CYP2C29 Produces Superoxide in Response to Shear Stress

Microcirculation

Volumn 19, Issue 8, 2012, Pages 696-704

  Sun, Dong ^a   Ojaimi, Caroline ^a   Wu, Hongyan ^a   Kaley, Gabor ^a   Huang, An ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Catalase; Cytochrome P450; Endothelium; Shear stress; Superoxide

Indexed keywords

3 BENZYL 7 (2 BENZOXAZOLYL)THIO 1,2,3 TRIAZOLO(4,5 D)PYRIMIDINE; 6 (2 PROPARGLYOXYPHENEL) HEXANOIC ACID; ALLOPURINOL; CYTOCHROME P450 2C; CYTOCHROME P450 2C29; EPOXIDE HYDROLASE; HYDROGEN PEROXIDE; OXIDOREDUCTASE INHIBITOR; PYRIMIDINE DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MESENTERIC ARTERY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS; SHEAR STRESS INDUCED DILATION; VASOCONSTRICTION;

ANIMALS; ANTIOXIDANTS; BENZOXAZOLES; CATALASE; CYCLIC N-OXIDES; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN PEROXIDE; MESENTERIC ARTERIES; MICE; MICE, KNOCKOUT; POLYETHYLENE GLYCOLS; SPIN LABELS; STRESS, PHYSIOLOGICAL; SUPEROXIDES; TRIAZOLES; UP-REGULATION; VASODILATION;

MUS;

EID: 84869847662     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2012.00202.x     Document Type: Article

References (44)

1. Barlow RS, El-Mowafy AM, White RE. H(2)O(2) opens BK(Ca) channels via the PLA(2)-arachidonic acid signaling cascade in coronary artery smooth muscle. Am J Physiol Heart Circ Physiol279: H475-H483, 2000.
2. Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM. Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol46: 978-988, 2009.
3. Busse R, Fleming I. Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces. Trends Pharmacol Sci24: 24-29, 2003.
4. Campbell WB, Fleming I. Epoxyeicosatrienoic acids and endothelium-dependent responses. Pflugers Arch459: 881-895, 2010.
5. Chen D, Whitcomb R, MacIntyre E, Tran V, Do ZN, Sabry J, Patel DV, Anandan SK, Gless R, Webb HK. Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects. J Clin Pharmacol52: 319-328, 2012.
6. Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, DeGraff LM, Lih FB, Foley J, Bradbury JA, Graves JP, Tomer KB, Falck JR, Zeldin DC, Lee CR. Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J25: 703-713, 2011.
7. Deng Y, Theken KN, Lee CR. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation. J Mol Cell Cardiol48: 331-341, 2010.
8. Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M. Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. Am J Physiol Heart Circ Physiol294: H724-H735, 2008.
9. Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, Lee CR, Zeldin DC. Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart. FASEB J25: 3436-3447, 2011.
10. Fleming I. DiscrEET regulators of homeostasis: epoxyeicosatrienoic acids, cytochrome P450 epoxygenases and vascular inflammation. Trends Pharmacol Sci28: 448-452, 2007.
11. Fleming I, Michaelis UR, Bredenkotter D, Fisslthaler B, Dehghani F, Brandes RP, Busse R. Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res88: 44-51, 2001.
12. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P Jr, Yeager M, Gottlieb RA. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A101: 1321-1326, 2004.
13. + channels. Heart Vessels13: 9-17, 1998.
14. Huang A, Kaley G. Gender-specific regulation of cardiovascular function: estrogen as key player. Microcirculation11: 9-38, 2004.
15. Huang A, Sun D, Carroll MA, Jiang H, Smith CJ, Connetta JA, Falck JR, Shesely EG, Koller A, Kaley G. EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. Am J Physiol Heart Circ Physiol280: H2462-H2469, 2001.
16. Huang A, Sun D, Jacobson A, Carroll MA, Falck JR, Kaley G. Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. Circ Res96: 376-383, 2005.
17. Huang A, Sun D, Wu Z, Yan C, Carroll MA, Jiang H, Falck JR, Kaley G. Estrogen elicits cytochrome P450-mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation. Circ Res94: 245-252, 2004.
18. Huang A, Wu Y, Sun D, Koller A, Kaley G. Effect of estrogen on flow-induced dilation in NO deficiency: role of prostaglandins and EDHF. J Appl Physiol91: 2561-2566, 2001.
19. Huang A, Yan C, Suematsu N, Cuevas A, Yang YM, Kertowidjojo E, Hintze TH, Kaley G, Sun D. Impaired flow-induced dilation of coronary arterioles of dogs fed a low-salt diet: roles of ANG II, PKC, and NAD(P)H oxidase. Am J Physiol Heart Circ Physiol299: H1476-H1483, 2010.
20. Huang A, Yang YM, Feher A, Bagi Z, Kaley G, Sun D. Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol302: R674-R681, 2012.
21. Jacobson A, Yan C, Gao Q, Rincon-Skinner T, Rivera A, Edwards J, Huang A, Kaley G, Sun D. Aging enhances pressure-induced arterial superoxide formation. Am J Physiol Heart Circ Physiol293: H1344-H1350, 2007.
22. Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H. Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res102: 59-67, 2008.
23. Liu L, Chen C, Gong W, Li Y, Edin ML, Zeldin DC, Wang DW. Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. J Pharmacol Exp Ther339: 451-463, 2011.
24. 2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. Circ Res108: 566-573, 2011.
25. Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, Kanaide H, Takeshita A. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest106: 1521-1530, 2000.
26. Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H. cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase. Biochim Biophys Acta1184: 299-301, 1994.
27. Mueller CF, Laude K, McNally JS, Harrison DG. ATVB in focus: redox mechanisms in blood vessels. Arterioscler Thromb Vasc Biol25: 274-278, 2005.
28. Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology35: 62-73, 2002.
29. Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim IH, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld AJ, Collen D, Busse R, Janssens S. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension47: 762-770, 2006.
30. + channels and p42/p44 MAPK pathway. Circ Res95: 506-514, 2004.
31. Sun D, Huang A, Yan EH, Wu Z, Yan C, Kaminski PM, Oury TD, Wolin MS, Kaley G. Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am J Physiol Heart Circ Physiol286: H2249-H2256, 2004.
32. Sun D, Jiang H, Wu H, Yang Y, Kaley G, Huang A. A novel vascular EET synthase: role of CYP2C7. Am J Physiol Regul Integr Comp Physiol301: R1723-R1730, 2011.
33. Sun D, Yang YM, Jiang H, Wu H, Ojaimi C, Kaley G, Huang A. Roles of CYP2C29 and RXR gamma in vascular EET synthesis of female mice. Am J Physiol Regul Integr Comp Physiol298: R862-R869, 2010.
34. Tsao CC, Coulter SJ, Chien A, Luo G, Clayton NP, Maronpot R, Goldstein JA, Zeldin DC. Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products. J Pharmacol Exp Ther299: 39-47, 2001.
35. Tsao CC, Wester MR, Ghanayem B, Coulter SJ, Chanas B, Johnson EF, Goldstein JA. Identification of human CYP2C19 residues that confer S-mephenytoin 4′-hydroxylation activity to CYP2C9. Biochemistry40: 1937-1944, 2001.
36. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol39: 44-84, 2007.
37. Wind S, Beuerlein K, Armitage ME, Taye A, Kumar AH, Janowitz D, Neff C, Shah AM, Wingler K, Schmidt HH. Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension56: 490-497, 2010.
38. Wolin MS. Reactive oxygen species and the control of vascular function. Am J Physiol Heart Circ Physiol296: H539-H549, 2009.
39. Wu D, Cederbaum AI. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol207: 70-76, 2005.
40. Wu Y, Huang A, Sun D, Falck JR, Koller A, Kaley G. Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation. Am J Physiol Heart Circ Physiol280: H2456-H2461, 2001.
41. Yan C, Huang A, Wu Z, Kaminski PM, Wolin MS, Hintze TH, Kaley G, Sun D. Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol288: H2225-H2231, 2005.
42. Yang B, Graham L, Dikalov S, Mason RP, Falck JR, Liao JK, Zeldin DC. Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol60: 310-320, 2001.
43. Yang YM, Huang A, Kaley G, Sun D. eNOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol Heart Circ Physiol297: H1829-H1836, 2009.
44. + channel activation. Circ Res110: 471-480, 2012.