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Volumn 32, Issue 2, 2012, Pages 196-205

Trypanosoma cruzi strains resistant to benznidazole occurring in Colombia;Sensibilidad al benzonidazol de cepas de trypanosoma cruzi sugiere la circulación de cepas naturalmente resistentes en Colombia

Author keywords

Chagas disease therapy; immunity; innate; Colombia; Trypanosoma cruzi

Indexed keywords

ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; NITROIMIDAZOLE DERIVATIVE;

EID: 84869839186     PISSN: 01204157     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 84882357587 scopus 로고    scopus 로고
    • Social and medical aspects: Morbidity and mortality in general population
    • En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition London: Elsevier
    • Pinto-Dias J, Schofield C. Social and medical aspects: Morbidity and mortality in general population. En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition. London: Elsevier; 2010. p. 45-54.
    • (2010) , pp. 45-54
    • Pinto-Dias, J.1    Schofield, C.2
  • 2
    • 84882402581 scopus 로고    scopus 로고
    • Geographical distribution of Chagas disease
    • En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition, London: Elsevier
    • Patterson J, Guhl F. Geographical distribution of Chagas disease. En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition. London: Elsevier; 2010. p. 83-114.
    • (2010) , pp. 83-114
    • Patterson, J.1    Guhl, F.2
  • 3
    • 84882423718 scopus 로고    scopus 로고
    • Current trends and future prospects for control of Chagas disease
    • En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition, London: Elsevier
    • Moncayo A, Silveira A. Current trends and future prospects for control of Chagas disease. En: Telleria J, Tibayrenc M, editors. American trypanosomiasis Chagas disease. One hundred years of research. First edition. London: Elsevier; 2010. p. 55-82.
    • (2010) , pp. 55-82
    • Moncayo, A.1    Silveira, A.2
  • 4
    • 0142197130 scopus 로고    scopus 로고
    • Chagas disease: Current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries
    • Moncayo A. Chagas disease: Current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries. Mem Inst Oswaldo Cruz. 2003;98:577-91.
    • (2003) Mem Inst Oswaldo Cruz. , vol.98 , pp. 577-591
    • Moncayo, A.1
  • 5
    • 0030773589 scopus 로고    scopus 로고
    • Quimioterapia de las infecciones producidas por Trypanosoma cruzi
    • López-Antuñano FJ. Quimioterapia de las infecciones producidas por Trypanosoma cruzi. Salud Pública Mex. 1997;39:463-71.
    • (1997) Salud Pública Mex. , vol.39 , pp. 463-471
    • López-Antuñano, F.J.1
  • 6
    • 0036359943 scopus 로고    scopus 로고
    • A critical review on Chagas disease chemotherapy
    • Rodrigues J, Castro S. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz. 2002;97:3-24.
    • (2002) Mem Inst Oswaldo Cruz. , vol.97 , pp. 3-24
    • Rodrigues, J.1    Castro, S.2
  • 7
    • 78751534394 scopus 로고    scopus 로고
    • Trypanocidal drugs: Mechanisms, resistance and new targets
    • Wilkinson SR, Kelly JM. Trypanocidal drugs: Mechanisms, resistance and new targets. Expert Rev Mol Med. 2009;11:1-24.
    • (2009) Expert Rev Mol Med. , vol.11 , pp. 1-24
    • Wilkinson, S.R.1    Kelly, J.M.2
  • 8
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
    • Filardi LS, Brener Z. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Soc Trop Med Hyg. 1987;81:755-9.
    • (1987) Trans R Soc Trop Med Hyg. , vol.81 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 9
    • 0025612231 scopus 로고
    • Molecular mechanisms of drug resistance
    • Hayes JD, Wolf CR. Molecular mechanisms of drug resistance. Biochem J. 1990;272:281-95.
    • (1990) Biochem J. , vol.272 , pp. 281-295
    • Hayes, J.D.1    Wolf, C.R.2
  • 10
    • 0034771312 scopus 로고    scopus 로고
    • Biochemical and molecular mechanisms of drug resistance in parasites
    • Ouellette M. Biochemical and molecular mechanisms of drug resistance in parasites. Trop Med Int Health. 2001;6:874-82.
    • (2001) Trop Med Int Health. , vol.6 , pp. 874-882
    • Ouellette, M.1
  • 11
    • 33745190490 scopus 로고    scopus 로고
    • Drug resistance mechanisms in clinical isolates of Leishmania donovani
    • Singh N. Drug resistance mechanisms in clinical isolates of Leishmania donovani. Indian J Med Res. 2006;123:411-22.
    • (2006) Indian J Med Res. , vol.123 , pp. 411-422
    • Singh, N.1
  • 12
    • 80052559869 scopus 로고    scopus 로고
    • Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to beznidazole in Trypanosoma cruzi
    • Mejía-Jaramillo AM, Fernández GJ, Palacio L, Triana O. Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to beznidazole in Trypanosoma cruzi. Parasit Vectors. 2011;4:1-12.
    • (2011) Parasit Vectors. , vol.4 , pp. 1-12
    • Mejía-Jaramillo, A.M.1    Fernández, G.J.2    Palacio, L.3    Triana, O.4
  • 15
    • 0029610833 scopus 로고
    • Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes
    • Nirdé P, Larroque C, Barnabé C. Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes. C R Acad Sci Ser. 1995;318:1239-44.
    • (1995) C R Acad Sci Ser. , vol.318 , pp. 1239-1244
    • Nirdé, P.1    Larroque, C.2    Barnabé, C.3
  • 17
    • 67349268793 scopus 로고    scopus 로고
    • Characterization of a gene encoding alcohol dehydroge- nase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi
    • Campos FM, Liarte DB, Mortara RA, Romanha AJ, Murta SM. Characterization of a gene encoding alcohol dehydroge- nase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi. Acta Trop. 2009;111:56-63.
    • (2009) Acta Trop. , vol.111 , pp. 56-63
    • Campos, F.M.1    Liarte, D.B.2    Mortara, R.A.3    Romanha, A.J.4    Murta, S.M.5
  • 18
    • 33644826561 scopus 로고    scopus 로고
    • Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P) H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi
    • Murta SM, Krieger MA, Montenegro LR, Campos FF, Probst CM, Avila AR, et al. Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P) H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi. Mol Biochem Parasitol. 2006;146:151-62.
    • (2006) Mol Biochem Parasitol. , vol.146 , pp. 151-162
    • Murta, S.M.1    Krieger, M.A.2    Montenegro, L.R.3    Campos, F.F.4    Probst, C.M.5    Avila, A.R.6
  • 19
    • 44649139139 scopus 로고    scopus 로고
    • Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole
    • Murta SM, Nogueira FB, dos Santos PF, Campos FF, Volpe C, Liarte DB, et al. Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Acta Trop. 2008;107:59-65.
    • (2008) Acta Trop. , vol.107 , pp. 59-65
    • Murta, S.M.1    Nogueira, F.B.2    dos Santos, P.F.3    Campos, F.F.4    Volpe, C.5    Liarte, D.B.6
  • 20
    • 33751423139 scopus 로고    scopus 로고
    • Increased expression of iron- containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole
    • Nogueira FB, Krieger MA, Nirde P, Goldenberg S, Romanha AJ, Murta SM. Increased expression of iron- containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole. Acta Trop. 2006;100:119-32.
    • (2006) Acta Trop. , vol.100 , pp. 119-132
    • Nogueira, F.B.1    Krieger, M.A.2    Nirde, P.3    Goldenberg, S.4    Romanha, A.J.5    Murta, S.M.6
  • 21
    • 65549139721 scopus 로고    scopus 로고
    • Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole
    • Nogueira FB, Ruiz JC, Robello C, Romanha AJ, Murta SM. Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Parasitol Res. 2009;104:835-44.
    • (2009) Parasitol Res. , vol.104 , pp. 835-844
    • Nogueira, F.B.1    Ruiz, J.C.2    Robello, C.3    Romanha, A.J.4    Murta, S.M.5
  • 22
    • 7444247888 scopus 로고    scopus 로고
    • Lack of correlation between in vitro susceptibility to benznidazole and phylogenetic diversity of Trypanosoma cruzi, the agent of Chagas disease
    • Villarreal D, Barnabe C, Sereno D, Tibayrenc M. Lack of correlation between in vitro susceptibility to benznidazole and phylogenetic diversity of Trypanosoma cruzi, the agent of Chagas disease. Exp Parasitol. 2004;108:24-31.
    • (2004) Exp Parasitol. , vol.108 , pp. 24-31
    • Villarreal, D.1    Barnabe, C.2    Sereno, D.3    Tibayrenc, M.4
  • 23
    • 17344379918 scopus 로고    scopus 로고
    • Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
    • Murta SM, Gazzinelli RT, Brener Z, Romanha AJ. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol Biochem Parasitol. 1998;93:203-14.
    • (1998) Mol Biochem Parasitol. , vol.93 , pp. 203-214
    • Murta, S.M.1    Gazzinelli, R.T.2    Brener, Z.3    Romanha, A.J.4
  • 24
    • 70449603346 scopus 로고    scopus 로고
    • Rapid negativization of serology after treatment with benznidazole for Chagas disease in a group of Colombian schoolchildren
    • Proceedings of the IX European Multicolloquim of Parasitology. Valencia: Medimond International Proceedings;
    • Guhl F, Nicholls R, Montoya R, Rosas F, Velasco V, Mora E, et al. Rapid negativization of serology after treatment with benznidazole for Chagas disease in a group of Colombian schoolchildren. Proceedings of the IX European Multicolloquim of Parasitology. Valencia: Medimond International Proceedings; 2004. p. 107-14.
    • (2004) , pp. 107-114
    • Guhl, F.1    Nicholls, R.2    Montoya, R.3    Rosas, F.4    Velasco, V.5    Mora, E.6
  • 25
    • 34547913653 scopus 로고    scopus 로고
    • Primer Taller Internacional Sobre Control de la Enfermedad de Chagas, Curso de diagnóstico, manejo y tratamiento de la enfermedad de Chagas, VI Reunión de la Iniciativa Andina para el Control de la Enfermedad de Chagas, Bogotá: CIMPAT
    • Padilla J. Situación de la enfermedad de Chagas en Colombia. Primer Taller Internacional Sobre Control de la Enfermedad de Chagas, Curso de diagnóstico, manejo y tratamiento de la enfermedad de Chagas, VI Reunión de la Iniciativa Andina para el Control de la Enfermedad de Chagas. Bogotá: CIMPAT; 2005. p. 19-22.
    • (2005) Situación de la enfermedad de Chagas en Colombia , pp. 19-22
    • Padilla, J.1
  • 26
    • 19444373108 scopus 로고    scopus 로고
    • Estado del arte de la enfermedad de Chagas en Colombia y estrategias de control
    • Guhl F, Angulo V, Restrepo M, Nicholls S, Montoya R. Estado del arte de la enfermedad de Chagas en Colombia y estrategias de control. Biomédica. 2003;23:31-3.
    • (2003) Biomédica. , vol.23 , pp. 31-33
    • Guhl, F.1    Angulo, V.2    Restrepo, M.3    Nicholls, S.4    Montoya, R.5
  • 27
    • 0036844185 scopus 로고    scopus 로고
    • Use of coefficient of variation in assessing variability of quantitative assays
    • Reed GF, Lynn F, Meade BD. Use of coefficient of variation in assessing variability of quantitative assays. Clin Diagn Lab Immunol. 2002;9:1235-9.
    • (2002) Clin Diagn Lab Immunol. , vol.9 , pp. 1235-1239
    • Reed, G.F.1    Lynn, F.2    Meade, B.D.3
  • 29
    • 0142227145 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: Controversies and advances
    • Urbina JA, Docampo R. Specific chemotherapy of Chagas disease: Controversies and advances. Trends Parasitol. 2003;19:495-501.
    • (2003) Trends Parasitol. , vol.19 , pp. 495-501
    • Urbina, J.A.1    Docampo, R.2
  • 30
    • 78349274397 scopus 로고    scopus 로고
    • Advances in Chagas disease drug development: 2009-2010
    • Buckner FS, Navabi N. Advances in Chagas disease drug development: 2009-2010. Curr Opin Infect Dis. 2010; 23:609-16.
    • (2010) Curr Opin Infect Dis. , vol.23 , pp. 609-616
    • Buckner, F.S.1    Navabi, N.2
  • 31
    • 70349777315 scopus 로고    scopus 로고
    • Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies
    • Boiani M, Boiani L, Merlino A, Hernández P, Chidichimo A, Cazzulo JJ, et al. Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies. Eur J Med Chem. 2009;44:4426-33.
    • (2009) Eur J Med Chem. , vol.44 , pp. 4426-4433
    • Boiani, M.1    Boiani, L.2    Merlino, A.3    Hernández, P.4    Chidichimo, A.5    Cazzulo, J.J.6
  • 32
    • 77951623379 scopus 로고    scopus 로고
    • Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?
    • Boiani M, Piacenza L, Hernández P, Boiani L, Cerecetto H, González M, et al. Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved? Biochem Pharmacol. 2010;79:1736-45.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1736-1745
    • Boiani, M.1    Piacenza, L.2    Hernández, P.3    Boiani, L.4    Cerecetto, H.5    González, M.6
  • 33
    • 70449685724 scopus 로고    scopus 로고
    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer- supported triphenylphosphine, biological evaluation and mechanism of action studies
    • Castro D, Boiani L, Benítez D, Hernández P, Merlino A, Gil C, et al. Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer- supported triphenylphosphine, biological evaluation and mechanism of action studies. Eur J Med Chem. 2009;44:5055-65.
    • (2009) Eur J Med Chem. , vol.44 , pp. 5055-5565
    • Castro, D.1    Boiani, L.2    Benítez, D.3    Hernández, P.4    Merlino, A.5    Gil, C.6
  • 34
    • 73949135846 scopus 로고    scopus 로고
    • 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
    • Gerpe A, Álvarez G, Benítez D, Boiani L, Quiroga M, Hernández P, et al. 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Bioorg Med Chem. 2009;17:7500-9.
    • (2009) Bioorg Med Chem. , vol.17 , pp. 7500-7509
    • Gerpe, A.1    Álvarez, G.2    Benítez, D.3    Boiani, L.4    Quiroga, M.5    Hernández, P.6
  • 36
    • 70450242912 scopus 로고    scopus 로고
    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones
    • Pagano M, Demoro B, Toloza J, Boiani L, González M, Cerecetto H, et al. Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones. Eur J Med Chem. 2009;44:4937-43.
    • (2009) Eur J Med Chem. , vol.44 , pp. 4937-4943
    • Pagano, M.1    Demoro, B.2    Toloza, J.3    Boiani, L.4    González, M.5    Cerecetto, H.6
  • 37
    • 71849091591 scopus 로고    scopus 로고
    • New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies
    • Rodríguez J, Arán VJ, Boiani L, Olea-Azar C, Lavaggi ML, González M, et al. New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies. Bioorg Med Chem. 2009;17:8186-96.
    • (2009) Bioorg Med Chem. , vol.17 , pp. 8186-8196
    • Rodríguez, J.1    Arán, V.J.2    Boiani, L.3    Olea-Azar, C.4    Lavaggi, M.L.5    González, M.6
  • 38
    • 77953082627 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches
    • Urbina JA. Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches. Acta Trop. 2010;115:55-68.
    • (2010) Acta Trop. , vol.115 , pp. 55-68
    • Urbina, J.A.1
  • 41
    • 77149159732 scopus 로고    scopus 로고
    • Exploiting the drug- activating properties of a novel trypanosomal nitroreductase
    • Hall BS, Wu X, Hu L, Wilkinson SR. Exploiting the drug- activating properties of a novel trypanosomal nitroreductase. Antimicrob Agents Chemother. 2010;54:1193-9.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 1193-1199
    • Hall, B.S.1    Wu, X.2    Hu, L.3    Wilkinson, S.R.4
  • 42
    • 79953882988 scopus 로고    scopus 로고
    • Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites
    • Hall BS, Bot C, Wilkinson SR. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J Biol Chem. 2011;286:13088-95.
    • (2011) J Biol Chem. , vol.286 , pp. 13088-13095
    • Hall, B.S.1    Bot, C.2    Wilkinson, S.R.3
  • 44
    • 0035487918 scopus 로고    scopus 로고
    • Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains
    • Veloso VM, Carneiro CM, Toledo MJ, Lana M, Chiari E, Tafuri WL, et al. Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains. Mem Inst Oswaldo Cruz. 2001;96:1005-11.
    • (2001) Mem Inst Oswaldo Cruz. , vol.96 , pp. 1005-1011
    • Veloso, V.M.1    Carneiro, C.M.2    Toledo, M.J.3    Lana, M.4    Chiari, E.5    Tafuri, W.L.6
  • 45
    • 0038538181 scopus 로고    scopus 로고
    • Trypanosoma cruzi: Susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain
    • Camandaroba EL, Reis EA, Goncalves MS, Reis MG, Andrade SG. Trypanosoma cruzi: Susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain. Rev Soc Bras Med Trop. 2003;36:201-9.
    • (2003) Rev Soc Bras Med Trop. , vol.36 , pp. 201-209
    • Camandaroba, E.L.1    Reis, E.A.2    Goncalves, M.S.3    Reis, M.G.4    Andrade, S.G.5
  • 46
    • 57049188442 scopus 로고    scopus 로고
    • Caracterización genética y sensibilidad al benzonidazole de cepas colombianas de Trypanosoma cruzi
    • Triana O, Mejía A, Zapata C, Arboleda A, Dib J. Caracterización genética y sensibilidad al benzonidazole de cepas colombianas de Trypanosoma cruzi. Biomédica. 2005;25:82-5.
    • (2005) Biomédica. , vol.25 , pp. 82-85
    • Triana, O.1    Mejía, A.2    Zapata, C.3    Arboleda, A.4    Dib, J.5
  • 47
    • 77954212702 scopus 로고    scopus 로고
    • In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole
    • Luna KP, Hernández IP, Rueda CM, Zorro MM, Croft SL, Escobar P. In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. Biomédica. 2009;29:448-55.
    • (2009) Biomédica. , vol.29 , pp. 448-455
    • Luna, K.P.1    Hernández, I.P.2    Rueda, C.M.3    Zorro, M.M.4    Croft, S.L.5    Escobar, P.6
  • 48
    • 0031984626 scopus 로고    scopus 로고
    • In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole
    • Murta SM, Romanha AJ. In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole. Parasitol. 1998;116:165-71.
    • (1998) Parasitol. , vol.116 , pp. 165-171
    • Murta, S.M.1    Romanha, A.J.2
  • 49
    • 78649290123 scopus 로고    scopus 로고
    • Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease
    • Moreno M, D'ávila DA, Silva MN, Galvão LM, Macedo AM, Chiari E, et al. Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease. Mem Inst Oswaldo Cruz. 2010;105:918-24.
    • (2010) Mem Inst Oswaldo Cruz. , vol.105 , pp. 918-924
    • Moreno, M.1    D'ávila, D.A.2    Silva, M.N.3    Galvão, L.M.4    Macedo, A.M.5    Chiari, E.6
  • 50
    • 0342636508 scopus 로고
    • Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure
    • Tibayrenc M, Ward P, Moya A, Ayala FJ. Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure. Proc Natl Acad Sci USA. 1986;83:115-9.
    • (1986) Proc Natl Acad Sci USA. , vol.83 , pp. 115-119
    • Tibayrenc, M.1    Ward, P.2    Moya, A.3    Ayala, F.J.4
  • 51
    • 1642444868 scopus 로고    scopus 로고
    • Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease
    • Macedo AM, Machado CR, Oliveira RP, Pena SD. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease. Mem Inst Oswaldo Cruz. 2004;99:1-12.
    • (2004) Mem Inst Oswaldo Cruz. , vol.99 , pp. 1-12
    • Macedo, A.M.1    Machado, C.R.2    Oliveira, R.P.3    Pena, S.D.4
  • 52
    • 0028822932 scopus 로고
    • New mechanism of drug resistance in parasitic protozoa
    • Borst P, Oullette M. New mechanism of drug resistance in parasitic protozoa. Annu Rev Microbiol. 1995;49:427-60.
    • (1995) Annu Rev Microbiol. , vol.49 , pp. 427-460
    • Borst, P.1    Oullette, M.2
  • 53
    • 20944442198 scopus 로고    scopus 로고
    • Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes
    • El Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, et al. Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes. Antimicrob Agents Chemother. 2005;49:1988-93.
    • (2005) Antimicrob Agents Chemother. , vol.49 , pp. 1988-1993
    • El Fadili, K.1    Messier, N.2    Leprohon, P.3    Roy, G.4    Guimond, C.5    Trudel, N.6
  • 55
    • 0035710254 scopus 로고    scopus 로고
    • Gene amplification in amphotericin B-resistant Leishmania tarentolae
    • Singh AK, Papadopoulou B, Ouellette M. Gene amplification in amphotericin B-resistant Leishmania tarentolae. Exp Parasitol. 2001;99:141-7.
    • (2001) Exp Parasitol. , vol.99 , pp. 141-147
    • Singh, A.K.1    Papadopoulou, B.2    Ouellette, M.3


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