EDA2R is associated with androgenetic alopecia

Journal of Investigative Dermatology

Volumn 128, Issue 9, 2008, Pages 2268-2270

  Prodi, Dionigio Antonio ^a   Pirastu, Nicola ^a,b   Maninchedda, Giuseppe ^a   Sassu, Alessandro ^a   Picciau, Andrea ^a   Palmas, Maria Antonietta ^a   Mossa, Alessandra ^a   Persico, Ivana ^a   Adamo, Mauro ^a   Angius, Andrea ^a,c   Pirastu, Mario ^a,c,d  

^a Shardna Life Sciences   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c CNR   (Italy)

^d Localit Piscinamanna   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ARTICLE; CHROMOSOME XQ; DNA MICROARRAY; EDA2R GENE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HEALTH SURVEY; HUMAN; MALE TYPE ALOPECIA; PRIORITY JOURNAL; X CHROMOSOME;

EID: 49549107108     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.60     Document Type: Article

References (21)

1. Angius A, Melis PM, Morelli L, Petretto E, Casu G, Maestrale GB et al. (2001) Archival, demographic and genetic studies define a Sardinian sub-isolate as a suitable model for mapping complex traits. Hum Genet 109:198-209
2. Botchkarev VA, Fessing MY (2005) Edar signaling in the control of hair follicle development. J Investig Dermatol Symp Proc 10:247-51
3. Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K et al. (2003) Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet 73:612-26
4. Bubulya A, Wise SC, Shen XQ, Burmeister LA, Shemshedini L (1996) c-Jun can mediate androgen receptor-induced transactivation. J Biol Chem 271:24583-9
5. Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-21
6. Ellis JA, Scurrah KJ, Cobb JE, Zaloumis SG, Duncan AE, Harrap SB (2007) Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia. Hum Genet 121:451-7
7. Ellis JA, Stebbing M, Harrap SB (1998) Genetic analysis of male pattern baldness and the 5a-reductase genes. J Invest Dermatol 110:849-53
8. Ellis JA, Stebbing M, Harrap SB (2001) Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol 116:452-5
9. Falchi M, Forabosco P, Mocci E, Borlino CC, Picciau A, Virdis E et al. (2004) A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia. Am J Hum Genet 75:1015-31
10. Fraumene C, Petretto E, Angius A, Pirastu M (2003) Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis. Hum Genet 114:1-10
11. Hamilton JB (1951) Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 53:708-28
12. Hayes VM, Severi G, Eggleton SA, Padilla EJ, Southey MC, Sutherland RL et al. (2005) The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia. Cancer Epidemiol Biomarkers Prev 14:993-6
13. Hillmer AM, Hanneken S, Ritzmann S, Becker T, Freudenberg J, Brockschmidt FF et al. (2005) Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet 77:140-8
14. Kuster W, Happle R (1984) The inheritance of baldness: two B or not two B? J Am Acad Dermatol 11:921-6
15. La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352:77-9
16. Levy-Nissenbaum E, Bar-Natan M, Frydman M, Pras E (2005) Confirmation of the association between male pattern baldness and the androgen receptor gene. Eur J Dermatol 15:339-40
17. Monreal AW, Ferguson BM, Headon DJ, Street SL, Overbeek PA, Zonana J (1999) Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Nat Genet 22:366-9
18. Naito A, Yoshida H, Nishioka E, Satoh M, Azuma S, Yamamoto T et al. (2002) TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci USA 99:8766-71
19. Newton K, French DM, Yan M, Frantz GD, Dixit VM (2004) Myodegeneration in EDA-A2 transgenic mice is prevented by EDA2R deficiency. Mol Cell Biol 24:1608-13
20. Sinha SK, Zachariah S, Quinones HI, Shindo M, Chaudhary PM (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem 277:44953-61
21. Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A et al. (2000) Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290:523-7