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Volumn 31, Issue 4, 2012, Pages 258-266

Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

Author keywords

Alopecia areata; Androgenetic alopecia; Female pattern hair loss; Genetics; Molecular diagnostic testing; Therapy

Indexed keywords

ABATACEPT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2; XEDAR RECEPTOR;

EID: 84869846337     PISSN: 10855629     EISSN: 15580768     Source Type: Journal    
DOI: 10.1016/j.sder.2012.08.003     Document Type: Review
Times cited : (10)

References (96)
  • 1
    • 73649148718 scopus 로고    scopus 로고
    • Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis
    • quiz 89-90
    • Alkhalifah A., Alsantali A., Wang E., et al. Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010, 62:177-188. quiz 89-90.
    • (2010) J Am Acad Dermatol , vol.62 , pp. 177-188
    • Alkhalifah, A.1    Alsantali, A.2    Wang, E.3
  • 2
    • 27944504611 scopus 로고    scopus 로고
    • The psychosocial impact of hair loss among men: A multinational European study
    • Alfonso M., Richter-Appelt H., Tosti A., et al. The psychosocial impact of hair loss among men: A multinational European study. Curr Med Res Opin 2005, 21:1829-1836.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1829-1836
    • Alfonso, M.1    Richter-Appelt, H.2    Tosti, A.3
  • 3
    • 79959568265 scopus 로고    scopus 로고
    • The genetics of alopecia areata: What's new and how will it help our patients?
    • Petukhova L., Cabral R.M., Mackay-Wiggan J., et al. The genetics of alopecia areata: What's new and how will it help our patients?. Dermatol Ther 2011, 24:326-336.
    • (2011) Dermatol Ther , vol.24 , pp. 326-336
    • Petukhova, L.1    Cabral, R.M.2    Mackay-Wiggan, J.3
  • 4
    • 79958207011 scopus 로고    scopus 로고
    • Future directions: Gene polymorphism diagnostics relavant to hair
    • Springer, London, R. Trueb, D. Tobin (Eds.)
    • Ellis J. Future directions: Gene polymorphism diagnostics relavant to hair. Aging Hair 2010, 291-332. Springer, London. R. Trueb, D. Tobin (Eds.).
    • (2010) Aging Hair , pp. 291-332
    • Ellis, J.1
  • 5
    • 79959545216 scopus 로고    scopus 로고
    • Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician?
    • Dy L.C., Whiting D.A. Histopathology of alopecia areata, acute and chronic: Why is it important to the clinician?. Dermatol Ther 2011, 24:369-374.
    • (2011) Dermatol Ther , vol.24 , pp. 369-374
    • Dy, L.C.1    Whiting, D.A.2
  • 6
    • 33645968083 scopus 로고    scopus 로고
    • The histopathology of noncicatricial alopecia
    • Eudy G., Solomon A.R. The histopathology of noncicatricial alopecia. Semin Cutan Med Surg 2006, 25:35-40.
    • (2006) Semin Cutan Med Surg , vol.25 , pp. 35-40
    • Eudy, G.1    Solomon, A.R.2
  • 7
    • 33645979642 scopus 로고    scopus 로고
    • Clinical approach to the patient with alopecia
    • Han A., Mirmirani P. Clinical approach to the patient with alopecia. Semin Cutan Med Surg 2006, 25:11-23.
    • (2006) Semin Cutan Med Surg , vol.25 , pp. 11-23
    • Han, A.1    Mirmirani, P.2
  • 9
    • 73449101114 scopus 로고    scopus 로고
    • Histopathology of alopecia: A clinicopathological approach to diagnosis
    • Stefanato C.M. Histopathology of alopecia: A clinicopathological approach to diagnosis. Histopathology 2010, 56:24-38.
    • (2010) Histopathology , vol.56 , pp. 24-38
    • Stefanato, C.M.1
  • 11
    • 33746932869 scopus 로고    scopus 로고
    • Alopecia areata: A long term follow-up study of 191 patients
    • Tosti A., Bellavista S., Iorizzo M. Alopecia areata: A long term follow-up study of 191 patients. J Am Acad Dermatol 2006, 55:438-441.
    • (2006) J Am Acad Dermatol , vol.55 , pp. 438-441
    • Tosti, A.1    Bellavista, S.2    Iorizzo, M.3
  • 12
    • 0032446742 scopus 로고    scopus 로고
    • Prevalence of male pattern hair loss in 18-49 year old men
    • Rhodes T., Girman C.J., Savin R.C., et al. Prevalence of male pattern hair loss in 18-49 year old men. Dermatol Surg 1998, 24:1330-1332.
    • (1998) Dermatol Surg , vol.24 , pp. 1330-1332
    • Rhodes, T.1    Girman, C.J.2    Savin, R.C.3
  • 13
    • 0016771059 scopus 로고
    • Male pattern baldness: Classification and incidence
    • Norwood O.T. Male pattern baldness: Classification and incidence. South Med J 1975, 68:1359-1365.
    • (1975) South Med J , vol.68 , pp. 1359-1365
    • Norwood, O.T.1
  • 14
    • 0001041124 scopus 로고
    • Patterned loss of hair in man; types and incidence
    • Hamilton J.B. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 1951, 53:708-728.
    • (1951) Ann N Y Acad Sci , vol.53 , pp. 708-728
    • Hamilton, J.B.1
  • 15
    • 33644874794 scopus 로고    scopus 로고
    • Prevalence of male and female pattern hair loss in Maryborough
    • Gan D.C., Sinclair R.D. Prevalence of male and female pattern hair loss in Maryborough. J Investig Dermatol Symp Proc 2005, 10:184-189.
    • (2005) J Investig Dermatol Symp Proc , vol.10 , pp. 184-189
    • Gan, D.C.1    Sinclair, R.D.2
  • 16
    • 0000285713 scopus 로고
    • Effect of castration in adolescent and young adult males upon further changes in the proportions of bare and hairy scalp
    • Hamilton J.B. Effect of castration in adolescent and young adult males upon further changes in the proportions of bare and hairy scalp. J Clin Endocrinol Metab 1960, 20:1309-1318.
    • (1960) J Clin Endocrinol Metab , vol.20 , pp. 1309-1318
    • Hamilton, J.B.1
  • 17
    • 0037203503 scopus 로고    scopus 로고
    • Androgens and alopecia
    • Kaufman K.D. Androgens and alopecia. Mol Cell Endocrinol 2002, 198:89-95.
    • (2002) Mol Cell Endocrinol , vol.198 , pp. 89-95
    • Kaufman, K.D.1
  • 18
    • 0026543274 scopus 로고
    • Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase
    • Jenkins E.P., Andersson S., Imperato-McGinley J., et al. Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase. J Clin Invest 1992, 89:293-300.
    • (1992) J Clin Invest , vol.89 , pp. 293-300
    • Jenkins, E.P.1    Andersson, S.2    Imperato-McGinley, J.3
  • 19
    • 0034858478 scopus 로고    scopus 로고
    • Female pattern hair loss
    • Olsen E.A. Female pattern hair loss. J Am Acad Dermatol 2001, 45(Suppl 3):S70-S80.
    • (2001) J Am Acad Dermatol , vol.45 , Issue.SUPPL. 3
    • Olsen, E.A.1
  • 20
    • 0035113748 scopus 로고    scopus 로고
    • Hair density, hair diameter and the prevalence of female pattern hair loss
    • Birch M.P., Messenger J.F., Messenger A.G. Hair density, hair diameter and the prevalence of female pattern hair loss. Br J Dermatol 2001, 144:297-304.
    • (2001) Br J Dermatol , vol.144 , pp. 297-304
    • Birch, M.P.1    Messenger, J.F.2    Messenger, A.G.3
  • 21
    • 0032834918 scopus 로고    scopus 로고
    • Diffuse female hair loss: Are androgens necessary?
    • Orme S., Cullen D.R., Messenger A.G. Diffuse female hair loss: Are androgens necessary?. Br J Dermatol 1999, 141:521-523.
    • (1999) Br J Dermatol , vol.141 , pp. 521-523
    • Orme, S.1    Cullen, D.R.2    Messenger, A.G.3
  • 22
    • 0000868562 scopus 로고
    • Effect of pregnancy on the human hair cycle
    • Lynfield Y.L. Effect of pregnancy on the human hair cycle. J Invest Dermatol 1960, 35:323-327.
    • (1960) J Invest Dermatol , vol.35 , pp. 323-327
    • Lynfield, Y.L.1
  • 23
    • 3042823862 scopus 로고    scopus 로고
    • Letrozole: A review of its use in postmenopausal women with breast cancer
    • Simpson D., Curran M.P., Perry C.M. Letrozole: A review of its use in postmenopausal women with breast cancer. Drugs 2004, 64:1213-1230.
    • (2004) Drugs , vol.64 , pp. 1213-1230
    • Simpson, D.1    Curran, M.P.2    Perry, C.M.3
  • 24
    • 33750096487 scopus 로고    scopus 로고
    • The hair follicle as an estrogen target and source
    • Ohnemus U., Uenalan M., Inzunza J., et al. The hair follicle as an estrogen target and source. Endocr Rev 2006, 27:677-706.
    • (2006) Endocr Rev , vol.27 , pp. 677-706
    • Ohnemus, U.1    Uenalan, M.2    Inzunza, J.3
  • 25
    • 0029998534 scopus 로고    scopus 로고
    • An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation
    • Oh H.S., Smart R.C. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc Natl Acad Sci USA 1996, 93:12525-12530.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12525-12530
    • Oh, H.S.1    Smart, R.C.2
  • 26
    • 73349137953 scopus 로고    scopus 로고
    • Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss
    • Yip L., Zaloumis S., Irwin D., et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol 2009, 161:289-294.
    • (2009) Br J Dermatol , vol.161 , pp. 289-294
    • Yip, L.1    Zaloumis, S.2    Irwin, D.3
  • 28
    • 0035007120 scopus 로고    scopus 로고
    • The genetics of androgenetic alopecia
    • Ellis J.A., Harrap S.B. The genetics of androgenetic alopecia. Clin Dermatol 2001, 19:149-154.
    • (2001) Clin Dermatol , vol.19 , pp. 149-154
    • Ellis, J.A.1    Harrap, S.B.2
  • 29
    • 0031838046 scopus 로고    scopus 로고
    • Genetic analysis of male pattern baldness and the 5alpha-reductase genes
    • Ellis J.A., Stebbing M., Harrap S.B. Genetic analysis of male pattern baldness and the 5alpha-reductase genes. J Invest Dermatol 1998, 110:849-853.
    • (1998) J Invest Dermatol , vol.110 , pp. 849-853
    • Ellis, J.A.1    Stebbing, M.2    Harrap, S.B.3
  • 30
    • 0035094402 scopus 로고    scopus 로고
    • Polymorphism of the androgen receptor gene is associated with male pattern baldness
    • Ellis J.A., Stebbing M., Harrap S.B. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 2001, 116:452-455.
    • (2001) J Invest Dermatol , vol.116 , pp. 452-455
    • Ellis, J.A.1    Stebbing, M.2    Harrap, S.B.3
  • 31
    • 0031829734 scopus 로고    scopus 로고
    • Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne
    • Sawaya M.E., Shalita A.R. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J Cutan Med Surg 1998, 3:9-15.
    • (1998) J Cutan Med Surg , vol.3 , pp. 9-15
    • Sawaya, M.E.1    Shalita, A.R.2
  • 32
    • 20544475696 scopus 로고    scopus 로고
    • Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    • Hillmer A.M., Hanneken S., Ritzmann S., et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet 2005, 77:140-148.
    • (2005) Am J Hum Genet , vol.77 , pp. 140-148
    • Hillmer, A.M.1    Hanneken, S.2    Ritzmann, S.3
  • 33
    • 34147166645 scopus 로고    scopus 로고
    • Baldness and the androgen receptor: The AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia
    • Ellis J.A., Scurrah K.J., Cobb J.E., et al. Baldness and the androgen receptor: The AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia. Hum Genet 2007, 121:451-457.
    • (2007) Hum Genet , vol.121 , pp. 451-457
    • Ellis, J.A.1    Scurrah, K.J.2    Cobb, J.E.3
  • 34
    • 55049136418 scopus 로고    scopus 로고
    • Susceptibility variants for male-pattern baldness on chromosome 20p11
    • Hillmer A.M., Brockschmidt F.F., Hanneken S., et al. Susceptibility variants for male-pattern baldness on chromosome 20p11. Nat Genet 2008, 40:1279-1281.
    • (2008) Nat Genet , vol.40 , pp. 1279-1281
    • Hillmer, A.M.1    Brockschmidt, F.F.2    Hanneken, S.3
  • 35
    • 41149165727 scopus 로고    scopus 로고
    • Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    • Hillmer A.M., Flaquer A., Hanneken S., et al. Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. Am J Hum Genet 2008, 82:737-743.
    • (2008) Am J Hum Genet , vol.82 , pp. 737-743
    • Hillmer, A.M.1    Flaquer, A.2    Hanneken, S.3
  • 36
    • 49549107108 scopus 로고    scopus 로고
    • EDA2R is associated with androgenetic alopecia
    • Prodi D.A., Pirastu N., Maninchedda G., et al. EDA2R is associated with androgenetic alopecia. J Invest Dermatol 2008, 128:2268-2270.
    • (2008) J Invest Dermatol , vol.128 , pp. 2268-2270
    • Prodi, D.A.1    Pirastu, N.2    Maninchedda, G.3
  • 37
    • 55049091451 scopus 로고    scopus 로고
    • Male-pattern baldness susceptibility locus at 20p11
    • Richards J.B., Yuan X., Geller F., et al. Male-pattern baldness susceptibility locus at 20p11. Nat Genet 2008, 40:1282-1284.
    • (2008) Nat Genet , vol.40 , pp. 1282-1284
    • Richards, J.B.1    Yuan, X.2    Geller, F.3
  • 38
    • 64549126059 scopus 로고    scopus 로고
    • Androgen receptor copy number variation and androgenetic alopecia: A case-control study
    • Cobb J.E., White S.J., Harrap S.B., et al. Androgen receptor copy number variation and androgenetic alopecia: A case-control study. PLoS One 2009, 4:e5081.
    • (2009) PLoS One , vol.4
    • Cobb, J.E.1    White, S.J.2    Harrap, S.B.3
  • 39
    • 77958527521 scopus 로고    scopus 로고
    • Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene
    • Cobb J.E., Zaloumis S.G., Scurrah K.J., et al. Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene. Exp Dermatol 2010, 19:1026-1028.
    • (2010) Exp Dermatol , vol.19 , pp. 1026-1028
    • Cobb, J.E.1    Zaloumis, S.G.2    Scurrah, K.J.3
  • 40
    • 0029744893 scopus 로고    scopus 로고
    • C-Jun can mediate androgen receptor-induced transactivation
    • Bubulya A., Wise S.C., Shen X.Q., et al. C-Jun can mediate androgen receptor-induced transactivation. J Biol Chem 1996, 271:24583-24589.
    • (1996) J Biol Chem , vol.271 , pp. 24583-24589
    • Bubulya, A.1    Wise, S.C.2    Shen, X.Q.3
  • 41
    • 82255164070 scopus 로고    scopus 로고
    • Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness
    • Brockschmidt F.F., Heilmann S., Ellis J.A., et al. Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness. Br J Dermatol 2011, 165:1293-1302.
    • (2011) Br J Dermatol , vol.165 , pp. 1293-1302
    • Brockschmidt, F.F.1    Heilmann, S.2    Ellis, J.A.3
  • 42
    • 66849124705 scopus 로고    scopus 로고
    • Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia
    • el-Samahy M.H., Shaheen M.A., Saddik D.E., et al. Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia. Int J Dermatol 2009, 48:584-587.
    • (2009) Int J Dermatol , vol.48 , pp. 584-587
    • el-Samahy, M.H.1    Shaheen, M.A.2    Saddik, D.E.3
  • 43
    • 79952367399 scopus 로고    scopus 로고
    • Physiological changes in scalp, facial and body hair after the menopause: A cross-sectional population-based study of subjective changes
    • Ali I., Wojnarowska F. Physiological changes in scalp, facial and body hair after the menopause: A cross-sectional population-based study of subjective changes. Br J Dermatol 2011, 164:508-513.
    • (2011) Br J Dermatol , vol.164 , pp. 508-513
    • Ali, I.1    Wojnarowska, F.2
  • 44
    • 33947220392 scopus 로고    scopus 로고
    • Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    • Haiman C.A., Dossus L., Setiawan V.W., et al. Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res 2007, 67:1893-1897.
    • (2007) Cancer Res , vol.67 , pp. 1893-1897
    • Haiman, C.A.1    Dossus, L.2    Setiawan, V.W.3
  • 45
    • 84860317363 scopus 로고    scopus 로고
    • Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss
    • Yip L., Zaloumis S., Irwin D., et al. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Br J Dermatol 2012, 166:1131-1134.
    • (2012) Br J Dermatol , vol.166 , pp. 1131-1134
    • Yip, L.1    Zaloumis, S.2    Irwin, D.3
  • 46
    • 0042634152 scopus 로고    scopus 로고
    • The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia
    • Tang L., Bernardo O., Bolduc C., et al. The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia. J Am Acad Dermatol 2003, 49:229-233.
    • (2003) J Am Acad Dermatol , vol.49 , pp. 229-233
    • Tang, L.1    Bernardo, O.2    Bolduc, C.3
  • 47
    • 33644877462 scopus 로고    scopus 로고
    • Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism
    • Wakisaka N., Taira Y., Ishikawa M., et al. Effectiveness of finasteride on patients with male pattern baldness who have different androgen receptor gene polymorphism. J Investig Dermatol Symp Proc 2005, 10:293-294.
    • (2005) J Investig Dermatol Symp Proc , vol.10 , pp. 293-294
    • Wakisaka, N.1    Taira, Y.2    Ishikawa, M.3
  • 48
    • 79952764866 scopus 로고    scopus 로고
    • Correlation between polymorphic CAG-repeats in the androgen receptor gene and therapeutic efficacy of finasteride in androgenetic alopecia
    • Sato A., Arima Y., Kojima Y., et al. Correlation between polymorphic CAG-repeats in the androgen receptor gene and therapeutic efficacy of finasteride in androgenetic alopecia. Skin Surg 2008, 17:80-86.
    • (2008) Skin Surg , vol.17 , pp. 80-86
    • Sato, A.1    Arima, Y.2    Kojima, Y.3
  • 49
    • 79959449602 scopus 로고    scopus 로고
    • Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients
    • Yamazaki M., Sato A., Toyoshima K.E., et al. Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients. J Dermatol 2011, 38:680-684.
    • (2011) J Dermatol , vol.38 , pp. 680-684
    • Yamazaki, M.1    Sato, A.2    Toyoshima, K.E.3
  • 50
    • 79952762129 scopus 로고    scopus 로고
    • Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics
    • Keene S., Goren A. Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics. Dermatol Ther 2011, 24:296-300.
    • (2011) Dermatol Ther , vol.24 , pp. 296-300
    • Keene, S.1    Goren, A.2
  • 51
    • 47749122543 scopus 로고    scopus 로고
    • Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss)
    • Kaufman K.D., Rotonda J., Shah A.K., et al. Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss). Eur J Dermatol 2008, 18:400-406.
    • (2008) Eur J Dermatol , vol.18 , pp. 400-406
    • Kaufman, K.D.1    Rotonda, J.2    Shah, A.K.3
  • 52
    • 84871048276 scopus 로고    scopus 로고
    • Accessed July 17, 2012
    • HairDx Accessed July 17, 2012. http://www.hairdx.com.
    • HairDx
  • 53
    • 34447288951 scopus 로고    scopus 로고
    • Alopecia in the United States: Outpatient utilization and common prescribing patterns
    • McMichael A.J., Pearce D.J., Wasserman D., et al. Alopecia in the United States: Outpatient utilization and common prescribing patterns. J Am Acad Dermatol 2007, 57(Suppl 2):S49-S51.
    • (2007) J Am Acad Dermatol , vol.57 , Issue.SUPPL. 2
    • McMichael, A.J.1    Pearce, D.J.2    Wasserman, D.3
  • 54
    • 0026664103 scopus 로고
    • Prevalence of alopecia areata in the first national health and nutrition examination survey
    • Safavi K. Prevalence of alopecia areata in the first national health and nutrition examination survey. Arch Dermatol 1992, 128:702.
    • (1992) Arch Dermatol , vol.128 , pp. 702
    • Safavi, K.1
  • 55
    • 79959566807 scopus 로고    scopus 로고
    • Alopecia areata: Clinical presentation, diagnosis, and unusual cases
    • Finner A.M. Alopecia areata: Clinical presentation, diagnosis, and unusual cases. Dermatol Ther 2011, 24:348-354.
    • (2011) Dermatol Ther , vol.24 , pp. 348-354
    • Finner, A.M.1
  • 56
    • 69949124773 scopus 로고    scopus 로고
    • History of atopy or autoimmunity increases risk of alopecia areata
    • National Alopecia Areata Registry
    • Barahmani N., Schabath M.B., Duvic M., et al. History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol 2009, 61:581-591. National Alopecia Areata Registry.
    • (2009) J Am Acad Dermatol , vol.61 , pp. 581-591
    • Barahmani, N.1    Schabath, M.B.2    Duvic, M.3
  • 57
    • 80054100770 scopus 로고    scopus 로고
    • Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study
    • Chu S.Y., Chen Y.J., Tseng W.C., et al. Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study. J Am Acad Dermatol 2011, 65:949-956.
    • (2011) J Am Acad Dermatol , vol.65 , pp. 949-956
    • Chu, S.Y.1    Chen, Y.J.2    Tseng, W.C.3
  • 58
    • 34547687736 scopus 로고    scopus 로고
    • Lymphocytes, neuropeptides, and genes involved in alopecia areata
    • Gilhar A., Paus R., Kalish R.S. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2007, 117:2019-2027.
    • (2007) J Clin Invest , vol.117 , pp. 2019-2027
    • Gilhar, A.1    Paus, R.2    Kalish, R.S.3
  • 60
    • 84861366665 scopus 로고    scopus 로고
    • Treatment options for alopecia: An update, looking to the future
    • Miteva M., Tosti A. Treatment options for alopecia: An update, looking to the future. Expert Opin Pharmacother 2012, 13:1271-1281.
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 1271-1281
    • Miteva, M.1    Tosti, A.2
  • 62
    • 0027704964 scopus 로고
    • Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?
    • Paus R., Slominski A., Czarnetzki B.M. Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?. Yale J Biol Med 1993, 66:541-554.
    • (1993) Yale J Biol Med , vol.66 , pp. 541-554
    • Paus, R.1    Slominski, A.2    Czarnetzki, B.M.3
  • 63
    • 1542379709 scopus 로고    scopus 로고
    • Collapse and restoration of MHC class-I-dependent immune privilege: Exploiting the human hair follicle as a model
    • Ito T., Ito N., Bettermann A., et al. Collapse and restoration of MHC class-I-dependent immune privilege: Exploiting the human hair follicle as a model. Am J Pathol 2004, 164:623-634.
    • (2004) Am J Pathol , vol.164 , pp. 623-634
    • Ito, T.1    Ito, N.2    Bettermann, A.3
  • 64
    • 34248508667 scopus 로고    scopus 로고
    • Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata)
    • Siebenhaar F., Sharov A.A., Peters E.M., et al. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol 2007, 127:1489-1497.
    • (2007) J Invest Dermatol , vol.127 , pp. 1489-1497
    • Siebenhaar, F.1    Sharov, A.A.2    Peters, E.M.3
  • 65
    • 42149108570 scopus 로고    scopus 로고
    • Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack
    • Ito T., Ito N., Saatoff M., et al. Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol 2008, 128:1196-1206.
    • (2008) J Invest Dermatol , vol.128 , pp. 1196-1206
    • Ito, T.1    Ito, N.2    Saatoff, M.3
  • 66
    • 0036288663 scopus 로고    scopus 로고
    • Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: Transfer to human scalp explants on Prkdc(scid) mice
    • Gilhar A., Landau M., Assy B., et al. Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: Transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 2002, 138:916-922.
    • (2002) Arch Dermatol , vol.138 , pp. 916-922
    • Gilhar, A.1    Landau, M.2    Assy, B.3
  • 67
    • 0031974909 scopus 로고    scopus 로고
    • Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice
    • Gilhar A., Ullmann Y., Berkutzki T., et al. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 1998, 101:62-67.
    • (1998) J Clin Invest , vol.101 , pp. 62-67
    • Gilhar, A.1    Ullmann, Y.2    Berkutzki, T.3
  • 68
    • 18244400239 scopus 로고    scopus 로고
    • Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model
    • McElwee K.J., Freyschmidt-Paul P., Hoffmann R., et al. Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 2005, 124:947-957.
    • (2005) J Invest Dermatol , vol.124 , pp. 947-957
    • McElwee, K.J.1    Freyschmidt-Paul, P.2    Hoffmann, R.3
  • 69
    • 0030003391 scopus 로고    scopus 로고
    • In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata
    • McElwee K.J., Spiers E.M., Oliver R.F. In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata. Br J Dermatol 1996, 135:211-217.
    • (1996) Br J Dermatol , vol.135 , pp. 211-217
    • McElwee, K.J.1    Spiers, E.M.2    Oliver, R.F.3
  • 70
    • 77954223152 scopus 로고    scopus 로고
    • Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    • Petukhova L., Duvic M., Hordinsky M., et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010, 466:113-117.
    • (2010) Nature , vol.466 , pp. 113-117
    • Petukhova, L.1    Duvic, M.2    Hordinsky, M.3
  • 71
    • 0036214286 scopus 로고    scopus 로고
    • Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination
    • Natarajan K., Dimasi N., Wang J., et al. Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination. Annu Rev Immunol 2002, 20:853-885.
    • (2002) Annu Rev Immunol , vol.20 , pp. 853-885
    • Natarajan, K.1    Dimasi, N.2    Wang, J.3
  • 72
    • 0036634504 scopus 로고    scopus 로고
    • Epidemiology and genetics of alopecia areata
    • McDonagh A.J., Tazi-Ahnini R. Epidemiology and genetics of alopecia areata. Clin Exp Dermatol 2002, 27:405-409.
    • (2002) Clin Exp Dermatol , vol.27 , pp. 405-409
    • McDonagh, A.J.1    Tazi-Ahnini, R.2
  • 73
    • 0031952818 scopus 로고    scopus 로고
    • Alopecia areata and cytomegalovirus infection in twins: Genes versus environment?
    • Jackow C., Puffer N., Hordinsky M., et al. Alopecia areata and cytomegalovirus infection in twins: Genes versus environment?. J Am Acad Dermatol 1998, 38:418-425.
    • (1998) J Am Acad Dermatol , vol.38 , pp. 418-425
    • Jackow, C.1    Puffer, N.2    Hordinsky, M.3
  • 74
    • 3242728308 scopus 로고    scopus 로고
    • Adult-onset alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    • Sundberg J.P., Silva K.A., Li R., et al. Adult-onset alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model. J Invest Dermatol 2004, 123:294-297.
    • (2004) J Invest Dermatol , vol.123 , pp. 294-297
    • Sundberg, J.P.1    Silva, K.A.2    Li, R.3
  • 75
    • 33748894922 scopus 로고    scopus 로고
    • Profile of 513 patients with alopecia areata: Associations of disease subtypes with atopy, autoimmune disease and positive family history
    • Goh C., Finkel M., Christos P.J., et al. Profile of 513 patients with alopecia areata: Associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol 2006, 20:1055-1060.
    • (2006) J Eur Acad Dermatol Venereol , vol.20 , pp. 1055-1060
    • Goh, C.1    Finkel, M.2    Christos, P.J.3
  • 76
    • 0028879967 scopus 로고
    • HLA class II antigen associations help to define two types of alopecia areata
    • Colombe B.W., Price V.H., Khoury E.L., et al. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol 1995, 33:757-764.
    • (1995) J Am Acad Dermatol , vol.33 , pp. 757-764
    • Colombe, B.W.1    Price, V.H.2    Khoury, E.L.3
  • 77
    • 33846623330 scopus 로고    scopus 로고
    • Genome-wide scan for linkage reveals evidence of several susceptibility loci for alopecia areata
    • Martinez-Mir A., Zlotogorski A., Gordon D., et al. Genome-wide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet 2007, 80:316-328.
    • (2007) Am J Hum Genet , vol.80 , pp. 316-328
    • Martinez-Mir, A.1    Zlotogorski, A.2    Gordon, D.3
  • 78
    • 67650709487 scopus 로고    scopus 로고
    • Recent advances in the genetics of autoimmune disease
    • Gregersen P.K., Olsson L.M. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol 2009, 27:363-391.
    • (2009) Annu Rev Immunol , vol.27 , pp. 363-391
    • Gregersen, P.K.1    Olsson, L.M.2
  • 79
    • 57749193136 scopus 로고    scopus 로고
    • Detecting shared pathogenesis from the shared genetics of immune-related diseases
    • Zhernakova A., van Diemen C.C., Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet 2009, 10:43-55.
    • (2009) Nat Rev Genet , vol.10 , pp. 43-55
    • Zhernakova, A.1    van Diemen, C.C.2    Wijmenga, C.3
  • 80
    • 79952738436 scopus 로고    scopus 로고
    • Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris
    • Muto M., Deguchi H., Tanaka A., et al. Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris. J Dermatol Sci 2011, 62:70-71.
    • (2011) J Dermatol Sci , vol.62 , pp. 70-71
    • Muto, M.1    Deguchi, H.2    Tanaka, A.3
  • 81
    • 77953644844 scopus 로고    scopus 로고
    • 8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder
    • Singh T.P., Schön M.P., Wallbrecht K., et al. 8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder. J Immunol 2010, 184:7257-7267.
    • (2010) J Immunol , vol.184 , pp. 7257-7267
    • Singh, T.P.1    Schön, M.P.2    Wallbrecht, K.3
  • 82
    • 84857169655 scopus 로고    scopus 로고
    • Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata
    • Forstbauer L.M., Brockschmidt F.F., Moskvina V., et al. Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata. Eur J Hum Genet 2012, 20:326-332.
    • (2012) Eur J Hum Genet , vol.20 , pp. 326-332
    • Forstbauer, L.M.1    Brockschmidt, F.F.2    Moskvina, V.3
  • 83
    • 84865314385 scopus 로고    scopus 로고
    • Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance
    • Jagielska D., Redler S., Brockschmidt F.F., et al. Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance. J Invest Dermatol 2012, 132:2192-2197.
    • (2012) J Invest Dermatol , vol.132 , pp. 2192-2197
    • Jagielska, D.1    Redler, S.2    Brockschmidt, F.F.3
  • 84
    • 77649224716 scopus 로고    scopus 로고
    • Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease
    • Beghé B., Hall I.P., Parker S.G., et al. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 2010, 65:474-481.
    • (2010) Allergy , vol.65 , pp. 474-481
    • Beghé, B.1    Hall, I.P.2    Parker, S.G.3
  • 85
    • 77952312683 scopus 로고    scopus 로고
    • Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma
    • Bottema R.W., Nolte I.M., Howard T.D., et al. Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma. Int Arch Allergy Immunol 2010, 153:259-267.
    • (2010) Int Arch Allergy Immunol , vol.153 , pp. 259-267
    • Bottema, R.W.1    Nolte, I.M.2    Howard, T.D.3
  • 86
    • 79955846991 scopus 로고    scopus 로고
    • Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris
    • Bowes J., Eyre S., Flynn E., et al. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Ann Rheum Dis 2011, 70:1016-1019.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1016-1019
    • Bowes, J.1    Eyre, S.2    Flynn, E.3
  • 87
    • 73449129721 scopus 로고    scopus 로고
    • Chromosomal region 16p13: Further evidence of increased predisposition to immune diseases
    • Martínez A., Perdigones N., Cénit M.C., et al. Chromosomal region 16p13: Further evidence of increased predisposition to immune diseases. Ann Rheum Dis 2010, 69:309-311.
    • (2010) Ann Rheum Dis , vol.69 , pp. 309-311
    • Martínez, A.1    Perdigones, N.2    Cénit, M.C.3
  • 88
    • 79954567814 scopus 로고    scopus 로고
    • More CLEC16A gene variants associated with multiple sclerosis
    • Nischwitz S., Cepok S., Kroner A., et al. More CLEC16A gene variants associated with multiple sclerosis. Acta Neurol Scand 2011, 123:400-406.
    • (2011) Acta Neurol Scand , vol.123 , pp. 400-406
    • Nischwitz, S.1    Cepok, S.2    Kroner, A.3
  • 89
    • 59149093799 scopus 로고    scopus 로고
    • Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia
    • Zoledziewska M., Costa G., Pitzalis M., et al. Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes Immun 2009, 10:15-17.
    • (2009) Genes Immun , vol.10 , pp. 15-17
    • Zoledziewska, M.1    Costa, G.2    Pitzalis, M.3
  • 90
    • 26444507067 scopus 로고    scopus 로고
    • Profiling of alopecia areata autoantigens based on protein microarray technology
    • Lueking A., Huber O., Wirths C., et al. Profiling of alopecia areata autoantigens based on protein microarray technology. Mol Cell Proteomics 2005, 4:1382-1390.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1382-1390
    • Lueking, A.1    Huber, O.2    Wirths, C.3
  • 91
    • 77955716421 scopus 로고    scopus 로고
    • Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures
    • Subramanya R.D., Coda A.B., Sinha A.A. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures. Genomics 2010, 96:146-153.
    • (2010) Genomics , vol.96 , pp. 146-153
    • Subramanya, R.D.1    Coda, A.B.2    Sinha, A.A.3
  • 92
    • 77958154635 scopus 로고    scopus 로고
    • Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity
    • Coda A.B., Qafalijaj Hysa V., Seiffert-Sinha K., et al. Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity. Genes Immun 2010, 11:531-541.
    • (2010) Genes Immun , vol.11 , pp. 531-541
    • Coda, A.B.1    Qafalijaj Hysa, V.2    Seiffert-Sinha, K.3
  • 93
    • 81955164769 scopus 로고    scopus 로고
    • Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in alopecia areata
    • Coda A.B., Sinha A.A. Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in alopecia areata. Genomics 2011, 98:431-439.
    • (2011) Genomics , vol.98 , pp. 431-439
    • Coda, A.B.1    Sinha, A.A.2
  • 94
    • 79954678367 scopus 로고    scopus 로고
    • Genetic variants in CTLA4 are strongly associated with alopecia areata
    • John K.K., Brockschmidt F.F., Redler S., et al. Genetic variants in CTLA4 are strongly associated with alopecia areata. J Invest Dermatol 2011, 131:1169-1172.
    • (2011) J Invest Dermatol , vol.131 , pp. 1169-1172
    • John, K.K.1    Brockschmidt, F.F.2    Redler, S.3
  • 96
    • 0036038262 scopus 로고    scopus 로고
    • Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans
    • Carroll J.M., McElwee K.J., E King L., et al. Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 2002, 119:392-402.
    • (2002) J Invest Dermatol , vol.119 , pp. 392-402
    • Carroll, J.M.1    McElwee, K.J.2    E King, L.3


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