Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers

Journal of Pharmaceutical Sciences

Volumn 98, Issue 1, 2009, Pages 215-228

  Voinovich, D ^a   Perissutti, B ^a   Magarotto, L ^a   Ceschia, D ^a   Guiotto, P ^a   A Bilia, R ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Bioavailability; Crosslinked sodium carboxymethylcellulose; Mechanical activation; Micronized crospovidone; Oral absorption; Physical characterization; Silybin A and B; Silybum marianum extract; Silychristin; Solid state

Indexed keywords

CARBOXYMETHYLCELLULOSE; CROSCARMELLOSE SODIUM; CROSPOVIDONE; FLAVONOLIGNAN; NARINGENIN; POLYMER; PVP CL; SILIBININ; SILICRISTIN; SILYBIN A; SILYBIN B; SILYBUM MARIANUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG RELEASE; MALE; NONHUMAN; RAT; SILYBUM MARIANUM; SOLUBILIZATION;

EID: 58149218166     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21417     Document Type: Article

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