Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients

Journal of Dermatology

Volumn 38, Issue 7, 2011, Pages 680-684

  Yamazaki, Masashi ^a   Sato, Akio ^b   Toyoshima, Koh Ei ^c   Kojima, Yuha ^c   Okada, Taro ^c   Ishii, Yoshinori ^d   Kurata, Sotaro ^e   Yoshizato, Katsutoshi ^c   Tsuboi, Ryoji ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b Tokyo Memorial Clinic   (Japan)

^c PhoenixBio USA Corporation   (Japan)

^d Omiya Skin Clinic   (Japan)

^e Kurata Clinic   (Japan)

Author keywords

androgen receptor; androgenetic alopecia; CAG repeats; female pattern hair loss; finasteride; X chromosome inactivation

Indexed keywords

ANDROGEN RECEPTOR; FINASTERIDE;

ADULT; AGED; ARTICLE; CAG REPEAT; CLINICAL ARTICLE; DRUG EFFICACY; FEMALE; FEMALE PATTERN HAIR LOSS; GENETIC ANALYSIS; HAIR LOSS; HUMAN; JAPANESE; X CHROMOSOME;

5-ALPHA REDUCTASE INHIBITORS; ADULT; AGED; ALOPECIA; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CHROMOSOMES, HUMAN, X; DNA PRIMERS; FEMALE; FINASTERIDE; HUMANS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; RECEPTORS, ANDROGEN; TREATMENT OUTCOME; TRINUCLEOTIDE REPEATS;

EID: 79959449602     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2010.01060.x     Document Type: Article

References (25)

1. Norwood OT,. Male pattern baldness: Classification and incidence. South Med J 1975; 68: 1359-1365.
2. Imperato-McGinley J, Guerrero L, Gautlier T, Peterson RE,. Steroid 5 α-reductase deficiency in men: an inherited form of male pseudohermaphroditism. Science 1974; 186: 1213-1215.
3. Drake L, Hardinsky M, Fiedler V, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenic alopecia. J Am Acad Dermatol 1999; 41: 550-554. (Pubitemid 29480402)
4. Price VH, Menefee E, Sanchez M, et al. Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. J Am Acad Dermatol 2002; 46: 517-523.
5. Zitzmann M, Nieschlag E,. The CAG repeat polymorphism within the androgen receptor gene and maleness. Int J Androl 2003; 26: 76-83. (Pubitemid 36408236)
6. Biancalana V, Serville F, Pommier J, et al. Moderate instability of the trinucleotide repeat in spino bulbar muscular atrophy. Hum Mol Genet 1992; 1: 255-258.
7. Hardy DO, Scher HI, Bogenreider T, et al. Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab 1996; 81: 4400-4405. (Pubitemid 26412051)
8. Stanford JL, Just JJ, Gibbs M, et al. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res 1997; 15: 57.
9. Suter NM, Malone KE, Daling JR, et al. Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women. Cancer Epidemiol Biomarkers Prev 2003; 12: 127-135. (Pubitemid 36194002)
10. Ellis JA, Stebbing M, Harrap SB,. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 2001; 116: 452-455. (Pubitemid 32202911)
11. Sawaya ME, Shalita AR,. Androgen receptor polymorphisms (CAG repeat lengths) in androgenic alopecia, hirsutism, and acne. J Cutan Med Surg 1998; 3: 1-9.
12. Sato A, Arima Y, Kojima Y, et al. Correlation between polymorphic CAG-repeats in the androgen-receptor gene and therapeutic efficiency of finasteride in androgenic alopecia. Skin Surgery 2008; 17: 80-86. (in Japanese)
13. Olsen EA,. Current and novel methods for assessing efficacy of hair growth promoters in pattern hair loss. J Am Acad Dermatol 2003; 48: 253-262. (Pubitemid 36232325)
14. Birch MP, Lalla SC, Messenger AG,. Female pattern hair loss. Clin Exp Dermatol 2002; 27: 383-388.
15. Ohnemus U, Uenalan M, Inzunza J, et al. The hair follicle as an estrogen target and source. Endocr Rev 2006; 27: 677-706. (Pubitemid 44592463)
16. Yip L, Zaloumis S, Irwin D, et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol 2009; 161: 298-294.
17. Ludwig E,. Classification of the types of androgenic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977; 97: 257-254.
18. Kaufman KD, Olsen EA, Whiting D, et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. Am Acad Dermatol 1998; 39: 578-589. (Pubitemid 28465881)
19. Gale RE, Wheadon H, Boulos P, Linch DC,. Tissue specificity of X-chromosome inactivation patterns. Blood 1994; 83: 2899-2905. (Pubitemid 24142722)
20. Platz EA, Rimm EB, Willett WC, et al. Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals. J Natl Cancer Inst 2000; 20: 92. 2009-17.
21. Sasaki M, Kaneuchi M, Sakuragi N, et al. The polyglycine and polyglutamine repeats in the androgen receptor gene in Japanese and Caucasian populations. Biochem Biophys Res Commun 2003; 312: 1244-1247. (Pubitemid 37490950)
22. The guideline committee for the treatment of androgenetic alopecia. Guidelines for the treatment of androgenetic alopecia (2010). Jpn J Dermatol 2010; 120: 977-986. (in Japanese)
23. Wiegratz I, Kuhl H,. Managing cutaneous manifestations of hyperandrogenic disorders: the role of oral contraceptives. Treat Endocrinol 2002; 1: 372-386.
24. Lappalainen S, Utriainen P, Kuulasmaa T, et al. Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche. L Clin Endocrinl Metab 2008; 93: 1304-1309. (Pubitemid 351519725)
25. Sun BK, Tsao H,. X-chromosome inactivation and skin disease. J Invest Dermatol 2008; 128: 2753-2759.