Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris

Annals of the Rheumatic Diseases

Volumn 70, Issue 6, 2011, Pages 1016-1019

  Bowes, John ^a   Eyre, Steve ^a   Flynn, Edward ^a   Ho, Pauline ^a,b   Salah, Salma ^a   Warren, Richard B ^a   Marzo Ortega, Helena ^c   Coates, Laura ^c   McManus, Ross ^d   Ryan, Anthony W ^d   Kane, David ^e   Korendowych, Eleanor ^f,g   McHugh, Neil ^f,g   FitzGerald, Oliver ^h,i   Packham, Jonathan ^j,k   Morgan, Ann W ^c   Griffiths, Christopher E M ^a   Bruce, Ian N ^a,b   Worthington, Jane ^a   Barton, Anne ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e ADELAIDE AND MEATH HOSPITAL   (Ireland)

^f ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES   (United Kingdom)

^g University of Bath   (United Kingdom)

^h ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

ⁱ UNIVERSITY COLLEGE DUBLIN   (Ireland)

^j HAYWOOD HOSPITAL   (United Kingdom)

^k KEELE UNIVERSITY   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; IL 13 GENE; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS VULGARIS; PSORIATIC ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGE OF ONSET; ARTHRITIS, PSORIATIC; CASE-CONTROL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-13; POLYMORPHISM, SINGLE NUCLEOTIDE; PSORIASIS; RHEUMATOID FACTOR;

EID: 79955846991     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.143123     Document Type: Article

References (21)

1. Gladman DD, Antoni C, Mease P, et al. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 2005; 64 (Suppl 2):ii14-17. (Pubitemid 40288513) (Pubitemid 40288513)
2. Chandran V, Schentag CT, Brockbank JE, et al. Familial aggregation of psoriatic arthritis. Ann Rheum Dis 2009 ; 68 : 664-7.
3. Moll J M, Wright V. Familial occurrence of psoriatic arthritis. Ann Rheum Dis 1973 ; 32 : 181-201.
4. Myers A, Kay LJ, Lynch SA, et al. Recurrence risk for psoriasis and psoriatic arthritis within sibships. Rheumatology (Oxford) 2005 ; 44 : 773-6. (Pubitemid 41487208) (Pubitemid 41487208)
5. Pedersen O B, Svendsen AJ, Ejstrup L, et al. On the heritability of psoriatic arthritis. Disease concordance among monozygotic and dizygotic twins. Ann Rheum Dis 2008 ; 67 : 1417-21.
6. Ho P Y, Barton A, Worthington J, et al. Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Ann Rheum Dis 2008 ; 67 : 677-82. (Pubitemid 351571933) (Pubitemid 351571933)
7. Filer C, Ho P, Smith RL, et al. Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Arthritis Rheum 2008 ; 58 : 3705-9.
8. Hüffmeier U, Estivill X, Riveira-Munoz E, et al. Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients. Ann Rheum Dis 2010 ; 69 : 876-8.
9. Bowes J, Flynn E, Ho P, et al. Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. Ann Rheum Dis 2010 ; 69 : 2199-203.
10. Chang M, Li Y, Yan C, et al. Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun 2008 ; 9 : 176-81. (Pubitemid 351351659) (Pubitemid 351351659)
11. Nair RP, Duffin KC, Helms C, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009 ; 41 : 199-204.
12. Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007 ; 39 : 830-2. (Pubitemid 47014496) (Pubitemid 47014496)
13. Heinzmann A, Mao XQ, Akaiwa M, et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 2000 ; 9 : 549-59. (Pubitemid 30154013) (Pubitemid 30154013)
14. Strange A, Capon F, Spencer CC, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010 ; 42 : 985-90.
15. Duffin KC, Freeny IC, Schrodi SJ, et al. Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. J Invest Dermatol 2009 ; 129 : 2777-83.
16. Chang YT, Chou CT, Yu CW, et al. Cytokine gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol 2007 ; 156 : 899-905. (Pubitemid 46642859) (Pubitemid 46642859)
17. Ho P, Bruce IN, Silman A, et al. Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Arthritis Rheum 2005; 52 : 3596-602. (Pubitemid 41612229) (Pubitemid 41612229)
18. Al-Heresh AM, Proctor J, Jones SM, et al. Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. Rheumatology (Oxford) 2002 ; 41 : 525-30. (Pubitemid 34567182) (Pubitemid 34567182)
19. Balding J, Kane D, Livingstone W, et al. Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. Arthritis Rheum 2003 ; 48 : 1408-13. (Pubitemid 36554540) (Pubitemid 36554540)
20. Taylor W, Gladman D, Helliwell P, et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 2006 ; 54 : 2665-73. (Pubitemid 44205029) (Pubitemid 44205029)
21. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 2007 ; 81 : 559-75. (Pubitemid 47330214) (Pubitemid 47330214)