Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: In vitro release kinetics and in vitro/in vivo correlations in beagle dogs

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 1-2, 2013, Pages 64-71

  Cao, Xia ^a   Deng, Wenwen ^a   Fu, Min ^a   Zhu, Yuan ^a   Liu, Hongfei ^a   Wang, Li ^a   Zeng, Jin ^a   Wei, Yawei ^a   Xu, Ximing ^a   Yu, Jiangnan ^a  

^a JIANGSU UNIVERSITY   (China)

Author keywords

In vitro in vivo correlations; Na2CO3; Poorly soluble drug; Porous silica nanoparticles; Release kinetics; Silybin

Indexed keywords

NANOCARRIER; POROUS SILICA NANOPARTICLE; SHUILINJIA; SILIBININ; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DOGS; GASTRIC JUICE; INTESTINAL SECRETIONS; KINETICS; MALE; NANOPARTICLES; SILICON DIOXIDE; SILYMARIN; SODIUM BICARBONATE; SOLUBILITY;

EID: 84869865253     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.10.012     Document Type: Article

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