Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

Genes and Immunity

Volumn 11, Issue 7, 2010, Pages 531-541

  Coda, A B ^a   Hysa, V Qafalijaj ^a   Seiffert Sinha, K ^a   Sinha, A A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

alopecia; alopecia areata; genetics; microarray; pathogenesis

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELL ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; WNT PROTEIN;

ADULT; AGED; ALOPECIA AREATA; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CYTOTOXICITY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HERITABILITY; HUMAN; IMMUNE RESPONSE; MALE; NATURAL KILLER CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ADULT; AGED; ALOPECIA AREATA; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 77958154635     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2010.32     Document Type: Article

References (65)

1. Safavi K. Prevalence of alopecia areata in the first national health and nutrition examination survey. Arch Dermatol 1992; 128: 702.
2. Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549-566; quiz 567-70.
3. Perret C, Wiesner-Menzel L, Happle R. Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata. Acta Derm Venereol 1984; 64: 26-30.
4. Ranki A, Kianto U, Kanerva L, Tolvanen E, Johansson E. Immunohistochemical and electron microscopic characterization of the cellular infiltrate in alopecia (areata, totalis, and universalis). J Invest Dermatol 1984; 83: 7-11.
5. Brocker EB, Echternacht-Happle K, Hamm H, Happle R. Abnormal expression of class I and class II major histocom-patibility antigens in alopecia areata: modulation by topical immunotherapy. J Invest Dermatol 1987; 88: 564-568.
6. Gupta AK, Ellis CN, Cooper KD, Nickoloff BJ, Ho VC, Chan LS et al. Oral cyclosporine for the treatment of alopecia areata. A clinical and immunohistochemical analysis. J Am Acad Dermatol 1990; 22(2 Part 1): 242-250.
7. McDonagh AJ, Snowden JA, Stierle C, Elliott K, Messenger AG. HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: the role of cytokines. Br J Dermatol 1993; 129: 250-256.
8. McElwee KJ, Tobin DJ, Bystryn JC, King Jr LE, Sundberg JP. Alopecia areata: an autoimmune disease? Exp Dermatol 1999; 8: 371-379.
9. Alexis AF, Dudda-Subramanya R, Sinha AA. Alopecia areata: autoimmune basis of hair loss. Eur J Dermatol 2004; 14: 364-370.
10. Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev 2006; 5: 64-69.
11. Paus R, Ito N, Takigawa M, Ito T. The hair follicle and immune privilege. J Investig Dermatol Symp Proc 2003; 8: 188-194.
12. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(3 Suppl): 483S-512S.
13. Martinez-Mir A, Zlotogorski A, Gordon D, Petukhova L, Mo J, Gilliam TC et al. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet 2007; 80: 316-328.
14. Blaumeiser B, van der Goot I, Fimmers R, Hanneken S, Ritzmann S, Seymons K et al. Familial aggregation of alopecia areata. J Am Acad Dermatol 2006; 54: 627-632.
15. van der Steen P, Traupe H, Happle R, Boezeman J, Strater R, Hamm H. The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol 1992; 72: 373-375.
16. Scerri L, Pace JL. Identical twins with identical alopecia areata. J Am Acad Dermatol 1992; 27(5 Part 1): 766-767.
17. Jackow C, Puffer N, Hordinsky M, Nelson J, Tarrand J, Duvic M. Alopecia areata and cytomegalovirus infection in twins: genes versus environment? J Am Acad Dermatol 1998; 38: 418-425.
18. Hendren OS. Identical alopecia areata in identical twins. Arch Derm Syphilol 1949; 60(5, Part. 1): 793-795.
19. Lenane P, Pope E, Krafchik B. Congenital alopecia areata. J Am Acad Dermatol 2005; 52(2 Suppl 1): 8-11.
20. de Viragh PA, Gianadda B, Levy ML. Congenital alopecia areata. Dermatology 1997; 195: 96-98.
21. Puavilai S, Puavilai G, Charuwichitratana S, Sakuntabhai A, Sriprachya-Anunt S. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol 1994; 33: 632-633.
22. Shellow WV, Edwards JE, Koo JY. Profile of alopecia areata: a questionnaire analysis of patient and family. Int J Dermatol 1992; 31: 186-189.
23. Muller SA, Winkelmann RK. Alopecia areata. An evaluation of 736 patients. Arch Dermatol 1963; 88: 290-297.
24. Kunz M. DNA microarray technology in dermatology. Semin Cutan Med Surg 2008; 27: 16-24.
25. Oertelt S, Selmi C, Invernizzi P, Podda M, Gershwin ME. Genes and goals: an approach to microarray analysis in autoimmunity. Autoimmun Rev 2005; 4: 414-422.
26. Orban T, Kis J, Szereday L, Engelmann P, Farkas K, Jalahej H et al. Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus. J Autoimmun 2007; 28: 177-187. (Pubitemid 46754764)
27. Fossey SC, Vnencak-Jones CL, Olsen NJ, Sriram S, Garrison G, Deng X et al. Identification of molecular biomarkers for multiple sclerosis. J Mol Diagn 2007; 9: 197-204.
28. Dudda-Subramanya R, Coda AB, Sinha AA. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease specific signatures. Genomics (in press).
29. Carroll JM, McElwee KJ, L EK, Byrne MC, Sundberg JP. Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 2002; 119: 392-402.
30. Muller-Rover S, Rossiter H, Lindner G, Peters EM, Kupper TS, Paus R. Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc 1999; 4: 272-277.
31. Deng YJ, Huang ZX, Zhou CJ, Wang JW, You Y, Song ZQ et al. Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus. Mol Immunol 2006; 43: 1497-1507.
32. Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13: 357-368.
33. Benson M, Carlsson L, Guillot G, Jernas M, Langston MA, Rudemo M et al. A network-based analysis of allergen-challenged CD4+ T cells from patients with allergic rhinitis. Genes Immun 2006; 7: 514-521.
34. Imai R, Takamori K, Ogawa H. Changes in populations of HLA-DR+CD3+ cells and CD57\-CD16+ cells in alopecia areata after corticosteroid therapy. Dermatology 1994; 188: 103-107.
35. Imai R, Miura J, Numata K, Takamori K. Increase in natural killer cells in the peripheral blood lymphocytes in patients with alopecia areata]. Nippon Hifuka Gakkai Zasshi 1988; 98: 1505-1507.
36. Ito T, Ito N, Saatoff M, Hashizume H, Fukamizu H, Nickoloff BJ et al. Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol 2008; 128: 1196-1206.
37. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: american college of chest physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008; 133(6 Suppl): 630S-669S.
38. Polakowska RR, Haake AR. Apoptosis: the skin from a new perspective. Cell Death Differ 1994; 1: 19-31.
39. Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev 2001; 81: 449-494.
40. Cantrell DA. GTPases and T cell activation. Immunol Rev 2003; 192: 122-130.
41. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001; 105: 533-545.
42. Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER. Transient activation of beta-catenin signaling in cutaneous keratino-cytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev 2003; 17: 1219-1224.
43. Meyer KC, Klatte JE, Dinh HV, Harries MJ, Reithmayer K, Meyer W et al. Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br J Dermatol 2008; 159: 1077-1085.
44. De Andrade M, Jackow CM, Dahm N, Hordinsky M, Reveille JD, Duvic M. Alopecia areata in families: association with the HLA locus. J Investig Dermatol Symp Proc 1999; 4: 220-223.
45. Rincon M, Flavell RA, Davis RA. The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. Free Radic Biol Med 2000; 28: 1328-1337.
46. Yu H, Leitenberg D, Li B, Flavell RA. Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med 2001; 194: 915-926.
47. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997; 16: 3797-3804.
48. Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE et al. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 2001; 107: 69-82.
49. Plikus MV, Mayer JA, de la Cruz D, Baker RE, Maini PK, Maxson R et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 2008; 451: 340-344.
50. Wang LC, Liu ZY, Gambardella L, Delacour A, Shapiro R, Yang J et al. Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol 2000; 114: 901-908.
51. Yamago G, Takata Y, Furuta I, Urase K, Momoi T, Huh N. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 2001; 293: 435-441.
52. Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK et al. Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol 1999; 205: 1-9.
53. Fathke C, Wilson L, Shah K, Kim B, Hocking A, Moon R et al. Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol 2006; 7: 4.
54. Holers VM, Boackle SA. Complement receptor 2 and autoimmunity. Curr Dir Autoimmun 2004; 7: 33-48.
55. Boackle SA, Holers VM. Role of complement in the development of autoimmunity. Curr Dir Autoimmun 2003; 6: 154-168.
56. Radny P, Bauer J, Caroli UM, Eigentler TK, Kamin A, Metzler G et al. Alopecia areata induced by adjuvant treatment with alpha-interferon in malignant melanoma? Dermatology 2004; 209: 249-250.
57. Kernland KH, Hunziker T. Alopecia areata induced by interferon alpha? Dermatology 1999; 198: 418-419.
58. Kartal ED, Alpat SN, Ozgunes I, Usluer G. Reversible alopecia universalis secondary to PEG-interferon alpha-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection. Eur J Gastroenterol Hepatol 2007; 19: 817-820.
59. Chakrabarti D, Hultgren B, Stewart TA. IFN-alpha induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2. J Immunol 1996; 157: 522-528.
60. Price VH, Willey A, Chen BK. Topical tacrolimus in alopecia areata. J Am Acad Dermatol 2005; 52: 138-139.
61. Feldmann KA, Kunte C, Wollenberg A, Wolfe H. Is topical tacrolimus effective in alopecia areata universalis? Br J Dermatol 2002; 147: 1031-1032.
62. Thiers BH. Topical tacrolimus: treatment failure in a patient with alopecia areata. Arch Dermatol 2000; 136: 124.
63. Park SW, Kim JW, Wang HY. Topical tacrolimus (FK506): treatment failure in four cases of alopecia universalis. Acta Derm Venereol 2002; 82: 387-388.
64. Duvic M, Norris D, Christiano A, Hordinsky M, Price V. Alopecia areata registry: an overview. J Investig Dermatol Symp Proc 2003; 8: 219-221.
65. Olsen E, Hordinsky M, McDonald-Hull S, Price V, Roberts J, Shapiro J et al. Alopecia areata investigational assessment guidelines. National alopecia areata foundation. J Am Acad Dermatol 1999; 40(2 Part 1): 242-246.