., Feng J., Baker J., Hart M., et al. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. J Thorac Cardiovasc Surg 128 (2004) 602-608
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 602-608
    • Khan, T.A.1    Bianchi, C.2    Voisine, O.3    Feng, J.4    Baker, J.5    Hart, M.6
  • 10
    • 0034997704 scopus 로고    scopus 로고
    • Aprotinin impairs endothelium-dependent relaxation in rat aorta and inhibits nitric oxide release from rat coronary endothelial cells
    • Ülker S., Cinar M.G., Bayraktutan U., and Evinc A. Aprotinin impairs endothelium-dependent relaxation in rat aorta and inhibits nitric oxide release from rat coronary endothelial cells. Cardiovasc Res 50 (2001) 589-596
    • (2001) Cardiovasc Res , vol.50 , pp. 589-596
    • Ülker, S.1    Cinar, M.G.2    Bayraktutan, U.3    Evinc, A.4
  • 11
    • 0036045149 scopus 로고    scopus 로고
    • Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells
    • Ülker S., McKeown P.P., and Bayraktutan U. Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells. Cardiovasc Res 55 (2002) 830-837
    • (2002) Cardiovasc Res , vol.55 , pp. 830-837
    • Ülker, S.1    McKeown, P.P.2    Bayraktutan, U.3
  • 12
    • 0025992843 scopus 로고
    • Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass
    • Blauhut B., Gross C., Necek S., Doran J.E., Spath P., and Lundsgaard-Hansen P. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass. J Thorac Cardiovasc Surg 101 (1991) 958-967
    • (1991) J Thorac Cardiovasc Surg , vol.101 , pp. 958-967
    • Blauhut, B.1    Gross, C.2    Necek, S.3    Doran, J.E.4    Spath, P.5    Lundsgaard-Hansen, P.6
  • 13
    • 0023204701 scopus 로고
    • Effect of aprotinin on need for blood transfusion after repeat open-heart surgery
    • Royston D., Bidstrup B.P., Taylor K.M., and Sapsford R.N. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 2 (1987) 1289-1291
    • (1987) Lancet , vol.2 , pp. 1289-1291
    • Royston, D.1    Bidstrup, B.P.2    Taylor, K.M.3    Sapsford, R.N.4
  • 14
    • 0028263118 scopus 로고
    • Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations
    • Murkin J.M., Lux J., Shannon N.A., Guiraudon G.M., Menkis A.H., McKenzie F.N., et al. Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations. J Thorac Cardiovasc Surg 107 (1994) 554-561
    • (1994) J Thorac Cardiovasc Surg , vol.107 , pp. 554-561
    • Murkin, J.M.1    Lux, J.2    Shannon, N.A.3    Guiraudon, G.M.4    Menkis, A.H.5    McKenzie, F.N.6
  • 15
    • 42949172327 scopus 로고    scopus 로고
    • The impact of aprotinin on blood loss and blood transfusion in off pump coronary artery bypass grafting
    • Bittner H.B., Lamke J., Lange M., Rastan A., and Mohr F.W. The impact of aprotinin on blood loss and blood transfusion in off pump coronary artery bypass grafting. Ann Thorac Surg 85 (2008) 1662-1668
    • (2008) Ann Thorac Surg , vol.85 , pp. 1662-1668
    • Bittner, H.B.1    Lamke, J.2    Lange, M.3    Rastan, A.4    Mohr, F.W.5
  • 16
    • 58749083266 scopus 로고    scopus 로고
    • CU-2010-a novel small molecule protease inhibitor with antifibrinolytic and anticoagulant properties
    • Dietrich W., Nicklisch S., Koster A., Spannagl M., Giersiefen H., and van de Locht A. CU-2010-a novel small molecule protease inhibitor with antifibrinolytic and anticoagulant properties. Anesthesiology 110 (2009) 123-130
    • (2009) Anesthesiology , vol.110 , pp. 123-130
    • Dietrich, W.1    Nicklisch, S.2    Koster, A.3    Spannagl, M.4    Giersiefen, H.5    van de Locht, A.6
  • 19
    • 0029951930 scopus 로고    scopus 로고
    • Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro
    • Despotis G.J., Filos K.S., Levine V., Alsoufiev A., and Spitznagel E. Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro. Anesth Analg 82 (1996) 1126-1131
    • (1996) Anesth Analg , vol.82 , pp. 1126-1131
    • Despotis, G.J.1    Filos, K.S.2    Levine, V.3    Alsoufiev, A.4    Spitznagel, E.5
  • 20
    • 0026787977 scopus 로고
    • In vitro effects of aprotinin on activated clotting time measured with different activators
    • Wang J.S., Lin C.Y., Hung W.T., Thisted R.A., and Karp R.B. In vitro effects of aprotinin on activated clotting time measured with different activators. J Thorac Cardiovasc Surg 104 (1992) 1135-1140
    • (1992) J Thorac Cardiovasc Surg , vol.104 , pp. 1135-1140
    • Wang, J.S.1    Lin, C.Y.2    Hung, W.T.3    Thisted, R.A.4    Karp, R.B.5
  • 21
    • 73149112047 scopus 로고    scopus 로고
    • Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass
    • Veres G., Radovits T., Schulz H., Linn L.N., Hütter J., Weigang E., et al. Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass. Eur J Cardiothorac Surg 28 (2007) 801-804
    • (2007) Eur J Cardiothorac Surg , vol.28 , pp. 801-804
    • Veres, G.1    Radovits, T.2    Schulz, H.3    Linn, L.N.4    Hütter, J.5    Weigang, E.6
  • 22
    • 28444438092 scopus 로고    scopus 로고
    • Effects of aprotinin on endothelium-dependent relaxation of large coronary arteries
    • Fischer J.H., and Steinhoff M. Effects of aprotinin on endothelium-dependent relaxation of large coronary arteries. Eur J Cardiothorac Surg 28 (2005) 801-804
    • (2005) Eur J Cardiothorac Surg , vol.28 , pp. 801-804
    • Fischer, J.H.1    Steinhoff, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.