In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery

Nanotechnology

Volumn 21, Issue 15, 2010, Pages

  Wang, Yancai ^a   Zhang, Dianrui ^a   Liu, Zhaoping ^a   Liu, Guangpu ^a   Duan, Cunxian ^a   Jia, Lejiao ^a   Feng, Feifei ^a   Zhang, Xiaoyu ^a   Shi, Yanqiu ^a   Zhang, Qiang ^b  

^a SHANDONG UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AFM; BEAGLE DOG; CACO-2 CELLS; COARSE POWDERS; CRYSTALLINE STATE; DRUG TRANSPORT; IN-VITRO; IN-VIVO; LOWER PRESSURES; NANO-SUSPENSIONS; ORAL ADMINISTRATION; PHYSICOCHEMICAL PROPERTY; SEM ANALYSIS; SILYBIN; SURFACE AREA; SUSTAINED DRUG RELEASE; TEM;

BIOCHEMISTRY; CRYSTALLINE MATERIALS; DISSOLUTION; DRUG PRODUCTS; MONOLAYERS; PHARMACOKINETICS; PRESSURE EFFECTS; SURFACE ACTIVE AGENTS;

PARTICLE SIZE ANALYSIS;

NANOPARTICLE; SILIBININ; SILYMARIN;

ANIMAL; ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DOG; DOSE RESPONSE; DRUG EFFECT; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; SOLUBILITY; SUSPENSION; TIME; ULTRASTRUCTURE; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL DEATH; CELL MEMBRANE PERMEABILITY; CRYSTALLIZATION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INJECTIONS, INTRAVENOUS; KINETICS; MICROSCOPY, ATOMIC FORCE; NANOPARTICLES; PARTICLE SIZE; SILYMARIN; SOLUBILITY; SUSPENSIONS; TIME FACTORS; X-RAY DIFFRACTION;

EID: 77949885658     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/21/15/155104     Document Type: Article

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