메뉴 건너뛰기




Volumn 23, Issue 6, 2012, Pages 948-956

A retrosynthetic biology approach to therapeutics: From conception to delivery

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL PATHWAY; BIOSYNTHETIC PATHWAY; CHEMICAL BUILDING BLOCKS; DESIGN CONCEPT; METABOLIC NETWORK; RENEWABLE RESOURCE; RETROSYNTHETIC ANALYSIS; SYNTHETIC DESIGN; SYSTEMS BIOLOGY; THERAPEUTIC APPLICATION;

EID: 84869862664     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2012.03.009     Document Type: Review
Times cited : (19)

References (58)
  • 1
  • 2
    • 79961179947 scopus 로고    scopus 로고
    • Synergies between synthetic biology and metabolic engineering
    • Nielsen J., Keasling J.D. Synergies between synthetic biology and metabolic engineering. Nat Biotechnol 2011, 29:693-695.
    • (2011) Nat Biotechnol , vol.29 , pp. 693-695
    • Nielsen, J.1    Keasling, J.D.2
  • 3
    • 79959991752 scopus 로고    scopus 로고
    • Engineering antibiotic production and overcoming bacterial resistance
    • Planson A.G., Carbonell P., Grigoras I., Faulon J.L. Engineering antibiotic production and overcoming bacterial resistance. Biotechnol J 2011, 6:812-825.
    • (2011) Biotechnol J , vol.6 , pp. 812-825
    • Planson, A.G.1    Carbonell, P.2    Grigoras, I.3    Faulon, J.L.4
  • 5
    • 79961116083 scopus 로고    scopus 로고
    • A retrosynthetic biology approach to metabolic pathway design for therapeutic production
    • Carbonell P., Planson A.G., Fichera D., Faulon J.L. A retrosynthetic biology approach to metabolic pathway design for therapeutic production. BMC Syst Biol 2011, 5:122.
    • (2011) BMC Syst Biol , vol.5 , pp. 122
    • Carbonell, P.1    Planson, A.G.2    Fichera, D.3    Faulon, J.L.4
  • 6
    • 77953329895 scopus 로고    scopus 로고
    • Prediction of novel synthetic pathways for the production of desired chemicals
    • Cho A., Yun H., Park J.H.H., Lee S.Y.Y., Park S. Prediction of novel synthetic pathways for the production of desired chemicals. BMC Syst Biol 2010, 4:35.
    • (2010) BMC Syst Biol , vol.4 , pp. 35
    • Cho, A.1    Yun, H.2    Park, J.H.H.3    Lee, S.Y.Y.4    Park, S.5
  • 7
    • 77952517931 scopus 로고    scopus 로고
    • Biosynthesis: is it time to go retro?
    • Bachmann B.O. Biosynthesis: is it time to go retro?. Nat Chem Biol 2010, 6:390-393.
    • (2010) Nat Chem Biol , vol.6 , pp. 390-393
    • Bachmann, B.O.1
  • 9
    • 84865284935 scopus 로고    scopus 로고
    • Synthetic signaling networks for therapeutic applications
    • Aurand T.C., Russell M.S., March J.C. Synthetic signaling networks for therapeutic applications. Curr Opin Biotechnol 2012, 10.1016/j.copbio.2012.1001.1001.
    • (2012) Curr Opin Biotechnol
    • Aurand, T.C.1    Russell, M.S.2    March, J.C.3
  • 11
    • 84859772410 scopus 로고    scopus 로고
    • Synthetic biology and the development of tools for metabolic engineering
    • Keasling J.D. Synthetic biology and the development of tools for metabolic engineering. Metab Eng 2012, 10.1016/j.ymben.2012.1001.1004.
    • (2012) Metab Eng
    • Keasling, J.D.1
  • 13
    • 84862910708 scopus 로고    scopus 로고
    • Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm
    • Yu L.H., Wei X., Ma M., Chen X.J., Xu S.B. Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. Antimicrob Agents Chemother 2012, 56:770-775.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 770-775
    • Yu, L.H.1    Wei, X.2    Ma, M.3    Chen, X.J.4    Xu, S.B.5
  • 14
    • 80052777068 scopus 로고    scopus 로고
    • Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix
    • Gomes F., Teixeira P., Cerca N., Azeredo J., Oliveira R. Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. Curr Microbiol 2011, 63:354-359.
    • (2011) Curr Microbiol , vol.63 , pp. 354-359
    • Gomes, F.1    Teixeira, P.2    Cerca, N.3    Azeredo, J.4    Oliveira, R.5
  • 15
    • 73249114946 scopus 로고    scopus 로고
    • Molecular mechanisms involved in farnesol-induced apoptosis
    • Joo J.H., Jetten A.M. Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett 2010, 287:123-135.
    • (2010) Cancer Lett , vol.287 , pp. 123-135
    • Joo, J.H.1    Jetten, A.M.2
  • 17
    • 79958715193 scopus 로고    scopus 로고
    • Optimization of a heterologous pathway for the production of flavonoids from glucose
    • Santos C.N., Koffas M., Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metab Eng 2011, 13:392-400.
    • (2011) Metab Eng , vol.13 , pp. 392-400
    • Santos, C.N.1    Koffas, M.2    Stephanopoulos, G.3
  • 20
    • 77249139318 scopus 로고    scopus 로고
    • Machine learning methods for metabolic pathway prediction
    • Dale J., Popescu L., Karp P. Machine learning methods for metabolic pathway prediction. BMC Bioinform 2010, 11:15.
    • (2010) BMC Bioinform , vol.11 , pp. 15
    • Dale, J.1    Popescu, L.2    Karp, P.3
  • 21
    • 84855946759 scopus 로고    scopus 로고
    • Compound toxicity screening and structure-activity relationship modeling in Escherichia coli
    • Planson A.G., Carbonell P., Paillard E., Pollet N., Faulon J.L. Compound toxicity screening and structure-activity relationship modeling in Escherichia coli. Biotechnol Bioeng 2012, 109:846-850.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 846-850
    • Planson, A.G.1    Carbonell, P.2    Paillard, E.3    Pollet, N.4    Faulon, J.L.5
  • 22
    • 79957989329 scopus 로고    scopus 로고
    • Molecular diversity-the toolbox for synthetic gene switches and networks
    • Weber W., Fussenegger M. Molecular diversity-the toolbox for synthetic gene switches and networks. Curr Opin Chem Biol 2011, 15:414-420.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 414-420
    • Weber, W.1    Fussenegger, M.2
  • 23
    • 84856579358 scopus 로고    scopus 로고
    • Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms
    • Carbonell P., Fichera D., Pandit S., Faulon J.L. Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms. BMC Syst Biol 2012, 6:10.
    • (2012) BMC Syst Biol , vol.6 , pp. 10
    • Carbonell, P.1    Fichera, D.2    Pandit, S.3    Faulon, J.L.4
  • 24
    • 77952585143 scopus 로고    scopus 로고
    • CASOP: a computational approach for strain optimization aiming at high productivity
    • Hädicke O., Klamt S. CASOP: a computational approach for strain optimization aiming at high productivity. J Biotechnol 2010, 147:88-101.
    • (2010) J Biotechnol , vol.147 , pp. 88-101
    • Hädicke, O.1    Klamt, S.2
  • 25
    • 77954590959 scopus 로고    scopus 로고
    • OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions
    • Ranganathan S., Suthers P.F., Maranas C.D. OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions. PLoS Comput Biol 2010, 6:e1000744.
    • (2010) PLoS Comput Biol , vol.6
    • Ranganathan, S.1    Suthers, P.F.2    Maranas, C.D.3
  • 26
    • 80052573483 scopus 로고    scopus 로고
    • Large-scale bi-level strain design approaches and mixed-integer programming solution techniques
    • Kim J., Reed J.L., Maravelias C.T. Large-scale bi-level strain design approaches and mixed-integer programming solution techniques. PLoS One 2011, 6:e24162.
    • (2011) PLoS One , vol.6
    • Kim, J.1    Reed, J.L.2    Maravelias, C.T.3
  • 27
    • 83255174106 scopus 로고    scopus 로고
    • Relative potential of biosynthetic pathways for biofuels and bio-based products
    • Dugar D., Stephanopoulos G. Relative potential of biosynthetic pathways for biofuels and bio-based products. Nat Biotechnol 2011, 29:1074-1078.
    • (2011) Nat Biotechnol , vol.29 , pp. 1074-1078
    • Dugar, D.1    Stephanopoulos, G.2
  • 28
    • 80053445630 scopus 로고    scopus 로고
    • In silico characterization of microbial electrosynthesis for metabolic engineering of biochemicals
    • Pandit A., Mahadevan R. In silico characterization of microbial electrosynthesis for metabolic engineering of biochemicals. Microb Cell Fact 2011, 10:76.
    • (2011) Microb Cell Fact , vol.10 , pp. 76
    • Pandit, A.1    Mahadevan, R.2
  • 29
    • 77952915373 scopus 로고    scopus 로고
    • Construction and optimization of synthetic pathways in metabolic engineering
    • Na D., Kim T.Y.Y., Lee S.Y.Y. Construction and optimization of synthetic pathways in metabolic engineering. Curr Opin Microbiol 2010, 13:363-370.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 363-370
    • Na, D.1    Kim, T.Y.Y.2    Lee, S.Y.Y.3
  • 30
    • 84869883983 scopus 로고    scopus 로고
    • Synthetic biology: new strategies for directing design
    • Lynch S.A., Gill R.T. Synthetic biology: new strategies for directing design. Metab Eng 2011, 10.1016/j.ymben.2011.1012.1007.
    • (2011) Metab Eng
    • Lynch, S.A.1    Gill, R.T.2
  • 31
    • 68049111471 scopus 로고    scopus 로고
    • Finding better protein engineering strategies
    • Kazlauskas R.J., Bornscheuer U.T. Finding better protein engineering strategies. Nat Chem Biol 2009, 5:526-529.
    • (2009) Nat Chem Biol , vol.5 , pp. 526-529
    • Kazlauskas, R.J.1    Bornscheuer, U.T.2
  • 32
    • 84865144344 scopus 로고    scopus 로고
    • Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli
    • Yuzawa S., Kim W., Katz L., Keasling J.D. Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli. Curr Opin Biotechnol 2012, 10.1016/j.copbio.2011.1012.1029.
    • (2012) Curr Opin Biotechnol
    • Yuzawa, S.1    Kim, W.2    Katz, L.3    Keasling, J.D.4
  • 33
    • 70349959824 scopus 로고    scopus 로고
    • A proteomics approach to discovering natural products and their biosynthetic pathways
    • Bumpus S.B., Evans B.S., Thomas P.M., Ntai I., Kelleher N.L. A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 2009, 27:951-956.
    • (2009) Nat Biotechnol , vol.27 , pp. 951-956
    • Bumpus, S.B.1    Evans, B.S.2    Thomas, P.M.3    Ntai, I.4    Kelleher, N.L.5
  • 34
    • 78650107130 scopus 로고    scopus 로고
    • Prokaryotic gene clusters: a rich toolbox for synthetic biology
    • Fischbach M., Voigt C.A. Prokaryotic gene clusters: a rich toolbox for synthetic biology. Biotechnol J 2010, 5:1277-1296.
    • (2010) Biotechnol J , vol.5 , pp. 1277-1296
    • Fischbach, M.1    Voigt, C.A.2
  • 35
    • 79952608261 scopus 로고    scopus 로고
    • Synthetic circuits, devices and modules
    • Zhang H., Jiang T. Synthetic circuits, devices and modules. Protein Cell 2010, 1:974-978.
    • (2010) Protein Cell , vol.1 , pp. 974-978
    • Zhang, H.1    Jiang, T.2
  • 36
    • 84867206834 scopus 로고    scopus 로고
    • Therapeutic synthetic gene networks
    • Karlsson M., Weber W. Therapeutic synthetic gene networks. Curr Opin Biotechnol 2012, 10.1016/j.copbio.2012.1001.1003.
    • (2012) Curr Opin Biotechnol
    • Karlsson, M.1    Weber, W.2
  • 37
    • 80052484996 scopus 로고    scopus 로고
    • Synthetic biology moving into the clinic
    • Ruder W.C., Lu T., Collins J.J. Synthetic biology moving into the clinic. Science 2011, 333:1248-1252.
    • (2011) Science , vol.333 , pp. 1248-1252
    • Ruder, W.C.1    Lu, T.2    Collins, J.J.3
  • 38
    • 83855163433 scopus 로고    scopus 로고
    • Emerging biomedical applications of synthetic biology
    • Weber W., Fussenegger M. Emerging biomedical applications of synthetic biology. Nat Rev Genet 2012, 13:21-35.
    • (2012) Nat Rev Genet , vol.13 , pp. 21-35
    • Weber, W.1    Fussenegger, M.2
  • 39
    • 79959514813 scopus 로고    scopus 로고
    • A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice
    • Ye H., Daoud-El Baba M., Peng R.W., Fussenegger M. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 2011, 332:1565-1568.
    • (2011) Science , vol.332 , pp. 1565-1568
    • Ye, H.1    Daoud-El Baba, M.2    Peng, R.W.3    Fussenegger, M.4
  • 40
    • 80052456127 scopus 로고    scopus 로고
    • Multi-input RNAi-based logic circuit for identification of specific cancer cells
    • Xie Z., Wroblewska L., Prochazka L., Weiss R., Benenson Y. Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science 2011, 333:1307-1311.
    • (2011) Science , vol.333 , pp. 1307-1311
    • Xie, Z.1    Wroblewska, L.2    Prochazka, L.3    Weiss, R.4    Benenson, Y.5
  • 43
    • 83955163721 scopus 로고    scopus 로고
    • Designing biological systems: systems engineering meets synthetic biology
    • Rollié S., Mangold M., Sundmacher K. Designing biological systems: systems engineering meets synthetic biology. Chem Eng Sci 2012, 69:1-29.
    • (2012) Chem Eng Sci , vol.69 , pp. 1-29
    • Rollié, S.1    Mangold, M.2    Sundmacher, K.3
  • 44
    • 63849290890 scopus 로고    scopus 로고
    • Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy
    • Lu T.K., Collins J.J. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc Natl Acad Sci U S A 2009, 106:4629-4634.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4629-4634
    • Lu, T.K.1    Collins, J.J.2
  • 45
    • 84856455259 scopus 로고    scopus 로고
    • Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model
    • Chen J., Yang B., Cheng X., Qiao Y., Tang B., Chen G., Wei J., Liu X., Cheng W., Du P., et al. Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model. Cancer Sci 2012, 103:325-333.
    • (2012) Cancer Sci , vol.103 , pp. 325-333
    • Chen, J.1    Yang, B.2    Cheng, X.3    Qiao, Y.4    Tang, B.5    Chen, G.6    Wei, J.7    Liu, X.8    Cheng, W.9    Du, P.10
  • 47
    • 57149095846 scopus 로고    scopus 로고
    • Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes
    • Duan F., Curtis K.L., March J.C. Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes. Appl Environ Microbiol 2008, 74:7437-7438.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 7437-7438
    • Duan, F.1    Curtis, K.L.2    March, J.C.3
  • 48
    • 77953359952 scopus 로고    scopus 로고
    • AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis
    • Caluwaerts S., Vandenbroucke K., Steidler L., Neirynck S., Vanhoenacker P., Corveleyn S., Watkins B., Sonis S., Coulie B., Rottiers P. AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncol 2010, 46:564-570.
    • (2010) Oral Oncol , vol.46 , pp. 564-570
    • Caluwaerts, S.1    Vandenbroucke, K.2    Steidler, L.3    Neirynck, S.4    Vanhoenacker, P.5    Corveleyn, S.6    Watkins, B.7    Sonis, S.8    Coulie, B.9    Rottiers, P.10
  • 50
    • 77954920911 scopus 로고    scopus 로고
    • Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model
    • Duan F., March J.C. Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model. Proc Natl Acad Sci U S A 2010, 107:11260-11264.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11260-11264
    • Duan, F.1    March, J.C.2
  • 51
    • 78649553739 scopus 로고    scopus 로고
    • Biological nanofactories target and activate epithelial cell surfaces for modulating bacterial quorum sensing and interspecies signaling
    • Hebert C.G., Gupta A., Fernandes R., Tsao C.Y., Valdes J.J., Bentley W.E. Biological nanofactories target and activate epithelial cell surfaces for modulating bacterial quorum sensing and interspecies signaling. ACS Nano 2010, 4:6923-6931.
    • (2010) ACS Nano , vol.4 , pp. 6923-6931
    • Hebert, C.G.1    Gupta, A.2    Fernandes, R.3    Tsao, C.Y.4    Valdes, J.J.5    Bentley, W.E.6
  • 52
    • 77949270750 scopus 로고    scopus 로고
    • Engineered biological nanofactories trigger quorum sensing response in targeted bacteria
    • Fernandes R., Roy V., Wu H.C., Bentley W.E. Engineered biological nanofactories trigger quorum sensing response in targeted bacteria. Nat Nanotechnol 2010, 5:213-217.
    • (2010) Nat Nanotechnol , vol.5 , pp. 213-217
    • Fernandes, R.1    Roy, V.2    Wu, H.C.3    Bentley, W.E.4
  • 55
    • 78649429678 scopus 로고    scopus 로고
    • Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins
    • Culler S.J., Hoff K.G., Smolke C.D. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science 2010, 330:1251-1255.
    • (2010) Science , vol.330 , pp. 1251-1255
    • Culler, S.J.1    Hoff, K.G.2    Smolke, C.D.3
  • 56
    • 78650633687 scopus 로고    scopus 로고
    • A tunable dual-promoter integrator for targeting of cancer cells
    • Nissim L., Bar-Ziv R.H. A tunable dual-promoter integrator for targeting of cancer cells. Mol Syst Biol 2010, 6:444.
    • (2010) Mol Syst Biol , vol.6 , pp. 444
    • Nissim, L.1    Bar-Ziv, R.H.2
  • 57
    • 77952679687 scopus 로고    scopus 로고
    • Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems
    • Chen Y.Y., Jensen M.C., Smolke C.D. Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems. Proc Natl Acad Sci U S A 2010, 107:8531-8536.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8531-8536
    • Chen, Y.Y.1    Jensen, M.C.2    Smolke, C.D.3
  • 58
    • 79951893203 scopus 로고    scopus 로고
    • A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms
    • Kemmer C., Fluri D.A., Witschi U., Passeraub A., Gutzwiller A., Fussenegger M. A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms. J Control Release 2011, 150:23-29.
    • (2011) J Control Release , vol.150 , pp. 23-29
    • Kemmer, C.1    Fluri, D.A.2    Witschi, U.3    Passeraub, A.4    Gutzwiller, A.5    Fussenegger, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.